Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

   Gaojian Lian et al.

   Metabolic reprogramming in suppressing oxidative stress during TH17 cell differentiation.
2. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion

   Katherine A Smith et al.
3. 1. Immunology and Inflammation
   2. Neuroscience

   Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody

   Karina Kaczmarek-Hajek et al.

   A novel BAC transgenic mouse model reveals glial restriction of P2X7 expression in the central and peripheral nervous systems.
4. 1. Cancer Biology
   2. Immunology and Inflammation

   Topography of cancer-associated immune cells in human solid tumors

   Jakob Nikolas Kather et al.

   Spatial patterns of lymphoid and myeloid cells in human solid tumors differ between cancer types, yielding a new classification of anti-tumor host response.
5. 1. Developmental Biology
   2. Immunology and Inflammation

   Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus

   Federico Andrea Moretti et al.

   T cell progenitor homing into the thymus requires kindlin-3 to stabilize their adhesion to vascular integrin ligands when blood flow velocities and shear rates increase during development.
6. 1. Cell Biology
   2. Immunology and Inflammation

   A two-hybrid antibody micropattern assay reveals specific in cis interactions of MHC I heavy chains at the cell surface

   Cindy Dirscherl et al.

   A generally applicable two-hybrid assay demonstrates that MHC class I heavy chains devoid of beta-2 microglobulin associate within and across allotypes, with implications for endocytosis and autoimmunity.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

   Tonya Kueck et al.

   Distinct antiviral signaling pathways, triggered by the aryl hydrocarbon receptor and Interferon-gamma, converge on CDK/cyclin repression, causing inhibition of viral DNA synthesis.
8. 1. Immunology and Inflammation

   CCR7 defines a precursor for murine iNKT cells in thymus and periphery

   Haiguang Wang, Kristin A Hogquist

   Adoptive transfer and genetic manipulation revealed a previously unknown sub-population of PLZFhi CCR7+ iNKT cells as precursors for all three iNKT effector subsets in both thymus and periphery in mice.
9. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity

   William S DeWitt et al.
10. 1. Cancer Biology
    2. Immunology and Inflammation

    The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

    Alison Caldwell et al.

    A recently discovered contagious cancer in the Tasmanian devil has the potential to become widespread in the population due to the loss of histocompatibility antigens that are allogeneic to its hosts.