Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila
- Chinese Academy of Sciences, China
- Shanghai Institutes for Biological Sciences, China
- Cited 23
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Abstract
Gap junctions are widely distributed in the brains across species and play essential roles in neural information processing. However, the role of gap junctions in insect cognition remains poorly understood. Using a flight simulator paradigm and genetic tools, we found that gap junctions are present in Drosophila Kenyon cells (KCs), the major neurons of the mushroom bodies (MBs), and showed that they play an important role in visual learning and memory. Using a dye coupling approach, we determined the distribution of gap junctions in KCs. Furthermore, we identified a single pair of MB output neurons (MBONs) that possess a gap junction connection to KCs, and provide strong evidence that this connection is also required for visual learning and memory. Together, our results reveal gap junction networks in KCs and the KC-MBON circuit, and bring new insight into the synaptic network underlying fly's visual learning and memory.
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Author details
Reviewing Editor
- K VijayRaghavan, Tata Institute of Fundamental Research, India
Publication history
- Received: November 20, 2015
- Accepted: May 20, 2016
- Accepted Manuscript published: May 24, 2016 (version 1)
- Version of Record published: June 15, 2016 (version 2)
- Version of Record updated: August 16, 2017 (version 3)
Copyright
© 2016, Liu et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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