Abstract
Recent work has uncovered relationships between evolutionarily new small and shallow cerebral indentations, or sulci, and human behavior. Yet, this relationship remains unexplored in the lateral parietal cortex (LPC) and the lateral parieto-occipital junction (LPOJ). After defining thousands of sulci in a young adult cohort, we revised the previous LPC/LPOJ sulcal landscape to include four previously overlooked, small, shallow, and variable sulci. One of these sulci (ventral supralateral occipital sulcus, slocs-v) is present in nearly every hemisphere and is morphologically, architecturally, and functionally dissociable from neighboring sulci. A data-driven, model-based approach, relating sulcal depth to behavior further revealed that the morphology of only a subset of LPC/LPOJ sulci, including the slocs-v, is related to performance on a spatial orientation task. Our findings build on classic neuroanatomical theories and identify new neuroanatomical targets for future “precision imaging” studies exploring the relationship among brain structure, brain function, and cognitive abilities in individual participants.
Introduction
A fundamental goal in psychology and neuroscience is to understand the complex relationship between brain structure and brain function, as well as how that relationship provides a scaffold for efficient cognition and behavior. Of all the neuroanatomical features to target, recent work shows that morphological features of the shallower, later developing, hominoid-specific indentations of the cerebral cortex (also known as putative tertiary sulci, PTS) are not only functionally and cognitively meaningful, but also are particularly impacted by multiple brain-related disorders and aging (Amiez et al., 2018, 2019; Ammons et al., 2021; Cachia et al., 2021; Fornito et al., 2004; Garrison et al., 2015; Harper et al., 2022; Lopez-Persem et al., 2019; Maboudian et al., 2024; Miller et al., 2021; Nakamura et al., 2020; Parker et al., 2023; Ramos Benitez et al., 2024; Voorhies et al., 2021; Weiner, 2019; Willbrand, Ferrer, et al., 2023; Willbrand, Parker, et al., 2022; Willbrand, Voorhies, et al., 2022; Yao et al., 2022). The combination of these findings provides growing support for a classic theory proposing that the late gestational emergence of these PTS in gestation within association cortices, as well as their prolonged development, may co-occur with specific functional and microstructural features that could support specific cognitive abilities that also have a protracted development (Sanides, 1964). Nevertheless, despite the developmental, evolutionary, functional, cognitive, and theoretical relevance of these findings, PTS have mainly been restricted to only a subset of association cortices such as the prefrontal, cingulate, and ventral occipitotemporal cortices (Amiez et al., 2018, 2019; Ammons et al., 2021; Cachia et al., 2021; Fornito et al., 2004; Garrison et al., 2015; Harper et al., 2022; Hathaway et al., 2023; Lopez-Persem et al., 2019; Miller et al., 2020, 2021; Nakamura et al., 2020; Parker et al., 2023; Voorhies et al., 2021; Weiner, 2019; Willbrand, Ferrer, et al., 2023; Willbrand, Maboudian, et al., 2023; Willbrand, Parker, et al., 2022; Willbrand, Voorhies, et al., 2022; Yao et al., 2022). Thus, examining the relationship among these PTS relative to architectonic and functional features of the cerebral cortex, as well as relative to cognition, remains uncharted in other association cortices such as the lateral parietal cortex (LPC).
As LPC is a cortical extent that has expanded extensively throughout evolution (Van Essen et al., 2018; Zilles et al., 2013), there is great interest in the structure and function of LPC in development, aging, across species, and in different patient populations. Yet, key gaps in knowledge relating individual differences in the structure of LPC to individual differences in the functional organization of LPC and cognitive performance remain for at least four main reasons. First, one line of recent work shows that LPC displays a much more complex sulcal patterning than previously thought (Drudik et al., 2023; Petrides, 2019; Segal & Petrides, 2012; Zlatkina & Petrides, 2014), while a second line of work shows that LPC is tiled with many maps and discrete functional regions spanning modalities and functions such as vision, memory, attention, action, haptics, and multisensory integration in addition to theory of mind, cognitive control, and subdivisions of the default mode network (Goodale & Milner, 1992; Harvey et al., 2013, 2015; Humphreys & Tibon, 2023; Konen & Kastner, 2008; Mackey et al., 2017; Schurz et al., 2017). Second, a majority of the time, the two lines of work are conducted independently from one another and the majority of human neuroimaging studies of LPC implement group analyses on average brain templates—which causes LPC sulci to disappear (Fig. 1). Third, despite the recently identified complexity of LPC sulcal patterning, recent studies have also uncovered previously overlooked PTS in association cortices (for example, in the posterior cingulate cortex; (Willbrand, Maboudian, et al., 2023; Willbrand, Parker, et al., 2022). Thus, fourth, it is unknown if additional LPC PTS are waiting to be detailed and if so, could improve our understanding of the structural-functional organization of LPC with potential cognitive insights as in other association cortices. Critically, while such findings would have developmental, evolutionary, functional, cognitive, and theoretical implications for addressing novel questions in future studies, they would also have translational applications as sulci serve as biomarkers in neurodevelopmental disorders (Ammons et al., 2021; Cachia et al., 2021; Garrison et al., 2015; Nakamura et al., 2020) and “corridors” for neurosurgery (Tomaiuolo et al., 2022; Tomaiuolo & Giordano, 2016).
In the present study, we first manually defined LPC sulci in 144 young adult hemispheres using the most recent definitions of LPC sulci (Petrides, 2019). By manually labeling over 2,000 sulci, we detail four previously undescribed (Supplementary Methods and Supplementary Figs. 1-4 for historical details) sulci in the cortical expanse between the caudal branches of the superior temporal sulcus (cSTS) and two parts of the intraparietal sulcus (IPS)—a cortical expanse recently referenced as containing sensory “bridge” regions of the temporal-parietal-occipital junction (Glasser et al., 2016)—which we term the supralateral occipital sulci (ventral: slocs-v; dorsal: slocs-d) and posterior angular sulci (ventral: pAngs-d; dorsal: pAngs-d). We then utilized morphological (depth and surface area), architectural (gray matter thickness and myelination), and functional (resting-state functional connectivity) data available in each participant to assess whether the most common of these structures (slocs-v) was dissociable from surrounding sulci. Finally, we assessed whether the updated view of the LPC/LPOJ sulcal landscape provided cognitive insights using a model-based, data-driven approach (Voorhies et al., 2021) relating sulcal morphology to behavior on tasks known to activate regions within this cortical expanse [for example, reasoning and spatial orientation (Gur et al., 2000; Karnath, 1997; Vendetti & Bunge, 2014; Wendelken, 2014)].
Results
Four previously undefined small and shallow sulci in the lateral parieto-occipital junction (LPOJ)
In previous research in small sample sizes, neuroanatomists noticed shallow sulci in this cortical expanse (Supplementary Methods and Supplementary Figs. 1-4 for historical details). In the present study, we fully update this sulcal landscape considering these overlooked indentations. In addition to defining the 13 sulci previously described within the LPC/LPOJ, as well as the posterior superior temporal cortex (Methods) (Petrides, 2019) in individual participants, we could also identify as many as four small and shallow PTS situated within the LPC/LPOJ that were highly variable across individuals and uncharted until now (Supplementary Methods and Supplementary Figs. 1-4). Macroanatomically, we could identify two sulci between the cSTS3 and the IPS-PO/lTOS ventrally and two sulci between the cSTS2 and the pips/IPS dorsally. We focus our analyses on the slocs-v since it was identifiable in nearly every hemisphere.
Ventrally, we refer to these sulci as ventral (slocs-v; sulcus 6 in Fig. 1) and dorsal (slocs-d; sulcus 7 in Fig. 1) components of the supralateral occipital sulcus. The slocs-v, located between the posterior cSTS3 and lTOS, was present in 98.6% of hemispheres (left hemisphere: N = 71/72; right hemisphere: N = 71/72; Fig. 1). Conversely, the more variable slocs-d, located between the cSTS3 and IPS-PO, was present 68.0% of the time (left hemisphere: N = 50/72; right hemisphere: N = 48/72; Fig. 1). Dorsally, we refer to the other newly described sulci as the ventral (pAngs-v; sulcus 8 in Fig. 1) and dorsal (pAngs-d; sulcus 9 in Fig. 1) components of the posterior angular sulcus. The pAng components were more rare than the slocs components. Specifically, pAngs-v, located between cSTS2 and pips, was identifiable 31.3% of the time (19 left and 26 right hemispheres; Fig. 1). Located between cSTS2 and the IPS, pAngs-d was identifiable only 13.2% of the time (8 left and 11 right hemispheres; Fig. 1). These incidence rates were significantly different (GLM, main effect of sulcus: χ2(3)L=L166.53, p < .0001; no hemispheric effects: ps > .68). The slocs-v was more common than the other three sulci (ps < .0001), slocs-d was more common than the pAngs components (ps < .0001), and pAngs-v was more common than pAngs-d (p = .002).
Beyond characterizing the incidence of sulci, it is also common in the neuroanatomical literature to qualitatively characterize sulci on the basis of fractionation and intersection with surrounding sulci (termed “sulcal types”; for examples in other cortical expanses, see (Chiavaras & Petrides, 2000; Drudik et al., 2023; Miller et al., 2021; Paus et al., 1996; Weiner et al., 2014; Willbrand, Parker, et al., 2022). All four sulci most commonly did not intersect with other sulci (see Supplementary Tables 1-4 for a summary of the sulcal types of the slocs and pAngs dorsal and ventral components). The sulcal types were also highly comparable between hemispheres (rs > .99, ps < .001). Though we characterize these sulci in this paper for the first time, the location of these four sulci is consistent with the presence of variable “accessory sulci” in this cortical expanse mentioned in prior modern and classic studies (Supplementary Methods). We could also identify these sulci in post-mortem hemispheres (Supplementary Figs. 2, 3), ensuring that these sulci were not an artifact of the cortical reconstruction process.
Given that sulcal incidence and patterning is also sometimes related to demographic features (Cachia et al., 2021; Leonard et al., 2009; Wei et al., 2017), subsequent GLMs relating the incidence and patterning of the three more variable sulci (slocs-d, pAngs-v, and pAngs-d) to demographic features (age and gender) revealed no associations for any sulcus (ps > .05). Finally, to help guide future research on these newly- and previously-classified LPC/LPOJ sulci, we generated probabilistic maps of each of these 17 sulci and share them with the field with the publication of this paper (Supplementary Fig. 6; Data availability).
The slocs-v is morphologically, architecturally, and functionally dissociable from nearby sulci
Given that the slocs-v was present in the majority of participants (98.6% across hemispheres) and the other three sulci were far more variable (<70% of hemispheres), we focused our analyses on this stable sulcal feature of the LPOJ. To do so, we first tested whether the slocs-v was morphologically (depth and surface area) and architecturally (gray matter thickness and myelination) distinct from the two sulci surrounding it: the cSTS3 and lTOS (Fig. 1). These metrics are provided for all 17 sulci in Supplementary Figure 7. An rm-ANOVA (within-participant factors: sulcus, metric, and hemisphere for standardized metric units) revealed a sulcus x metric interaction (F(4, 276.19) = 179.15, η2 = 0.38, p < .001). Post hoc tests showed four main differences: (i) the slocs-v was shallower than cSTS3 (p < .001) but not lTOS (p = .60), (ii) the slocs-v was smaller than both the cSTS3 and lTOS (ps < .001), (iii) the slocs-v showed thicker gray matter than both the cSTS3 and lTOS (ps < .001), and iv) the slocs-v was less myelinated than both the cSTS and lTOS (ps < .001; Fig. 2a). There was also a sulcus x metric x hemisphere interaction (F(4.20, 289.81) = 4.16, η2 = 0.01, p = .002; hemispheric effects discussed in Supplementary Results).
We then tested whether the slocs-v was also functionally distinct from the cSTS3 and lTOS by leveraging resting-state network parcellations for each individual participant to quantify “connectivity fingerprints” for each sulcus in each hemisphere of each participant (Methods) (Kong et al., 2019). An rm-ANOVA (within-participant factors: sulcus, network, and hemisphere for Dice coefficient overlap) revealed a sulcus x network interaction (F(32, 2144) = 80.18, η2 = 0.55, p < .001). Post hoc tests showed that this interaction was driven by four effects: (i) the cSTS3 overlapped more with the Default A subnetwork than both the slocs-v and lTOS (ps < .001), (ii) the slocs-v overlapped more with the Default C subnetwork than the lTOS (p < .001) and marginally than the cSTS3 (p = .077), (iii) the slocs-v overlapped more with the Dorsal Attention A subnetwork than both the cSTS3 and lTOS (ps < .001), and iv) the lTOS overlapped more with the Visual A and Visual B subnetworks than both the cSTS3 and slocs-v (ps < .004; Fig. 2b). There was also a sulcus x network x hemisphere interaction (F(32, 2144) = 3.99, η2 = 0.06, p < .001; hemispheric effects discussed in Supplementary Results). Together, these results indicate that the slocs-v is a morphologically, architecturally, and functionally distinct structure from its sulcal neighbors, and thus, deserves a distinct neuroanatomical definition.
We further found that the three caudal STS rami (Petrides, 2019; Segal & Petrides, 2012) and intermediate parietal sulci (aipsJ and pips) (Petrides, 2019; Zlatkina & Petrides, 2014) are morphologically, architecturally, and functionally distinct structures for the first time (to our knowledge), which empirically supports their distinctions with separate sulcal labels (Supplementary Results and Supplementary Fig. 8).
The morphology of LPC/LPOJ sulci, including the slocs-v, is related to cognitive performance
Finally, leveraging a data-driven approach of cross-validated LASSO feature selection, we sought to determine whether sulcal depth, a main defining feature of sulci, related to cognitive performance (Methods). To do so, we primarily focused on spatial orientation and reasoning given that these abilities recruit multiple subregions of lateral parietal and/or occipital cortices (Gur et al., 2000; Karnath, 1997; Vendetti & Bunge, 2014; Wendelken, 2014). As in prior work (Voorhies et al., 2021; Willbrand et al., 2024; Willbrand, Ferrer, et al., 2023; Willbrand, Voorhies, et al., 2022; Yao et al., 2022), we chose the model at the alpha that minimized MSEcv. Participants with a slocs-v in both hemispheres and all behavioral metrics were included (N = 69). Due to their rarity (being in less than 70% of hemispheres at most), we did not include the slocs-d or pAng components in this analysis.
This method revealed an association between spatial orientation scores and normalized sulcal depth in the left hemisphere (MSEcv = 25.63, alpha = 0.05; Fig. 3a), but not in the right hemisphere (MSEcv = 26.41, alpha = 0.3). Further, we found that no LPC/LPOJ sulci were selected for reasoning in either hemisphere (right: alpha = 0.3, MSE = 24.01; left: alpha = 0.3, MSE = 24.01). Six left hemisphere LPC/LPOJ sulci were related to spatial orientation task performance (Fig. 3a, b). Four of these sulci were positioned ventrally: cSTS3 (β = −9.77), slocs-v (β = −3.36), lTOS (β = −4.91), and mTOS (β = −0.06), whereas two were positioned dorsally: pips (β = 5.02), and SPS (β = 4.30; Fig. 3a, b). Using LooCV to construct models that predict behavior, the LASSO-selected model explained variation in spatial orientation score (R2cv = 0.06, MSEcv = 23.99) above and beyond a model with all left hemisphere sulci (R2 < 0.01, MSEcv = 27.12). This model also showed a moderate correspondence (rs = 0.29, p = .01; Fig. 3c) between predicted and actual measured scores. We then tested for anatomical and behavioral specificity using the AIC, which revealed two primary findings. First, we found that the LASSO-selected sulcal depth model outperformed a model using the cortical thickness of the six LASSO-selected sulci (R2cv < .01, MSEcv = 26.02, AICcortical thickness – AICsulcal depth = 2.19). This model also showed task specificity as these sulci outperformed a model with processing speed (R2cv < .01, MSEcv = 254.65, AICprocessing speed – AICspatial orientation = 63.57). Thus, our data-driven model explains a significant amount of variance on a spatial orientation task and shows behavioral and morphological specificity.
Discussion
Overview
In the present study, we examined the relationship between LPC/LPOJ sulcal morphology, functional connectivity fingerprints, and cognition. We report five main findings. First, while manually defining sulci in LPC/LPOJ across 144 hemispheres, we uncovered four small and shallow sulci that are not included in present or classic neuroanatomy atlases or neuroimaging software packages. Second, we found that the most common of these structures (the slocs-v; identifiable 98.6% of the time) was morphologically, architecturally, and functionally differentiable from nearby sulci. Third, using a model-based, data-driven approach quantifying the relationship between sulcal morphology and cognition, we found a relationship between the depths of six LPC/LPOJ sulci and performance on a spatial orientation processing task. Fourth, the model identified distinct dorsal and ventral sulcal networks in LPC/LPOJ: ventral sulci had negative weights while dorsal sulci had positive weights (Fig. 3b). These findings are consistent with previous neuroimaging work from Gur et al. (Gur et al., 2000) who demonstrated separate functional activations in dorsal parietal and the more ventrally situated occipital-parietal cortices for the judgment of line orientation task used in the present study. Fifth, the model identified that the slocs-v is cognitively relevant, further indicating the importance of this neuroanatomical structure. In the sections below, we discuss (i) the slocs-v relative to modern functional and cytoarchitectonic parcellations in the LPC/LPOJ, as well as anatomical connectivity to other parts of the brain, (ii) underlying anatomical mechanisms relating sulcal morphology and behavior more broadly, and (iii) limitations of the present study. Implications for future studies are distributed throughout each section.
The slocs-v relative to modern functional and cytoarchitectonic parcellations in the LPC/LPOJ, as well as anatomical connectivity to other parts of the brain
To lay the foundation for future studies relating the newly-described slocs-v to different anatomical and functional organizational features of LPC/LPOJ, we situate probabilistic predictions of slocs-v relative to probabilistic cortical areas identified using multiple modalities. For example, when examining the correspondence between the slocs-v and modern multimodal (HCP-MMP) (Glasser et al., 2016) and observer-independent cytoarchitectural (Julich-Brain atlas) (Amunts et al., 2020) areas (Methods), the slocs-v is located within distinct areas. In particular, the slocs-v aligns with the multimodally- and cytoarchitecturally-defined area PGp bilaterally and cytoarchitecturally-defined hIP4 in the right hemisphere (Fig. 4). In classic neuroanatomical terms (Cunningham, 1892), this indicates that the slocs-v is a putative “axial sulcus” for these regions, which future work can assess with analyses in individual participants.
Aside from recent multimodal and observer-independent cytoarchitectonic parcellations, an immediate question is: What is the relationship between the slocs-v and other functional regions at this junction between the occipital and parietal lobes, as well as potential anatomical connectivity? For example, there are over a dozen visual field maps in the cortical expanse spanning the TOS, IPS-PO, and the IPS proper (see (i), (ii), and (iii), respectively in Fig. 5a) (Mackey et al., 2017). When projecting probabilistic locations of retinotopic maps from over 50 individuals from Wang and colleagues (L. Wang et al., 2015) (Methods), the slocs-v is likely located outside of visual field maps extending into this cortical expanse (Fig. 5a). Nevertheless, when also projecting the map of the mean R2 metric from the HCP retinotopy dataset from 181 participants shared by Benson and colleagues (Benson et al., 2018) (Methods), the slocs-v is in a cortical expanse that explains a significant amount of variance (left hemisphere: R2 = 19.29, R2max = 41.73; right hemisphere: R2mean = 21.17, R2max = 44.23; Fig. 5b).
In terms of anatomical connectivity, as the slocs-v co-localizes with cytoarchitectonically defined PGp (Fig. 4) and previous studies have examined the anatomical connectivity of the probabilistically defined PGp, we can glean insight regarding the anatomical connectivity of slocs-v from these previous studies (Caspers et al., 2011; J. Wang et al., 2012). This prior work showed that PGp was anatomically connected to temporo-occipital regions, other regions in the temporal lobe, middle and superior frontal cortex, as well as the inferior frontal cortex and insula (Caspers et al., 2011; J. Wang et al., 2012). Furthermore, the slocs-v appears to lie at the junction of scene-perception and place-memory activity (a transition that also consistently co-localizes with the HCP-MMP area PGp) as identified by Steel and colleagues (Steel et al., 2021). Of course, the location of the slocs-v relative to multimodal, cytoarchitectonic, and retinotopic areas, as well as the anatomical connectivity of the slocs-v, would need to be examined in individual participants, but the present work makes clear predictions for future studies as fleshed out here. To conclude this section, as the multimodal area PGp (Fig. 4) was recently proposed as a “transitional area” by Glasser and colleagues (Glasser et al., 2016) (Supplementary Table 5), future studies can also further functionally and anatomically test the transitional properties of slocs-v.
Underlying anatomical mechanisms relating sulcal morphology and behavior
In this section, we discuss potential anatomical mechanisms contributing to the relationship between sulcal depth and behavior in two main ways. First, long-range white matter fibers have a gyral bias, while short-range white matter fibers have a sulcal bias in which some fibers project directly from the deepest points of a sulcus (Cottaar et al., 2021; Reveley et al., 2015; K. Schilling et al., 2018; K. G. Schilling et al., 2023; Van Essen et al., 2014). As such, recent work hypothesized a close link between sulcal depth and short-range white matter properties (Bodin et al., 2021; Pron et al., 2021; Voorhies et al., 2021; Willbrand, Ferrer, et al., 2023; Yao et al., 2022): deeper sulci would reflect even shorter short-range white matter fibers, which would result in faster communication between local, cortical regions and in turn, contribute to improved cognitive performance. This increased neural efficiency could underlie individual differences in cognitive performance. Ongoing work is testing this hypothesis which can be further explored in future studies incorporating anatomical, functional, and behavioral measures, as well as computational modeling.
Second, our model-based approach identified separate dorsal and ventral sulcal networks in which deeper sulci dorsally and shallower sulci ventrally contributed to the most explained variance on the spatial orientation task. A similar finding was identified by our previous work in the lateral prefrontal cortex (Yao et al., 2022). These previous and present findings may be explained by the classic anatomical compensation theory, which proposes that the size and depth of a sulcus counterbalance those of the neighboring sulci (Armstrong et al., 1995; Connolly, 1950; Zilles et al., 2013). Thus, a larger, deeper sulcus would be surrounded by sulci that are smaller and shallower, rendering the overall degree of cortical folding within a given region approximately equal (Armstrong et al., 1995; Connolly, 1950; Zilles et al., 2013). Future work can incorporate underlying white matter architecture into the compensation theory, as well as a recent modification that proposed to also incorporate local morphological features such as the deepest sulcal point (e.g., sulcal pit or sulcal root (Régis et al., 2005)), which has recently been shown to be related to different functional features of the cerebral cortex (Bodin et al., 2018; Leroy et al., 2015; Natu et al., 2021). Altogether, these and recent findings begin to build a multimodal mechanistic neuroanatomical understanding underlying the complex relationship between sulcal depth and cognition relative to other anatomical features.
Limitations
The main limitation of our study is that presently, the most accurate methodology to define sulci —especially the small, shallow, and variable PTS—requires researchers to manually trace each structure on the cortical surface reconstructions. This method is limited due to the individual variability of cortical sulcal patterning (Fig. 1, Supplementary Fig. 5), which makes it challenging to identify sulci without extensive experience and practice. However, we anticipate that our probabilistic maps will provide a starting point and hopefully, expedite the identification of these sulci in new participants. This should accelerate the process of subsequent studies confirming the accuracy of our updated schematic of LPC/LOPJ. This manual method is also arduous and time-consuming, which, on the one hand, limits the sample size in terms of number of participants, while on the other, results in thousands of precisely defined sulci. This push-pull relationship reflects a broader conversation in the human brain mapping and cognitive neuroscience fields between a balance of large N studies and “precision imaging” studies in individual participants (Allen et al., 2022; Gratton et al., 2022; Naselaris et al., 2021; Rosenberg & Finn, 2022). Though our sample size is comparable to other studies that produced reliable results relating sulcal morphology to brain function and cognition (e.g., (Cachia et al., 2021; Garrison et al., 2015; Lopez-Persem et al., 2019; Miller et al., 2021; Roell et al., 2021; Voorhies et al., 2021; Weiner, 2019; Willbrand, Parker, et al., 2022; Willbrand, Voorhies, et al., 2022; Yao et al., 2022), ongoing work that uses deep learning algorithms to automatically define sulci should result in much larger sample sizes in future studies (Borne et al., 2020; Lyu et al., 2021). The time-consuming manual definitions of primary, secondary, and PTS also limit the cortical expanse explored in each study, thus restricting the present study to LPC/LPOJ.
It is also worth noting that the morphological-behavioral relationship identified in the present study explains a modest amount of variance; however, the more important aspect of our findings is that multiple sulci identified in our model-based approach are recently-characterized sulci in LPC/LOPJ identified by our group and others (Petrides, 2019), and thus, the relationship would have been overlooked or lost if these sulci were not identified. Finally, although we did not focus on the relationship between the other three PTS (slocs-d, pAngs-v, and pAngs-d) to anatomical and functional features of LPC and cognition, given that variability in sulcal incidence is cognitively (Amiez et al., 2018; Cachia et al., 2021; Garrison et al., 2015; Willbrand et al., 2024; Willbrand, Voorhies, et al., 2022), anatomically (Amiez et al., 2021; Vogt et al., 1995), functionally (Lopez-Persem et al., 2019), and translationally (Clark et al., 2010; Le Provost et al., 2003; Meredith et al., 2012; Nakamura et al., 2020; Yücel et al., 2002, 2003) relevant, future work can also examine the relationship between the more variable slocs-d, pAngs-v, and pAngs-d and these features.
Conclusion
In conclusion, we uncovered four previously-undefined sulci in LPC/LPOJ and quantitatively showed that the slocs-v is a stable sulcal landmark that is morphologically, architecturally, and functionally differentiable from surrounding sulci. We further used a data-driven, model-based approach relating sulcal morphology to behavior, which identified different relationships of ventral and dorsal LPC/LPOJ sulcal networks contributing to the perception of spatial orientation. The model identified the slocs-v, further indicating the importance of this newly-described neuroanatomical structure. Altogether, this work provides a scaffolding for future “precision imaging” studies interested in understanding how anatomical and functional features of LPC/LPOJ relate to cognitive performance at the individual level.
Methods
Participants
Data for the young adult human cohort analyzed in the present study were from the Human Connectome Project (HCP) database (https://www.humanconnectome.org/study/hcp-young-adult/overview). Here, we used 72 randomly-selected participants, balanced for gender (following the terminology of the HCP data dictionary), from the HCP database (50% female, 22-36 years old, and 90% right-handed; there was no effect of handedness on our behavioral tasks; Supplementary Methods) that were also analyzed in several prior studies (Hathaway et al., 2023; Miller et al., 2020, 2021; Willbrand, Ferrer, et al., 2023; Willbrand, Maboudian, et al., 2023; Willbrand, Parker, et al., 2022). HCP consortium data were previously acquired using protocols approved by the Washington University Institutional Review Board (Mapping the Human Connectome: Structure, Function, and Heritability; IRB # 201204036). Informed consent was obtained from all participants.
Neuroimaging data acquisition
Anatomical T1-weighted (T1-w) MRI scans (0.8 mm voxel resolution) were obtained in native space from the HCP database. Reconstructions of the cortical surfaces of each participant were generated using FreeSurfer (v6.0.0), a software package used for processing and analyzing human brain MRI images (surfer.nmr.mgh.harvard.edu) (Dale et al., 1999; Fischl et al., 1999). All subsequent sulcal labeling and extraction of anatomical metrics were calculated from these native space reconstructions generated through the HCP’s version of the FreeSurfer pipeline (Glasser et al., 2013).
Behavioral data
In addition to structural and functional neuroimaging data, the HCP also includes a wide range of behavioral metrics from the NIH toolbox (Barch et al., 2013). To relate LPC/LPOJ sulcal morphology to behavior, we leveraged behavioral data related to spatial orientation (Variable Short Penn Line Orientation Test), relational reasoning (Penn Progressive Matrices Test), and processing speed (Pattern Completion Processing Speed Test; Supplementary Methods for task details). We selected these tasks as previous functional neuroimaging studies have shown the crucial role of LPC/LPOJ in relational reasoning and spatial orientation (Gur et al., 2000; Karnath, 1997; Vendetti & Bunge, 2014; Wendelken, 2014), while our previous work relating sulcal morphology to cognition uses processing speed performance as a control behavioral task (Voorhies et al., 2021; Willbrand, Voorhies, et al., 2022).
Anatomical analyses
Manual labeling of LPC sulci
Sulci were manually defined in 72 participants (144 hemispheres) guided by the most recent atlas by Petrides (Petrides, 2019), as well as recent empirical studies (Drudik et al., 2023; Segal & Petrides, 2012; Zlatkina & Petrides, 2014), which together offer a comprehensive definition of cerebral sulcal patterns, including PTS. For a historical analysis of sulci in this cortical expanse, please refer to Segal & Petrides (Segal & Petrides, 2012) and Zlatkina & Petrides (Zlatkina & Petrides, 2014). Our cortical expanse of interest was bounded by the following sulci and gyri: (i) the postcentral sulcus (PoCS) served as the anterior boundary, (ii) the superior temporal sulcus (STS) served as the inferior boundary, (iii) the superior parietal lobule (SPL) served as the superior boundary, and (iv) the medial and lateral transverse occipital sulci (mTOS and lTOS) served as the posterior boundary. We also considered the following sulci within this cortical expanse: the three different branches of the caudal superior temporal sulcus (posterior to anterior: cSTS3, 2, 1), the supramarginal sulcus (SmgS), posterior intermediate parietal sulcus (pips), sulcus of Brissaud (sB), anterior intermediate parietal sulcus of Jensen (aipsJ), paroccipital intraparietal sulcus (IPS-PO), intraparietal sulcus (IPS), and the superior parietal sulcus (SPS). Of note, the IPS-PO is the portion of the IPS extending ventrally into the occipital lobe. The IPS-PO was first identified as the paroccipital sulcus by Wilder (1886). There is often an annectant gyrus separating the horizontal portion of the IPS proper from the IPS-PO (Roell et al., 2021; Zlatkina & Petrides, 2014).
Additionally, we identified as many as four previously uncharted and variable LPC/LPOJ PTS for the first time: the supralateral occipital sulcus (slocs; composed of ventral (slocs-v) and dorsal (slocs-d) components) and the posterior angular sulcus (pAngs; composed of ventral (pAngs-v) and dorsal (pAngs-d) components). In the Supplementary Methods and Supplementary Figs. 1-4, we discuss the slocs and pAngs within the context of modern and historical sources.
For each participant in each hemisphere, the location of each sulcus was confirmed by first trained independent raters (Y.T. and T.G.), then confirmed by a trained expert (E.H.W.), and finally, finalized by a neuroanatomist (K.S.W.). All LPC sulci were then manually defined in FreeSurfer using tksurfer tools, as in previous work (Hathaway et al., 2023; Miller et al., 2020, 2021; Parker et al., 2023; Voorhies et al., 2021; Willbrand, Ferrer, et al., 2023; Willbrand, Maboudian, et al., 2023; Willbrand, Parker, et al., 2022; Willbrand, Voorhies, et al., 2022; Yao et al., 2022), from which morphological and anatomical features were extracted. We defined LPC/LPOJ sulci for each participant based on the most recent schematics of sulcal patterning by Petrides (2019) as well as pial, inflated, and smoothed white matter (smoothwm) FreeSurfer cortical surface reconstructions of each individual. In some cases, the precise start or end point of a sulcus can be difficult to determine on a surface (Borne et al., 2020); however, examining consensus across multiple surfaces allowed us to clearly determine each sulcal boundary in each individual. For four example hemispheres with these 13-17 sulci identified, see Fig. 1a (Supplementary Fig. 5 for all hemispheres). The specific criteria to identify the slocs and pAngs are outlined in Fig. 1b.
To test whether the incidence rates of the slocs and pAngs components were statistically different, we implemented a binomial logistic regression GLM with sulcus (slocs-v, slocs-d, pAngs-v, and pAngs-d) and hemisphere (left and right), as well as their interaction, as predictors for sulcal presence [0 (absent), 1 (present)]. Additional GLMs were run relating the incidence of the more variable sulci (slocs-d, pAngs-v, and pAngs-d) to demographic features (gender and age) were also run. GLMs were carried out with the glm function from the built-in stats R package. ANOVA χ2 tests were applied to each GLM with the Anova function from the car R package, from which results were reported.
Probability maps
Sulcal probability maps were generated to show the vertices with the highest alignment across participants for a given sulcus. To create these maps, the label file for each sulcus was transformed from the individual to the fsaverage surface with the FreeSurfer mri_label2label command (https://surfer.nmr.mgh.harvard.edu/fswiki/mri_label2label). Once each label was transformed into this common template space, we calculated the proportion of participants for which each vertex was labeled as the given sulcus with custom Python code (Miller et al., 2021; Voorhies et al., 2021). For vertices with overlap between sulci, we employed a “winner-take-all” approach such that the sulcus with the highest overlap across participants was assigned to that vertex. Alongside the thresholded maps, we also provide constrained maps [maximum probability maps (MPMs)] at 20% participant overlap to increase interpretability (20% MPMs shown in Supplementary Fig. 6). To aid future studies interested in investigating LPC/LPOJ sulci, we share these maps with the field (Data availability).
Extracting and comparing the morphological and architectural features from sulcal labels
Morphologically, we compared sulcal depth and surface area across sulci, as these are two of the primary morphological features used to define and characterize sulci (Armstrong et al., 1995; Chi et al., 1977; Leroy et al., 2015; Lopez-Persem et al., 2019; Miller et al., 2020, 2021; Natu et al., 2021; Sanides, 1964; Voorhies et al., 2021; Weiner, 2019; Welker, 1990; Willbrand, Ferrer, et al., 2023; Willbrand, Parker, et al., 2022; Yao et al., 2022). As in our prior work (Voorhies et al., 2021; Yao et al., 2022), mean sulcal depth values (in standard FreeSurfer units) were computed in native space from the .sulc file generated in FreeSurfer (Dale et al., 1999) with custom Python code (Voorhies et al., 2021). Briefly, depth values are calculated based on how far removed a vertex is from what is referred to as a “mid-surface,” which is determined computationally so that the mean of the displacements around this “mid-surface” is zero. Thus, generally, gyri have negative values, while sulci have positive values. Each depth value was also normalized by the deepest point in the given hemisphere. Surface area (mm2) was calculated with the FreeSurfer mris_anatomical_stats function (https://surfer.nmr.mgh.harvard.edu/fswiki/mris_anatomical_stats). The morphological features of all LPC/LPOJ sulci are documented in Supplementary Fig. 7.
Architecturally, we compared cortical thickness and myelination, as in our prior work in other cortical expanses (Miller et al., 2021; Voorhies et al., 2021; Willbrand, Ferrer, et al., 2023; Willbrand, Parker, et al., 2022). Mean gray matter cortical thickness (mm) was extracted using the FreeSurfer mris_anatomical_stats function. To quantify myelin content, we used the T1-w/T2-w maps for each hemisphere, an in vivo myelination proxy (Glasser & Van Essen, 2011). To generate the T1-w/T2-w maps, two T1-w and T2-w structural MR scans from each participant were registered together and averaged as part of the HCP processing pipeline (Glasser et al., 2013). The averaging helps to reduce motion-related effects or blurring. Additionally, and as described by Glasser and colleagues (Glasser et al., 2013), the T1-w/T2-w images were bias-corrected for distortion effects using field maps. We then extracted the average T1-w/T2-w ratio values across each vertex for each sulcus using custom Python code (Miller et al., 2021). The architectural features of all LPC/LPOJ sulci are documented in Supplementary Fig. 7.
To assess whether these four metrics differed between the slocs-v and surrounding sulci (cSTS3 and lTOS), we ran a repeated measure analysis of variance (rm-ANOVA) with the within-participant effects of sulcus (slocs-v, cSTS3, and lTOS), metric (surface area, depth, cortical thickness, and myelination), and hemisphere (left and right). Rm-ANOVAs (including sphericity correction) were implemented with the aov_ez function from the afex R package. Effect sizes for the ANOVAs are reported with the partial eta-squared metric (η2). Post-hoc analyses were computed with the emmeans function from the emmeans R package (p-values corrected with Tukey’s method). We also repeated these analyses for the three cSTS components (Petrides, 2019; Segal & Petrides, 2012) and the two intermediate parietal sulcal components (ips: aipsJ and pips (Petrides, 2019; Zlatkina & Petrides, 2014); detailed in the Supplementary Results and Supplementary Fig. 8) as these components, to our knowledge, have not been quantitatively compared in previous work.
Functional analyses
To determine if the slocs-v is functionally distinct from surrounding sulci, we generated functional connectivity profiles using recently developed analyses (Miller et al., 2021; Willbrand, Bunge, et al., 2023; Willbrand, Parker, et al., 2022). First, we used resting-state network parcellations for each individual participant from Kong and colleagues (Kong et al., 2019), who generated individual network definitions by applying a hierarchical Bayesian network algorithm to produce maps for each of the 17 networks in individual HCP participants. Importantly, this parcellation was conducted blind to both cortical folding and our sulcal definitions. Next, we resampled the network profiles for each participant onto the fsaverage cortical surface, and then to each native surface using CBIG tools (https://github.com/ThomasYeoLab/CBIG). We then calculated the spatial overlap between a sulcus and each of the 17 individual resting-state networks via the Dice coefficient (Equation 1):
This process of calculating the overlap between each sulcus and the 17-network parcellation generated a “connectivity fingerprint” for each sulcus in each hemisphere of each participant. We then ran an rm-ANOVA with within-participant factors of sulcus (slocs-v, cSTS3, and lTOS), network (17 networks), and hemisphere (left and right) to determine if the network profiles (i.e., the Dice coefficient overlap with each network) of the slocs-v was differentiable from the surrounding sulci (i.e., cSTS3 and lTOS). Here we discuss effects related to networks that at least showed minor overlap with one sulcus (i.e., Dice ≥ .10). As in the prior analysis, we also repeated these analyses for the three cSTS components and the two intermediate parietal sulcal components (Supplementary Results and Supplementary Fig. 8).
Behavioral analyses
Model selection
The analysis relating sulcal morphology to spatial orientation and/or reasoning consisted of using a cross-validated (CV) least absolute shrinkage and selection operator (LASSO) regression to select the sulci that explained the most variance in the data and determined how much variance is explained by sulcal depth as a predictor of behavior, as implemented in our previous work (Maboudian et al., 2023; Voorhies et al., 2021; Willbrand, Ferrer, et al., 2023; Yao et al., 2022). A LASSO regression is well suited to address our question since it facilitates the model selection process and increases the generalizability of a model by providing a sparse solution that reduces coefficient values and decreases variance in the model without increasing bias (Heinze et al., 2018). Further, regularization is recommended in cases where there are many predictors (X > 10), as in this study, because this technique guards against overfitting and increases the likelihood that a model will generalize to other datasets. A LASSO performs L1 regularization by applying a penalty, or shrinking parameter (alpha, α), to the absolute magnitude of the coefficients. In this manner, low coefficients are set to zero and eliminated from the model. Therefore, LASSO affords data-driven variable selection that results in simplified models containing only the most predictive features, in this case, sulci predicting cognitive performance. This methodology improves model interpretability and prediction accuracy, as well as protects against overfitting, which improves generalizability (Ghojogh & Crowley, 2019; Heinze et al., 2018).
The depths of all LPC/LPOJ sulci were included as predictors in the LASSO regression model (Supplementary Methods for details on demographic control variables). We used nested CV to optimize the shrinking parameter for the LASSO regression. By convention (Heinze et al., 2018), we selected the model parameters that minimized the CV mean squared error (MSEcv). Optimization was performed with the GridSearchCV function from the SciKit-learn package in Python. This function allowed us to determine the model parameters minimizing the MSEcv by performing an exhaustive search across a range of α values. Nested CV was done as non-nested CV leads to biased performance (Cawley & Talbot, 2010; Vabalas et al., 2019).
To evaluate the performance of the model selected by the LASSO regression and verify the result of our feature selection, we used linear regression with leave-one-out CV (LooCV) to fit these selected models and to compare various models. Specifically, we measured the model performance for the relevant behavioral task using nested model comparison. With LooCV, we compared the LASSO-selected model with the predictors to a model with all left hemisphere sulci as predictors. All regression models were implemented with functions from the SciKit-learn Python package.
Assessing morphological and behavioral specificity
To assess whether our findings generalized to other anatomical features, we considered cortical thickness, which is consistently studied in cognitive neuroscience studies relating morphology to cognition (Dickerson et al., 2008; Gogtay et al., 2004; Voorhies et al., 2021; Willbrand, Ferrer, et al., 2023; Yao et al., 2022). To do so, we replaced sulcal depth with cortical thickness as the predictive metric in our LASSO-selected model. As with depth, the model was fit to the data with LooCV. To compare the thickness model to the depth model, we used the Akaike Information Criterion (AIC), which provides an estimate of in-sample prediction error and is suitable for non-nested model comparison. By comparing AIC scores, we are able to assess the relative performance of the two models. If the ΔAIC is > 2, it suggests an interpretable difference between models. If the ΔAIC is > 10, it suggests a strong difference between models, with the lower AIC value indicating the preferred model (Wagenmakers & Farrell, 2004). To also ascertain whether the relationship between LPC/LPOJ sulcal depth and cognition is specific to spatial orientation performance, or transferable to other general measures of cognitive processing, we investigated the generalizability of the sulcal-behavior relationship to another widely used measure of cognitive functioning: processing speed (Kail & Salthouse, 1994). Specifically, we used LooCV to predict processing speed instead of spatial orientation score. As with thickness, we compared the two models with the AIC.
Situating the slocs-v within modern group-level cortical parcellations
To putatively relate the slocs-v to modern multimodal (HCP multimodal parcellation, HCP-MMP (Glasser et al., 2016)) and cytoarchitectural (Julich-Brain atlas (Amunts et al., 2020)) regions of the cerebral cortex located in fsaverage template space, we quantified the Dice coefficient overlap between the slocs-v of each participant (resampled to fsaverage space) and the individual regions of interest comprising the HCP-MMP and Julich-Brain parcellations.
Retinotopic response mapping of LPC/LPOJ sulci
To assess whether any of the LPC/LPOJ sulci related to retinotopic representations, we leveraged population receptive field mapping data (Benson et al., 2018). For each sulcal MPM (as the retinotopic data were only available in this template space), we extracted the mean R2 values (i.e., the percentage of variance in each vertex explained by the population receptive field model) for vertices that showed meaningful retinotopic responses across participants (thresholded at R2 > 10%) (Mackey et al., 2017).
Competing interests
The authors declare no competing financial interests.
Data availability
The processed data required to perform all statistical analyses and reproduce all Figures, as well as the probability maps, are available on GitHub (https://github.com/cnl-berkeley/stable_projects). Anonymized HCP neuroimaging data are publicly available on ConnectomeDB (db.humanconnectome.org). Raw data will be made available from the corresponding author upon request.
Code availability
The code is available on GitHub (https://github.com/cnl-berkeley/stable_projects) and Open Science Framework (https://osf.io/7fwqk/).
Acknowledgements
This research was supported by NSF CAREER Award 2042251 (PI Weiner) and NIH MSTP Grant T32 GM140935 (Willbrand). Neuroimaging and behavioral data were provided by the HCP, WU-Minn Consortium (PIs: David Van Essen and Kamil Ugurbil; NIH Grant 1U54-MH-091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research, and the McDonnell Center for Systems Neuroscience at Washington University. We thank Jacob Miller, Benjamin Parker, and Willa Voorhies for helping develop the analysis pipelines implemented in this project. We also thank the HCP researchers for participant recruitment and data collection and sharing, as well as the participants who participated in the study.
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