Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation

    CD56dimCD16dim NK cells are the dominant effector cells against HIV-infected primary T-cells

    William Howell, Courtney Branch ... Edward Barker
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Bacterial and viral gut microbiome alterations characterize microbiome-immune-pathophysiology axes in sickle cell disease

    Zachary N Flamholz, Jennifer De Los Santos ... Libusha Kelly
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions

    Yueh-Chien Lin, Takahiro Seno ... Timothy Hla
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Medicine

    Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

    Hengqi Betty Zheng, Benjamin A Doran ... Leslie S Kean
    Single-cell profiling of untreated pediatric Crohn’s disease identifies coordinated immune and epithelial cell states that stratify patients by disease severity and future anti-TNF response.
    1. Immunology and Inflammation

    Allosteric disulfide control of ligand binding and endocytosis of KIR2DL4, the natural killer cell receptor for HLA-G

    Sumati Rajagopalan, Joyce Chiu ... Eric O Long
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation

    Simplifying principles underlying the highly complex peptide motif of the promiscuous chicken MHC class I molecule, BF2*21:01

    Michael Harrison, Paul E Chappell ... Jim Kaufman
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation

    Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signaling

    Sung Hoon Cho, Shawna K Brookens ... Mark R Boothby
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cell Biology
    2. Immunology and Inflammation

    MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide

    Michelle C Rice, Maria Imun ... Changhan Lee
    MOTS-c, a mitochondrial-encoded microprotein, has immunological origins and functions, revealing for the first time that our immune system is encoded by both co-evolved nuclear and mitochondrial genomes.
    1. Immunology and Inflammation

    TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis

    Philip V Seegren, Amir Rattner ... Jeremy Nathans
    In a mouse model of E. coli meningitis, non-myeloid TLR4 signaling is a key determinant of the inflammatory response in all leptomeningeal cells and of the increase in vascular permeability.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Sequential and coordinated control of human plasma cell differentiation by IRF4 and BLIMP1 utilizing a discriminating ISRE/EICE motif lexicon

    Louis C Lau, Sneha Lal ... Harinder Singh
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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Highlights

    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Antibody Language Models: Taking the biology seriously makes models better

    Antonio Matas-Gil, Andreas Tiffeau-Mayer
    1. Immunology and Inflammation
    2. Neuroscience

    Microglia: Replacing the immune system of the brain

    Julie Rebejac, Soyon Hong

Senior editors

  1. Wendy S Garrett
    Wendy S Garrett
    Harvard T.H. Chan School of Public Health, United States
  2. Tony Ng
    King's College London, United Kingdom
  3. Joshua T Schiffer
    Fred Hutchinson Cancer Research Center, United States
  4. See more editors