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A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.
Biochemistry and Chemical Biology
Human Biology and Medicine
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism
Erin G Conlon et al.
Structural Biology and Molecular Biophysics
How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion
Luke H Chao et al.
Phase-tuned neuronal firing encodes human contextual representations for navigational goals
Andrew J Watrous et al.
Prospective navigational goals are represented by single neuron firing rates and firing relative to slow oscillatory phase (phase coding) in the human medial temporal lobe.
Chromosomes and Gene Expression
Computational and Systems Biology
TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the integrated stress response
Dmitry E Andreev et al.
A model reveals how translation of an mRNA leader could provide resistance to global downregulation of translation.
Host autophagy machinery is diverted to the pathogen interface to mediate focal defense responses against the Irish potato famine pathogen
Yasin F Dagdas et al.
Defense-related selective autophagy mediated by the antimicrobial autophagy cargo receptor NBR1/Joka2 is diverted to pathogen penetration sites to restrict plant colonization by the oomycete pathogen Phytophthora infestans.
Proteolytic maturation of α
δ controls the probability of synaptic vesicular release
Laurent Ferron et al.
Proteolytic maturation of auxiliary α2δ subunits of voltage-gated calcium channels increases neuronal communication by controlling the synaptic release of neurotransmitter.
Epidemiology and Global Health
Predicting the likelihood and intensity of mosquito infection from sex specific
John Bradley et al.
Malaria transmission between human and mosquito depends on the number of male and female gametocytes in the blood.
Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau
Maxime WC Rousseaux et al.
Loss of a developmentally essential gene in adulthood is tolerated in mice, thus offering potential therapeutic options for Alzheimer's and Parkinson's disease.
Chromosomes and Gene Expression
G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst
Jan J Zylicz et al.
Loss of a maternally inherited epigenetic modifier leads to establishment of an aberrant regulatory network in preimplantation embryos, developmental delay and destabilisation of cell-fate choices.
Directional selectivity of afferent neurons in zebrafish neuromasts is regulated by Emx2 in presynaptic hair cells
Young Rae Ji et al.
Emx2 mediates the directional selectivity of neuromasts by regulating hair bundle orientation in hair cells, and by selecting afferent neuronal targets.
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