A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity

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Abstract

The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the cerebellar nuclei may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells.

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Lea Ankri

Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel

Competing interests
The authors declare that no competing interests exist.
Zoé Husson

Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France

Competing interests
The authors declare that no competing interests exist.
Katarzyna Pietrajtis

Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France

Competing interests
The authors declare that no competing interests exist.
Rémi Proville

Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France

Competing interests
The authors declare that no competing interests exist.
Clément Léna

Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France

Competing interests
The authors declare that no competing interests exist.
Yosef Yarom

Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel

Competing interests
The authors declare that no competing interests exist.
Stéphane Dieudonné

Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France

For correspondence
dieudon@biologie.ens.fr

Competing interests
The authors declare that no competing interests exist.
Marylka Yoe Uusisaari

Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel

Competing interests
The authors declare that no competing interests exist.

Ethics

Animal experimentation: All animal manipulations were made in strict accordance with guidelines of the Centre National de la Recherche Scientifique and the Hebrew University's Animal Care and Use Committee (Ethic permission # NS-12-12505-4).

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This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.