The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled
- Institut de Génétique et de Biologie Moléculaire et Cellulaire, France
- University of California, Riverside, United States
- Tata Institute for Fundamental Research, India
Abstract
Collective migration is a complex process that contributes to build precise tissue and organ architecture. Several molecules involved in cell interaction control collective migration, but what their precise role is and how is their expression finely tuned to orchestrate the different steps of the process is poorly understood. Here we show that the timely and threshold expression of the Netrin receptor Frazzled triggers the initiation of glia migration in the Drosophila wing. Frazzled expression is induced by the Glide/Gcm transcription factor in a dose dependent manner. Thus, the glial determinant also regulates the efficiency of collective migration. NetrinB but not NetrinA serves as a chemoattractant and Unc5 contributes as a repellant Netrin receptor for glia migration. Our model includes strict spatial localization of a ligand, a cell autonomously acting receptor and a fate determinant that act coordinately to direct glia towards their final destination.
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Funding
CEFIPRA-4403-1 (graduate student fellowship)
- K VijayRaghavan
- Angela Giangrande
Agence Nationale de la Recherche (international award)
- Angela Giangrande
Fondation pour la Recherche Médicale (labelisation)
- Angela Giangrande
ARC Centre of Excellence for Coherent X-Ray Science (Projet grant)
- Angela Giangrande
Ligue Contre le Cancer (Grant regional)
- Angela Giangrande
USIAS
- Angela Giangrande
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Copyright
© 2016, Gupta et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled
eLife 5:e15983.
https://doi.org/10.7554/eLife.15983
