Coverage of chromosome 13 for parasites with pfhrp3 deletion pattern 13-.
Heatmap coverage normalized to genomic coverage of the sub-telomeric region of chromosome 13 (spanning 2,817,793 - 2,844,785 bp, 26,992bp in length) for the 50 parasites with pfhrp3 deletion pattern 13-. Each row is a parasite, and each column is a genomic location. The top annotates which gene the region falls within. The right side annotation shows which parasites have evidence of TARE1 at the location where genomic coverage drops to zero within this region (n=20) and which parasites have evidence of genomic rearrangement with chromosome 5 from discordant paired-end reads, which results in duplication of pfmdr1 (n=28). The top 2 parasites lack evidence of either deletion type. The next 28 parasites have evidence of rearrangement with chromosome 5 with discordant reads with mates mapping to chromosome 13 and other mates mapping to chromosome 5. The next 20 parasites have evidence of TARE1 contiguous with chromosome 13 sequence on various locations consistent with breakage and telomere healing. These breaks occur on chromosome 13 at 2,836,793 (n=9), 2,830,793 (n=4), 2,829,793 (n=2), 2,821,793 (n=1), 2,822,793 (n=1), 2,833,793 (n=1), 2,834,793 (n=1), 2,836,793 (n=1), and 2,840,793 (n=1).