A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.
A comparison of how two nematode species sense salts highlights how evolution can find different ways to establish asymmetry in small nervous systems to optimize the processing of chemosensory cues.
Jessie Kulsuptrakul, Michael Emerman, Patrick S Mitchell
During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.
A local-ancestry-aware association model identified a suggestive association peak within the HLA class II region linked to TB in a complex, highly admixed Southern African population.
Elise Miedlar, Grace E Hamilton ... Trisha N Davis
Biochemical reconstitution and laser trapping show that centromeric DNA sequences are important for the transmission of microtubule-based forces to chromosomes.
Daniela Piña Novo, Mang Gao ... Gordon MG Shepherd
'Phototactile' hand stimulation rapidly activates first the somatosensory then the motor cortex, broadly consistent with constraints suggested by the previously described circuit architecture of this transcortical loop.
A built-in solution for correcting optical aberrations in long (> 6 mm) gradient index (GRIN) lenses enables unbiased two-photon functional recordings of large neuronal populations in the deep mouse brain.
Dharmendra Kumar Nath, Subash Dhakal, Youngseok Lee
TRPγ is essential for maintaining lipid homeostasis in Drosophila melanogaster, linking neuronal regulation to fat metabolism and suggesting potential therapeutic avenues for metabolic disorders.
Reserpine, previously identified through high-throughput screening in CEP290 retinal degeneration models, enhances photoreceptor survival in P23H rhodopsin retinal degeneration models, particularly in female rats, indicating its gene-agnostic and sex-specific effectiveness.
The asymmetrically segregated Notch pathway inhibitor Numb is essential for intestinal stem cell self-renewal in adult Drosophila midguts when the stem cell niche signaling is compromised.
Ana Cristina Chang-Gonzalez, Aoi Akitsu ... Wonmuk Hwang
Recognition of antigenic ligand by T-cell receptors is a nuanced process where mechanical force can be leveraged to diversify functional outcomes of different T-cells for the same ligand.
