Microbiology and Infectious Disease

Latest articles

1. 1. Microbiology and Infectious Disease

   Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy

   Weiwei Sun, Yelizaveta Rassadkina ... Mathias Lichterfeld
2. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth

   Francesca G Tomasi, Satoshi Kimura ... Matthew K Waldor

   Surveying Mycobacterium tuberculosis tRNA modification leads to identification of a modification promoting Mtb pathogenesis.
3. 1. Cell Biology
   2. Microbiology and Infectious Disease

   Synchronization of oscillatory growth prepares fungal hyphae for fusion

   Valentin Wernet, Marius Kriegler ... Reinhard Fischer

   Fungal hyphae constantly undergo signal oscillations, comparable to a cell 'monologue' until they meet another hypha with which they then coordinate signal oscillations and transit into a cell-to-cell dialogue.
4. 1. Cell Biology
   2. Microbiology and Infectious Disease

   A CRISPR-based rapid DNA repositioning strategy and the early intranuclear life of HSV-1

   Juan Xiang, Chaoyang Fan ... Pei Xu

   An inducible two-component CRISPR-based platform that rapidly repositions HSV-1 genomes to the nuclear edge unveils intranuclear space heterogeneity for the incoming viral genomes and dynamic stages of the host-virus interplay during early infection.
5. 1. Microbiology and Infectious Disease
   2. Structural Biology and Molecular Biophysics

   A pH-sensitive switch activates virulence in Salmonella

   Dasvit Shetty, Linda J Kenney

   A single conserved residue – histidine 12 – confers pH-sensitive DNA binding to the Salmonella Typhimurium SPI-2 transcriptional regulator SsrB, thereby regulating Salmonella virulence.
6. 1. Evolutionary Biology
   2. Microbiology and Infectious Disease

   Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance

   Rebecca EK Mandt, Madeline R Luth ... Amanda K Lukens
7. 1. Cell Biology
   2. Microbiology and Infectious Disease

   PerTurboID, A targeted in situ method reveals the impact of kinase deletion on its local protein environment in the cytoadhesion complex of malaria causing parasites

   Heledd Davies, Hugo Belda ... Moritz Treeck
8. 1. Microbiology and Infectious Disease

   Genetic validation of PfFKBP35 as an antimalarial drug target

   Basil T. Thommen, Jerzy M. Dziekan ... Nicolas M. B. Brancucci
9. 1. Microbiology and Infectious Disease

   Evolution of a functionally intact but antigenically distinct DENV fusion loop

   Rita M Meganck, Deanna Zhu ... Longping V Tse

   Operating as a serum profiling tool for dengue infection and vaccination, the D2-FLM variant, which is insensitive to antibody-dependent enhancement-prone fusion loop antibodies, also offers potential for a safer dengue virus vaccine.
10. 1. Microbiology and Infectious Disease

    Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis

    Somnath Shee, Reshma T Veetil ... Amit Singh

    Genome-scale integration of transposon mutagenesis with a redox biosensor identified a hypothetical transcription factor- Rv0158 required to calibrate the growth, cytoplasmic redox potential, and respiration of Mycobacterium tuberculosis in response to metabolic switching from glucose to fatty acids.