Immunology and Inflammation

Latest articles

1. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans

   Gurmeet Kaur et al.

   Prokaryotic TRADD-N and Death-like adaptor domains in diverse predicted apoptosis and immune systems from multicellular prokaryotes and metazoans indicate the common origin of key apoptosis mechanisms required for the stabilization of multicellularity.
2. 1. Cell Biology
   2. Immunology and Inflammation

   T cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1

   Yujiao He et al.
3. 1. Immunology and Inflammation

   Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

   Shuaijie Dou et al.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Reshaping of bacterial molecular hydrogen metabolism contributes to the outgrowth of commensal E. coli during gut inflammation

   Elizabeth R Hughes et al.

   Bioinformatics analyses and experiments in mouse models reveal how Escherichia coli accesses the molecular hydrogen pool to boost colonization during acute colitis.
5. 1. Cell Biology
   2. Immunology and Inflammation

   Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

   Timurs Maculins et al.

   Multiplexed mass spectrometry shows how the autophagy gene Atg16l1 regulates macrophage innate immunity against intracellular bacterial pathogens by modulating basal oxidative stress responses.
6. 1. Immunology and Inflammation

   Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells

   Isobel C Mouat et al.
7. 1. Cell Biology
   2. Immunology and Inflammation

   Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

   Nadja Kern et al.

   Manipulating nanoscale spacing of Fcγ receptors using DNA origami demonstrates that ligand clustering regulates receptor phosphorylation and phagocytosis.
8. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Inflammation drives alternative first exon usage to regulate immune genes including a novel iron regulated isoform of Aim2

   Elektra Kantzari Robinson et al.
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

   Tania Lebratti et al.

   Type I IFN is a key determinant of pathogenic neutrophil activity and drives tissue pathology through modulation of IL-18 levels during genital HSV infection.
10. 1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo

    Gerald Willimsky et al.

    Analysis of neo-splicetope-specific T cell responses strongly questions the idea that in vitro proteasome-catalyzed peptide splicing reaction simulates the in vivo situation with the same high fidelity as the in vitro generation of non-spliced epitopes.