Research Advances

A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.

Latest articles

    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Phases of cortical actomyosin dynamics coupled to the neuroblast polarity cycle

    Chet Huan Oon, Kenneth E Prehoda
    Oon and Prehoda discover cortical actomyosin dynamics that polarize asymmetrically dividing neural stem cells.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers

    Mark Ferris et al.
    Healthcare workers working on COVID-19 wards experience a 31-fold increased risk of infection with SARS-CoV-2 compared to colleagues on non-COVID-19 wards whilst wearing fluid-resistant surgical masks, and FFP3 respirators provide up to 100% protection against infection.
    1. Neuroscience

    Subpopulations of neurons in lOFC encode previous and current rewards at time of choice

    David L Hocker et al.
    A distinct subpopulation of neurons in the rat orbitofrontal cortex encodes reward history at the time of choice, providing a potential neural substrate by which reward history may influence decisions.
    1. Neuroscience

    Urgency forces stimulus-driven action by overcoming cognitive control

    Christian H Poth
    Under time-pressure, human action is temporarily dominated by stimuli in the environment, and this results in behavior conflicting with current goals.
    1. Cell Biology
    2. Developmental Biology

    Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts

    Amrutha Kizhedathu et al.
    Reactive oxygen species can activate the ATR/Chk1 pathway in the absence of detectable DNA damage and without a requirement for DNA damage response proteins.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8

    Lukas M Langer et al.
    Structures of human SMG1-9 and SMG1-8-9 reveal how the SMG1 kinase active site is targeted by a specific inhibitor and provide insights into the regulation of the SMG1-8-9 kinase complex in nonsense-mediated mRNA decay.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD

    Ginto George et al.
    Biochemical analysis reveals the entire route of oligosaccharide processing from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), and the enzymes (EDEM2 and EDEM3/1) responsible for endoplasmic reticulum-associated degradation of misfolded glycoproteins.
    1. Biochemistry and Chemical Biology

    Fusion of tethered membranes can be driven by Sec18/NSF and Sec17/αSNAP without HOPS

    Hongki Song, William T Wickner
    The coordinate activity of Sec17/SNAP and Sec18/NSF for membrane fusion is not limited to systems with homotypic fusion and vacuole protein sorting (HOPS), the lysosomal/vacuolar tethering, and SNARE assembly complex.
    1. Neuroscience

    All-trans retinoic acid induces synaptopodin-dependent metaplasticity in mouse dentate granule cells

    Maximilian Lenz et al.
    All-trans retinoic acid increases the number of excitatory synapses in the dorsal hippocampus of mice and improves the ability of neurons to express synaptopodin-dependent synaptic plasticity.
    1. Developmental Biology

    A functional genetic toolbox for human tissue-derived organoids

    Dawei Sun et al.
    To facilitate human developmental biology research, CRISPR-mediated homologous recombination, tightly inducible gene knockdowns (CRISPRi) and overexpression (CRISPRa) have been efficiently applied to human organoids.