Microbiology and Infectious Disease

Latest articles

1. 1. Microbiology and Infectious Disease

   Heavy isotope labeling and mass spectrometry reveal unexpected remodeling of bacterial cell wall expansion in response to drugs

   Heiner Atze et al.

   Labeling with ¹³C and ¹⁵N in the absence of metabolic engineering enabled the exploration of peptidoglycan metabolism at a very fine level of detail based on kinetic characterization of isotopologues predicted to occur according to known recycling and biosynthesis pathways.
2. 1. Microbiology and Infectious Disease

   Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite

   Pengge Qian et al.
3. 1. Microbiology and Infectious Disease

   High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy

   Claudia A Vera-Arias et al.

   A novel high-throughput method for Plasmodium falciparum genotyping will enable malaria control programs to make informed decisions about the best tool to use for the diagnosis of malaria.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

   Ceri Alan Fielding et al.

   SARS-CoV-2 host-shutoff inhibits innate NK surveillance by suppressing activating ligands, however ADCC provides a potent NK stimulus that is mediated by antibodies targeting Nucleocapsid, ORF3a, and Membrane, with those targeting Spike being significantly weaker.
5. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Antibacterial potency of Type VI amidase effector toxins is dependent on substrate topology and cellular context

   Atanas Radkov et al.
6. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Natural Killer Cells: Taking on SARS-CoV-2

   Paola Kučan Brlić, Ilija Brizić

   A new study sheds light on how SARS-CoV-2 influences the way natural killer cells can recognize and kill infected cells.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat

   Mengyao Wang et al.

   The Toll-like receptor 2-4 genetic modification goat improves effectively resistance against Staphylococcus aureus infection by enhancing autophagy level, and it provides a novel strategy for challenge of S. aureus-caused infections.
8. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Cytotoxic CD4⁺ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts

   Carlos-Henrique D Barbosa et al.

   Cytotoxic CD4 T lymphocytes are abundantly generated in T. cruzi-infected mice, predominantly infiltrate infected hearts, depend on T-cell intrinsic IL-18R/MyD88 signaling for expansion and their blood frequency correlates with the severity of chronic myocarditis in patients with Chagas disease.
9. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

   Liselot Dewachter et al.
10. 1. Microbiology and Infectious Disease

    Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant

    Dallas L Mould et al.

    Microbial variants that arise during chronic lung infections have an increased ability to use nutrients that are abundant in lung infections.