Immunology and Inflammation

Immunology and Inflammation

eLife publishes research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation

    Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells

    Anders Laustsen et al.
    Probing of various culture conditions leads to fundamental advances in ex vivo production of plasmacytoid dendritic cells for use in immunotherapy.
    1. Cell Biology
    2. Immunology and Inflammation

    Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

    Janine JG Arts et al.
    Neutrophils use dorsal membrane protrusions of endothelial cells to cross the vascular wall.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    Inflammation: Western diet shifts immune cell balance

    Christina M Bergey
    The immune cells of macaques fed a Western-like diet adopt a pro-inflammatory profile.
    Insight
    Available as:
    • HTML
    • PDF
    1. Immunology and Inflammation
    2. Neuroscience

    Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

    Lindsay A Hohsfield et al.
    In an empty microglial niche, repopulating microglia arise from subventricular zone and white matter-associated areas without contributions from the bone marrow to fill the mouse brain via a spreading wave.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model

    Corbin SC Johnson et al.
    Modern human diet patterns alter primate behavior and monocyte gene expression leading to monocyte polarization–experimental evidence of the evolutionary mismatch hypothesis.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Evolution of cytokine production capacity in ancient and modern European populations

    Jorge Domínguez-Andrés et al.
    Neolithic was a turning point for immune responses in Europeans, favoring tolerance against intracellular pathogens, promoting inflammation against extracellular microbes, and being related to current auto-immune diseases.
    1. Immunology and Inflammation

    ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation

    Miaomiao Tian et al.
    Metabolic flux analysis, biochemistry assays, and functional confirmation in mice show that the ubiquitination and degradation of ATP-citrate lyase (ACLY) mediated by CUL3-KLHL25 promotes the switch from fatty acid synthesis to fatty acid oxidation for iTreg differentiation.
    1. Cell Biology
    2. Immunology and Inflammation

    Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages

    Andrea Santeford et al.
    MicroRNA-146b regulates aging, activation, and mitochodrial function in thioglycollate-elicited peritoneal macrophages.

Senior editors

  1. Miles P Davenport
    University of New South Wales, Australia
  2. Betty Diamond
    The Feinstein Institute for Medical Research, United States
  3. Sara L Sawyer
    University of Colorado Boulder, United States
  4. See more editors