Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation

    Cas9+ conditionally immortalized neutrophil progenitors as a tool for genome-wide CRISPR screening for neutrophil differentiation and function

    Robyn M Jong, Krystal L Ching ... Sarah A Stanley
    Cas9+ER-Hoxb8 neutrophils are a new tool for investigating neutrophil biology in vitro and in vivo.
    1. Immunology and Inflammation

    TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

    Josselyn D Barahona, Liping Yang ... Wayne M Yokoyama
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation

    Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

    Peter Georgiev, Sheila Johnson ... Arlene H Sharpe
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation

    Deciphering interferon functions in avian influenza: Insights from receptor knockout models in the natural host

    Mohanned Naif Alhussien, Hanna-Kaisa Vikkula ... Benjamin Schusser
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Solid
    1. Immunology and Inflammation

    Beta-Glucan modulates monocyte plasticity and differentiation capacity to mitigate DSS-induced colitis

    Yinyin Lv, Yanyun Fan ... Hongzhi Xu
    Trained monocytes alleviate DSS-induced colitis via bacterial clearance and monocyte differentiation reprogramming.
    1. Cell Biology
    2. Immunology and Inflammation

    Digest before Ingest: Early Recruitment of Membrane-bound DNaseX to Phagocytic Cups in Macrophages

    Arghajit Pyne, Vivek Pandey ... Xuefeng Wang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Immunology and Inflammation

    Mitochondrial metabolic remodeling drives innate immune activation in Drosophila hemocytes

    Daewon Lee, Ferdinand Koranteng ... Jiwon Shim
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation

    Dana MS Cheung, Momchil Razsolkov ... J Simon C Arthur
    B cell activation and antibody class switching requires coordinated metabolic rewiring, with essential roles for amino acid transport, cholesterol metabolism, and prenylation in driving proliferation across multiple activating stimuli.
    1. Immunology and Inflammation

    Macrophages drive inguinal fat pad and lymph node remodelling in response to peripheral inflammation

    Robin Bartolini, Deepika Sharma ... Gerard J Graham
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Redirection of SARS-CoV-2 to phagocytes by intranasal sACE2-Fc as a universal decoy confers complete prophylactic protection

    Jingyi Wang, Jiangchuan Li ... Bo Feng
    Functional and mechanistic analyses reveal that intranasal decoys engage phagocytic clearance beyond viral neutralization to provide effective protection, establishing immune redirection for developing broad-spectrum countermeasures against airborne viral threats.
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Highlights

    1. Evolutionary Biology
    2. Immunology and Inflammation

    Antibody Language Models: Taking the biology seriously makes models better

    Antonio Matas-Gil, Andreas Tiffeau-Mayer
    1. Immunology and Inflammation
    2. Neuroscience

    Microglia: Replacing the immune system of the brain

    Julie Rebejac, Soyon Hong
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.

Senior editors

  1. Diane M Harper
    University of Michigan, United States
  2. Satyajit Rath
    National Institute of Immunology, New Delhi, India
  3. Tadatsugu Taniguchi
    Tadatsugu Taniguchi
    Research Center for Advanced Science and Technology, The University of Tokyo, Japan
  4. See more editors