Immunology and Inflammation

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

   Lina Sagert et al.

   A dedicated structural element facilitates chaperone and antigenic peptide selector function of TAP-associated glycoprotein, a major quality assurance auditor in adaptive immunity.
2. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Identifying the immune interactions underlying HLA class I disease associations

   Bisrat J Debebe et al.
3. 1. Immunology and Inflammation
   2. Neuroscience

   CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization

   Xiao Yang et al.
4. 1. Immunology and Inflammation

   Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy

   Alok Kumar et al.

   Downregulation of mitochondrial activity by immunosuppressive tumor-derived soluble factors leads to systemic unresponsiveness to the PD-1 blockade therapy.
5. 1. Immunology and Inflammation

   Reversible promoter methylation determines fluctuating expression of acute phase proteins

   Shi-Chao Zhang et al.
6. 1. Immunology and Inflammation

   Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

   Marisa Stebegg et al.

   Older individuals have impaired conventional dendritic cell and T follicular helper cell formation upon vaccination, which can be rescued by treatment with a TLR7 agonist.
7. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes

   Peter C de Greef et al.

   Combining experiments, bioinformatics, and mathematical modelling, we find large heterogeneity in naive T cell clone sizes.
8. 1. Human Biology and Medicine
   2. Immunology and Inflammation

   SLAMF6​ deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint

   Emma Hajaj et al.

   SLAMF6 is an inhibitory checkpoint of T cells, the lack of which leads to better tumor control, suggesting a new immunotherapy target.
9. 1. Genetics and Genomics
   2. Immunology and Inflammation

   PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation

   Kenneth T Farabaugh et al.
10. 1. Human Biology and Medicine
    2. Immunology and Inflammation

    p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

    Hui Che et al.

    A novel IVDD mechanism that involves p16 is demonstrated and theoretical evidence is provided for effective methods to downregulate p16 and so reverse IVDD.