Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation
   2. Structural Biology and Molecular Biophysics

   Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality

   Mohamed A Badawy et al.

   Electron paramagnetic resonance spectroscopy quantitatively correlates structural damages of serum albumin with COVID-19 severity and mortality thus suggesting albumin replacement therapy as a strategy to rescue patients at risk of mortality.
2. 1. Immunology and Inflammation

   Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model

   Takemichi Fukasawa et al.

   Single-cell analysis revealed that autoantigen-reactive B cells changed the type of cytokines they produced from anti-inflammatory IL-10 and IL-35 to pro-inflammatory IL-6 and IL-23 as affinity to autoantigen increased.
3. 1. Immunology and Inflammation

   Histone deacetylase 3 represses cholesterol efflux during CD4⁺ T-cell activation

   Drew Wilfahrt et al.

   Histone deacetylase 3 is required for CD4+ T cells to downregulate two cholesterol efflux transport proteins, ABCA1 and ABCG1, for successful proliferation after antigenic stimulation.
4. 1. Epidemiology and Global Health
   2. Immunology and Inflammation

   A recombinant protein containing influenza viral conserved epitopes and superantigen induces broad-spectrum protection

   Yansheng Li et al.

   By fusing influenza viral conserved epitopes and a superantigen fragment, we constructed a recombinant protein that might be a candidate universal broad-spectrum vaccine for the prevention and treatment of multiple influenza viruses.
5. 1. Immunology and Inflammation

   The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice

   Rafael Bayarri-Olmos et al.

   Functional characterization of the alpha/B1.1.7 SARS-CoV-2 variant revealed an eightfold affinity increase of the N501Y RBD to human ACE-2 and that even a low inoculation dose of the alpha variant induces severe disease and fast progression in transgenic hACE2 mice.
6. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs

   Koshlan Mayer-Blackwell et al.

   Distance-based TCR analysis enables grouping of biochemically similar clonotypes into meta-clonotypes that have increased publicity, and therefore statistical power, for population-level detection of antigen-specific T cells in infection and vaccination.
7. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Remote immune processes revealed by immune-derived circulating cell-free DNA

   Ilana Fox-Fisher et al.
8. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis

   Andreas Hober et al.

   Immuno-affinity enrichment combined with liquid chromatography-mass spectrometry can be used to detect viral proteins to confirm the presence of SARS-CoV-2 in clinical samples.
9. 1. Cell Biology
   2. Immunology and Inflammation

   Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

   Shannon Rausser et al.

   A high-throughput mitochondrial phenotyping approach quantifies mitochondrial features among purified human immune cell subtypes and provides foundational knowledge to map inter- and intra-individual variation in mitochondrial energetics with high biological specificity.
10. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response

    Amelia E Hinman et al.

    The pathogenic success of Mycobacterium tuberculosis relies in part on its ability to blunt a component of the TLR2-dependent immune response.