Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Unraveling the role of Ctla-4 in intestinal immune homeostasis through a novel Zebrafish model of inflammatory bowel disease

   Lulu Qin, Chongbin Hu ... Jianzhong Shao

   The generation of a Ctla-4-deficient zebrafish line has established a direct link between Ctla-4 and IBD in zebrafish.
2. 1. Immunology and Inflammation

   Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4⁺ T cells through STAT1-related epigenetic mechanisms

   Jie Zhang, Hui Tang ... Yu Zhang

   Dendritic cell (DC)-derived IL-27 establishes CD4⁺ T cell bias against IFN-γ via STAT1 and epigenetics, linking thymic development to autoimmune mechanisms.
3. 1. Immunology and Inflammation

   Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation

   Israel Ríos, Cristina Herrero ... Angel L Corbí

   Chemical inhibition or genetic downregulation of glycogen synthase kinase-3 reprograms human monocyte-derived macrophages by enhancing their anti-inflammatory, homeostatic, and reparative functions.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Phase transition of WTAP regulates m⁶A modification of interferon-stimulated genes

   Sihui Cai, Jie Zhou ... Jun Cui
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

   Li Tian, Zongzheng Zhao ... Zhaolong Li

   E3 ligases UBR5 and MARCHF7 restrict SARS-CoV-2 replications through targeting nsp16.
6. 1. Immunology and Inflammation

   PIM kinase control of CD8 T cell protein synthesis and cell trafficking

   Julia M Marchingo, Laura Spinelli ... Doreen A Cantrell

   Parallel proteomics and transcriptomics data reveal that PIM kinases have a context-dependent role in promoting mouse CD8 T cell protein translation, effector function, and cell homing.
7. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   Tissue resident memory CD4⁺ T cells are sustained by site-specific levels of self-renewal and continuous replacement

   Jodie Chandler, M Elise Bullock ... Andrew J Yates
8. 1. Immunology and Inflammation

   Diversity and functional specialization of oyster immune cells uncovered by integrative single-cell level investigations

   Sebastien De La Forest Divonne, Juliette Pouzadoux ... Emmanuel Vignal

   Single-cell and functional analyses uncover distinct immune cell types, revealing specialized functions and deepening insight into invertebrate cellular immunity.
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   CARD8 inflammasome activation during HIV-1 cell-to-cell transmission

   Jessie Kulsuptrakul, Michael Emerman, Patrick S Mitchell
10. 1. Immunology and Inflammation

    Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein

    Kentarou Waki, Hideki Tani ... Nobuyuki Kurosawa

    Analysis of monoclonal immunoglobulin A (IgA) antibodies after intranasal immunization highlights the crucial role of secretory IgA in mucosal immunity, enhancing our understanding of how intranasal vaccines can protect against SARS-CoV-2 infection.