Sex-specific single transcript level atlas of vasopressin and its receptor (AVPR1a) in the mouse brain
- Institute for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, United States
Figures
Figure 1 with 1 supplement
Sex-specific Avp transcript density in the brain.
(A) Avp transcript density in main brain regions detected by RNAscope. Female 3V region and hypothalamus and male hypothalamus had the highest Avp transcript density. (B) Avp transcript density in nuclei, subnuclei, and regions of the hypothalamus and forebrain. (C) Representative micrographs of some of the hypothalamic and forebrain regions with highest Avp expression. Scale bar: 20 µm. (D) Novel Avp transcripts found in nuclei, subnuclei, and regions of the hippocampus, thalamus, and cerebral cortex. Scale bar: 10 µm. Note that Avp transcripts were found only in the female 3V ependymal layer and thalamus. N=3 mice per sex, values are shown as means ± SE . ***p<0.001 and **p<0.01, unpaired Student’s t test and two-way ANOVA.
Figure 1—figure supplement 1
Sex-specific Avp-positive cells in the brain.
(A) Total numbers of Avp-positive cells in main brain regions detected by RNAscope. (B) Total numbers of Avp-positive cells in nuclei, subnuclei, and regions of the hypothalamus, hippocampus, forebrain, and cortex. Note that Avp-positive cells were found only in the female 3V ependymal layer and thalamus. Also shown are representative RNAscope micrographs of hypothalamic regions with highest Avp expression; i.e., supraoptic nucleus (SO), paraventricular hypothalamic nucleus, lateral magnocellular part (PaLM), retrochiasmatic area (RCh), supraoptic nucleus, retrochiasmatic part (SOR), and suprachiasmatic nucleus (SCh). Scale bar: 20 µm. N=3 mice per sex, values are shown as means ± SE . ***p<0.001 and *p<0.05, unpaired Student’s t test and two-way ANOVA.
Figure 2 with 1 supplement
Sex-specific Avpr1a transcript density in main brain divisions.
(A) Probe specificity was established by a positive signal in renal tubules of the kidney (positive control) with an absent signal in the frontal association cortex (FrA) (negative control). Sale bar: 20 µm. (B) Representative micrographs of medullary central canal (CC) and hypothalamic arcuate nucleus (Arc). (C) Avpr1a transcript density in main brain regions detected by RNAscope. N=3 mice per sex. Scale bar: 25 µm (controls).
Figure 2—figure supplement 1
Sex-specific Avpr1a transcript numbers in main brain divisions.
(A) Total Avpr1a transcript numbers in main brain regions detected by RNAscope. (B) Representative RNAscope micrographs of medullary regions with highest Avpr1a expression; i.e., hypoglossal nucleus (12N), intermediate reticular nucleus (IRt), lateral reticular nucleus (LRt), and medullary reticular nucleus, ventral part (MdV). N=3 mice per sex. N=3 mice per sex. Scale bar: 20 µm.
Figure 3 with 1 supplement
Sex-specific Avpr1a transcript density in the brain.
Avpr1a transcript density in nuclei, subnuclei, and regions of the ventricular regions, hypothalamus, medulla, forebrain, olfactory bulb, and hippocampus. N=3 mice per sex, values are shown as means ± SE. ***p<0.001, **p<0.01, and *p<0.05, unpaired Student’s t test and two-way ANOVA.
Figure 3—figure supplement 1
Sex-specific Avpr1a transcript numbers in the brain.
Avpr1a transcript density in nuclei, subnuclei, and regions of the medulla, hypothalamus, cortex, and forebrain. N=3 mice per sex, values are shown as means ± SE. ***p<0.001, **p<0.01, and *p<0.05, unpaired Student’s t test and two-way ANOVA.
Figure 4 with 1 supplement
Sex-specific Avpr1a transcript density in the brain.
Avpr1a transcript density in nuclei, subnuclei, and regions of the midbrain and pons, thalamus, cortex, and cerebellum. N=3 mice per sex, values are shown as means ± SE. ***p<0.001, **p<0.01, and *p<0.05, unpaired Student’s t test and two-way ANOVA.
Figure 4—figure supplement 1
Sex-specific Avpr1a transcript numbers in the brain.
Avpr1a transcript density in nuclei, subnuclei, and regions of the midbrain and pons, thalamus, cerebellum, olfactory bulb, hippocampus, and ventricular regions. N=3 mice per sex, values are shown as means ± SE. ***p<0.001, **p<0.01, and *p<0.05, unpaired Student’s t test and two-way ANOVA.
Figure 5
Avp and Avpr1a co-localization in the brain.
We found that various nuclei and subnuclei exhibited Avp and Avpr1a co-localization in the brain of both sexes. (A) Female and (B) male Avpr1a to Avp ratios in the cortex, forebrain, hippocampus, 3rd ventricular region, thalamus, and hypothalamus.
Figure 6
Avp and Avpr1a transcript densities in the pituitary gland.
RNAscope revealed Avp and Avpr1a expression in the posterior pituitary lobe with Avp and Avpr1a transcript densities that were higher in male compared with female mice. N=3 mice per sex, values are shown as means ± SE. Unpaired Student’s t test.
Tables
Appendix 1—table 1
Glossary of the brain nuclei, sub–nuclei and regions.
| Olfactory bulb | |
|---|---|
| aci | anterior commissure, intrabulbar part |
| AOE | anterior olfactory nucleus, external part |
| AOL | anterior olfactory nucleus, lateral part |
| BAOT | bed nucleus of the accessory olfactory tract |
| EPI | external plexiform layer of the olfactory bulb |
| EPIA | external plexiform layer of the accessory olfactory bulb |
| G1 | glomerular layer of the olfactory bulb |
| GrA | granule cell layer of the accessory olfactory bulb |
| GrO | granular cell layer of the olfactory bulb |
| IPI | interpeduncular nucleus, intermediate subnucleus |
| lo | lateral olfactory tract |
| LOT | nucleus of the lateral olfactory tract |
| Mi | mitral cell layer of the olfactory bulb |
| MiA | mitral cell layer of the accessory olfactory bulb |
| ON | olfactory nerve layer |
| Tu | olfactory tubercle |
| Cerebral cortex | |
| AID | agranular insular cortex, dorsal part |
| AIP | agranular insular cortex, posterior part |
| AIV | agranular insular cortex, ventral part |
| Au1 | primary auditory cortex |
| AuD | secondary auditory cortex, dorsal area |
| AuV | secondary auditory cortex, ventral area |
| Cg/RS | cingular/retrosplenial cortex |
| Cg1 | cingulate cortex, area 1 |
| Cg2 | cingulate cortex, area 2 |
| C1 | C1 adrenaline cells |
| DEn | dorsal endopiriform nucleus |
| DI | dysgranular insular cortex |
| Ect | ectorhinal cortex |
| GI | granular insular cortex |
| LEnt | lateral entorhinal cortex |
| LO | lateral orbital cortex |
| LPtA | lateral parietal association cortex |
| M1 | primary motor cortex |
| M2 | secondary motor cortex |
| MEnt | medial entorhinal cortex |
| MPtA | medial parietal association cortex |
| Pir | piriform cortex |
| PRh | perirhinal cortex |
| RSA | retrosplenial agranular cortex |
| RSG | retrosplenial granular cortex |
| S1 | primary somatosensory cortex |
| S1BF | primary somatosensory cortex, barrel field |
| S1DZ | primary somatosensory cortex, dysgranular region |
| S1FL | primary somatosensory cortex, forelimb region |
| S1HL | primary somatosensory cortex, hindlimb region |
| S1Sh | primary somatosensory cortex, shoulder region |
| S1ShNc | primary somatosensory cortex, shoulder/neck region |
| S1Tr | primary somatosensory cortex, trunk region |
| S2 | secondary somatosensory cortex |
| TeA | temporal association cortex |
| V1 | primary visual cortex |
| V2L | secondary visual cortex, lateral area |
| V2ML | secondary visual cortex, mediolateral area |
| V2MM | secondary visual cortex, mediomedial area |
| VEn | ventral endopiriform nucleus |
| Forebrain | |
| AC | anterior commissural nucleus |
| aca | anterior commissure, anterior part |
| ADP | anterodorsal preoptic nucleus |
| AVPe | anteroventral periventricular nucleus |
| BAC | bed nucleus of the anterior commissure |
| BST | bed nucleus of the stria terminalis |
| BSTIA | bed nucleus of the stria terminalis, intraamygdaloid division |
| BSTLI | bed nucleus of the stria terminalis, lateral division, intermediate part |
| BSTLP | bed nucleus of the stria terminalis, lateral division, posterior part |
| BSTLV | bed nucleus of the stria terminalis, lateral division, ventral part |
| BSTMA | bed nucleus of the stria terminalis, medial division, anterior part |
| BSTMPI | bed nucleus of the stria terminalis, medial division, posterointermediate part |
| BSTMPL | bed nucleus of the stria terminalis, medial division, posterolateral part |
| BSTMPM | bed nucleus of the stria terminalis, medial division, posteromedial part |
| BSTS | bed nucleus of stria terminalis, supracapsular part |
| CPu | caudate putamen (striatum) |
| HDB | nucleus of the horizontal limb of the diagonal band |
| IPACL | interstitial nucleus of the posterior limb of the anterior commissure, lateral part |
| IPACM | interstitial nucleus of the posterior limb of the anterior commissure, medial part |
| LPO | lateral preoptic area |
| LSD | lateral septal nucleus, dorsal part |
| LSI | lateral septal nucleus, intermediate part |
| LSV | lateral septal nucleus, ventral part |
| MCPO | magnocellular preoptic nucleus |
| MnPO | median preoptic nucleus |
| MPOC | medial preoptic nucleus, central part |
| MPOL | medial preoptic nucleus, lateral part |
| MPOM | medial preoptic nucleus, medial part |
| MS | medial septal nucleus |
| SFi | septofimbrial nucleus |
| SI | substantia innominata |
| VLPO | ventrolateral preoptic nucleus |
| VMPO | ventromedial preoptic nucleus |
| VOLT | vascular organ of the lamina terminalis |
| VP | ventral pallidum |
| ZL | zona limitans |
| Hippocampus | |
| CA1 | field ca1 of hippocampus |
| CA3 | field CA3 of hippocampus |
| df | dorsal fornix |
| DG | dentate gyrus |
| dhc | dorsal hippocampal commissure |
| f | fornix |
| fi | fimbria of the hippocampus |
| GrDG | granular layer of the dentate gyrus |
| LMol | lacunosum moleculare layer of the hippocampus |
| Mol | molecular layer of the dentate gyrus |
| Or | oriens layer of the hippocampus |
| PoDG | polymorph layer of the dentate gyrus |
| PrS | presubiculum |
| Py | pyramidal tract |
| S | subiculum |
| TS | triangular septal nucleus |
| Thalamus | |
| AD | anterodorsal thalamic nucleus |
| AM | anteromedial thalamic nucleus |
| APT | anterior pretectal nucleus |
| APTD | anterior pretectal nucleus, dorsal part |
| APTV | anterior pretectal nucleus, ventral part |
| CL | centrolateral thalamic nucleus |
| CM | central medial thalamic nucleus |
| DLG | dorsal lateral geniculate nucleus |
| eml | external medullary lamina |
| Eth | ethmoid thalamic nucleus |
| F | nucleus of the fields of Forel |
| FF | fields of Forel |
| fr | fasciculus retroflexus |
| Gus | gustatory thalamic nucleus |
| hbc | habenular commissure |
| IAD | interanterodorsal thalamic nucleus |
| IAM | interanteromedial thalamic nucleus |
| ic | internal capsule |
| IGL | intergeniculate leaf |
| IMD | intermediodorsal thalamic nucleus |
| LDDM | laterodorsal thalamic nucleus, dorsomedial part |
| LDVL | laterodorsal thalamic nucleus, ventrolateral part |
| LGP | lateral globus pallidus |
| LHb | lateral habenular nucleus |
| LHbL | lateral habenular nucleus, lateral part |
| LHbM | lateral habenular nucleus, medial part |
| LPLR | lateral posterior thalamic nucleus, laterorostral part |
| LPMC | lateral posterior thalamic nucleus, mediocaudal part |
| LPMR | lateral posterior thalamic nucleus, mediorostral part |
| MD | mediodorsal thalamic nucleus |
| MDC | mediodorsal thalamic nucleus, central part |
| MDL | mediodorsal thalamic nucleus, lateral part |
| MDM | mediodorsal thalamic nucleus, medial part |
| MGD | medial geniculate nucleus, dorsal part |
| MGM | medial geniculate nucleus, medial part |
| MGP | medial globus pallidus (entopeduncular nucleus) |
| MGV | medial geniculate nucleus, ventral part |
| MHb | medial habenular nucleus |
| MZMG | marginal zone of the medial geniculate |
| OPC | oval paracentral thalamic nucleus |
| OPT | olivary pretectal nucleus |
| PC | paracentral thalamic nucleus |
| PF | parafascicular thalamic nucleus |
| PIL | posterior intralaminar thalamic nucleus |
| Po | posterior thalamic nuclear group |
| PoMn | posteromedian thalamic nucleus |
| PP | peripeduncular nucleus |
| PPT | posterior pretectal nucleus |
| PR | prerubral field |
| PrC | precommissural nucleus |
| pv | periventricular fiber system |
| PV | paraventricular thalamic nucleus |
| PVA | paraventricular thalamic nucleus, anterior part |
| PVP | paraventricular thalamic nucleus, posterior part |
| Re | reuniens thalamic nucleus |
| REth | retroethmoid nucleus |
| Rh | rhomboid thalamic nucleus |
| RI | rostral interstitial nucleus of medial longitudinal fasciculus |
| Rt | reticular thalamic nucleus |
| SCO | subcommissural organ |
| SG | suprageniculate thalamic nucleus |
| sm | stria medullaris of the thalamus |
| SPF | subparafascicular thalamic nucleus |
| STh | subthalamic nucleus |
| Sub | submedius thalamic nucleus |
| SubG | subgeniculate nucleus |
| VL | ventrolateral thalamic nucleus |
| VLGMC | ventral lateral geniculate nucleus, magnocellular part |
| VLGPC | ventral lateral geniculate nucleus, parvicellular part |
| VM | ventromedial thalamic nucleus |
| VPL | ventral posterolateral thalamic nucleus |
| VPM | ventral posteromedial thalamic nucleus |
| VRe | ventral reuniens thalamic nucleus |
| Xi | xiphoid thalamic nucleus |
| Hypothalamus | |
| AAV | anterior amygdaloid area, ventral part |
| ACo | anterior cortical amygdaloid nucleus |
| AHA | anterior hypothalamic area, anterior part |
| AHC | anterior hypothalamic area, central part |
| AHiAL | amygdalohippocampal area, anterolateral part |
| AHiPM | amygdalohippocampal area, posteromedial part |
| AHP | anterior hypothalamic area, posterior part |
| APir | amygdalopiriform transition area |
| Arc | arcuate hypothalamic nucleus |
| ArcL | arcuate hypothalamic nucleus, lateral part |
| ArcLP | arcuate hypothalamic nucleus, lateroposterior part |
| ArcMP | arcuate hypothalamic nucleus, medial posterior part |
| AStr | amygdalostriatal transition area |
| BLA | basolateral amygdaloid nucleus, anterior part |
| BLP | basolateral amygdaloid nucleus, posterior part |
| BLV | basolateral amygdaloid nucleus, ventral part |
| BMA | basolateral amygdaloid nucleus, anterior part |
| BMP | basomedial amygdaloid nucleus, posterior part |
| CeC | central amygdaloid nucleus, capsular part |
| CeL | central amygdaloid nucleus, lateral division |
| CeM | central amygdaloid nucleus, medial division |
| CeMAD | central amygdaloid nucleus, medial division, anterodorsal part |
| CeMPV | central amygdaloid nucleus, medial posteroventral part |
| cp | cerebral peduncle, basal part |
| CxA | cortex-amygdala transition zone |
| DM | dorsomedial hypothalamic nucleus |
| DMC | dorsomedial hypothalamic nucleus, compact part |
| DMD | dorsomedial hypothalamic nucleus, dorsal part |
| DMV | dorsomedial hypothalamic nucleus, ventral part |
| DTM | dorsal tuberomammillary nucleus |
| I | intercalated nuclei of the amygdala |
| IM | intercalated amygdaloid nucleus, main part |
| IPAC | interstitial nucleus of the posterior limb of the anterior commissure |
| LA | lateroanterior hypothalamic nucleus |
| LaDL | lateral amygdaloid nucleus, dorsolateral part |
| LaVL | lateral amygdaloid nucleus, ventrolateral part |
| LaVM | lateral amygdaloid nucleus, ventromedial part |
| LH | lateral hypothalamic area |
| LM | lateral mammillary nucleus |
| MCLH | magnocellular nucleus of the lateral hypothalamus |
| MeA | medial amygdaloid nucleus, anterior part |
| MeAD | medial amygdaloid nucleus, anteriodorsal part |
| MePD | medial amygdaloid nucleus, posterodorsal part |
| MePV | medial amygdaloid nucleus, posteroventral part |
| ML | medial mammillary nucleus, lateral part |
| MM | medial mammillary nucleus, medial part |
| MMn | medial mammillary nucleus, median part |
| MPA | medial preoptic area |
| mt | mammillothalamic tract |
| mtg | mammillotegmental tract |
| MTu | medial tuberal nucleus |
| ns | nigrostriatal bundle |
| opt | optic tract |
| PaAP | paraventricular hypothalamic nucleus, anterior parvicellular part |
| PaDC | paraventricular hypothalamic nucleus, dorsal cap |
| PaLM | paraventricular hypothalamic nucleus, lateral magnocellular part |
| PaMM | paraventricular hypothalamic nucleus, medial magnocellular part |
| PaMP | paraventricular hypothalamic nucleus, medial parvicellular part |
| PaPo | paraventricular hypothalamic nucleus, posterior part |
| PaV | paraventricular hypothalamic nucleus, ventral part |
| Pe | periventricular hypothalamic nucleus |
| PeF | perifornical nucleus |
| PH | posterior hypothalamic area |
| PLCo | posterolateral cortical amygdaloid nucleus |
| PMCo | posteromedial cortical amygdaloid nucleus (C3) |
| PMD | premammillary nucleus, dorsal part |
| PMV | premammillary nucleus, ventral part |
| PSTh | parasubthalamic nucleus |
| RCh | retrochiasmatic area |
| SCh | suprachiasmatic nucleus |
| SChDM | suprachiasmatic nucleus, dorsomedial part |
| SChVL | suprachiasmatic nucleus, ventrolateral part |
| SHy | septohypothalamic nucleus |
| SMT | submammillothalamic nucleus |
| SO | supraoptic nucleus |
| SOR | supraoptic nucleus, retrochiasmatic part |
| sox | supraoptic decussation |
| SPa | subparaventricular zone of the hypothalamus |
| Stg | stigmoid hypothalamic nucleus |
| Subl | subincertal nucleus |
| SuM | supramammillary nucleus |
| SuML | supramammillary nucleus, lateral part |
| SuMM | supramammillary nucleus, medial part |
| sumx | supramammillary decussation |
| TC | tuber cinereum area |
| Te | terete hypothalamic nucleus |
| VMH | ventromedial hypothalamic nucleus |
| VMHC | ventromedial hypothalamic nucleus, central part |
| VMHDM | ventromedial hypothalamic nucleus, dorsomedial part |
| VMHVL | ventromedial hypothalamic nucleus, ventrolateral part |
| ZI | zona incerta |
| ZID | zona incerta, dorsal part |
| ZIV | zona incerta, ventral part |
| Midbrain and pons | |
| 3 N | oculomotor nucleus |
| 3PC | oculomotor nucleus, parvicellular part |
| ATg | anterior tegmental nucleus |
| bic | brachium of the inferior colliculus |
| BIC | nucleus of the brachium of the inferior colliculus |
| CGA | central gray, alpha part |
| CGPn | central gray of the pons |
| CIC | central nucleus of the inferior colliculus |
| CnF | cuneiform nucleus |
| csc | commissure of the superior colliculus |
| DCIC | dorsal cortex of the inferior colliculus |
| Dk | nucleus of Darkschewitsch |
| DLPAG | dorsolateral periaqueductal gray |
| DMPAG | dorsomedial periaqueductal gray |
| DMPn | dorsomedial pontine nucleus |
| DMTg | dorsomedial tegmental area |
| DpG | deep gray layer of the superior colliculus |
| DpMe | deep mesencephalic nucleus |
| DpWh | deep white layer of the superior colliculus |
| DRC | dorsal raphe nucleus, caudal part |
| DRI | dorsal raphe nucleus, interfascicular part |
| DRV | dorsal raphe nucleus, ventral part |
| DRVL | dorsal raphe nucleus, ventrolateral part |
| DTgC | dorsal tegmental nucleus, central part |
| DTgP | dorsal tegmental nucleus, pericentral part |
| ECIC | external cortex of the inferior colliculus |
| EMi | epimicrocellular nucleus |
| EW | Edinger-Westphal nucleus |
| IF | interfascicular nucleus |
| InC | interstitial nucleus of Cajal |
| InCG | interstitial nucleus of Cajal, greater part |
| InCo | intercollicular nucleus |
| InG | intermediate gray layer of the superior colliculus |
| InWh | intermediate white layer of the superior colliculus |
| IPC | interpeduncular nucleus, caudal subnucleus |
| IPDL | interpeduncular nucleus, dorsolateral subnucleus |
| IPDM | interpeduncular nucleus, dorsomedial subnucleus |
| IPF | interpeduncular fossa |
| IPI | interpeduncular nucleus, intermediate subnucleus |
| IPL | interpeduncular nucleus, lateral subnucleus |
| IPR | interpeduncular nucleus, rostral subnucleus |
| KF | Ko¨lliker-Fuse nucleus |
| LC | locus coeruleus |
| LDTg | laterodorsal tegmental nucleus |
| LDTgV | laterodorsal tegmental nucleus, ventral part |
| lfp | longitudinal fasciculus of the pons |
| LPAG | lateral periaqueductal gray |
| LPBC | lateral parabrachial nucleus, central part |
| LPBS | lateral parabrachial nucleus, superior part |
| LPBV | lateral parabrachial nucleus, ventral part |
| MA3 | medial accessory oculomotor nucleus |
| MCPC | magnocellular nucleus of the posterior commissure |
| MiTg | microcellular tegmental nucleus |
| ml | medial lemniscus |
| mlf | medial longitudinal fasciculus |
| MnR | median raphe nucleus |
| Mo5 | motor trigeminal nucleus |
| mp | mammillary peduncle |
| MPB | medial parabrachial nucleus |
| MT | medial terminal nucleus of the accessory optic tract |
| Op | optic nerve layer of the superior colliculus |
| Pa4 | paratrochlear nucleus |
| PAG | periaqueductal gray |
| PBP | parabrachial pigmented nucleus |
| PCom | nucleus of the posterior commissure |
| PMnR | paramedian raphe nucleus |
| Pn | pontine nuclei |
| PN | paranigral nucleus |
| PnC | pontine reticular nucleus, caudal part |
| PnO | pontine reticular nucleus, oral part |
| PnV | pontine reticular nucleus, ventral part |
| PPTg | pedunculopontine tegmental nucleus |
| RC | raphe cap |
| RLi | rostral linear nucleus of the raphe |
| RMC | red nucleus, magnocellular part |
| RPC | red nucleus, parvicellular part |
| RPF | retroparafascicular nucleus |
| RPO | rostral periolivary region |
| RRF | retrorubral field |
| RtTg | reticulotegmental nucleus of the pons |
| RtTgP | reticulotegmental nucleus of the pons, pericentral part |
| Sag | sagulum nucleus |
| SC | superior colliculus |
| scp | superior cerebellar peduncle (brachium conjunctivum) |
| SNC | substantia nigra, compact part |
| SNL | substantia nigra, lateral part |
| SNR | substantia nigra, reticular part |
| Su3 | supraoculomotor periaqueductal gray |
| Su3C | supraoculomotor cap |
| SubB | subbrachial nucleus |
| SuG | superficial gray layer of the superior colliculus |
| ts | tectospinal tract |
| VLPAG | ventrolateral periaqueductal gray |
| VLTg | ventrolateral tegmental area |
| VTA | ventral tegmental area |
| vtgx | ventral tegmental decussation |
| VTRZ | visual tegmental relay zone |
| xscp | decussation of the superior cerebellar peduncle |
| Zo | zonal layer of the superior colliculus |
| Medulla | |
| 7 N | facial nucleus |
| 10 N | dorsal motor nucleus of vagus |
| 12 N | hypoglossal nucleus |
| Amb | ambiguus nucleus |
| AP | area postrema |
| CeCv | central cervical nucleus |
| cu | cuneate fasciculus |
| Cu | cuneate nucleus |
| DMSp5 | dorsomedial spinal trigeminal nucleus |
| DPGi | dorsal paragigantocellular nucleus |
| DPO | dorsal periolivary region |
| ECu | external cuneate nucleus |
| EVe | nucleus of origin of efferents of the vestibular nerve |
| FVe | F cell group of the vestibular complex |
| Gi | gigantocellular reticular nucleus |
| GiA | gigantocellular reticular nucleus, alpha part |
| GiV | gigantocellular reticular nucleus, ventral part |
| Gr | gracile nucleus |
| icp | inferior cerebellar peduncle (restiform body) |
| In | intercalated nucleus of the medulla |
| InM | intermedius nucleus of the medulla |
| IOB | inferior olive, subnucleus B of medial nucleus |
| IOBe | inferior olive, subnucleus B of medial nucleus |
| IOC | inferior olive, subnucleus C of medial nucleus |
| IOD | inferior olive, dorsal nucleus |
| IOK | inferior olive, cap of Kooy of the medial nucleus |
| IOVL | inferior olive, ventrolateral protrusion |
| IRt | intermediate reticular nucleus |
| Li | linear nucleus of the medulla |
| LPGi | lateral paragigantocellular nucleus |
| LRt | lateral reticular nucleus |
| LRtPC | lateral reticular nucleus, parvicellular part |
| LSO | lateral superior olive |
| LVe | lateral vestibular nucleus |
| LVPO | lateroventral periolivary nucleus |
| MdD | medullary reticular nucleus, dorsal part |
| MdV | medullary reticular nucleus, ventral part |
| MVe | medial vestibular nucleus |
| MVeMC | medial vestibular nucleus, magnocellular part |
| MVePC | medial vestibular nucleus, parvicellular part |
| PCRt | parvicellular reticular nucleus |
| PCRtA | parvicellular reticular nucleus, alpha part |
| PMn | paramedian reticular nucleus |
| PPy | parapyramidal nucleus |
| Pr | prepositus nucleus |
| Pr5DM | principal sensory trigeminal nucleus, dorsomedial part |
| Pr5VL | principal sensory trigeminal nucleus, ventrolateral part |
| PSol | parasolitary nucleus |
| py | pyramidal tract |
| pyx | pyramidal decussation |
| RAmb | retroambiguus nucleus |
| RMg | raphe magnus nucleus |
| Ro | nucleus of Roller |
| ROb | raphe obscurus nucleus |
| RPa | raphe pallidus nucleus |
| RVL | rostroventrolateral reticular nucleus |
| Sol | nucleus of the solitary tract |
| SolC | nucleus of the solitary tract, commissural part |
| SolCe | nucleus of the solitary tract, central part |
| SolDL | solitary nucleus, dorsolateral part |
| SolDM | nucleus of the solitary tract, dorsomedial part |
| SolG | nucleus of the solitary tract, gelatinous part |
| SolI | nucleus of the solitary tract, interstitial part |
| SolIM | nucleus of the solitary tract, intermediate part |
| SolM | nucleus of the solitary tract, medial part |
| SolV | solitary nucleus, ventral part |
| SolVL | nucleus of the solitary tract, ventrolateral part |
| sp5 | spinal trigeminal tract |
| Sp5C | spinal trigeminal nucleus, caudal part |
| Sp5I | spinal trigeminal nucleus, interpolar part |
| Sp5O | spinal trigeminal nucleus, oral part |
| Sp5ODM | spinal trigeminal nucleus, oral part, dorsomedial division |
| Sp5OVL | spinal trigeminal nucleus, oral part, ventrolateral division |
| SPO | superior paraolivary nucleus |
| SpVe | spinal vestibular nucleus |
| SuVe | superior vestibular nucleus |
| VCA | ventral cochlear nucleus, anterior part |
| vsc | ventral spinocerebellar tract |
| X | nucleus X |
| Cerebellum | |
| 1Cb | 1st Cerebellar lobule |
| 2Cb | 2nd Cerebellar lobule |
| 3Cb | 3rd Cerebellar lobule |
| 4&5Cb | 4&5th Cerebellar lobules |
| 6Cb | 6th Cerebellar lobule |
| 7Cb | 7th Cerebellar lobule |
| 8Cb | 8th Cerebellar lobule |
| 9Cb | 9th Cerebellar lobule |
| 10Cb | 10th Cerebellar lobule |
| Crus1 | crus 1 of the ansiform lobule |
| Crus2 | crus 2 of the ansiform lobule |
| FI | flocculus |
| PFI | paraflocculus |
| PM | paramedian lobule |
| Sim | simple lobule |
| Ventricular zones | |
| 3 V | 3rd ventricle |
| OV | olfactory ventricle (olfactory part of lateral ventricle) |
| OV | olfactory ventricle (olfactory part of lateral ventricle) |
| SVZ | subventricular zone |
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Sex-specific single transcript level atlas of vasopressin and its receptor (AVPR1a) in the mouse brain
eLife 14:RP105355.
https://doi.org/10.7554/eLife.105355.4
