Microbiology and Infectious Disease

Latest articles

1. 1. Ecology
   2. Microbiology and Infectious Disease

   Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens

   Benedikt M Mortzfeld, Shakti K Bhattarai, Vanni Bucci

   12 new class IIb microcins have been structurally identified, phylogenetically assessed, and functionally tested for their antimicrobial activity, increasing the total number of these bacteriocins to 17.
2. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis

   Amanda Mixon Blackwell, Yasaman Jami-Alahmadi ... Paul A Sigala

   Plasmodium parasites have repurposed the heme oxygenase scaffold from its canonical heme-degrading function to fulfill an essential and adaptive role in gene expression within the apicoplast organelle.
3. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Lipid discovery enabled by sequence statistics and machine learning

   Priya M Christensen, Jonathan Martin ... Kelli L Palmer

   A previously unknown lipid modification by a bacterial antibiotic resistance enzyme was identified through the analysis of a family of antibiotic resistance enzyme sequences with a machine learning approach.
4. 1. Microbiology and Infectious Disease

   Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens

   Francesca Torelli, Diogo M da Fonseca ... Moritz Treeck

   Secreted effector proteins of Toxoplasma gondii parasites create a supportive immune environment in mice, allowing individually less fit mutants to thrive and evade detection by in vivo CRISPR screens.
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

   Marisa S Egan, Emily A O’Rourke ... Sunny Shin
6. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification

   Louna Fruchard, Anamaria Babosan ... Zeynep Baharoglu
7. 1. Chromosomes and Gene Expression
   2. Microbiology and Infectious Disease

   PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

   Zeinab M Chahine, Mohit Gupta ... Karine G Le Roch

   The PfMORC protein is proven to play a crucial role in chromatin structure, gene regulation and heterochromatin stability, categorizing PfMORC as a strong potential candidate for novel therapeutic interventions.
8. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   β-1,6-Glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall

   Clara Bekirian, Isabel Valsecchi ... Thierry Fontaine

   β-1,6-Glucan is crucial for Candida albicans cell wall structure and integrity, adapting dynamically to environmental stresses and compensating for mannan deficiencies in cell wall organization.
9. 1. Cell Biology
   2. Microbiology and Infectious Disease

   A conserved cell-pole determinant organizes proper polar flagellum formation

   Erick E Arroyo-Pérez, John C Hook ... Simon Ringgaard

   FipA is a novel component required for bacteria that rely on FlhF/FlhG to properly localize their flagella to the cell pole.
10. 1. Microbiology and Infectious Disease

    Blocking Toxin Function and Modulating the Gut Microbiota: Caffeic Acid and its Derivatives as Potential Treatments for Clostridioides difficile Infection

    Yan Guo, Yong Zhang ... Jiazhang Qiu