Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C

   Cilia R Pothast, Ian Derksen ... Ferenc A Scheeren
2. 1. Evolutionary Biology
   2. Immunology and Inflammation

   Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

   Elizabeth J Fay, Kolya Isterabadi ... Matthew D Daugherty

   Combining phylogenetic analyses and functional assays to study the receptor interacting protein kinase family reveals conserved and non-conserved functions in immune signaling across vertebrates.
3. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Phase transition of WTAP regulates m⁶A modification of interferon-stimulated genes

   Sihui Cai, Jie Zhou ... Jun Cui

   IFN-β-induced WTAP phase transition bridges STAT1 and MTC, which orchestrates m⁶A dynamics on ISG mRNAs to suppress excessive immune response and sustain immune homeostasis.
4. 1. Immunology and Inflammation

   Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

   Nobuyuki Nosaka, Vanessa Borges ... Kenichi Shimada
5. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape

   Ursula E Schoeberl, Johanna Fitz ... Rushad Pavri
6. 1. Immunology and Inflammation

   T-follicular helper cell profiles differ by malaria antigen and for children compared to adults

   Catherine Suzanne Forconi, Christina Nixon ... Ann M Moormann

   Pf-GARP antigen seems to be a better malaria vaccine candidate compared to PfSEA-1A, as it triggered the activation of cTFH17, involved in the maintenance of memory antibody responses in adults.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Single-cell profiling of the lung immune cells of diabetes-tuberculosis comorbidity reveals reduced type-II interferon and elevated Th17 responses

   Shweta Chaudhary, Mothe Sravya ... Ranjan Kumar Nanda
8. 1. Immunology and Inflammation

   Modeling hereditary diffuse leukoencephalopathy with axonal spheroids using microglia-sufficient brain organoids

   Wei Jie Wong, Yi Wen Zhu ... Florent Ginhoux

   Co-culture between donor-derived iPSC-induced macrophages and forebrain organoids revealed microglial impairment leading to the degenerative neuro-environment in HDLS.
9. 1. Immunology and Inflammation

   Unraveling the role of Ctla-4 in intestinal immune homeostasis through a novel Zebrafish model of inflammatory bowel disease

   Lulu Qin, Chongbin Hu ... Jianzhong Shao

   The generation of a Ctla-4-deficient zebrafish line has established a direct link between Ctla-4 and IBD in zebrafish.
10. 1. Immunology and Inflammation

    Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation

    Israel Ríos, Cristina Herrero ... Angel L Corbí

    Chemical inhibition or genetic downregulation of glycogen synthase kinase-3 reprograms human monocyte-derived macrophages by enhancing their anti-inflammatory, homeostatic, and reparative functions.