Microbiology and Infectious Disease

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

   Seyi Falekun et al.

   Malaria parasites have simplified and adapted their mitochondrial metabolism to lack fatty acid synthesis but retain an unusual acyl carrier protein required for stability of the core iron-sulfur cluster biogenesis complex.
2. 1. Medicine
   2. Microbiology and Infectious Disease

   An open label randomized controlled trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis

   Nguyen Thi Thuy Ngan et al.

   Despite evidence of significant anti-cryptococcal activity in vitro and animal models, including synergy with other antifungal agents, high-dose tamoxifen has no impact on cerebrospinal fluid sterilization in cryptococcal meningitis.
3. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Virophages and retrotransposons colonize the genomes of a heterotrophic flagellate

   Thomas Hackl et al.

   Mutualistic viruses called virophages are common genome inhabitants of a marine protist, where they may protect host populations from giant viruses.
4. 1. Microbiology and Infectious Disease

   Pathogen clonal expansion underlies multiorgan dissemination and organ-specific outcomes during murine systemic infection

   Karthik Hullahalli, Matthew K Waldor

   During Escherichia coli systemic infection, the replication of a minuscule fraction of the inoculum drives organ-specific clearance failures, systemic dissemination, and stochastic infection outcomes.
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status

   Jason Neidleman et al.

   COVID-19 mRNA vaccine-elicited T cells recognize variants of concern and phenotypically differ depending on number of vaccine doses and prior SARS-CoV-2 infection status.
6. 1. Cell Biology
   2. Microbiology and Infectious Disease

   The Lon protease temporally restricts polar cell differentiation events during the Caulobacter cell cycle

   Deike J Omnus et al.

   A proteomics-based approach identifies novel substrate proteins of the Lon protease in Caulobacter crescentus and reveals a critical role of Lon in regulating flagella assembly and stalk biogenesis during the cell cycle.
7. 1. Microbiology and Infectious Disease

   Effect of SARS-CoV-2 proteins on vascular permeability

   Rossana Rauti et al.

   A specific SARS-CoV-2 proteins that affect the vascular permeability and impairs the functionality of other significant organs has been identified.
8. 1. Microbiology and Infectious Disease

   Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients

   João L Silva-Filho et al.

   Data exploring host and parasite signatures in the peripheral blood indicate that total parasite biomass is a better predictor of P. vivax-induced host responses and pathogenesis than peripheral parasitemia.
9. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Short-chain fatty acids activate acetyltransferase p300

   Sydney P Thomas, John M Denu
10. 1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A single synonymous nucleotide change impacts the male-killing phenotype of prophage WO gene wmk

    Jessamyn I Perlmutter et al.