(A) White matter values (mean fractional anisotropy ± s.e.m.) were extracted from the bilateral corticospinal tracts of each participant, and laterality indices were computed to determine the level …
(A) An illustration of the human sensorimotor homunculus, projected on a cortical surface map. Coloured lines show brain areas activated during execution of movements of the arms (blue), hands …
Demographic details of individuals with congenital limb absence
Participant | Age | Level of limb deficiency | Affected limb |
---|---|---|---|
A01 | 33 | below elbow | Right |
A02 | 26 | below elbow | Left |
A03 | 37 | below elbow | Left |
A04 | 33 | wrist | Left |
A05 | 27 | below elbow | Left |
A06 | 56 | below elbow | Left |
A07 | 51 | wrist | Left |
A08 | 24 | below elbow | Right |
A09 | 51 | below elbow | Right |
A10 | 20 | below elbow | Left |
A11 | 48 | above elbow | Left |
A12 | 24 | below elbow | Left |
A13 | 35 | below elbow | Right |
A14 | 48 | below elbow | Left |
Cluster statistics for presented statistical maps
Statistical parametric map | Voxels | Max value | X | Y | Z | Region |
---|---|---|---|---|---|---|
Hand-evoked activation (intact hand ROI) | 305 | 9.09 (Z) | −38 | −26 | 58 | Primary sensorimotor cortex, intact/dominant hemisphere |
Hand-evoked activation | 166 | 9.84 (Z) | 22 | −50 | −24 | Intact cerebellum, lobule VI, intact/dominant hemisphere |
Seed-based functional connectivity, between group t-test | 239 | 4.26 (t) | −38 | −24 | 60 | Primary sensorimotor cortex, intact/dominant hemisphere |
Seed-based functional connectivity, between group t-test | 159 | 4.22 (t) | 6 | 38 | 40 | Dorsomedial prefrontal cortex, missing/nondominant hemisphere |
Seed-based functional connectivity, between group t-test | 72 | 3.92 (t) | 70 | −36 | −2 | Middle temporal gyrus, missing/nondominant hemisphere |
Seed-based functional connectivity, between group t-test | 7 | 3.21 (t) | −68 | −26 | −12 | Middle temporal gyrus, intact/dominant hemisphere |
Correlations between voxel-wise functional connectivity values and behavioural scores | 225 | 0.81 (r) | −30 | −28 | 44 | Primary sensorimotor cortex, intact/dominant hemisphere |
Columns present the cluster size (no. of voxels), the value of the maximum ‘intensity’ within the cluster (Max value), the location of the maximum intensity voxel given as X/Y/Z values in MNI coordinates, and the functional region. Intact/dominant hemisphere relates to the hemisphere contralateral to the intact/dominant hand in one-handers/controls, respectively. Missing/nondominant hemisphere relates to the hemisphere contralateral to the missing/nondominant hand in one-handers/controls, respectively.