Microbiology and Infectious Disease

Microbiology and Infectious Disease

eLife publishes research covering virology, bacteriology and mycology. Learn more about what we publish and sign up for the latest research.
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Latest articles

    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

    Liselot Dewachter et al.
    High-throughput single-cell based, genome-wide gene silencing screening (sCRilecs-seq) revealed that drugging the mevalonate pathway resensitizes amoxicillin-resistant pneumococci.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of resistance to a last-resort antibiotic

    Pramod K Jangir et al.
    Interactions between a mobile resistance gene and chromosomal mutations drive the evolution of high-level antibiotic resistance.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14

    Kathrin Tomasek et al.
    By binding with their type 1 pili to the cell surface receptor CD14, pathogenic E. coli suppress the capacity of dendritic cells to activate T cells.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    An entropic safety catch controls hepatitis C virus entry and antibody resistance

    Lenka Stejskal et al.
    The entry glycoproteins of hepatitis C virus, E1E2, possess a novel regulatory mechanism in which protein disorder is harnessed to control their activity and their ability to evade antibodies.
    1. Medicine
    2. Microbiology and Infectious Disease

    Reconstruction of transmission chains of SARS-CoV-2 amidst multiple outbreaks in a geriatric acute-care hospital: a combined retrospective epidemiological and genomic study

    Mohamed Abbas et al.
    Nosocomial transmission of SARS-Cov-2 in geriatric settings is complex, with different patterns between patients and healthcare workers working in Covid/non-Covid wards that should be taken into account when designing infection control strategies.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms

    Julia M Flynn et al.
    Comprehensive mutational scanning of the SARS-CoV-2 protease, Mpro, provides functional and structural information to aid in the design of more effective inhibitors against the protease with reduced potential of evolving viral resistance.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Protease Inhibitors: Developing evolution-resistant drugs for COVID-19

    Daniel M Weinreich
    Analyzing how mutations affect the main protease of SARS-CoV-2 may help researchers develop drugs that are effective against current and future variants of the virus.
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Senior editors

  1. Arturo Casadevall
    Johns Hopkins Bloomberg School of Public Health, United States
  2. Diane M Harper
    University of Michigan, United States
  3. Bavesh Kana
    University of the Witwatersrand, South Africa
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