Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders
- BCM, United States
- Baylor College of Medicine, United States
- UCSD, United States
Abstract
Many postnatal onset neurological disorders such as autism spectrum disorders (ASDs) and intellectual disability are thought to arise largely from disruption of excitatory/inhibitory homeostasis. Although mouse models of Rett syndrome (RTT), a postnatal neurological disorder caused by loss-of-function mutations in MECP2, display impaired excitatory neurotransmission, the RTT phenotype can be largely reproduced in mice simply by removing MeCP2 from inhibitory GABAergic neurons. To determine what role excitatory signaling impairment might play in RTT pathogenesis, we generated conditional mouse models with Mecp2 either removed from or expressed solely in glutamatergic neurons. MeCP2 deficiency in glutamatergic neurons leads to early lethality, obesity, tremor, altered anxiety-like behaviors, and impaired acoustic startle response, which is distinct from the phenotype of mice lacking MeCP2 only in inhibitory neurons. These findings reveal a role for excitatory signaling impairment in specific neurobehavioral abnormalities shared by RTT and other postnatal neurological disorders.
Article and author information
Author details
Reviewing Editor
- Catherine Dulac, Howard Hughes Medical Institute, Harvard University, United States
Ethics
Animal experimentation: Mice were housed in an AAALAS-certified animal facility. All procedures to maintain and use these mice were approved by the Institutional Animal Care and Use committee for Baylor College of Medicine (Animal protocol number AN-1013 ).
Version history
- Received: January 4, 2016
- Accepted: June 1, 2016
- Accepted Manuscript published: June 21, 2016 (version 1)
- Version of Record published: July 15, 2016 (version 2)
Copyright
© 2016, Meng et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders
eLife 5:e14199.
https://doi.org/10.7554/eLife.14199
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