Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate

    Minato Hirano, Gaddiel Galarza-Muñoz ... Mariano A Garcia-Blanco
    RNA processing regulates gene expression of the key transcription factor FOXP3 in T regulatory cells impacting immune tolerance and susceptibility to autoimmune disease.
    1. Immunology and Inflammation

    Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

    Pedro P Cunha, Eleanor Minogue ... Randall S Johnson
    Oxygen levels at the time of T cell activation are major determinants of function, even when T cells are subsequently expanded in high levels of oxygen.
    1. Immunology and Inflammation

    Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)

    Sindhu Mohandas, Prasanna Jagannathan ... RECOVER Mechanistic Pathways Task Force
    Immune dysregulation is thought to be a hallmark of long COVID or PASC but there is a need for understanding the underlying mechanisms which drive the disease progression.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Statistical inference reveals the role of length, GC content, and local sequence in V(D)J nucleotide trimming

    Magdalena L Russell, Noah Simon ... Frederick A Matsen IV
    Local sequence context, length, and GC nucleotide content in both directions of the trimming site, together, are highly predictive of V(D)J trimming probabilities for both TR and IG adaptive immune receptor loci.

Senior editors

  1. Arturo Casadevall
    Johns Hopkins Bloomberg School of Public Health, United States
  2. Betty Diamond
    The Feinstein Institute for Medical Research, United States
  3. Diane M Harper
    University of Michigan, United States
  4. See more editors