Figures and data
(a) Top: 192 gyral peak clusters of human on human brain template (Conte69, Van Essen et al. (2012b)). Middle: 85 gyral peak clusters of macaque on macaque brain template (Yerkes19, Van Essen et al. (2012a)). Bottom: The results of mapping macaque gyral peak clusters on the human brain template by the cross-species registration (Xu et al. (2020)). The same color of middle and bottom surface indicates the corresponding cluster. (b) Peak clusters shared by human and macaque (LH-25, RH-26). On the same hemisphere of the brain, the corresponding-colored regions on both human and macaque represent the corresponding shared peak clusters. In addition, the color of the left and right hemisphere clusters are not related. (c) Unique peak clusters of two species map on the surface of their respective template.
Location of shared peak clusters on human.
(a)-(b) Pie chart showing the count of shared peaks across different brain regions. (c)-(d) Pie chart showing the count of shared peaks across different brain regions. The left and right columns represent human and macaque, respectively. (e) The Cole-Anticevic (CA) networks (Ji et al. (2019)) for human. The colors of different regions on the surface correspond to the colors in the pie charts.
(a) Mean count covered by shared and unique peak clusters in two species. ***indicates p<0.001. (b) Linear regression results of the consistency of peak clusters shared between macaque and human brains. The pink and blue colors represent the left and right hemispheres, respectively.
Peak cluster extraction pipeline. The two rows represent the human brain and the macaque brain, respectively. (a) shows the locations of all extracted peaks in an individual. (b) Due to resampling of the human and macaque surface, there is a vertex-to-vertex correspondence between individuals. Therefore, all individual peaks were placed on the template brain surface and undergo isotropic smoothing, resulting in the count map shown in (b), where the highlighted regions indicate a higher frequency of peak occurrences across individuals. (c) shows the results of clustering the count map using watershed algorithm, resulting in peak clusters for both species. A total of 192 peak clusters were detected in the human brain, while 85 peak clusters were detected in the macaque brain.
Comparison of anatomical features of shared and unique gyral peaks of two species. The bold font is the one with the larger values of shared and unique peaks. *indicates p<0.05; **indicates p<0.01,***indicates p<0.001
Functional connectivity characteristics of shared and unique peak clusters of human and macaque. The bold font represent the larger values between the shared peak and unique peaks. *indicates p<0.05; **indicates p<0.01,***indicates p<0.001
The number of brain regions where shared and unique peaks appeared within a 3-ring neighborhood in 10 common human atlases. All the shared peaks in the table have a greater number of neighboring brain regions compared to the unique peaks. ***indicates p<0.001
The original form of AHBA data is region × gene. The accuracy and MSE line charts of the training set and testing set corresponding to lambda from 10−4 to 1. Purple and orange respectively represent the accuracy and mse obtained by 10-fold cross verification. The final lambda determined is 0.027, which can ensure the maximum accuracy and minimum MSE at the same time.
Parameter selection of gyral peaks detection in human and macaque.
The location of human peak clusters.
The location of macaque peak cluster.
(a)-(b) Pie chart showing the normalized count of shared peaks across different brain regions. (c)-(d) Pie chart showing the normalized count of unique peaks across different brain regions. The left and right columns represent human and macaque, respectively. (e) The Cole-Anticevic (CA) networks (Ji et al. (2019)) for human. The colors of different regions on the surface correspond to the colors in the pie charts.
(a) Location of shared peaks. (b) Confidence of shared peak clusters defined by the coincidence rate of clusters between human and macaque. (c) Confidence of shared peak clusters defined by the distance of cluster centers between human and macaque.
