Microbiology and Infectious Disease

Latest articles

1. 1. Microbiology and Infectious Disease

   Distinct regions of H. pylori’s bactofilin CcmA regulate protein–protein interactions to control helical cell shape

   Sophie R Sichel, Benjamin P Bratton, Nina R Salama

   The helical cell shape of Helicobacter pylori depends on the polymerizing cytoskeletal protein CcmA’s recruitment to the cell envelope by Csd5 and CcmA’s indirect stabilization of a periplasmic cell wall hydrolase via interactions with the transmembrane protein Csd7.
2. 1. Microbiology and Infectious Disease

   The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

   Anne Günther, Matthias Hose ... Wiebke Hansen

   Host cell acid ceramidase activity contributes to the regulation of erythrocyte maturation and thereby affects the frequency of target cells for rodent Plasmodium yoelii parasites.
3. 1. Microbiology and Infectious Disease
   2. Structural Biology and Molecular Biophysics

   The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield

   Alejandro Villalta, Alain Schmitt ... Chantal Abergel

   As a Russian doll, mimivirus dsDNA genome is folded in a nucleocapsid-like structure enclosed in the nucleoid compartment, encased in the icosahedral capsid itself decorated by long glycosylated fibrils surprisingly made of the same protein as the genomic fiber.
4. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Group II truncated haemoglobin YjbI prevents reactive oxygen species-induced protein aggregation in Bacillus subtilis

   Takeshi Imai, Ryuta Tobe ... Hisaaki Mihara
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants

   Jing Zhang, Zi Bo Han ... Qi Ming Li

   Animal experiments show that the mosaic-type immunogen integrating key mutations from Omicron and other circulating variants elicits broad neutralization against divergent SARS-CoV-2 strains.
6. 1. Microbiology and Infectious Disease

   Mobilome-driven segregation of the resistome in biological wastewater treatment

   Laura de Nies, Susheel Bhanu Busi ... Paul Wilmes
7. 1. Microbiology and Infectious Disease

   Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface

   Liheng Yang, Eleanor C Semmes ... Carolyn B Coyne

   Organoids developed from matched human placental tissue define differences in antiviral signaling between cell types comprising the maternal-fetal interface.
8. 1. Epidemiology and Global Health
   2. Microbiology and Infectious Disease

   Regional importation and asymmetric within-country spread of SARS-CoV-2 variants of concern in the Netherlands

   Alvin X Han, Eva Kozanli ... Chantal Reusken

   Flight restrictions targeted at countries where SARS-CoV-2 variant-of-concern first emerged have limited effectiveness in deterring their introduction into the Netherlands due to the strength of regional travel importation risks in Europe.
9. 1. Epidemiology and Global Health
   2. Microbiology and Infectious Disease

   Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: multicenter, prospective study

   Oliver Stirrup, James Blackstone ... Judith Breuer
10. 1. Microbiology and Infectious Disease

    Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

    Rebecca CS Edgar, Ghizal Siddiqui ... Tania F de Koning-Ward

    Plasmodium falciparum aminopeptidase PfA-M17 is essential to parasite survival and plays a role in hemoglobin digestion, providing a rationale for further development of inhibitors against this enzyme.