Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

    Morgane Boone et al.
    Genetically induced conformational modulation of eIF2B activates the Integrated Stress Response by impairing nucleotide exchange.
    1. Neuroscience

    Human visual gamma for color stimuli

    Benjamin J Stauch et al.
    Colored surfaces induce gamma oscillations in human early visual cortex that are equally strong for red and green colors when L-M cone contrast is controlled for.
    1. Cell Biology
    2. Physics of Living Systems

    Single-cell monitoring of dry mass and dry mass density reveals exocytosis of cellular dry contents in mitosis

    Teemu P Miettinen et al.
    A high-resolution approach for monitoring dry mass and the density of that dry mass on a single-cell level is developed and used to reveal that mammalian cells can lose components in mitosis due to lysosomal exocytosis.
    1. Neuroscience

    The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice

    Han Zhang et al.
    The role of genetically identified V3 interneurons with ascending propriospinal projections in the spinal locomotor circuitry and their contribution to the limb coordination and speed-dependent gait expression during locomotion were investigated using a combination of experimental studies and computational modeling.
    1. Neuroscience

    Short-term plasticity in the human visual thalamus

    Jan W Kurzawski et al.
    Short-term monocular deprivation effects are widespread in the visual cortex and extend subcortically to the ventral pulvinar, while sparing the dorsal pulvinar and the lateral geniculate nucleus.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of complexin clamping and activation function

    Manindra Bera et al.
    Complexin, in conjunction with Synaptotagmin, clamps the SNARE-assembly process under resting conditions and promote vesicle fusion in response to calcium signal.
    1. Epidemiology and Global Health

    Inference of the SARS-CoV-2 generation time using UK household data

    William S Hart et al.
    Updated estimates of the generation time of SARS-CoV-2 infections indicate that the generation time has become shorter.
    1. Cell Biology

    Cortical microtubule pulling forces contribute to the union of the parental genomes in the Caenorhabditis elegans zygote

    Griselda Velez-Aguilera et al.
    Cortical microtubule pulling forces influence nuclear envelope breakdown, while nuclear envelope remodeling, particularly lamina depolymerization, impacts mitotic spindle length during mitosis.
    1. Cell Biology

    A light-gated transcriptional recorder for detecting cell-cell contacts

    Kelvin F Cho et al.
    TRACC (Transcriptional Readout Activated by Cell-cell Contacts) is an engineered molecular tool that detects and records cell-cell contacts in mammalian systems.