Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   CARD14^E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation

   Joan Manils et al.

   Expression of a psoriasis-associated CARD14^E138A mutant in keratinocytes induces TNF-dependent localised skin and systemic inflammation independently of the adaptive immune system.
2. 1. Immunology and Inflammation

   Resident macrophages acquire innate immune memory in staphylococcal skin infection

   Reinhild Feuerstein et al.

   Resident dermal Mφ are programmed locally, independently of bone-marrow monocytes during Staphylococcus aureus infection, leading to transiently increased resistance, which is limited by a decrease in macrophage life span.
3. 1. Immunology and Inflammation

   Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells

   Yvette Robbins et al.

   Human NK cells engineered to express a PD-L1 chimeric antigen receptor can control murine and human tumors and reduce myeloid cells expressing high levels of PD-L1.
4. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60

   Chun Kew et al.

   The splicing factor RNP-6/PUF60 suppresses immunity by modulating host splicing and transcriptional responses to infection.
5. 1. Immunology and Inflammation

   Human Fcγ-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in Lyme arthritis

   Heike Danzer et al.
6. 1. Cell Biology
   2. Immunology and Inflammation

   Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

   Emma J Fenech et al.

   Interaction mapping of ubiquitin ligase complexes embedded in the endoplasmic reticulum membrane has identified interactors of RNF26 that influence innate immune signalling.
7. 1. Developmental Biology
   2. Immunology and Inflammation

   Developmental Immunology: An atlas for hemocytes in an insect

   Samuel Liegeois, Dominique Ferrandon

   Single-cell RNA sequencing has revealed distinct subpopulations of hemocytes in fruit fly larvae.
8. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Topologically correct synthetic reconstruction of pathogen social behavior found during Yersinia growth in deep tissue sites

   Stacie A Clark et al.

   Tissue infection by an extracellular pathogen is recapitulated by encasing a bacterial colony within a droplet gel to allow immune cell attack, driving spatially-controlled microbial social behavior.
9. 1. Immunology and Inflammation

   Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway

   Eui Ho Kim et al.

   Experiments in mice provide insights into the immunological mechanisms of action the vaccine adjuvant MF59.
10. 1. Immunology and Inflammation
    2. Neuroscience

    Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain

    Jeremy Carlos Burns et al.