Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation

    A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

    Jordan Z Zhou, Bihui Huang ... Kang Chen
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Cell Biology
    2. Immunology and Inflammation

    Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response

    Shiqiang Xu, Alix Buridant ... Henri-François Renard
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Temporal single-cell analysis reveals age-associated delay in immune resolution after respiratory viral infection

    Yue Wu, Chaofan Li ... Jie Sun
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

    Kely C Matteucci, Nathalia PS Leite ... Ricardo T Gazzinelli
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Developmental Biology
    2. Immunology and Inflammation

    HEB collaborates with TCR signaling to upregulate Id3 and enable γδT17 cell maturation in the fetal thymus

    Johanna S Selvaratnam, Juliana Dutra Barbosa da Rocha ... Michele K Anderson
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation
    2. Neuroscience

    Microglia: Replacing the immune system of the brain

    Julie Rebejac, Soyon Hong
    A new method enables engineered immune progenitor cells to replace microglia in mice and reveals how a genetic mutation can lead to inflammation in the brain.
    Version of Record
    Insight
    1. Immunology and Inflammation
    2. Evolutionary Biology

    Separating selection from mutation in antibody language models

    Frederick A Matsen, Will Dumm ... Hugh K Haddox
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Immunology and Inflammation

    Contrasting roles for IKK regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive 𝛄δ T cells

    Farjana Islam, Cayman Williams ... Benedict Seddon
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

    Conor J Howard, Nathan S Abell ... Diane E Dickel
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Immunology and Inflammation

    Ex vivo and in vivo CRISPR/Cas9 screenings identify the roles of protein N-glycosylation in regulating T-cell activation and functions

    Yu Hong, Xiaofang Si ... Yu Zhang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
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Highlights

    1. Immunology and Inflammation
    2. Neuroscience

    The brain's immune system

    Julie Rebejac, Soyon Hong
    1. Developmental Biology
    2. Immunology and Inflammation

    A hemocyte atlas for an insect

    Samuel Liegeois, Dominique Ferrandon
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The immune basis of disease susceptibility

    Ruy M Ribeiro, Luis Graca

Senior editors

  1. Diane M Harper
    University of Michigan, United States
  2. Tony Ng
    King's College London, United Kingdom
  3. Aleksandra Walczak
    Ecole Normale Superieure, France
  4. See more editors