Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Doubling dolutegravir dosage reduces the viral reservoir in ART-treated people with HIV

    Céline Fombellida-Lopez, Aurelija Valaitienė ... Gilles Darcis
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation
    2. Neuroscience

    Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammation

    Alina Malita, Anne H Skakkebaek ... Kim Rewitz
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin

    Cheryll M Sia, Rebecca L Ambrose ... Danielle J Ingle
    The most comprehensive analysis of Salmonella Dublin to date uncovers distinct genotypic adaptations, antimicrobial resistance patterns, and virulence strategies that influence epidemiological success.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

    Jodie Chandler, M Elise Bullock ... Andrew J Yates
    Memory CD4 T cells within tissues are highly dynamic, and their continuous replacement may erode immunity to previous infections.
    1. Immunology and Inflammation

    Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

    Nobuyuki Nosaka, Vanessa Borges ... Kenichi Shimada
    Therapeutic hypothermia mitigates ventilator-induced lung injury by suppressing macrophage-derived IL-1β release, thereby reducing neutrophil extracellular trap formation, vascular leakage, and hypoxemia in a two-hit acute lung injury model.
    1. Immunology and Inflammation

    Trained immunity: A new player in cancer immunotherapy

    Shu Li, Yi Zou ... Jun Yan
    Trained immunity is a form of innate immune cell memory that is being developed as a novel immunotherapeutic approach for cancer treatment.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CARD8 inflammasome activation during HIV-1 cell-to-cell transmission

    Jessie Kulsuptrakul, Michael Emerman, Patrick S Mitchell
    During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.
    1. Immunology and Inflammation

    Susceptibility of Kit-mutant mice to sepsis caused by enteral dysbiosis, not mast cell deficiency

    Thorsten B Feyerabend, Fabienne Schochter ... Hans-Reimer Rodewald
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    Layers of immunity: Deconstructing the Drosophila effector response

    Faustine Ryckebusch, Yao Tian ... Bruno Lemaitre
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Opposing Regulation of TNF Responses by IFN-γ and a PGE2-cAMP Axis that is Apparent in Rheumatoid and Immune Checkpoint Inhibitor-induced Arthritis IL-1β+ Macrophages

    Upneet K Sokhi, Ruoxi Yuan ... Lionel B Ivashkiv
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
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Highlights

    1. Immunology and Inflammation

    Immobilizing bacteria

    Patricia Reist Iscar, Petr Broz
    1. Developmental Biology
    2. Immunology and Inflammation

    A hemocyte atlas for an insect

    Samuel Liegeois, Dominique Ferrandon
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The immune basis of disease susceptibility

    Ruy M Ribeiro, Luis Graca

Senior editors

  1. Wendy S Garrett
    Wendy S Garrett
    Harvard T.H. Chan School of Public Health, United States
  2. Diane M Harper
    University of Michigan, United States
  3. Tony Ng
    King's College London, United Kingdom
  4. See more editors