A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.
Combined with high-throughput yeast genetics, a split green fluorescent protein encoded directly in the mitochondrial DNA helps to identify targeting signals and functions of dually localized proteins.
Distinct SMC5/6 subcomplexes mediate the transcriptional silencing of circular extrachromosomal DNA (SIMC1–SLF2) and repair of chromosomal DNA lesions (SLF1–SLF2), thus enabling exploration of SMC5/6 functions in innate immunity and cancer.
Rupinder Singh Jandu, Ashim Bhattacharya ... Franck Duong van Hoa
Peptidisc-based thermal proteome profiling enables detergent-free mapping of membrane protein–ligand interactions, advancing the discovery of druggable targets in membrane-mimetic environments.
Aalimah Akinosho, Joseph Alexander ... Andres Gabriel Vidal-Gadea
Independent replication confirms that avoidance of pathogenic PA14 learned by Caenorhabditis elegans persists through the F2 generation using standardized sodium azide immobilization choice assays, clarifying prior reproducibility concerns.
Computational modeling of the memory modification process reveals biased internal states in an Alzheimer’s disease mouse model, providing a new approach for early cognitive assessment and diagnosis.
Daria M Odermatt, Frank Chidawanyika ... Meredith C Schuman
'Push-pull' agro-ecosystems appear to protect maize against the fall armyworm, but volatiles from Desmodium intercrops are not sufficient to reliably repel this herbivore, indicating that additional mechanisms contribute to protection.
Wojciech Wietrzynski, Lorenz Lamm ... Benjamin D Engel
Cryo-electron tomography reveals plant photosynthetic membranes with single-complex precision, supporting a simple two-domain model of membrane organization.
Bruno Cuevas Zuviría, Franka Detemple ... Betül Kaçar
Structural reconstruction of thousands of ancient nitrogenases through Earth’s history uncovers architectural constraints that shaped their evolution under global environmental transitions.
Jessica Mella, Regan F Volk ... Abigail Buchwalter
The inner nuclear membrane protein emerin readily traffics through the secretory pathway via its hydrophobic transmembrane domain when tagged with C-terminal GFP.
