Normalisation of brain connectivity through compensatory behaviour, despite congenital hand absence

  1. Avital Hahamy
  2. Stamatios N Sotiropoulos
  3. David Henderson Slater
  4. Rafael Malach
  5. Heidi Johansen-Berg
  6. Tamar R Makin  Is a corresponding author
  1. Weizmann Institute of Science, Israel
  2. University of Oxford, United Kingdom
  3. Nuffield Orthopaedic Centre, United Kingdom
2 figures and 2 tables

Figures

Increased structural asymmetry in one-handers.

(A) White matter values (mean fractional anisotropy ± s.e.m.) were extracted from the bilateral corticospinal tracts of each participant, and laterality indices were computed to determine the level …

https://doi.org/10.7554/eLife.04605.002
Decreased functional asymmetry in hand region functional connectivity during rest is associated with increased residual arm usage in daily tasks.

(A) An illustration of the human sensorimotor homunculus, projected on a cortical surface map. Coloured lines show brain areas activated during execution of movements of the arms (blue), hands …

https://doi.org/10.7554/eLife.04605.003

Tables

Table 1

Demographic details of individuals with congenital limb absence

https://doi.org/10.7554/eLife.04605.005
ParticipantAgeLevel of limb deficiencyAffected limb
A0133below elbowRight
A0226below elbowLeft
A0337below elbowLeft
A0433wristLeft
A0527below elbowLeft
A0656below elbowLeft
A0751wristLeft
A0824below elbowRight
A0951below elbowRight
A1020below elbowLeft
A1148above elbowLeft
A1224below elbowLeft
A1335below elbowRight
A1448below elbowLeft
Table 2

Cluster statistics for presented statistical maps

https://doi.org/10.7554/eLife.04605.004
Statistical parametric mapVoxelsMax valueXYZRegion
Hand-evoked activation (intact hand ROI)3059.09 (Z)−38−2658Primary sensorimotor cortex, intact/dominant hemisphere
Hand-evoked activation1669.84 (Z)22−50−24Intact cerebellum, lobule VI, intact/dominant hemisphere
Seed-based functional connectivity, between group t-test2394.26 (t)−38−2460Primary sensorimotor cortex, intact/dominant hemisphere
Seed-based functional connectivity, between group t-test1594.22 (t)63840Dorsomedial prefrontal cortex, missing/nondominant hemisphere
Seed-based functional connectivity, between group t-test723.92 (t)70−36−2Middle temporal gyrus, missing/nondominant hemisphere
Seed-based functional connectivity, between group t-test73.21 (t)−68−26−12Middle temporal gyrus, intact/dominant hemisphere
Correlations between voxel-wise functional connectivity values and behavioural scores2250.81 (r)−30−2844Primary sensorimotor cortex, intact/dominant hemisphere
  1. Columns present the cluster size (no. of voxels), the value of the maximum ‘intensity’ within the cluster (Max value), the location of the maximum intensity voxel given as X/Y/Z values in MNI coordinates, and the functional region. Intact/dominant hemisphere relates to the hemisphere contralateral to the intact/dominant hand in one-handers/controls, respectively. Missing/nondominant hemisphere relates to the hemisphere contralateral to the missing/nondominant hand in one-handers/controls, respectively.

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