Immunology and Inflammation

Immunology and Inflammation

eLife publishes research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we publish and sign up for the latest research.
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Latest articles

    1. Immunology and Inflammation

    CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation

    Joan Manils et al.
    Expression of a psoriasis-associated CARD14E138A mutant in keratinocytes induces TNF-dependent localised skin and systemic inflammation independently of the adaptive immune system.
    1. Immunology and Inflammation

    Resident macrophages acquire innate immune memory in staphylococcal skin infection

    Reinhild Feuerstein et al.
    Resident dermal Mφ are programmed locally, independently of bone-marrow monocytes during Staphylococcus aureus infection, leading to transiently increased resistance, which is limited by a decrease in macrophage life span.
    1. Immunology and Inflammation

    Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells

    Yvette Robbins et al.
    Human NK cells engineered to express a PD-L1 chimeric antigen receptor can control murine and human tumors and reduce myeloid cells expressing high levels of PD-L1.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60

    Chun Kew et al.
    The splicing factor RNP-6/PUF60 suppresses immunity by modulating host splicing and transcriptional responses to infection.
    1. Cell Biology
    2. Immunology and Inflammation

    Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

    Emma J Fenech et al.
    Interaction mapping of ubiquitin ligase complexes embedded in the endoplasmic reticulum membrane has identified interactors of RNF26 that influence innate immune signalling.
    1. Developmental Biology
    2. Immunology and Inflammation

    Developmental Immunology: An atlas for hemocytes in an insect

    Samuel Liegeois, Dominique Ferrandon
    Single-cell RNA sequencing has revealed distinct subpopulations of hemocytes in fruit fly larvae.
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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Topologically correct synthetic reconstruction of pathogen social behavior found during Yersinia growth in deep tissue sites

    Stacie A Clark et al.
    Tissue infection by an extracellular pathogen is recapitulated by encasing a bacterial colony within a droplet gel to allow immune cell attack, driving spatially-controlled microbial social behavior.
    1. Immunology and Inflammation

    Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway

    Eui Ho Kim et al.
    Experiments in mice provide insights into the immunological mechanisms of action the vaccine adjuvant MF59.

Senior editors

  1. Miles P Davenport
    University of New South Wales, Australia
  2. Wendy S Garrett
    Wendy S Garrett
    Harvard T.H. Chan School of Public Health, United States
  3. Tadatsugu Taniguchi
    Tadatsugu Taniguchi
    Research Center for Advanced Science and Technology, The University of Tokyo, Japan
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