Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature

   Chao Yang et al.

   T-bet suppresses the expression of immature NK cell-defining genes.
2. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Identifying the immune interactions underlying HLA class I disease associations

   Bisrat J Debebe et al.

   HLA class I-disease associations have been studied for decades; a new approach for investigating the underlying mechanism can overcome past problems with interpretation and help to understand the etiology of human diseases.
3. 1. Immunology and Inflammation
   2. Neuroscience

   Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

   Kevin G Burfeind et al.

   Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst

   Giang T Nguyen et al.

   SKAP2 is critical for hematopoietic cell protection against Klebsiella infection in mouse lungs, for full phosphorylation of Src Family Kinases, Syk, and Pyk2, and for Klebsiella-induced reactive oxygen species production.
5. 1. Developmental Biology
   2. Immunology and Inflammation

   Linker histone H1.2 and H1.4 affect the neutrophil lineage determination

   Gabriel Sollberger et al.

   Linker histones affect the lineage determination of granulocyte precursor cells via regulation of the transcription factor GATA-2.
6. 1. Cell Biology
   2. Immunology and Inflammation

   Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception

   Stefanie Gryzik et al.
7. 1. Developmental Biology
   2. Immunology and Inflammation

   A single-cell survey of Drosophila blood

   Sudhir Gopal Tattikota et al.

   Single-cell RNA sequencing of Drosophila hemocytes in blood distinguishes various states within known blood cell types and implicates a novel role for fibroblast growth factor receptor signaling in inter-hemocyte crosstalk.
8. 1. Immunology and Inflammation

   Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma

   Kenji Murata et al.

   A library of the paired peptide/HLA multimers and artificial APCs allows for construction of a large database of class I-restricted peptides and cognate tumor-reactive TCR genes at an unprecedented scale.
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   A helminth-derived suppressor of ST2 blocks allergic responses

   Francesco Vacca et al.

   HpBARI is a protein secreted by a parasitic helminth, which binds to and blocks the IL-33 receptor, suppressing IL-33-dependent type 2 immune responses.
10. 1. Computational and Systems Biology
    2. Immunology and Inflammation

    Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling

    Claire Y Ma et al.