A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity

  1. Lea Ankri
  2. Zoé Husson
  3. Katarzyna Pietrajtis
  4. Rémi Proville
  5. Clément Léna
  6. Yosef Yarom
  7. Stéphane Dieudonné  Is a corresponding author
  8. Marylka Yoe Uusisaari
  1. Hebrew University of Jerusalem, Israel
  2. Ecole Normale Supérieure, France

Abstract

The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the cerebellar nuclei may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells.

Article and author information

Author details

  1. Lea Ankri

    Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    Competing interests
    The authors declare that no competing interests exist.
  2. Zoé Husson

    Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France
    Competing interests
    The authors declare that no competing interests exist.
  3. Katarzyna Pietrajtis

    Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France
    Competing interests
    The authors declare that no competing interests exist.
  4. Rémi Proville

    Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France
    Competing interests
    The authors declare that no competing interests exist.
  5. Clément Léna

    Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France
    Competing interests
    The authors declare that no competing interests exist.
  6. Yosef Yarom

    Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    Competing interests
    The authors declare that no competing interests exist.
  7. Stéphane Dieudonné

    Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France
    For correspondence
    dieudon@biologie.ens.fr
    Competing interests
    The authors declare that no competing interests exist.
  8. Marylka Yoe Uusisaari

    Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    Competing interests
    The authors declare that no competing interests exist.

Ethics

Animal experimentation: All animal manipulations were made in strict accordance with guidelines of the Centre National de la Recherche Scientifique and the Hebrew University's Animal Care and Use Committee (Ethic permission # NS-12-12505-4).

Reviewing Editor

  1. Michael Häusser, University College London, United Kingdom

Version history

  1. Received: December 27, 2014
  2. Accepted: May 11, 2015
  3. Accepted Manuscript published: May 12, 2015 (version 1)
  4. Version of Record published: June 10, 2015 (version 2)

Copyright

© 2015, Ankri et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Lea Ankri
  2. Zoé Husson
  3. Katarzyna Pietrajtis
  4. Rémi Proville
  5. Clément Léna
  6. Yosef Yarom
  7. Stéphane Dieudonné
  8. Marylka Yoe Uusisaari
(2015)
A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity
eLife 4:e06262.
https://doi.org/10.7554/eLife.06262

Share this article

https://doi.org/10.7554/eLife.06262

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