Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry

   Valeria Ramaglia et al.

   Imaging mass cytometry simultaneously lights up distinct immune cells in the brain.
2. 1. Immunology and Inflammation

   Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

   Eugene Park et al.

   Toxoplasma gondii infection leads to conversion of natural killer cells into cells resembling innate lymphoid cells, group 1, that circulate widely, disrupting current notions suggesting that these cells have distinct lineages.
3. 1. Immunology and Inflammation

   B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota

   Lieselotte SM Kreuk et al.

   Microbial-sensing TLRs drive responses to the microbiota, while nucleic-acid sensing TLRs control responses to endogenous ligands, revealing novel regulation of B-1a responses through integrated BCR/TLR mediated activation.
4. 1. Immunology and Inflammation

   TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections

   Hannah P Savage et al.

   B-1 cell unresponsiveness to antigen-stimulation is overcome during infections when Toll-like receptor engagement removes negative regulators of B cell receptor signaling, thereby supporting B-1 cell differentiation to IgM-secreting plasmablasts.
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence

   Lu Yu et al.

   Polarizing susceptibilities to recurrent bladder infection are shaped by a duality in TNFɑ-mediated inflammation dynamics upon challenge infection that is dictated by the outcome of the initial infection.
6. 1. Immunology and Inflammation

   Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α

   Yu-Tung Li et al.

   Blood flow-driven shear forces guide the sequential signaling of two antagonistic paired receptors, a critical bi-facet step that first supports leukocyte docking, then initiates transmigration through endothelium.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Complement and CD4⁺ T cells drive context-specific corneal sensory neuropathy

   Derek J Royer et al.
8. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   PHLPP1 counter-regulates STAT1-mediated inflammatory signaling

   Ksenya Cohen Katsenelson et al.

   Uncovering a mechanism for how inflammatory signaling is opposed by a phosphatase identifies a potential druggable target to treat E. coli sepsis.
9. 1. Immunology and Inflammation

   B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism

   Eric E Irons et al.
10. 1. Computational and Systems Biology
    2. Immunology and Inflammation

    IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

    Rachel A Gottschalk et al.

    Inflammatory dynamics are tailored to bacterial class through macrophage integration of microbial stimuli and cytokine feedback.