Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Chromosomes and Gene Expression
    2. Developmental Biology and Stem Cells

    G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst

    Jan J Zylicz et al.
    Loss of a maternally inherited epigenetic modifier leads to establishment of an aberrant regulatory network in preimplantation embryos, developmental delay and destabilisation of cell-fate choices.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Directional selectivity of afferent neurons in zebrafish neuromasts is regulated by Emx2 in presynaptic hair cells

    Young Rae Ji et al.
    Emx2 mediates the directional selectivity of neuromasts by regulating hair bundle orientation in hair cells, and by selecting afferent neuronal targets.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

    Neel H Shah et al.
    A high-throughput comparison of substrate specificities of the Src-family kinases Lck and c-Src against a library of proteome-derived phosphorylation sites reveals that Lck has evolved divergent electrostatic features reflecting its involvement in T-cell signaling.
    1. Neuroscience

    Shorter cortical adaptation in dyslexia is broadly distributed in the superior temporal lobe and includes the primary auditory cortex

    Sagi Jaffe-Dax et al.
    BOLD activity throughout the cortex, including auditory cortex and associative regions, reveals that adaptation is shorter in dyslexia.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanochemical coupling and bi-phasic force-velocity dependence in the ultra-fast ring ATPase SpoIIIE

    Ninning Liu et al.
    Probing the DNA motor SpoIIIE at the single-molecule level has revealed its force-generating step, rich translocation dynamics during motor operation and a novel, bi-phasic mechanical response to opposing force.
    1. Biochemistry and Chemical Biology

    Serine is the major residue for ADP-ribosylation upon DNA damage

    Luca Palazzo et al.
    Serine residues in proteins are the primary targets for PARP-dependent ADP-ribosylation signalling upon DNA damage.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes

    Yao Liang Wong et al.
    Vanishing White Matter Disease mutations compromise the function of the essential translation initiation factor eIF2B by destabilizing the holoenzyme, and the small molecule ISRIB reverses their pathogenic effect by promoting complex formation.
    1. Developmental Biology and Stem Cells

    Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition

    Masatoshi Hara et al.
    The threonine kinase controls maternal mRNA translation phosphorylate components of the translational machinery, including translational repressors, which appear to inactivate to promote the oocyte-to-embryo transition.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response

    Joanna Krakowiak et al.
    Dynamic regulation of the heat shock response depends on a negative feedback loop in which Hsf1 activates expression of Hsp70 and Hsp70 specifically and directly represses Hsf1 transactivation.
    1. Cancer Biology

    MELK expression correlates with tumor mitotic activity but is not required for cancer growth

    Christopher J Giuliano et al.
    Cancer cells can grow in vitro and in vivo in the absence of maternal embryonic leucine zipper kinase (MELK).