Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development

   Sayumi Fujimori et al.

   Highly specific gene manipulation in mouse thymic epithelial cells (TECs) shows that fine-tuning of β-catenin expression is required for TECs to generate an optimal thymic microenvironment to support T-cell development.
2. 1. Cell Biology
   2. Immunology and Inflammation

   Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

   Dasmanthie De Silva et al.

   Binding of the translation initiation factor eIF3 to the messenger RNAs encoding the T cell receptor subunits alpha and beta is required to drive a short burst in their translation and promote a strong T cell response.
3. 1. Immunology and Inflammation

   ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

   Riem Gawish et al.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

   Thomas Laval et al.

   Infection with Mycobacterium tuberculosis triggers de novo synthesis of polyunsaturated fatty acids by host macrophages, which promote their antimicrobial responses but feed the intracellular pathogen.
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Human MAIT cells respond to and suppress HIV-1

   Chansavath Phetsouphanh et al.

   In depth phenotyping from tissues and in vitro activation studies reveal antiviral function of MAIT cells- with particular emphasis on HIV infection.
6. 1. Cell Biology
   2. Immunology and Inflammation

   Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis

   Darian Williams et al.
7. 1. Cell Biology
   2. Immunology and Inflammation

   RNA N⁶-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice

   Bochuan Li et al.
8. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving

   Kenneth B Hoehn et al.

   Influenza vaccination in humans stimulates novel B cell evolution that is detectable in germinal centers, but not the peripheral blood.
9. 1. Immunology and Inflammation

   Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen

   Katherine A Deets et al.

   A mouse model of inducible inflammasome activation in intestinal epithelial cells reveals separate inflammasome-dependent and -independent cross-presentation pathways for epithelial cell-derived antigen.
10. 1. Immunology and Inflammation

    SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

    Shahanshah Khan et al.

    Recognition of SARS-CoV-2 spike protein by innate immune sensor TLR2 leads to the induction of inflammatory mediators and constitutes a mechanism for cytokine storm during COVID-19.