Immunology and Inflammation

Immunology and Inflammation

eLife publishes research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality

    Mohamed A Badawy et al.
    Electron paramagnetic resonance spectroscopy quantitatively correlates structural damages of serum albumin with COVID-19 severity and mortality thus suggesting albumin replacement therapy as a strategy to rescue patients at risk of mortality.
    1. Immunology and Inflammation

    Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model

    Takemichi Fukasawa et al.
    Single-cell analysis revealed that autoantigen-reactive B cells changed the type of cytokines they produced from anti-inflammatory IL-10 and IL-35 to pro-inflammatory IL-6 and IL-23 as affinity to autoantigen increased.
    1. Immunology and Inflammation

    Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation

    Drew Wilfahrt et al.
    Histone deacetylase 3 is required for CD4+ T cells to downregulate two cholesterol efflux transport proteins, ABCA1 and ABCG1, for successful proliferation after antigenic stimulation.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    A recombinant protein containing influenza viral conserved epitopes and superantigen induces broad-spectrum protection

    Yansheng Li et al.
    By fusing influenza viral conserved epitopes and a superantigen fragment, we constructed a recombinant protein that might be a candidate universal broad-spectrum vaccine for the prevention and treatment of multiple influenza viruses.
    1. Immunology and Inflammation

    The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice

    Rafael Bayarri-Olmos et al.
    Functional characterization of the alpha/B1.1.7 SARS-CoV-2 variant revealed an eightfold affinity increase of the N501Y RBD to human ACE-2 and that even a low inoculation dose of the alpha variant induces severe disease and fast progression in transgenic hACE2 mice.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs

    Koshlan Mayer-Blackwell et al.
    Distance-based TCR analysis enables grouping of biochemically similar clonotypes into meta-clonotypes that have increased publicity, and therefore statistical power, for population-level detection of antigen-specific T cells in infection and vaccination.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis

    Andreas Hober et al.
    Immuno-affinity enrichment combined with liquid chromatography-mass spectrometry can be used to detect viral proteins to confirm the presence of SARS-CoV-2 in clinical samples.
    1. Cell Biology
    2. Immunology and Inflammation

    Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

    Shannon Rausser et al.
    A high-throughput mitochondrial phenotyping approach quantifies mitochondrial features among purified human immune cell subtypes and provides foundational knowledge to map inter- and intra-individual variation in mitochondrial energetics with high biological specificity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response

    Amelia E Hinman et al.
    The pathogenic success of Mycobacterium tuberculosis relies in part on its ability to blunt a component of the TLR2-dependent immune response.

Senior editors

  1. Miles P Davenport
    University of New South Wales, Australia
  2. Betty Diamond
    The Feinstein Institute for Medical Research, United States
  3. Satyajit Rath
    Indian Institute of Science Education and Research (IISER), Pune, India
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