Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Neuroscience

    Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA

    David S Jacobs, Madeleine C Allen ... Bita Moghaddam
    A novel approach to studying anxiety reveals that learned anxiety and diazepam treatment have unique roles on prefrontal cortex and ventral tegmental area activity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

    Edmundo G Vides, Ayan Adhikari ... Suzanne R Pfeffer
    1. Developmental Biology

    Innexin function dictates the spatial relationship between distal somatic cells in the Caenorhabditis elegans gonad without impacting the germline stem cell pool

    Theadora Tolkin, Ariz Mohammad ... David Greenstein
    Somatic gonad architecture is regulated by innexin function, but sheath cell position does not determine germ cell exit from the stem cell pool.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The C. elegans gonadal sheath Sh1 cells extend asymmetrically over a differentiating germ cell population in the proliferative zone

    Xin Li, Noor Singh ... Kacy Lynn Gordon
    As Caenorhabditis elegans adult hermaphrodite germ cells leave the stem cell niche, they associate with a pair of somatic gonad cells that were thought to be symmetrical, but that actually take on dramatically different positions in the organ.
    1. Biochemistry and Chemical Biology

    DNA passes through cohesin’s hinge as well as its Smc3–kleisin interface

    James E Collier, Kim A Nasmyth
    By identifying cohesin's DNA entry gate(s) and through understanding the corresponding topology between the two the mechanism behind cohesin's activity is slowly deciphered and will aid in understanding how the SMC family at large functions.
    1. Neuroscience

    Impact of blindness onset on the representation of sound categories in occipital and temporal cortices

    Stefania Mattioni, Mohamed Rezk ... Olivier Collignon
    Early and late visual deprivation trigger a redeployment mechanism that reallocate part of the processing typically tagging the preserved senses (i.e. the temporal cortex for auditory stimulation) to the occipital cortex deprived of its most salient visual input.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    In situ single particle classification reveals distinct 60S maturation intermediates in cells

    Bronwyn A Lucas, Kexin Zhang ... Nikolaus Grigorieff
    Comparing the relative similarity of cellular molecules to alternate templates allows classification of related complexes in the cell using fewer particles than needed for 3D classification and is more practicable for low abundance complexes.
    1. Computational and Systems Biology
    2. Neuroscience

    Parallel processing, hierarchical transformations, and sensorimotor associations along the ‘where’ pathway

    Raymond Doudlah, Ting-Yu Chang ... Ari Rosenberg
    Hierarchical transformations of visual representations, saccade-related activity, and sensorimotor associations occur in parallel at the juncture of visual and parietal cortex.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PH domain-mediated autoinhibition and oncogenic activation of Akt

    Hwan Bae, Thibault Viennet ... Philip A Cole
    Structural and biochemical analysis of semisynthetic Akt forms and mutants has revealed the importance of a key interaction network involving Arg86, Glu17, and Tyr18 that controls Akt conformation and activity.