Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Neuroscience

    Development of frequency tuning shaped by spatial cue reliability in the barn owl’s auditory midbrain

    Keanu Shadron, José Luis Peña
    The juvenile barn owl displays wide heterogeneity in tuning properties in the auditory midbrain, which is shaped during development to match the pattern of sensory statistics experienced in early life and maintained into adulthood.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Improved isolation of extracellular vesicles by removal of both free proteins and lipoproteins

    Dmitry Ter-Ovanesyan, Tal Gilboa ... David R Walt
    A novel immunoassay for ApoB-100, the main protein component of lipoproteins, enables the development of methods to enrich extracellular vesicles from human plasma while depleting both lipoproteins and free proteins.
    1. Cell Biology
    2. Computational and Systems Biology

    Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response

    Rania Garde, Abhyudai Singh ... David Pincus
    The chaperones Hsp70 and Sis1 collaborate to repress the heat shock response and are both transcriptional targets of the heat shock response, yet only Hsp70 acts as a negative feedback regulator of the heat shock response.
    1. Cancer Biology
    2. Cell Biology

    ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    ERK3 controls actin cytoskeleton.
    1. Cell Biology
    2. Neuroscience

    Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a C. elegans thermal nociceptor

    Domenica Ippolito, Dominique A Glauser
    A refined analysis of the mechanisms controlling CaM kinase-1 subcellular localization in sensory neurons, a cell-autonomous process known to control nociceptive plasticity and to adjust avoidance behaviors.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2

    Laura M Nocka, Timothy J Eisen ... John Kuriyan
    The adaptor protein Grb2 is able to enhance the activity of the cytoplasmic tyrosine kinase Btk through a novel mechanism, revealing a new role for Grb2 in B-cell signaling.
    1. Structural Biology and Molecular Biophysics

    Structural and functional properties of a plant NRAMP-related aluminum transporter

    Karthik Ramanadane, Márton Liziczai ... Cristina Manatschal
    The structure of an NRAMP-related Al3+ transporter illustrates the evolution of a branch of a conserved protein family of metal ion transporters in plants to combat Al3+ toxicity in acidic soil.
    1. Computational and Systems Biology
    2. Ecology

    Emergent regulation of ant foraging frequency through a computationally inexpensive forager movement rule

    Lior Baltiansky, Guy Frankel, Ofer Feinerman
    Rather than complex decisions, it is the motion of individuals that allows for collective foraging regulation in ant colonies.