Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity

   Brogan Yarzabek et al.

   Lymphocytes and monocytes maintain their cell surface HLA-B via different mechanisms, which in turn differently influence cell-surface expression, half-life and peptide receptivity of HLA-B allotypes.
2. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity

   Michael J Moore et al.

   By attenuating the translation of key mRNA targets, ZFP36 RNA binding proteins restrain the expansion and effector activity of T cells.
3. 1. Immunology and Inflammation

   Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function

   Marie Bettonville et al.

   Long-term exposure to recipient's alloantigens promotes major metabolic defects in T cells that are independent of PD-1-mediated regulation.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity

   Gunjan Arora et al.

   Red blood cells infected by the malaria parasite Plasmodium falciparum are destroyed by human natural killer cells in the presence of antibodies from people who have acquired clinical immunity to malaria.
5. 1. Immunology and Inflammation

   Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses

   Brian Webster et al.

   In vivo study of arbovirus infections reveals the dominant role of pDC IRF7-signaling in directing both type I and II IFN responses, and leading to viral control.
6. 1. Cancer Biology
   2. Immunology and Inflammation

   Tumor-derived CSF-1 induces the NKG2D ligand RAE-1δ on tumor-infiltrating macrophages

   Thornton W Thompson et al.

   Macrophages respond to elevated levels of CSF-1 in tumor micro-environments by expressing a ligand for the NKG2D immunoreceptor.
7. 1. Immunology and Inflammation

   Empty conformers of HLA-B preferentially bind CD8 and regulate CD8⁺ T cell function

   Jie Geng et al.

   HLA-B*35:01 molecules that are peptide-deficient are thermostable, bind CD8 with higher affinity than their peptide-filled versions, accumulate at immunological synapses and enhance antigen-specific CD8+ T cell immune responses.
8. 1. Developmental Biology
   2. Immunology and Inflammation

   Chemokines: The cell sets the tone

   Jonna Alanko, Michael Sixt

   In zebrafish larvae, it is the cell type that determines how the cell responds to a chemokine signal.
9. 1. Developmental Biology
   2. Immunology and Inflammation

   Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors

   Divyanshu Malhotra et al.

   A new form of chemokine signaling bias that depends on cell state is identified.
10. 1. Immunology and Inflammation

    mTORC1 and mTORC2 differentially promote natural killer cell development

    Chao Yang et al.

    mTORC1 and mTORC2 play a central role in the development of natural killer (NK) cells.