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Maturation of metabolic connectivity of the adolescent rat brain

  1. Hongyoon Choi
  2. Yoori Choi
  3. Kyu Wan Kim
  4. Hyejin Kang
  5. Do Won Hwang
  6. E Edmund Kim
  7. June-Key Chung
  8. Dong Soo Lee  Is a corresponding author
  1. Seoul National University College of Medicine, Republic of Korea
Research Article
  • Cited 17
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Cite this article as: eLife 2015;4:e11571 doi: 10.7554/eLife.11571

Abstract

Neuroimaging has been used to examine developmental changes of the brain. While PET studies revealed maturation related changes, maturation of metabolic connectivity of the brain is not yet understood. Here, we show that rat brain metabolism is reconfigured to achieve long-distance connections with higher energy efficiency during maturation. Metabolism increased in anterior cerebrum and decreased in thalamus and cerebellum during maturation. When functional covariance patterns of PET images were examined, metabolic networks including default mode network (DMN) were extracted. Connectivity increased between the anterior and posterior parts of DMN and sensory-motor cortices during maturation. Energy efficiency, a ratio of connectivity strength to metabolism of a region, increased in medial prefrontal and retrosplenial cortices. Our data revealed that metabolic networks mature to increase metabolic connections and establish its efficiency between large-scale spatial components from childhood to early adulthood. Neurodevelopmental diseases might be understood by abnormal reconfiguration of metabolic connectivity and efficiency.

Article and author information

Author details

  1. Hongyoon Choi

    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Competing interests
    The authors declare that no competing interests exist.
  2. Yoori Choi

    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Competing interests
    The authors declare that no competing interests exist.
  3. Kyu Wan Kim

    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Competing interests
    The authors declare that no competing interests exist.
  4. Hyejin Kang

    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Competing interests
    The authors declare that no competing interests exist.
  5. Do Won Hwang

    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Competing interests
    The authors declare that no competing interests exist.
  6. E Edmund Kim

    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Competing interests
    The authors declare that no competing interests exist.
  7. June-Key Chung

    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Competing interests
    The authors declare that no competing interests exist.
  8. Dong Soo Lee

    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    For correspondence
    dsl@snu.ac.kr
    Competing interests
    The authors declare that no competing interests exist.

Ethics

Animal experimentation: All the experimental procedures were approved by Institutional Animal Care and Use Committee at Seoul National University Hospital (IACUC Number 13-0224).

Reviewing Editor

  1. David Kleinfeld, University of California, San Diego, United States

Publication history

  1. Received: September 12, 2015
  2. Accepted: November 27, 2015
  3. Accepted Manuscript published: November 27, 2015 (version 1)
  4. Version of Record published: January 5, 2016 (version 2)

Copyright

© 2015, Choi et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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