Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation
   2. Structural Biology and Molecular Biophysics

   Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation

   Toshiyuki Oda et al.

   A honeycomb-lattice assembly within the skin and mucosa protects us from invading pathogens.
2. 1. Immunology and Inflammation

   The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

   Sigrid Wahlen et al.

   RUNX2 plays an important role in human NK cell biology by driving differentiation, inhibiting cytokine production, and inducing a tissue-resident phenotype, which has implications for improving NK cell therapy for cancer patients.
3. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV

   Tongcui Ma et al.

   Glycans are remodeled by HIV and are determinants of CD4+ T cell susceptibility to HIV infection.
4. 1. Immunology and Inflammation

   A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding

   Brooke D Huisman et al.
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

   Ceri Alan Fielding et al.

   SARS-CoV-2 host-shutoff inhibits innate NK surveillance by suppressing activating ligands, however ADCC provides a potent NK stimulus that is mediated by antibodies targeting Nucleocapsid, ORF3a, and Membrane, with those targeting Spike being significantly weaker.
6. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Natural Killer Cells: Taking on SARS-CoV-2

   Paola Kučan Brlić, Ilija Brizić

   A new study sheds light on how SARS-CoV-2 influences the way natural killer cells can recognize and kill infected cells.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat

   Mengyao Wang et al.

   The Toll-like receptor 2-4 genetic modification goat improves effectively resistance against Staphylococcus aureus infection by enhancing autophagy level, and it provides a novel strategy for challenge of S. aureus-caused infections.
8. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Cytotoxic CD4⁺ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts

   Carlos-Henrique D Barbosa et al.

   Cytotoxic CD4 T lymphocytes are abundantly generated in T. cruzi-infected mice, predominantly infiltrate infected hearts, depend on T-cell intrinsic IL-18R/MyD88 signaling for expansion and their blood frequency correlates with the severity of chronic myocarditis in patients with Chagas disease.
9. 1. Immunology and Inflammation

   Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

   Laura Medina-Ruiz et al.

   The use of multi-chemokine receptor reporter mice helps to unravel the dynamics of receptor involvement in leukocyte migration in vivo and suggests specificity, rather than redundancy, in receptor use.
10. 1. Cell Biology
    2. Immunology and Inflammation

    Tongue immune compartment analysis reveals spatial macrophage heterogeneity

    Ekaterini Maria Lyras et al.

    The tongue is a unique barrier organ, which is constantly exposed to environmental pathogens, and therefore is expected to host an immune cell network ensuring local immune defence, which we characterised during development, health, and disease.