Immunology and Inflammation

Immunology and Inflammation

eLife publishes research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation

    Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation

    Jaime James et al.
    PTPN22 function is regulated by reactive oxygen species, and redox regulation of PTPN22 impacts T-cell-dependent autoimmune inflammation.
    1. Immunology and Inflammation

    Autoimmunity: Redoxing PTPN22 activity

    Magdalena Shumanska, Ivan Bogeski
    The oxidative state of a critical cysteine residue determines the enzymatic activity of a phosphatase involved in T-cell immune responses.
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    1. Immunology and Inflammation

    Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

    Takahisa MIyao et al.
    The combination of single-cell analysis and cell fate mapping studies evidenced the presence of AIRE-expressing transit-amplifying thymic epithelial cells, which differentiate into mature medullary thymic epithelial cells expressing tissue-specific antigens.
    1. Developmental Biology
    2. Immunology and Inflammation

    A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells

    David J Turner et al.
    A genetic screening approach identifies RNA binding proteins that enhance or inhibit the accumulation of CD138+ plasma cells in vitro, and chimeric mouse models demonstrate that YTHDF2 promotes the accumulation of antibody secreting cells in vivo.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells

    Boyang Ren et al.
    Hematopoietic progenitor cells employ CD47 to engage thymic portal endothelial signal regulatory protein alpha for their transendothelial migration and thymic homing.
    1. Immunology and Inflammation

    Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation

    Claudio Tripodo et al.
    Neutrophil extracellular traps are an immunogenic source of leukemia antigens in dendritic cell-based vaccination and are able to instruct antileukemia CD8 T-cell responses.

Senior editors

  1. Arturo Casadevall
    Johns Hopkins Bloomberg School of Public Health, United States
  2. Miles P Davenport
    University of New South Wales, Australia
  3. Betty Diamond
    The Feinstein Institute for Medical Research, United States
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