Figures and data
Schematic of the proposed SAPHIRE neurocognitive architecture
Below, specialised modules characterised by robust redundant functional interactions process information about the environment. Information is then collected by workspace gateways through synergistic interactions [Stage (i)]; synergistic interactions integrate information within the synergistic global workspace [Stage (ii)]; workspace broadcasters spread the integrated information back to the specialised modules, through redundant interactions [Stage (iii)], for further processing and to guide behaviour. Orange links represent redundant interactions, and violet links represent synergistic interactions. Grey arrows represent interactions between the system and its environment.
Gateways and broadcaster regions identified by their network connectivity profiles
(A) Group-average matrix of synergistic interactions between regions of the 454-ROI augmented Schaefer atlas. (B) Group-average matrix of redundant interactions. For ease of visualization, the colorscale in (B) pertains to log-transformed values. We highlighted modular allegiance to the canonical resting-state networks by using the colour scheme shown in between A and B. (C) Regions are identified as gateways (violet) or broadcasters (orange) based on the difference between rank of participation coefficient for synergy and redundancy, (only shown for brain regions identified as belonging to the synergistic global workspace, as per Luppi et al., 2022). Violet indicates synergy rank > redundancy rank, corresponding to workspace regions that combine information of many brain modules (gateways); orange indicates the opposite, identifying workspace regions that broadcast information to many modules. Inset: illustration of the synergistic workspace. Legend: DMN, default mode network. Som, somatomotor network. Vis, visual network. VAN, ventral attention network. DAN, dorsal attention network. FPN, fronto-parietal control network. Lim, limbic network. Sub, subcortical network (comprised of 54 regions of the Tian 2020 atlas 64). These results were also replicated using an alternative parcellation with 232 cortical and subcortical nodes (Figure S3).
Integrated information decomposition
Integrated information decomposition identifies how two sources X and Y jointly convey information across time, corresponding to all possible 4×4 combinations of redundancy, unique information (of X and of Y), and synergistic information. This decomposition highlights why the original whole-minus-sum Φ measure introduced by Balduzzi and Tononi can be negative: because it involves the subtraction of the persistent redundancy that is present in the system, leading to negative values in systems that are redundancy-dominated. This shortcoming can be corrected with the revised measure of Φ, termed ΦR.
Loss of consciousness induces similar reorganisation of cortical integrated information across anaesthesia and disorders of consciousness
Top: Brain regions exhibiting overall NBS-corrected increases (red) and decreases (blue) in integrated information exchange when consciousness is lost. (A) DOC patients minus awake healthy volunteers; (B), propofol anaesthesia minus pre-induction wakefulness; (C) propofol-anaesthesia minus post-anaesthetic recovery. (D) Overlaps between the three contrasts in (A-C), showing increases and decreases that are common across anaesthesia and disorders of consciousness.
Synergistic core of human consciousness
(A) Surface representations of medial and lateral views of the brain (L indicates left, R indicates right). Colours indicate brain regions that belong to the synergistic workspace, as identified from HCP data. Orange indicates broadcasters, and violet indicates gateways. Blue indicates regions that exhibit an overall significant reduction in integrated information across anaesthesia and disorders of consciousness. All blue regions overlap with violet ones. The network representation indicates edges with significantly reduced integrated information (ΦR) during both propofol anaesthesia and disorders of consciousness. The color of the nodes (violet or orange) indicates whether the corresponding regions are workspace gateways (violet) or broadcasters (orange); all regions are gateways (violet). (B) Circular graph representation of significant reductions in integrated information (ΦR) between brain regions, observed in all three contrasts, indicating membership of canonical resting-state networks. Connections indicate pairs of regions with a significant decrease of integrated information. Colour of the circle border indicates the RSN affiliation of the corresponding regions. Legend: DMN, default mode network. Som, somatomotor network. Vis, visual network. VAN, ventral attention network. DAN, dorsal attention network. FPN, fronto-parietal control network. Lim, limbic network. Sub, subcortical network (comprised of 54 regions of the Tian 2020 atlas).
