Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables tunable self-amplifying RNA expression with reduced immunotoxicity

    Tony KY Lim, Anne Ritoux ... Ewan St. John Smith
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation

    Opposing regulation of TNF responses by IFN-γ and a PGE2-cAMP axis that is apparent in rheumatoid and immune checkpoint inhibitor-induced arthritis human IL-1β+ macrophages

    Upneet K Sokhi, Ruoxi Yuan ... Lionel B Ivashkiv
    Interferon-γ and prostaglandin E2 signaling oppose each other to determine the balance between two distinct TNF-induced inflammatory gene expression programs relevant for rheumatoid and immune checkpoint inhibitor-induced arthritis.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention

    Alisa Sukhina, Clemence Queriault ... Will Bailis
    Dysregulated myelopoiesis is identified as a driver of nutritionally acquired immunodeficiency that persists after refeeding and nutritional recovery, indicating exposure to food scarcity may be an immunologic risk factor.
    1. Medicine
    2. Immunology and Inflammation

    A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies

    Thomas Balligand, Claire Carpenet ... Maarten Dewilde
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Glycosylated IgG antibodies accelerated the recovery of haemorrhagic fever with renal syndrome patients

    Chuansong Quan, Lu Wang ... Haifeng Hou
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    Coenzyme A governs proinflammatory macrophage metabolism

    Greg. A Timblin, Kevin. M Tharp ... Valerie M Weaver
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Immunology and Inflammation

    β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury

    Renaud Prevel, Erwan Pernet ... Maziar Divangahi
    β-Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids

    David Saeb, Emma E Lietzke ... Kayla G Sprenger
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Immunology and Inflammation

    Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

    Wesley H Godfrey, Judy J Lee ... Michael D Kornberg
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation

    Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

    Tianhan Li, Liaoxun Lu ... Lichen Zhang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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Highlights

    1. Immunology and Inflammation

    The double-edged nature of trained immunity

    Chrissy M Leopold Wager, Larry S Schlesinger
    1. Developmental Biology
    2. Immunology and Inflammation

    A hemocyte atlas for an insect

    Samuel Liegeois, Dominique Ferrandon
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The immune basis of disease susceptibility

    Ruy M Ribeiro, Luis Graca

Senior editors

  1. Wendy S Garrett
    Wendy S Garrett
    Harvard T.H. Chan School of Public Health, United States
  2. Diane M Harper
    University of Michigan, United States
  3. Tadatsugu Taniguchi
    Tadatsugu Taniguchi
    Research Center for Advanced Science and Technology, The University of Tokyo, Japan
  4. See more editors