Dismantling the Papez circuit for memory in rats
- Cardiff University, United Kingdom
Figures
Figure 1
Photomicrographs depicting typical lesions.
(A) Acetylcholinesterase-stained section showing ventral tegmental nucleus of Gudden lesion. (B) Acetylcholinesterase-stained section showing the ventral tegmental nucleus of Gudden (indicated by …
Figure 2
T-maze alternation.
(A). Experimental design for the three stages: solid lines indicate the forced sample phase while dashed lines indicate the correct response in the choice phase. By placing a barrier at the entrance …
Figure 3
Radial-arm maze task.
(A) Mean number of errors (±SEM). First five blocks represent acquisition of the tasks and the final two blocks include rotation of the maze; (B) Mean number of correct entries in first eight arm …
Figure 4
Geometric discrimination in the water-maze.
(A) A schematic of the platform positions for the half of the animals (i.e., short wall to the right of long wall). (B) Mean escape latencies (±SEM) for task acquisition. (C) Probe performance. The …
Figure 5
Mean c-Fos-positive cell counts (±SEM).
(A) Retrosplenial cortex and hippocampal formation (dentate gyrus, CA1, CA3); (B) Frontal cortices (infralimbic cortex and prelimbic cortex) and somatosensory cortex. (C) Supramammillary nuclei, …
Figure 6
Photomicrographs of Fos-positive nuclei in the retrosplenial cortex in the four groups: (A) mammillothalamic tract lesion (B) ventral tegmental nucleus of Gudden lesion; (C) descending …
