Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination

   Joseph J Campo et al.

   Panproteome array analysis of antibody responses to a pneumococcal whole cell vaccine reveals consistent induction of immune responses to multiple surface proteins, despite individuals' unique pre-existing antibody profiles.
2. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

   Sydney Lavoie et al.

   Gnotobiotic and conventional mouse models of the IBD ATG16L1T300A SNP reveal gene-microbiota-immune interactions.
3. 1. Immunology and Inflammation
   2. Neuroscience

   Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization

   Wenxin Ma et al.

   TGFβ signaling to retinal microglia is central to the regulation of neuroinflammatory responses relevant to age-related macular degeneration (AMD), a leading cause of blindness in the developed world.
4. 1. Immunology and Inflammation

   HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4⁺CD8⁺ thymocytes for CD4-lineage commitment

   Rachael Laura Philips et al.

   CD4 lineage commitment requires HDAC3 to prevent premature upregulation of CD8 lineage genes during T cell development.
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Reprogramming the antigen specificity of B cells using genome-editing technologies

   James E Voss et al.
6. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement

   Xiaoli Wang et al.

   Rodent herpesvirus Peru overcomes NK ‘missing-self’ killing using a non-classical MHC-I like protein resistant todownregulation by its own ubiquitin ligase that potently sabotages antigen presentation to T-cells.
7. 1. Immunology and Inflammation

   TAPBPR mediates peptide dissociation from MHC class I using a leucine lever

   F Tudor Ilca et al.

   Immunopeptidomics in combination with novel cell-based assays that assess peptide exchange reveal a critical role for the K22-D35 loop of TAPBPR in mediating peptide dissociation and peptide selection on MHC I.
8. 1. Immunology and Inflammation

   A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death

   Shigetoshi Yokoyama et al.

   A novel pathway was discovered for cellular uptake of LPS through secretory protein secretoglobin3A2 and a receptor syndecan-1, causing activation of non-canonical inflammasome pathway leading to pyroptosis of cancer cells.
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Plasmodium-specific atypical memory B cells are short-lived activated B cells

   Damián Pérez-Mazliah et al.

   Plasmodium-specific atypical memory B cells generated to naturally (mosquito) transmitted rodent malaria infection are short-lived activated B cells, and do not prevent resolution of infection or generation of long-lived memory.
10. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A bacterial immunomodulatory protein with lipocalin-like domains facilitates host–bacteria mutualism in larval zebrafish

    Annah S Rolig et al.

    Discovery of a secreted protein from resident gut bacteria that reduced intestinal innate immune responses which would otherwise simultaneously compromise both bacterial and host survival.