Immunology and Inflammation

Immunology and Inflammation

eLife publishes research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Immunology and Inflammation

    A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice

    Edouard Charlebois, Carine Fillebeen ... Kostas Pantopoulos
    Under systemic iron overload, translational derepression of ferroportin mRNA via the IRE/IRP system antagonizes hepcidin-mediated ferroportin degradation to coordinately control serum iron.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inerthydroxymethylene diphosphonate

    Hiroko Okawa, Takeru Kondo ... Ichiro Nishimura
    The targeted removal of legacy bisphosphonate from the jawbone by competitive equilibrium therapy not only elucidated the pathological mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) but also established a highly translatable therapeutic option for BRONJ.
    1. Cancer Biology
    2. Immunology and Inflammation

    Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy

    Amit Gutwillig, Nadine Santana-Magal ... Yaron Carmi
    Tumors escape killing by the immune system through generating transient spatial cell-in-cell structures that are impenetrable to cytotoxic compounds including lytic granules and chemotherapy.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants

    Jing Zhang, Zi Bo Han ... Qi Ming Li
    Animal experiments show that the mosaic-type immunogen integrating key mutations from Omicron and other circulating variants elicits broad neutralization against divergent SARS-CoV-2 strains.
    1. Cell Biology
    2. Immunology and Inflammation

    HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages

    Wei-Jia Luo, Sung-Liang Yu ... Kang-Yi Su
    Single-cell RNA sequencing reveals HLJ1 as a novel immunomodulator for multicellular pathway of macrophages and NK cells, contributing to organ injury and sepsis death through amplified IL-12/IFN-γ axis.

Senior editors

  1. Arturo Casadevall
    Johns Hopkins Bloomberg School of Public Health, United States
  2. Miles P Davenport
    University of New South Wales, Australia
  3. Wendy S Garrett
    Wendy S Garrett
    Harvard T.H. Chan School of Public Health, United States
  4. See more editors