A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.
Janice M Reimer, Morgan E DeSantis ... Andres E Leschziner
Structures of human cytoplasmic dynein-1 bound to its regulator LIS1 reveal the interfaces involved in forming the complex and provide a context for disease-linked mutations.
Justin L Roncaioli, Janet Peace Babirye ... Russell E Vance
Genetic analyses using a new oral infection mouse model demonstrate that cell death pathways protect against the gastrointestinal bacterial pathogen Shigella flexneri.
Ankit Sabharwal, Mark D Wishman ... Stephen C Ekker
A revertible Leigh Syndrome French Canadian Type (LSFC) disease model recapitulates the clinical phenotypes which can be rescued using a liver-specific genetic model therapy.
An evolutionarily conserved protein sequence present in diverse species like yeast, frogs, chickens, and humans binds a well-known template for microtubule nucleation, the gamma-tubulin ring complex, activating and enhancing its ability to nucleate microtubules, even under low tubulin concentrations.
Genetic and biochemical analyses reveal that the bacterial nucleases PNPase and RNase R work in concert with a type III-A CRISPR-Cas immune system to process small CRISPR RNAs and ensure robust immunity against foreign nucleic acid invaders.
