A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.
Healthcare workers working on COVID-19 wards experience a 31-fold increased risk of infection with SARS-CoV-2 compared to colleagues on non-COVID-19 wards whilst wearing fluid-resistant surgical masks, and FFP3 respirators provide up to 100% protection against infection.
A distinct subpopulation of neurons in the rat orbitofrontal cortex encodes reward history at the time of choice, providing a potential neural substrate by which reward history may influence decisions.
Reactive oxygen species can activate the ATR/Chk1 pathway in the absence of detectable DNA damage and without a requirement for DNA damage response proteins.
Structures of human SMG1-9 and SMG1-8-9 reveal how the SMG1 kinase active site is targeted by a specific inhibitor and provide insights into the regulation of the SMG1-8-9 kinase complex in nonsense-mediated mRNA decay.
Biochemical analysis reveals the entire route of oligosaccharide processing from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), and the enzymes (EDEM2 and EDEM3/1) responsible for endoplasmic reticulum-associated degradation of misfolded glycoproteins.
The coordinate activity of Sec17/SNAP and Sec18/NSF for membrane fusion is not limited to systems with homotypic fusion and vacuole protein sorting (HOPS), the lysosomal/vacuolar tethering, and SNARE assembly complex.
All-trans retinoic acid increases the number of excitatory synapses in the dorsal hippocampus of mice and improves the ability of neurons to express synaptopodin-dependent synaptic plasticity.
To facilitate human developmental biology research, CRISPR-mediated homologous recombination, tightly inducible gene knockdowns (CRISPRi) and overexpression (CRISPRa) have been efficiently applied to human organoids.
