Figures and data
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Training induced plasticity of hippocampal subfield volume.
A) Training modules; B) Training design; C) Subfield volumes in left and right hemispheres across individuals and timepoints; D) Scatterplot of subfield volumes as a function of timepoints and groups.
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Changes in mean hippocampal subfield functional network between training and active control cohorts [T0-T1] and [T1-T3]
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Correlating change in subfield volume and diurnal cortisol indices in Affect.
![](https://prod--epp.elifesciences.org/iiif/2/87634%2Fv1%2Fcontent%2F531039v1_tbl3.tif/full/max/0/default.jpg)
Correlating change in subfield functional network and diurnal cortisol indices in Affect.
![](https://prod--epp.elifesciences.org/iiif/2/87634%2Fv1%2Fcontent%2F531039v1_fig2.tif/full/max/0/default.jpg)
Training induced plasticity of CA1-3 functional connectivity.
A) upper: CA1-3 functional connectivity at baseline, top 10% of regions representing the CA1-3 functional network; lower: scatter plot visualizing change within the CA1-3 network across timepoints and groups; networks and scatters of SUB and CA4/DG are available in the supplements; B) Regional change within CA1-3 functional network Affect versus Perspective (FDRq<0.05); right: scatter plot visualizing mean change within the CA1-3, FDRq<0.05 regions across timepoints and groups.
![](https://prod--epp.elifesciences.org/iiif/2/87634%2Fv1%2Fcontent%2F531039v1_fig3.tif/full/max/0/default.jpg)
Associations between changes in structure and function of hippocampal subfield volume and markers of stress change in Affect.
A). Upper left: Correlation between hippocampal subfield volume change in Affect and CAR, slope, and AUC markers of stress change, Upper right: Correlation between hippocampal subfield intrinsic functional change in Affect and CAR, slope, and AUC markers of stress change, middle: Scatter plots visualize the correlation between volume change and cortisol marker change (below p<0.05), bottom: region level change within left CA1-3, FDRq<0.05; B). Upper: Overall impact of diurnal cortisol markers on hippocampal subfield volume and function over Presence, Affect and Perspective; Lower: Overall impact of hair cortisol markers on hippocampal subfield volume and function over Presence, Affect and Perspective
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Sample size per timepoint.
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Reason for missing data across the study duration.
MR incidental findings are based on T0 radiological evaluations; participants who did not meet MRI quality control criteria refers to movement and/or artefacts in the T1-weighted MRI; dropout details can be found in (69); no MRT: due to illness / scheduling issues / discomfort in scanner; other: non-disclosed; functional MRI missing: no complete functional MRI; functional MRI quality: >0.3mm movement (low quality in volume + surface)
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Reason for missing data across the study duration.
MR incidental findings are based on T0 radiological evaluations; participants who did not survive MRI quality control refers to movement and/or artefacts in the T1-weighted MRI; dropout details can be found in (69); no MRT: due to illness / scheduling issues / discomfort in scanner; other: non-disclosed.
![](https://prod--epp.elifesciences.org/iiif/2/87634%2Fv1%2Fcontent%2F531039v1_tbls1.tif/full/max/0/default.jpg)
Descriptive statistics T0-T1
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![](https://prod--epp.elifesciences.org/iiif/2/87634%2Fv1%2Fcontent%2F531039v1_tbls2a.tif/full/max/0/default.jpg)
Descriptive statistics T1-T3
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T0-T1 change statistics
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T1-T3 change statistics
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T1-T3 change statistics – Training cohort 1 and 2 Affect versus Perspective
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T1-T2 change
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T2-T3 change
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Overall change in subfield volume.
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Descriptive statistics mean subfield functional network change T0-T1
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Descriptive statistics mean subfield functional network change T1-T3
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Functional connectivity network change T0-T1
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Functional connectivity network change T1-T3
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Functional connectivity network change T1-T3: Training cohort 1 and 2 Affect versus Perspective
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Functional connectivity network change T1-T2
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Functional connectivity network change T2-T3
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Association between stress-markers and within functional network sub-regions.
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Overall effects of cortisol markers on hippocampal volume in Presence, Affect, and Perspective.
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Overall effects of cortisol markers on hippocampal function in Presence, Affect, and Perspective.
![](https://prod--epp.elifesciences.org/iiif/2/87634%2Fv1%2Fcontent%2F531039v1_tbls18.tif/full/max/0/default.jpg)
Effects of hair cortisol markers on hippocampal subfield volume in Presence, Affect, and Perspective (cortisol (HC) and cortisone (HE))
![](https://prod--epp.elifesciences.org/iiif/2/87634%2Fv1%2Fcontent%2F531039v1_tbls19.tif/full/max/0/default.jpg)
Effects of hair cortisol markers on hippocampal subfield function in Presence, Affect, and Perspective (cortisol (HC) and cortisone (HE))
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Mean change in functional network of subiculum and CA4/DG.