Microbiology and Infectious Disease

Latest articles

1. 1. Genomics and Evolutionary Biology
   2. Microbiology and Infectious Disease

   Stochastic processes constrain the within and between host evolution of influenza virus

   John T McCrone et al.
2. 1. Genomics and Evolutionary Biology
   2. Microbiology and Infectious Disease

   Mapping mutational effects along the evolutionary landscape of HIV envelope

   Hugh K Haddox et al.

   Deep mutational scanning of Env proteins from two transmitted-founder strains of HIV shows how the accessible evolutionary space changes as the virus evolves.
3. 1. Microbiology and Infectious Disease

   Research: A comprehensive and quantitative exploration of thousands of viral genomes

   Gita Mahmoudabadi, Rob Phillips

   A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
4. 1. Microbiology and Infectious Disease

   Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

   Fernando J Sánchez-Valdéz et al.

   Intracellular amastigotes of the Chagas disease agent Trypanosoma cruzi can spontaneously enter an extended state of replicative dormancy, during which time they are resistant to drug treatment both in vitro and in vivo.
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Immunodeficiency: Back from the brink of obscurity

   Donald C Vinh

   A mutation in a transcription factor makes people susceptible to Trophyrema whippelii, the bacterium that causes a rare condition called Whipple's disease.
6. 1. Microbiology and Infectious Disease

   Resilience of small intestinal beneficial bacteria to the toxicity of soybean oil fatty acids

   Sara C Di Rienzi et al.

   Comparisons between lactobacilli bacteria in the small intestine and those evolved in the lab reveal several modes of resistance to toxic fatty acids.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

   Jonas Klinkhammer et al.
8. 1. Genomics and Evolutionary Biology
   2. Microbiology and Infectious Disease

   Codon usage bias controls mRNA and protein abundance in trypanosomatids

   Laura Jeacock et al.

   Global relative mRNA and protein abundance in trypanosomatids can be effectively estimated at transcriptomic and proteomic scales based on protein-coding sequences alone.
9. 1. Chromosomes and Gene Expression
   2. Microbiology and Infectious Disease

   Codon choice directs constitutive mRNA levels in trypanosomes

   Janaina de Freitas Nascimento et al.

   The information for mRNAs expression level is set by codon choice in trypanosomes and requires translation to be interpreted into a turnover rate.
10. 1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

    Laurelle Jackson et al.

    Under conditions where the force of HIV infection per cell is high, partial attenuation of infection with inhibitors can increase the number of live infected cells and may paradoxically be beneficial for viral spread.