Flowchart showing Mendelian randomization

MR, Mendelian randomization; MR-PRESSO, Mendelian randomization pleiotropy residual sum and outlier; SNPs, single-nucleotide polymorphisms; MVMR, multivariable Mendelian randomization; IVW: inverse variance weighting; PUFA: polyunsaturated fatty acids; COLOC: colocalization.

Mendelian randomization analysis of the association between PUFA and IA

PUFA: polyunsaturated fatty acids; IA: intracranial aneurysm;OR: odds ratio; CI: confidence interval; MR, Mendelian randomization; IVW: inverse variance weighting; DHA: docosahexaenoic acid.

Mendelian randomization analysis of the association between PUFA and aSAH

PUFA: polyunsaturated fatty acids; aSAH: aneurysmal subarachnoid hemorrhage; OR: odds ratio; CI: confidence interval; MR, Mendelian randomization; IVW, inverse variance weighting; DHA: docosahexaenoic acid.

Mendelian randomization analysis of the association between PUFA and uIA

PUFA: polyunsaturated fatty acids; uIA: unruptured intracranial aneurysm; OR: odds ratio; CI: confidence interval; MR, Mendelian randomization; IVW, inverse variance weighting; DHA: docosahexaenoic acid.

Multivariable Mendelian randomization analysis of the association between PUFA and IA

IA: intracranial aneurysm; DHA: docosahexaenoic acid; LDL: low density lipoprotein; HDL: high density lipoprotein.

Multivariable Mendelian randomization analysis of the association between PUFA and aSAH

aSAH: aneurysmal subarachnoid hemorrhage; DHA: docosahexaenoic acid; LDL: low density lipoprotein; HDL: high density lipoprotein.

Multivariable Mendelian randomization analysis of the association between PUFA and uIA

uIA: unruptured intracranial aneurysm; DHA: docosahexaenoic acid; LDL: low density lipoprotein; HDL: high density lipoprotein.

The sensitivity analysis of the association between PUFA and CA after remove FADS2 locus

IA: intracranial aneurysm; aSAH: aneurysmal subarachnoid hemorrhage; uIA: unruptured intracranial aneurysm; DHA: docosahexaenoic acid; IVW: inverse variance weighting