Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Connexin-43-dependent ATP release mediates macrophage activation during sepsis

   Michel Dosch et al.

   Autocrine activation of macrophages is modulated by Connexin-43-mediated ATP release in response to TLR-4 and -2 agonists in a P2Y1-dependent manner, ultimately determining sepsis survival.
2. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Functional proteomic atlas of HIV infection in primary human CD4+ T cells

   Adi Naamati et al.

   Identification and characterisation of proteins and processes regulated by HIV in primary human CD4+ T cells using an HIV reporter virus for one-step, antibody-free magnetic selection.
3. 1. Immunology and Inflammation

   Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

   Mark Austin Hanson et al.

   While antimicrobial cocktails are highly effective for defence against pathogenic microbes, the innate immune response may instead employ highly specific peptidic antibiotics to combat certain natural enemies.
4. 1. Immunology and Inflammation

   MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway

   Hui Xu et al.

   The liver-specific miRNA microRNA-122 plays a previously unknown role in hepatocyte intrinsic innate immunity by targeting the RTKs/STAT3 signaling pathway.
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

   Simon Langer et al.

   By inhibiting the activation of NF-κB, HIV-1 Vpu exerts much broader immunosuppressive effects than previously anticipated and may be an important determinant of chronic inflammation in HIV-1 infected individuals.
6. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Reprogramming the antigen specificity of B cells using genome-editing technologies

   James E Voss et al.

   Antibody paratopes can be added to the human repertoire by CRISPR-Cas9 editing of B lymphocytes using a strategy that allows for hypermutation and class switching of resulting B cell receptors.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection

   Molly A Matty et al.

   An in vivo drug screen of FDA-approved compounds in zebrafish identified host-directed therapies against mycobacterial infection, including the drug clemastine, which targets the P2RX7-inflammasome axis to enhance bacterial control.
8. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination

   Joseph J Campo et al.

   Panproteome array analysis of antibody responses to a pneumococcal whole cell vaccine reveals consistent induction of immune responses to multiple surface proteins, despite individuals' unique pre-existing antibody profiles.
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

   Sydney Lavoie et al.

   Gnotobiotic and conventional mouse models of the IBD ATG16L1T300A SNP reveal gene-microbiota-immune interactions.
10. 1. Immunology and Inflammation
    2. Neuroscience

    Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization

    Wenxin Ma et al.

    TGFβ signaling to retinal microglia is central to the regulation of neuroinflammatory responses relevant to age-related macular degeneration (AMD), a leading cause of blindness in the developed world.