Microbiology and Infectious Disease

Latest articles

1. 1. Epidemiology and Global Health
   2. Microbiology and Infectious Disease

   Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations

   Daniel M Parker et al.

   Given sufficient population adherence, mass drug administration for falciparum malaria can provide group level benefits, also known as ‘herd effects’.
2. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Panton–Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS

   Bernadette C Young et al.

   Genome-wide association studies have established staphylococcal pyomyositis as a disease whose pathogenesis depends critically on expression of a single toxin, Panton–Valentine leukocidin.
3. 1. Microbiology and Infectious Disease

   Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

   Elizabeth A Mueller et al.

   Environmental specialization of bacterial cell wall synthases influences intrinsic resistance to cell wall active antibiotics.
4. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration

   Zachary F Hallberg et al.

   A newfound signaling enzyme that diverged from a protein family ubiquitous in bacteria provides mechanistic insights into how new signaling activity emerges to control distinct cellular function and physiology.
5. 1. Microbiology and Infectious Disease

   Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members

   Elena Gonzalo-Gil et al.

   A subset of EC/VCs have CD4+T cells with resistance specific to R5-tropic HIV infection associated with transcriptional down-regulation of ccr5, a phenotype that appears to be heritable, across multiple generations.
6. 1. Microbiology and Infectious Disease

   A switch in surface polymer biogenesis triggers growth-phase-dependent and antibiotic-induced bacteriolysis

   Josué Flores-Kim et al.

   Penicillin induces bacterial cell lysis by altering cell surface polymer biogenesis to cause the misactivation of a cell wall degrading enzyme.
7. 1. Evolutionary Biology
   2. Microbiology and Infectious Disease

   An updated phylogeny of the Alphaproteobacteria reveals that the parasitic Rickettsiales and Holosporales have independent origins

   Sergio A Muñoz-Gómez et al.

   Diverse sophisticated phylogenetic analyses update the phylogeny of the Alphaproteobacteria and show that the parasitic Holosporales is a derived group within the Rhodospirillales order which comprises primarily free-living alphaproteobacteria.
8. 1. Microbiology and Infectious Disease

   A type III-A CRISPR-Cas system employs degradosome nucleases to ensure robust immunity

   Lucy Chou-Zheng, Asma Hatoum-Aslan

   Degradosome-associated nucleases PNPase and RNase J2 are required for type III CRISPR immunity against diverse nucleic acid invaders originating from plasmid and phage.
9. 1. Chromosomes and Gene Expression
   2. Microbiology and Infectious Disease

   A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis

   Nick D Pokorzynski et al.
10. 1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Extensive transmission of microbes along the gastrointestinal tract

    Thomas SB Schmidt et al.

    Microbial populations are continuous along the gastrointestinal tract, with increased transmission in colorectal cancer and rheumatoid arthritis patients.