Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Computational and Systems Biology
    2. Developmental Biology

    Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration

    Emanuel Cura Costa et al.
    Computational modeling and a cell cycle-reporting axolotl reveal how spinal cord regeneration can be achieved by a signal that propagates 828 μm from the injury site during the first 85 hours post-amputation.
    1. Ecology
    2. Evolutionary Biology

    Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions

    Samuel Frederick Mock Hart et al.
    Mutations that directly benefit both self and cooperative partner can readily evolve to promote cooperation.
    1. Neuroscience

    Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness

    Jacob Graves McPherson, Maria F Bandres
    Persistent, non-random sensorimotor connectivity reveals the capacity of intrinsic spinal networks to purposefully replay and modify learned patterns of neural transmission during unconsciousness.
    1. Neuroscience

    Punishment insensitivity in humans is due to failures in instrumental contingency learning

    Philip Jean-Richard-dit-Bressel et al.
    Punishment insensitive individuals are not more impulsive or anxious, they dislike aversive outcomes and predictors of these outcomes, but are simply less likely to learn their control over them.
    1. Structural Biology and Molecular Biophysics

    The crystal structure of bromide-bound GtACR1 reveals a pre-activated state in the transmembrane anion tunnel

    Hai Li et al.
    Substrate-induced structural changes in GtACR1 provide new insight into the chemical mechanism of natural light-gated anion conductance and facilitate its optimization for photoinhibition of neuron firing in optogenetics.
    1. Neuroscience

    Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing

    Colin M Cleary et al.
    Cellular and chemogenetic approaches identify a novel mode of chemotransduction involving regulation of basal breathing by CO2/H+-dependent disinhibition.
    1. Structural Biology and Molecular Biophysics

    Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations

    Qingqing Zhao et al.
    BEST1 autosomal dominant loss-of-function mutations surprisingly behave in a dominant-negative manner, whereas gain-of-function mutations exhibit a strong dominant effect that necessitates CRISPR/Cas9-mediated suppression of the endogenous mutant allele in gene therapy.
    1. Cancer Biology
    2. Cell Biology

    A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma

    Alvaro Gonzalez Rajal et al.
    Platinum chemotherapy resistance is a complex process involving multiple signalling pathways and a novel, non-genetic, cell cycle-dependent mechanism that promotes tumour regrowth and highlights potential complications for combination therapies in human lung adenocarcinoma.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Design principles of the ESCRT-III Vps24-Vps2 module

    Sudeep Banjade et al.
    Laterally associating specific ESCRT-III subunits can replace one another with simple modifications, providing insights into the design principles of ESCRT-III heteropolymerization.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Mapping single-cell atlases throughout Metazoa unravels cell type evolution

    Alexander J Tarashansky et al.
    Mapping single-cell atlases throughout Metazoa systematically characterizes cell type diversity and the evolution of their associated gene expression programs.