Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Genetic timestamping of plasma cells in vivo reveals tissue-specific homeostatic population turnover

   An Qi Xu et al.

   A new system to genetically label and manipulate plasma cells in vivo in their microenvironment resolves current technical limitations and reveals tissue-specific homeostatic population turnover.
2. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Combined transient ablation and single cell RNA sequencing reveals the development of medullary thymic epithelial cells

   Kristen L Wells et al.
3. 1. Immunology and Inflammation

   Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest

   Amijai Saragovi et al.
4. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Deciphering the combinatorial landscape of immunity

   Antonio Cappuccio et al.
5. 1. Immunology and Inflammation
   2. Medicine

   Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis

   Shubhanshi Trivedi et al.

   Mucosal-associated invariant T (MAIT) cells, highly activated and dysfunctional in sepsis patients, contribute to tissue-specific cytokine responses that are protective against mortality during experimental sepsis.
6. 1. Immunology and Inflammation

   LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

   Jack P Green et al.

   Depletion of LRRC8A provides genetic evidence for the importance of Cl^- channels in NLRP3 activation.
7. 1. Immunology and Inflammation

   MicroRNAs of the miR-17~9 family maintain adipose tissue macrophage homeostasis by sustaining IL-10 expression

   Xiang Zhang et al.

   miR-17~92 family of miRNAs control the balance between pro- and anti-inflammatory cytokines in adipose tissue macrophages, the absence of which leads to disturbed adipose homeostasis.
8. 1. Cell Biology
   2. Immunology and Inflammation

   Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells

   Elizabeth Rivers et al.

   WASp is an immunometabolic regulator of human myeloid cells and regulates autophagy and mitochondrial homeostasis.
9. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Cytotoxic T cells swarm by homotypic chemokine signalling

   Jorge Luis Galeano Niño et al.

   Killer T cells swarm around tumour targets by accelerating the recruitment of distant T cells, which upon arrival and target engagement augment the chemotactic signal in a positive feedback loop.
10. 1. Immunology and Inflammation

    Sepsis impedes EAE disease development and diminishes autoantigen-specific naïve CD4 T cells

    Isaac J jensen et al.