Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Cell Biology
    2. Developmental Biology

    Whole-organism 3D quantitative characterization of zebrafish melanin by silver deposition micro-CT

    Spencer R Katz et al.
    Melanin staining for micro-CT imaging, using a novel application of ionic silver deposition, enables qualitative and quantitative 3D analysis of zebrafish pigmentation and reveals subtle phenotypes missed by light microscopy.
    1. Cell Biology
    2. Developmental Biology

    Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans

    Mor Levi-Ferber et al.
    Neuronal circuits can be disrupted by ire-1-dependent mRNA decay to affect germline tumor cell identity by regulating cross-tissue communication in Caenorhabditis elegans.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The roles of history, chance, and natural selection in the evolution of antibiotic resistance

    Alfonso Santos-Lopez et al.
    Selection imposed by antibiotics may dominate evolutionary forces acting on opportunistic pathogens like Acinetobacter baumannii, yet chance effects and a prior history in biofilm may constrain resistance and impose collateral sensitivities.
    1. Chromosomes and Gene Expression

    A CTP-dependent gating mechanism enables ParB spreading on DNA

    Adam SB Jalal et al.
    A structural and biochemical approach shows that CTP binding and hydrolysis regulate nucleation, spreading, and recycling of a chromosome segregation protein ParB.
    1. Physics of Living Systems

    Effect of malaria parasite shape on its alignment at erythrocyte membrane

    Anil K Dasanna et al.
    A numerical model of malaria parasite adhesion to an erythrocyte shows that the original egg-like shape of merozoites is more robust than other shapes in negotiating various physiological conditions during the alignment process upon erythrocyte invasion.
    1. Neuroscience

    Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD

    Joshua B Burt et al.
    Computational models of large-scale cortical dynamics, integrating gene expression mapping to pattern pharmacological modulation across cortex, capture inter-areal topographies of functional connectivity alterations induced by lysergic acid diethylamide, providing a framework for simulating effects of pharmacology in the human brain.
    1. Cell Biology
    2. Developmental Biology

    The GNU subunit of PNG kinase, the developmental regulator of mRNA translation, binds BIC-C to localize to RNP granules

    Emir E Avilés-Pagán et al.
    The Drosophila PNG kinase controls mRNA translation at the oocyte-to-embryo transition, and its GNU activating subunit is shown here to bind translational repressors and be a component of RNP granules.