Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structures of human dynein in complex with the lissencephaly 1 protein, LIS1

    Janice M Reimer, Morgan E DeSantis ... Andres E Leschziner
    Structures of human cytoplasmic dynein-1 bound to its regulator LIS1 reveal the interfaces involved in forming the complex and provide a context for disease-linked mutations.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A hierarchy of cell death pathways confers layered resistance to shigellosis in mice

    Justin L Roncaioli, Janet Peace Babirye ... Russell E Vance
    Genetic analyses using a new oral infection mouse model demonstrate that cell death pathways protect against the gastrointestinal bacterial pathogen Shigella flexneri.
    1. Developmental Biology
    2. Genetics and Genomics

    Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality

    Ankit Sabharwal, Mark D Wishman ... Stephen C Ekker
    A revertible Leigh Syndrome French Canadian Type (LSFC) disease model recapitulates the clinical phenotypes which can be rescued using a liver-specific genetic model therapy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)

    Michael J Rale, Brianna Romer ... Sabine Petry
    An evolutionarily conserved protein sequence present in diverse species like yeast, frogs, chickens, and humans binds a well-known template for microtubule nucleation, the gamma-tubulin ring complex, activating and enhancing its ability to nucleate microtubules, even under low tubulin concentrations.
    1. Cancer Biology
    2. Evolutionary Biology

    Parallel evolution of reduced cancer risk and tumor suppressor duplications in Xenarthra

    Juan Manuel Vazquez, Maria T Pena ... Vincent J Lynch
    Sloths, armadillos, and anteaters evolved genetic and cellular traits that make them remarkably cancer resistant.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Survival of mineral-bound peptides into the Miocene

    Beatrice Demarchi, Meaghan Mackie ... Julia Clarke
    Ostrich eggshell from the Liushu Formation in northwestern China push ancient protein preservation into the Miocene.
    1. Neuroscience

    Thalamocortical contributions to cognitive task activity

    Kai Hwang, James M Shine ... Evan Sorenson
    Human thalamic activity transformed via thalamocortical functional connectivity to support task representations across functional domains.
    1. Microbiology and Infectious Disease

    Critical roles for ‘housekeeping’ nucleases in type III CRISPR-Cas immunity

    Lucy Chou-Zheng, Asma Hatoum-Aslan
    Genetic and biochemical analyses reveal that the bacterial nucleases PNPase and RNase R work in concert with a type III-A CRISPR-Cas immune system to process small CRISPR RNAs and ensure robust immunity against foreign nucleic acid invaders.