Research Advances

Latest articles

1. 1. Computational and Systems Biology
   2. Developmental Biology

   Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration

   Emanuel Cura Costa et al.

   Computational modeling and a cell cycle-reporting axolotl reveal how spinal cord regeneration can be achieved by a signal that propagates 828 μm from the injury site during the first 85 hours post-amputation.
2. 1. Ecology
   2. Evolutionary Biology

   Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions

   Samuel Frederick Mock Hart et al.

   Mutations that directly benefit both self and cooperative partner can readily evolve to promote cooperation.
3. 1. Neuroscience

   Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness

   Jacob Graves McPherson, Maria F Bandres

   Persistent, non-random sensorimotor connectivity reveals the capacity of intrinsic spinal networks to purposefully replay and modify learned patterns of neural transmission during unconsciousness.
4. 1. Neuroscience

   Punishment insensitivity in humans is due to failures in instrumental contingency learning

   Philip Jean-Richard-dit-Bressel et al.

   Punishment insensitive individuals are not more impulsive or anxious, they dislike aversive outcomes and predictors of these outcomes, but are simply less likely to learn their control over them.
5. 1. Structural Biology and Molecular Biophysics

   The crystal structure of bromide-bound GtACR1 reveals a pre-activated state in the transmembrane anion tunnel

   Hai Li et al.

   Substrate-induced structural changes in GtACR1 provide new insight into the chemical mechanism of natural light-gated anion conductance and facilitate its optimization for photoinhibition of neuron firing in optogenetics.
6. 1. Neuroscience

   Somatostatin-expressing parafacial neurons are CO₂/H⁺ sensitive and regulate baseline breathing

   Colin M Cleary et al.

   Cellular and chemogenetic approaches identify a novel mode of chemotransduction involving regulation of basal breathing by CO₂/H+-dependent disinhibition.
7. 1. Structural Biology and Molecular Biophysics

   Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations

   Qingqing Zhao et al.

   BEST1 autosomal dominant loss-of-function mutations surprisingly behave in a dominant-negative manner, whereas gain-of-function mutations exhibit a strong dominant effect that necessitates CRISPR/Cas9-mediated suppression of the endogenous mutant allele in gene therapy.
8. 1. Cancer Biology
   2. Cell Biology

   A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma

   Alvaro Gonzalez Rajal et al.

   Platinum chemotherapy resistance is a complex process involving multiple signalling pathways and a novel, non-genetic, cell cycle-dependent mechanism that promotes tumour regrowth and highlights potential complications for combination therapies in human lung adenocarcinoma.
9. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Design principles of the ESCRT-III Vps24-Vps2 module

   Sudeep Banjade et al.

   Laterally associating specific ESCRT-III subunits can replace one another with simple modifications, providing insights into the design principles of ESCRT-III heteropolymerization.
10. 1. Computational and Systems Biology
    2. Evolutionary Biology

    Mapping single-cell atlases throughout Metazoa unravels cell type evolution

    Alexander J Tarashansky et al.

    Mapping single-cell atlases throughout Metazoa systematically characterizes cell type diversity and the evolution of their associated gene expression programs.