Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Neuroscience

    Proteome dynamics during homeostatic scaling in cultured neurons

    Aline Ricarda Dörrbaum et al.
    Dynamic SILAC labeling in combination with mass spectrometry revealed substantial regulation of protein synthesis, degradation, turnover, and abundance during homeostatic scaling in neurons.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Impact of community piped water coverage on re-infection with urogenital schistosomiasis in rural South Africa

    Polycarp Mogeni et al.
    Scale-up of piped water coverage in the local community strongly protects against S. haematobium re-infection intensity among primary school-going children following treatment with praziquantel.
    1. Developmental Biology

    Enhanced ER-associated degradation of HMG CoA reductase causes embryonic lethality associated with Ubiad1 deficiency

    Youngah Jo et al.
    Embryonic lethality associated with deficiency of UBIAD1, which synthesizes a vitamin K2 subtype, results from aberrant ER-associated degradation of the cholesterol biosynthetic enzyme HMG CoA reductase.
    1. Immunology and Inflammation

    Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

    Heledd H Jarosz-Griffiths et al.
    CFTR modulators have potent innate anti-inflammatory properties that can be measured in clinic, both ex vivo and in vitro, which can be used to predict treatment efficacy.
    1. Epidemiology and Global Health

    Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19

    Katelyn Gostic et al.
    Even in the best-case scenario, screening for COVID-19 misses well over half of infected travellers.
    1. Immunology and Inflammation

    Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α

    Liku B Tezera et al.
    Immune checkpoint inhibition therapy for cancer paradoxically activates tuberculosis infection, and advanced human cell culture modelling demonstrates excess TNF-α section is the primary driver.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    New approach for membrane protein reconstitution into peptidiscs and basis for their adaptability to different proteins

    Gabriella Angiulli et al.
    Cryo-EM structures reveal how the peptidisc scaffold can adapt to different membrane proteins, establishing it as a universal membrane mimetic to stabilize membrane proteins in solution.
    1. Cell Biology
    2. Immunology and Inflammation

    Microtubule plus-end dynamics link wound repair to the innate immune response

    Clara Taffoni et al.
    Microtubules orchestrate wound repair and innate immune response in the Caenorhabditis elegans epidermis.
    1. Evolutionary Biology

    Rank orders and signed interactions in evolutionary biology

    Kristina Crona
    Rectangular order perturbations generalize sign epistasis, capture global aspects of fitness landscapes, and clarify how rank order approaches relate.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency

    Tara L Mastro et al.
    Deletion of one copy of the postsynaptic density protein synGAP in rodents causes an increase in the level of the AMPA receptor auxiliary protein TARP in PSDs only in females.