Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires

   Artem Mikelov, Evgeniia I Alekseeva ... Ivan V Zvyagin

   High degree of clonal persistence and excess of inter-individual convergence are observed in human memory B cell repertoires, along with signatures of both negative and positive selection in most abundant clonal lineages.
2. 1. Immunology and Inflammation

   A neutrophil–B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4

   Riem Gawish, Barbara Maier ... Sylvia Knapp

   LPS pre-exposure is tissue protective during a subsequent lethal E. coli peritonitis by long-term modulation the bone marrow B-cell and neutrophil pool which affects neutrophil tissue damaging properties and therapeutic activation of Cxcr4 promotes tissue damage control during sepsis.
3. 1. Immunology and Inflammation

   Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses

   Mimmi LE Lundahl, Morgane Mitermite ... Ed C Lavelle
4. 1. Immunology and Inflammation

   Bronchus-associated macrophages efficiently capture and present soluble inhaled antigens and are capable of local Th2 cell activation

   Xin-Zi Tang, Lieselotte S M Kreuk ... Christopher D C Allen
5. 1. Immunology and Inflammation
   2. Medicine

   Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

   Iago de Castro Silva, Anna Bianchi ... Jashodeep Datta

   A neutrophil-CAF-tumor cell IL-1β/IL-6/STAT-3 signaling axis in the pancreatic tumor microenvironment underlies the association between neutrophil-to-lymphocyte ratio dynamics and pathologic response in patients with pancreatic ductal adenocarcinoma undergoing neoadjuvant therapy.
6. 1. Immunology and Inflammation
   2. Medicine

   Bone marrow adipocytes drive the development of tissue invasive Ly6C^high monocytes during obesity

   Parastoo Boroumand, David C Prescott ... Amira Klip

   Diet-induced obesity in mice led to a duration of diet-dependent bone marrow adipocyte whitening, which drove monocyte expansion and skewing towards a tissue-invasive phenotype, likely contributing to ensuing tissue infiltration that accompanies obesity and diabetes.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors

   Hadar Cohen, Noam Baram ... Motti Gerlic
8. 1. Cell Biology
   2. Immunology and Inflammation

   A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice

   Edouard Charlebois, Carine Fillebeen ... Kostas Pantopoulos

   Under systemic iron overload, translational derepression of ferroportin mRNA via the IRE/IRP system antagonizes hepcidin-mediated ferroportin degradation to coordinately control serum iron.
9. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate

   Hiroko Okawa, Takeru Kondo ... Ichiro Nishimura

   The targeted removal of legacy bisphosphonate from the jawbone by competitive equilibrium therapy not only elucidated the pathological mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) but also established a highly translatable therapeutic option for BRONJ.
10. 1. Cancer Biology
    2. Immunology and Inflammation

    Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy

    Amit Gutwillig, Nadine Santana-Magal ... Yaron Carmi

    Tumors escape killing by the immune system through generating transient spatial cell-in-cell structures that are impenetrable to cytotoxic compounds including lytic granules and chemotherapy.