A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper.
The unusually high genetic diversity of MHC genes cannot be explained by heterozygote advantage alone because heterozygote advantage is not expected without some other driver of diversity.
Mathieu DM Renard, Johann Ukrow ... Gilles Laurent
The spatial organization of chromatophore-muscle innervation by motoneurons enables the generation of chromatophore-shaped noise, virtual or composite chromatophores, and shape elements such as lines or small blobs.
The subthalamic nucleus contains subpopulations with different contributions to deliberative decision-making based on noisy evidence and reward-driven preferences.
An analysis of the largest publicly available collection of scanning electron microscopy images of explanted multielectrode arrays reveals that electrolytic lesioning causes no significant additional damage to array electrodes.
Dirk EM Geurts, Hanneke EM den Ouden ... Roshan Cools
Catecholaminergic modulation by methylphenidate affects appetitive and aversive Pavlovian biases of approach and avoidance in humans depending on individual differences in working memory capacity.
Steven A Calle-Schuler, Alexis Santana-Cruz ... Andrew M Seeds
A synaptic-resolution map reveals how spatially organized touch pathways in the fly brain shape aimed head grooming through parallel excitatory circuits and inhibitory control.
Resolving the mechanism of RXR ligand-dependent NR4A-RXR nuclear receptor heterodimer activation requires a diverse ligand set that includes heterodimer-selective agonists.
Movie alignment software uses a 3D spline model to capture beam-induced motion in cryo-electron microscopy movie frames, correct local sample distortions, and improve two-dimensional template matching signal-to-noise ratios in the corrected images.
The JAX Animal Behavior System integrates standardized hardware, machine learning methods, and annotated datasets to enable reproducible behavioral phenotyping and genetic analysis across diverse mouse strains.
Preethi Somasundaram, Madeline M Farley ... Trent A Watkins
A secondary stress signaling pathway in the response to optic axon injury is an unexpectedly strong contributor to both neurodegeneration and axon regenerative potential.
