Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   IRF4 haploinsufficiency in a family with Whipple’s disease

   Antoine Guérin et al.

   Autosomal dominant IRF4 deficiency is the first genetic etiology of Whipple's disease, a very rare chronic condition following a rather common infection by Tropheryma whipplei.
2. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Immunodeficiency: Back from the brink of obscurity

   Donald C Vinh

   A mutation in a transcription factor makes people susceptible to Trophyrema whippelii, the bacterium that causes a rare condition called Whipple's disease.
3. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Computer-guided design of optimal microbial consortia for immune system modulation

   Richard R Stein et al.
4. 1. Immunology and Inflammation

   Histone deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T-Cells

   Herbert G Kasler et al.
5. 1. Immunology and Inflammation

   Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus

   Jeannine A Ott et al.
6. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

   Jonas Klinkhammer et al.
7. 1. Immunology and Inflammation

   IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

   Mark Noviski et al.

   Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.
8. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

   Neel H Shah et al.

   A high-throughput comparison of substrate specificities of the Src-family kinases Lck and c-Src against a library of proteome-derived phosphorylation sites reveals that Lck has evolved divergent electrostatic features reflecting its involvement in T-cell signaling.
9. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Method for identification of condition-associated public antigen receptor sequences

   Mikhail V Pogorelyy et al.

   Without using control cohorts, a statistical method identifies candidates for immune receptors associated with diseases from repertoire sequencing datasets.
10. 1. Immunology and Inflammation

    C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation

    Chang Hoon Lee et al.

    The bZIP transcription factor C/EBPδ enhances expression both of selectin ligands and the chemokine receptor CCR6 on human mucosal-associated invariant T cells, supporting their efficient extravasation into inflamed tissue.