Correction: Structural basis for the prion-like MAVS filaments in antiviral innate immunity

  1. Hui Xu
  2. Xiaojing He
  3. Hui Zheng
  4. Lily J Huang
  5. Fajian Hou
  6. Zhiheng Yu
  7. Michael Jason de la Cruz
  8. Brian Borkowski
  9. Xuewu Zhang  Is a corresponding author
  10. Zhijian J Chen  Is a corresponding author
  11. Qiu-Xing Jiang  Is a corresponding author
  1. University of Texas Southwestern Medical Center, United States
  2. CryoEM Shared Resources, Janelia Farm Research Campus, Howard Hughes Medical Institute, United States
  3. Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, United States
3 figures and 1 video

Figures

Analyses of high-resolution cryoEM images of MAVS CARD filaments.

(A) A representative EM image after motion correction. (B) The power spectrum of a motion-corrected image showing Thon rings up to ∼3 Å (bottom arrow), with the CTF fittings (white concentric rings) …

https://doi.org/10.7554/eLife.07546.001
Molecular modeling based on the near-atomic resolution cryoEM map.

(A) A side view of the cryoEM map with an atomic model of human MAVS CARD docked as a rigid body (blue: atomic model of residues 1–97, PDB: 3J6J). The N- and C- termini face the periphery of the …

https://doi.org/10.7554/eLife.07546.002
Molecular interfaces of the pseudoatomic model based on the C1 map.

(A) A model of the MAVS CARD filament based on the cryoEM map, showing three helical turns. Each MAVS CARD interacts with six nearest neighbors: two neighbors along the helical trajectory (grey and …

https://doi.org/10.7554/eLife.07546.004

Videos

Video 1
CryoEM structure of the MAVS CARD filament.
https://doi.org/10.7554/eLife.07546.003

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