A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.
A built-in solution for correcting optical aberrations in long (> 6 mm) gradient index (GRIN) lenses enables unbiased two-photon functional recordings of large neuronal populations in the deep mouse brain.
Dharmendra Kumar Nath, Subash Dhakal, Youngseok Lee
TRPγ is essential for maintaining lipid homeostasis in Drosophila melanogaster, linking neuronal regulation to fat metabolism and suggesting potential therapeutic avenues for metabolic disorders.
Reserpine, previously identified through high-throughput screening in CEP290 retinal degeneration models, enhances photoreceptor survival in P23H rhodopsin retinal degeneration models, particularly in female rats, indicating its gene-agnostic and sex-specific effectiveness.
The asymmetrically segregated Notch pathway inhibitor Numb is essential for intestinal stem cell self-renewal in adult Drosophila midguts when the stem cell niche signaling is compromised.
Ana Cristina Chang-Gonzalez, Aoi Akitsu ... Wonmuk Hwang
Recognition of antigenic ligand by T-cell receptors is a nuanced process where mechanical force can be leveraged to diversify functional outcomes of different T-cells for the same ligand.
David C Williams, Amanda Chu ... Michael A McDannald
A more complete, bidirectional relationship between fear conditioning and behavior is established when many behaviors are examined, as opposed to single behavior such as freezing.
Gene duplication in antibiotic-resistant bacteria mitigates elevated demand for expression, facilitating adaptation to antibiotics and alleviating costs of proteolytic instability of the drug target.
