Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Immunology and Inflammation

    Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

    Sara E Vazquez, Sabrina A Mann ... Joseph L DeRisi
    A high-throughput extension of PhIP-seq reveals novel antigen specificities leading to new insights across multiple human autoimmune and inflammatory diseases, enables application of machine learning approaches to PhIP-seq datasets, and highlights the importance of controlled PhIP-seq cohorts.
    1. Evolutionary Biology
    2. Neuroscience

    Whole-brain comparison of rodent and human brains using spatial transcriptomics

    Antoine Beauchamp, Yohan Yee ... Jason P Lerch
    A novel machine learning approach improves quantitative comparisons of mouse and human brains using spatial transcriptomics data sets.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Landscape of epithelial–mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks

    Kishore Hari, Varun Ullanat ... Mohit Kumar Jolly
    Investigation of regulatory network topology reveals latent design principles of multistable phenotypic landscape.
    1. Neuroscience

    Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii

    Wanyue Wang, Hany KM Dweck ... John R Carlson
    Drosophila suzukii, which lays eggs on ripe fruits, differs from Drosophila melanogaster in sweet sensation, mechanosensation, and their integration.
    1. Neuroscience

    Transversal functional connectivity and scene-specific processing in the human entorhinal-hippocampal circuitry

    Xenia Grande, Magdalena M Sauvage ... David Berron
    The human entorhinal-hippocampal circuitry is characterized by an information-specific functional organization where two routes, that are preferentially connected to the parahippocampal cortex or the perirhinal and retrosplenial cortices, divide the entorhinal cortex as well as hippocampal subiculum and CA1 subregions.
    1. Genetics and Genomics

    A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene

    Yonghe Ding, Di Lang ... Xiaolei Xu
    Dnajb6 is identified as a novel sick sinus syndrome causative gene that exhibits a unique expression pattern within a subpopulation of sinus node pacemaker cells.
    1. Cell Biology
    2. Physics of Living Systems

    Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle

    Pooja Suresh, Vahe Galstyan ... Sophie Dumont
    Coarse-grained modeling of mammalian kinetochore-fiber shapes generated under microneedle manipulation reveals the need for lateral anchorage 1-3 μm from the kinetochore to robustly preserve their orientation in the spindle center, promoting mechanical integrity in the dynamic spindle.