A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.
Immune cell motility and vascular response are imaged in vivo and label free in the CNS for the first time, using high-resolution phase-contrast adaptive optics retinal imaging.
An interdisciplinary approach uncovers a new antinociceptive molecular mechanism and shows that the adhesion GPCR CIRL adjusts the sensation of gentle touch and noxious mechanical insult in opposite directions.
Activation and autophosphorylation of CaMKII releases the regulatory segment, which can then bind to and destabilize the hub assembly by trapping large fluctuations in the hub architecture.
The terminal selector-type transcription factor UNC-3/Ebf partially modifies the suite of its target genes at different life stages to establish and maintain the identity of C. elegans motor neurons.
A dominant sensory map provides positional information through correlated activity and transposed molecular cues to guide secondary sensory projections for alignment and organization.
Understanding how loss of CO2/H+ vascular reactivity affects respiratory control may facilitate development of treatments for breathing problems in this population.
Whether central vestibular neurons implement faithful stimulus encoding for the vestibulo-occular reflex or optimized coding via temporal whitening for other vestibular functions is determined by neural variability.
