Immunology and Inflammation

Latest articles

1. 1. Developmental Biology
   2. Immunology and Inflammation

   Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila

   Katrin Kierdorf et al.
2. 1. Cancer Biology
   2. Immunology and Inflammation

   Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth

   Mark David Hayes et al.

   Natural IgE supports epithelial cell growth and differentiation in healthy skin, but during chronic tissue inflammation, IgE drives tumour outgrowth of epithelial cells harbouring oncogenic mutations.
3. 1. Developmental Biology
   2. Immunology and Inflammation

   Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

   Ken-ichi Hirano et al.
4. 1. Cell Biology
   2. Immunology and Inflammation

   A role for phagocytosis in inducing cell death during thymocyte negative selection

   Nadia S Kurd et al.

   Self-reactive thymocyte death is most efficient when peptide-presenting cells are phagocytic, and blocking phagocytosis inhibits self-reactive thymocyte death, suggesting that phagocytes play central roles during thymocyte negative selection.
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion

   Ivana Strazic Geljic et al.

   Single mouse cytomegalovirus protein, m154, downmodulates surface expression of numerous targets important for NK and CD8 T cell activation by perturbing adaptor protein-1 sorting and redirecting targets to lysosomal degradation.
6. 1. Immunology and Inflammation

   Defining murine monocyte differentiation into colonic and ileal macrophages

   Mor Gross-Vered et al.

   Detailed analysis of the sequence of monocyte differentiation into distinct gut tissue macrophages provides insights into monocyte biology and can serve as a platform for the design of cell therapies.
7. 1. Immunology and Inflammation

   Ribosome biogenesis restricts innate immune responses to virus infection and DNA

   Christopher Bianco, Ian Mohr

   Ribosome production is unexpectedly integrated into innate cell-intrinsic responses that regulate double strand DNA-sensing and inflammatory cytokine induction in infected and uninfected cells.
8. 1. Immunology and Inflammation

   Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells

   Rebeca Jimeno et al.

   The tissue environment shapes the lipid recognition capacity of natural killer T cells.
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

   Natasha D Durham et al.

   Identification of viral and host determinants of broadly neutralizing antibodies targeting a new epitope on dengue virus that can be used to guide vaccine design.
10. 1. Immunology and Inflammation

    Tight nuclear tethering of cGAS is essential for preventing autoreactivity

    Hannah E Volkman et al.

    Tight nuclear tethering of the cGAS DNA sensor maintains it in its resting state and prevents activation by self-DNA.