Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   A bacterial immunomodulatory protein with lipocalin-like domains facilitates host–bacteria mutualism in larval zebrafish

   Annah S Rolig et al.

   Discovery of a secreted protein from resident gut bacteria that reduced intestinal innate immune responses which would otherwise simultaneously compromise both bacterial and host survival.
2. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Gut Microbiome: Everyone wins

   Renata C Matos, François Leulier

   Aeromonas bacteria living in the gut of zebrafish produce a specific molecule to pacify the immune system of their host.
3. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Plasmodium-specific atypical memory B cells are short-lived activated B cells

   Damian Pérez-Mazliah et al.
4. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   The allosteric activation of cGAS underpins its dynamic signaling landscape

   Richard M Hooy, Jungsan Sohn

   Rigorous biophysical studies reconcile several conflicting views on how cGAS is activated, and present a new unifying allosteric activation mechanism.
5. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation

   Arda Halu et al.

   Enriching the interactome with context-specific information from proteomics helps the identification of novel regulators of macrophage activation.
6. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion

   Katherine A Smith et al.

   Immune expulsion of helminth parasites is driven by two key pathways mediated by soluble cytokines ligating to the IL-4 and IL-25 receptors acting on innate effector cells throughout the course of infection.
7. 1. Immunology and Inflammation

   α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster

   Oliver Gordon et al.

   The Drosophila response to injection of alpha-actinin reinforces the notion that exposure of cytoskeletal components acts as a sign of cell damage conserved throughout metazoan evolution.
8. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity

   William S DeWitt III et al.

   An analysis of T cell receptor occurrence patterns that accounts for MHC restriction reveals striking imprints of common viral pathogens and patterns of TCR-HLA sequence covariation in a large human cohort.
9. 1. Immunology and Inflammation

   Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

   Gaojian Lian et al.

   Metabolic reprogramming in suppressing oxidative stress during TH17 cell differentiation.
10. 1. Immunology and Inflammation
    2. Neuroscience

    Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody

    Karina Kaczmarek-Hajek et al.

    A novel BAC transgenic mouse model reveals glial restriction of P2X7 expression in the central and peripheral nervous systems.