Immunology and Inflammation

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   Synergy between serum amyloid A and secretory phospholipase A₂ suggests a vital role for an ancient protein in lipid clearance

   Shobini Jayaraman et al.
2. 1. Immunology and Inflammation

   IFNγ induces epigenetic programming of human T-bet^hi B cells and promotesTLR7/8 and IL-21 induced differentiation

   Esther Zumaquero et al.
3. 1. Immunology and Inflammation

   IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

   Qian Wang et al.

   Osteoarthritis pathogenesis is driven by IgE-mediated mast cell activation.
4. 1. Immunology and Inflammation

   Identification of potential biomarkers of vaccine inflammation in mice

   Paul F McKay et al.
5. 1. Human Biology and Medicine
   2. Immunology and Inflammation

   HIF-1α regulates IL-1β and IL-17 in sarcoidosis

   Jaya Talreja et al.

   Sarcoidosis, a granulomatous disease characterized by macrophage and T-cell activation, is found to be associated with increased HIF-1α transcriptional activity, and modulation of HIF-1α regulates inflammatory immune responses.
6. 1. Immunology and Inflammation

   IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus

   Rosanne Spolski et al.

   Neutrophil-dependent innate immune responses to the human pathogen, methicillin-resistant Staphylococcus aureus, are modulated by an interplay between interleukin-21 and type 1 interferons.
7. 1. Immunology and Inflammation

   Antigen receptor control of methionine metabolism in T cells

   Linda V Sinclair et al.

   Antigen receptor control of methionine transport is critical to co-ordinate protein synthesis and the production of methyl donors for nucleotide and protein methylations which are required for T cell differentiation.
8. 1. Immunology and Inflammation

   T Cell Activation: The importance of methionine metabolism

   Ramon I Klein Geltink, Erika L Pearce

   T helper cells import methionine to synthesize new proteins and to provide the methyl groups needed for the methylation of RNA and DNA that drives T cell proliferation and differentiation.
9. 1. Immunology and Inflammation

   Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

   O Sascha Yousefi et al.

   Controlling the duration of ligand binding to the T cell receptor by light shows that T cells discriminate stimulatory from non-stimulatory ligands by measuring the dynamics of ligand binding.
10. 1. Immunology and Inflammation
    2. Physics of Living Systems

    Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling

    Doug K Tischer, Orion David Weiner

    Direct control of ligand binding half-life with light shows that lifetime strongly affects T cell signaling.