Immunology and Inflammation

Latest articles

1. 1. Cell Biology
   2. Immunology and Inflammation

   A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice

   Edouard Charlebois, Carine Fillebeen ... Kostas Pantopoulos

   Under systemic iron overload, translational derepression of ferroportin mRNA via the IRE/IRP system antagonizes hepcidin-mediated ferroportin degradation to coordinately control serum iron.
2. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inerthydroxymethylene diphosphonate

   Hiroko Okawa, Takeru Kondo ... Ichiro Nishimura

   The targeted removal of legacy bisphosphonate from the jawbone by competitive equilibrium therapy not only elucidated the pathological mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) but also established a highly translatable therapeutic option for BRONJ.
3. 1. Cancer Biology
   2. Immunology and Inflammation

   Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy

   Amit Gutwillig, Nadine Santana-Magal ... Yaron Carmi

   Tumors escape killing by the immune system through generating transient spatial cell-in-cell structures that are impenetrable to cytotoxic compounds including lytic granules and chemotherapy.
4. 1. Immunology and Inflammation
   2. Physics of Living Systems

   Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation

   Derek M Britain, Jason P Town, Orion David Weiner
5. 1. Immunology and Inflammation
   2. Medicine

   Bone marrow adipocytes drive the development of tissue invasive Ly6C^high monocytes during obesity

   Parastoo Boroumand, David C Prescott ... Amira Klip
6. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants

   Jing Zhang, Zi Bo Han ... Qi Ming Li

   Animal experiments show that the mosaic-type immunogen integrating key mutations from Omicron and other circulating variants elicits broad neutralization against divergent SARS-CoV-2 strains.
7. 1. Cell Biology
   2. Immunology and Inflammation

   Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes

   Judith Pineau, Léa Pinon ... Paolo Pierobon
8. 1. Immunology and Inflammation
   2. Medicine

   Neutrophil-mediated fibroblast-tumor cell IL-6/STAT-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: a hybrid clinical-preclinical study

   Iago de Castro Silva, Anna Bianchi ... Jashodeep Datta
9. 1. Immunology and Inflammation

   Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires

   Artem I Mikelov, Evgeniia I Alekseeva ... Ivan V Zvyagin
10. 1. Cell Biology
    2. Immunology and Inflammation

    HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages

    Wei-Jia Luo, Sung-Liang Yu ... Kang-Yi Su

    Single-cell RNA sequencing reveals HLJ1 as a novel immunomodulator for multicellular pathway of macrophages and NK cells, contributing to organ injury and sepsis death through amplified IL-12/IFN-γ axis.