Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation

   Jaime James et al.

   PTPN22 function is regulated by reactive oxygen species, and redox regulation of PTPN22 impacts T-cell-dependent autoimmune inflammation.
2. 1. Immunology and Inflammation

   Autoimmunity: Redoxing PTPN22 activity

   Magdalena Shumanska, Ivan Bogeski

   The oxidative state of a critical cysteine residue determines the enzymatic activity of a phosphatase involved in T-cell immune responses.
3. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

   Ceri Alan Fielding et al.
4. 1. Immunology and Inflammation
   2. Structural Biology and Molecular Biophysics

   T cells discriminate between groups C1 and C2 HLA-C

   Malcolm JW Sim et al.
5. 1. Immunology and Inflammation

   Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

   Takahisa MIyao et al.

   The combination of single-cell analysis and cell fate mapping studies evidenced the presence of AIRE-expressing transit-amplifying thymic epithelial cells, which differentiate into mature medullary thymic epithelial cells expressing tissue-specific antigens.
6. 1. Immunology and Inflammation
   2. Structural Biology and Molecular Biophysics

   Structure of the IL-27 quaternary receptor signaling complex

   Nathanael A Caveney et al.
7. 1. Developmental Biology
   2. Immunology and Inflammation

   A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells

   David J Turner et al.

   A genetic screening approach identifies RNA binding proteins that enhance or inhibit the accumulation of CD138+ plasma cells in vitro, and chimeric mouse models demonstrate that YTHDF2 promotes the accumulation of antibody secreting cells in vivo.
8. 1. Immunology and Inflammation
   2. Neuroscience

   Single-cell profiling reveals periventricular CD56^bright NK cell accumulation in multiple sclerosis

   Sabela Rodríguez-Lorenzo et al.
9. 1. Immunology and Inflammation
   2. Stem Cells and Regenerative Medicine

   Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells

   Boyang Ren et al.

   Hematopoietic progenitor cells employ CD47 to engage thymic portal endothelial signal regulatory protein alpha for their transendothelial migration and thymic homing.
10. 1. Immunology and Inflammation

    Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation

    Claudio Tripodo et al.

    Neutrophil extracellular traps are an immunogenic source of leukemia antigens in dendritic cell-based vaccination and are able to instruct antileukemia CD8 T-cell responses.