A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.
Humans can appropriately use relationships among pieces of sensory evidence (pairwise correlations) to inform decisions, rather than relying only on the physical features of individual evidence samples.
Foveal sensitivity to the features of an imminent saccade target increases with the target’s conspicuity, supporting foveal prediction as a viable mechanism for maintaining visual continuity in high-contrast, naturalistic environments.
Humans estimate different forms of uncertainty during learning, but do so imprecisely, leading to the misattribution of random fluctuations as fundamental shifts.
Marwa O Mikati, Petra Erdmann-Gilmore ... Ream Al-Hasani
An analytical approach increases spatiotemporal resolution, optimizes real-time, in vivo detection of Met- and Leu-enkephalin, and provides novel insight into the relationship between Met- and Leu-enkephalin following stress.
A comparison of how two nematode species sense salts highlights how evolution can find different ways to establish asymmetry in small nervous systems to optimize the processing of chemosensory cues.
Jessie Kulsuptrakul, Michael Emerman, Patrick S Mitchell
During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.
A local-ancestry-aware association model identified a suggestive association peak within the HLA class II region linked to TB in a complex, highly admixed Southern African population.
Elise Miedlar, Grace E Hamilton ... Trisha N Davis
Biochemical reconstitution and laser trapping show that centromeric DNA sequences are important for the transmission of microtubule-based forces to chromosomes.
Daniela Piña Novo, Mang Gao ... Gordon MG Shepherd
'Phototactile' hand stimulation rapidly activates first the somatosensory then the motor cortex, broadly consistent with constraints suggested by the previously described circuit architecture of this transcortical loop.
A built-in solution for correcting optical aberrations in long (> 6 mm) gradient index (GRIN) lenses enables unbiased two-photon functional recordings of large neuronal populations in the deep mouse brain.
