Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Developmental Biology

    Emx2 regulates hair cell rearrangement but not positional identity within neuromasts

    Sho Ohta et al.
    Emx2 is not required for sibling HCs to acquire their designated locations within the neuromast, inferring that Emx2 mediates opposite HC orientation by changing location of hair bundle establishment.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    The interplay between asymmetric and symmetric DNA loop extrusion

    Edward J Banigan, Leonid A Mirny
    Models of chromosome compaction by condensins demonstrate that two-sided loop extrusion and long residence times are required for high compaction, suggesting a tight coupling between these two properties in vivo.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cardiac endothelial cells maintain open chromatin and expression of cardiomyocyte myofibrillar genes

    Nora Yucel et al.
    Endothelial cells in the heart have transcriptional and epigenetic signatures of cardiomyocytes.
    1. Neuroscience

    Ultrastructural comparison of dendritic spine morphology preserved with cryo and chemical fixation

    Hiromi Tamada et al.
    Cryo preservation of brain tissue reveals dendritic spines with thinner necks compared to those prepared with chemical fixation.
    1. Neuroscience

    Neuropeptide VF neurons promote sleep via the serotonergic raphe

    Daniel A Lee et al.
    Experiments using zebrafish identify a novel sleep-promoting neuronal circuit in which hypothalamic NPVF neurons promote sleep via the hindbrain serotonergic raphe nuclei, which promote sleep in both zebrafish and mice.
    1. Neuroscience

    Preserving inhibition with a disinhibitory microcircuit in the retina

    Qiang Chen et al.
    A disinhibitory motif in the retina mediates noise resilience of motion detection using an inverted algorithm of disinhibition due to the interplay between network activity and synaptic plasticity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

    Xiaowei Hou et al.
    Structure of the Ca2+ channel Orai in an open conformation provides insights into the opening mechanism and the channel's role in regulating Ca2+ entry into immune and other non-excitable cells.
    1. Cell Biology
    2. Physics of Living Systems

    A physical mechanism of TANGO1-mediated bulky cargo export

    Ishier Raote et al.
    TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.
    1. Neuroscience

    Frontal eye field and caudate neurons make different contributions to reward-biased perceptual decisions

    Yunshu Fan et al.
    In monkeys making decisions that balance noisy evidence and reward expectation, frontal cortical and caudate activity reflect different computational components that are related to the monkeys' strategy.