Research Advances

A Research Advance is a short article that allows the authors of an eLife paper to publish new results that build on their original research paper in an important way.

Latest articles

    1. Neuroscience

    Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila

    Zachary A Knecht et al
    1. Developmental Biology and Stem Cells

    Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

    Wenxuan Liu et al
    Building on previous work (Liu et al., 2015), it is shown that depletion or rescue of adult skeletal muscle stem cells is sufficient to induce or attenuate age-associated neuromuscular junction deterioration respectively.
    Research Advance Updated
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    1. Cell Biology

    The Sec61 translocon limits IRE1α signaling during the unfolded protein response

    Arunkumar Sundaram et al
    Building on previous work (Plumb et al., 2015), it is shown that the Sec61 translocon controls the oligomerization, activation and inactivation of Ire1α during endoplasmic reticulum stress.
    Research Advance Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Biophysics and Structural Biology

    Control of lipid domain organization by a biomimetic contractile actomyosin cortex

    Sven Kenjiro Vogel et al
    Building on previous work (Vogel et al., 2013b), it is shown that myosin-driven actin filament rearrangements actively move, split or fuse individual lipid domains and change their overall shape.
    Research Advance Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Noradrenaline blockade specifically enhances metacognitive performance

    Tobias U Hauser et al
    The neurotransmitter noradrenaline selectively modulates metacognition, the conscious insight into one's performance, but does not alter perceptual decision making, revealing that different neuromodulators affect different stages of a decision making process.
    Research Advance
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Microbiology and Infectious Disease

    Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa

    Elin Näsström et al
    Mass spectrometry on plasma from patients with typhoid fever and other febrile disease identified and validated 24 metabolites that can distinguish typhoid from other febrile diseases, providing a new approach for typhoid diagnostics.
    Research Advance
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Biophysics and Structural Biology

    Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

    Jixin Cui et al
    Fam20A, a pseudokinase involved in the formation of tooth enamel, binds ATP in an unexpected orientation.
    Research Advance Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology

    Centriolar remodeling underlies basal body maturation during ciliogenesis in Caenorhabditis elegans

    Inna V Nechipurenko et al
    Building on previous work (Doroquez et al., 2014), it is shown that the centriole core of the basal body degenerates, but the outer wall remodels to template the ciliary axoneme in a subset of C. elegans ciliated sensory neurons.
    Research Advance
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Stimulus background influences phase invariant coding by correlated neural activity

    Michael G Metzen, Maurice J Chacron
    Building on previous work (Metzen et al., 2016), a combination of neurophysiological and behavioral approaches reveals that changes in the background strongly impacts invariant coding and perception of behaviourally relevant signals.
    Research Advance Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    A cellular mechanism for inverse effectiveness in multisensory integration

    Torrey LS Truszkowski et al
    Building on previous work (Felch et al., 2016), it is shown that inverse effectiveness, a central property of multisensory integration, in the optic tectum is mediated by the activation of NMDA-type glutamate receptors, resulting in a response greater than the sum of responses to each individual sensory modality.
    Research Advance Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf