Immunology and Inflammation

Immunology and Inflammation

eLife publishes research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation

    Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development

    Sayumi Fujimori et al.
    Highly specific gene manipulation in mouse thymic epithelial cells (TECs) shows that fine-tuning of β-catenin expression is required for TECs to generate an optimal thymic microenvironment to support T-cell development.
    1. Cell Biology
    2. Immunology and Inflammation

    Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

    Dasmanthie De Silva et al.
    Binding of the translation initiation factor eIF3 to the messenger RNAs encoding the T cell receptor subunits alpha and beta is required to drive a short burst in their translation and promote a strong T cell response.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

    Thomas Laval et al.
    Infection with Mycobacterium tuberculosis triggers de novo synthesis of polyunsaturated fatty acids by host macrophages, which promote their antimicrobial responses but feed the intracellular pathogen.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Human MAIT cells respond to and suppress HIV-1

    Chansavath Phetsouphanh et al.
    In depth phenotyping from tissues and in vitro activation studies reveal antiviral function of MAIT cells- with particular emphasis on HIV infection.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving

    Kenneth B Hoehn et al.
    Influenza vaccination in humans stimulates novel B cell evolution that is detectable in germinal centers, but not the peripheral blood.
    1. Immunology and Inflammation

    Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen

    Katherine A Deets et al.
    A mouse model of inducible inflammasome activation in intestinal epithelial cells reveals separate inflammasome-dependent and -independent cross-presentation pathways for epithelial cell-derived antigen.
    1. Immunology and Inflammation

    SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

    Shahanshah Khan et al.
    Recognition of SARS-CoV-2 spike protein by innate immune sensor TLR2 leads to the induction of inflammatory mediators and constitutes a mechanism for cytokine storm during COVID-19.

Senior editors

  1. Miles P Davenport
    University of New South Wales, Australia
  2. Betty Diamond
    The Feinstein Institute for Medical Research, United States
  3. Tadatsugu Taniguchi
    Tadatsugu Taniguchi
    Research Center for Advanced Science and Technology, The University of Tokyo, Japan
  4. See more editors