Training induced plasticity of hippocampal subfield volume.

A) Training modules; B) Training design; C) Subfield volumes in left and right hemispheres across individuals and timepoints; D) Scatterplot of subfield volumes as a function of timepoints and groups.

Changes in mean hippocampal subfield functional network between training and active control cohorts [T0-T1] and [T1-T3]

Correlating change in subfield volume and diurnal cortisol indices in Affect.

Correlating change in subfield functional network and diurnal cortisol indices in Affect.

Training induced plasticity of CA1-3 functional connectivity.

A) upper: CA1-3 functional connectivity at baseline, top 10% of regions representing the CA1-3 functional network; lower: scatter plot visualizing change within the CA1-3 network across timepoints and groups; networks and scatters of SUB and CA4/DG are available in the supplements; B) Regional change within CA1-3 functional network Affect versus Perspective (FDRq<0.05); right: scatter plot visualizing mean change within the CA1-3, FDRq<0.05 regions across timepoints and groups.

Associations between changes in structure and function of hippocampal subfield volume and markers of stress change in Affect.

A). Upper left: Correlation between hippocampal subfield volume change in Affect and CAR, slope, and AUC markers of stress change, Upper right: Correlation between hippocampal subfield intrinsic functional change in Affect and CAR, slope, and AUC markers of stress change, middle: Scatter plots visualize the correlation between volume change and cortisol marker change (below p<0.05), bottom: region level change within left CA1-3, FDRq<0.05; B). Upper: Overall impact of diurnal cortisol markers on hippocampal subfield volume and function over Presence, Affect and Perspective; Lower: Overall impact of hair cortisol markers on hippocampal subfield volume and function over Presence, Affect and Perspective

Sample size per timepoint.

Reason for missing data across the study duration.

MR incidental findings are based on T0 radiological evaluations; participants who did not meet MRI quality control criteria refers to movement and/or artefacts in the T1-weighted MRI; dropout details can be found in (69); no MRT: due to illness / scheduling issues / discomfort in scanner; other: non-disclosed; functional MRI missing: no complete functional MRI; functional MRI quality: >0.3mm movement (low quality in volume + surface)

Reason for missing data across the study duration.

MR incidental findings are based on T0 radiological evaluations; participants who did not survive MRI quality control refers to movement and/or artefacts in the T1-weighted MRI; dropout details can be found in (69); no MRT: due to illness / scheduling issues / discomfort in scanner; other: non-disclosed.

Descriptive statistics T0-T1

Descriptive statistics T1-T3

T0-T1 change statistics

T1-T3 change statistics

T1-T3 change statistics – Training cohort 1 and 2 Affect versus Perspective

T1-T2 change

T2-T3 change

Overall change in subfield volume.

Descriptive statistics mean subfield functional network change T0-T1

Descriptive statistics mean subfield functional network change T1-T3

Functional connectivity network change T0-T1

Functional connectivity network change T1-T3

Functional connectivity network change T1-T3: Training cohort 1 and 2 Affect versus Perspective

Functional connectivity network change T1-T2

Functional connectivity network change T2-T3

Association between stress-markers and within functional network sub-regions.

Overall effects of cortisol markers on hippocampal volume in Presence, Affect, and Perspective.

Overall effects of cortisol markers on hippocampal function in Presence, Affect, and Perspective.

Effects of hair cortisol markers on hippocampal subfield volume in Presence, Affect, and Perspective (cortisol (HC) and cortisone (HE))

Effects of hair cortisol markers on hippocampal subfield function in Presence, Affect, and Perspective (cortisol (HC) and cortisone (HE))

Mean change in functional network of subiculum and CA4/DG.