Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation

    A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation

    Huaming Xu, Zhijian Li ... Martin Zenke
    A novel lncRNA marks the Irf8 downstream enhancer that is crucial for differentiation of plasmacytoid dendritic cells (pDC) and classical dendritic cells type 1 (cDC1) and confers feedback inhibition of Irf8 transcription.
    1. Immunology and Inflammation

    Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling

    Xing Feng, Ruifeng Sun ... Joao Pedro Pereira
    Acute lymphoblastic and myeloblastic leukemias activate lymphotoxin beta receptor in mesenchymal stem cells in the bone marrow to turn off interleukin-7 production and lymphopoiesis and gain competitive advantage.
    1. Cell Biology
    2. Immunology and Inflammation

    HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

    Sara Scinicariello, Adrian Soderholm ... Gijs A Versteeg
    HUWE1 indirectly mediates the return to cellular homeostasis after pro-inflammatory responses, which it does by controling the stability of the immune suppressor tristetraprolin.
    1. Immunology and Inflammation

    PTPN22 R620W gene editing in T cells enhances low avidity TCR responses

    Warren Anderson, Fariba Barahmand-pour-Whitman ... David J Rawlings
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)

    Zaki A Sherif, Christian R Gomez ... RECOVER Mechanistic Pathway Task Force
    PASC (post-acute sequelae of SARS-CoV-2 infection) is an enduring and debilitating illness caused by a persistent virus that promotes inflammation, coagulation, and autoimmunity complications in millions of patients initially diagnosed with COVID-19, but with no known standardized treatment regimen.
    1. Immunology and Inflammation

    Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata

    Rimma Laufer Britva, Aviad Keren ... Amos Gilhar
    Innate lymphoid cells type 1 suffice to induce hallmarks of alopecia areata phenotype in organ-cultured human scalp hair follicles ex vivo and in human scalp skin xenotransplants in vivo, suggesting that these cells play a role in early AA pathogenesis.

Senior editors

  1. Miles P Davenport
    University of New South Wales, Australia
  2. Tony Ng
    King's College London, United Kingdom
  3. Satyajit Rath
    Indian Institute of Science Education and Research (IISER), Pune, India
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