Overview of Study.

Shared and species-specific biological pathways.

Shared Networks between mice and humans.

(A) Vascular (B) Non-vascular. Red border diamonds represent recent CAD GWAS hits and pink border diamonds represent GWAS hits pre-CARDIOGRAM+C4D GWAS hits.

Species Specific Networks.

(A) Human Vascular (B) Human Non-vascular (C) Mouse Vascular (D) Mouse Non-vascular. Red border diamonds represent recent CAD GWAS hits and pink border diamonds represent GWAS hits pre-CARDIOGRAM+C4D GWAS hits.

In silico validation of KDs and their subnetwork genes and associated cell type.

(A-D) Aorta KDs and subnetwork genes. (E-H) Liver OIT3 and subnetwork genes. Five end genes are randomly selected genes. * indicate p<0.05