Evidence of grid-like activity aligned to putative grid orientation in the right orbitofrontal cortex and the right posterior-medial entorhinal cortex
(A) Theoretical prediction of grid-like activity (B-C) ROIs for deriving putative grid orientations: (B) right FP ROI from quadrature filter analysis showing sensitivity to hexagonal modulation. A 5-mm sphere was defined around the peak coordinate to compute grid angle. Display threshold: voxel-level p < 0.001, cluster-level p < 0.05 FWE-corrected. (C) Anatomically defined right pmEC ROI used to compute grid angle. (D-G) Grid like activity aligned to putative grid orientations in the right FP ROI (D-E) and right pmEC (F-G) ROI respectively. Left panels: clusters from whole-brain hexagonal consistency analysis. Color indicates T statistics as shown in the colorbar in B. Display threshold: voxel-level p < 0.005, cluster-level p < 0.05 FWE-corrected. Middle panels: hexagonal consistency effects plotted as contrast estimates of the 12 trial-bin regressors extracted from corresponding cluster in the left panel; To illustrate effect in EC in E, estimates were extracted from the intersection of the suprathreshold cluster and anatomical mask of EC. Right panels: such effects were specific to six-fold. Notes: n.s., p>0.05, * p<0.05, ** p<0.01, *** p<0.001. Abbreviations: FP, frontal pole; pmEC, posterior-medial entorhinal cortex; vmPFC, ventral medial prefrontal cortex; STP, superior temporal pole.