Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation

    A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

    Jordan Z Zhou, Bo Pei ... Kang Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Immunology and Inflammation

    Heterogeneity and Ontogeny of Mouse Thymic Macrophages Reveal a Requirement for Csf1r-Expressing Myeloid Cells During Early T Cell Development

    Helen Wang, Vinothkumar Rajan ... Juan Carlos Zúñiga-Pflücker
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation

    Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival

    Magdalena A Czubala, Patricia Rodrigues ... Philip R Taylor
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Linear antibody epitope prediction using AlphaFold2

    Jacob DeRoo, James S Terry ... Brian J Geiss
    AlphaFold2 can be used to accurately determine linear epitopes of antibodies with known heavy and light chain sequences.
    1. Immunology and Inflammation

    DGKα and ζ deficiency causes regulatory T-cell dysregulation, destabilization, and conversion to pathogenic T-follicular helper cells to trigger IgG1-predominant autoimmunity

    Lei Li, Hongxiang Huang ... Xiao-Ping Zhong
    Diacylglycerol kinases (DGKs) α and ζ secure Treg stability, enforce CD28-dependence, and block conversion to pathogenic Tfh cells, safeguarding against autoimmune disease.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    IFNγ and IFNγ mimetics prevent IFN-I-mediated TB susceptibility by regulating iron metabolism and lipid peroxidation

    Prasanna Babu Araveti, Shivraj M Yabaji ... Igor Kramnik
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    A predictive systems vaccinology framework enables rational optimization of MVA-based vaccines

    Vincent Deman, Philippe Castera ... Anne-Sophie Beignon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    +Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

    Darren Wethington, Saeed Ahmad ... Jayajit Das
    Stochastic fluctuations play an important role in the MCMV-induced NK cell clonal expansion that ultimately gives rise to memory NK cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The C3–C3aR axis modulates trained immunity in alveolar macrophages

    Alexander P Earhart, Alberto E Lopez ... Hrishikesh S Kulkarni
    Complement component C3, a key component of immune responses at mucosal sites, affects alveolar macrophage reprogramming via the C3aR.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Human CD1c-autoreactive T-cells recognise Mycobacterium tuberculosis–infected antigen-presenting cells and display cytotoxic effector programmes

    Matthew Milton, Sahar H Farag ... Salah Mansour
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
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Highlights

    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Antibody Language Models: Taking the biology seriously makes models better

    Antonio Matas-Gil, Andreas Tiffeau-Mayer
    1. Immunology and Inflammation
    2. Neuroscience

    Microglia: Replacing the immune system of the brain

    Julie Rebejac, Soyon Hong

Senior editors

  1. Wendy S Garrett
    Wendy S Garrett
    Harvard T.H. Chan School of Public Health, United States
  2. Diane M Harper
    University of Michigan, United States
  3. Tony Ng
    King's College London, United Kingdom
  4. See more editors