Data from empirical fitness landscapes can be used to compute two metrics: variant vulnerability (for allelic variants) and drug applicability (for drugs).
Growth of allelic variants, relative to control (wild-type), for seven drug treatments. Bars represent the mean value for each group; orange bars indicate significantly lower growth with respect to control (one-tailed t-test, P < 0.01), grey bars otherwise. The bars, from left to right, along the bottom correspond to the variant vulnerability of the variants. The bars along the right side, from top to bottom, describe the drug applicability the seven drugs analyzed in this study. Dashed lines correspond to the TEM-1 growth rate in the putative drug environment.