Developmental Biology

Latest articles

1. 1. Developmental Biology

   Tatton-Brown-Rahman Syndrome-associated DNMT3A mutations de-repress cortical interneuron differentiation to disrupt neuronal network function

   Gareth Chapman, Julianna J Determan ... Kristen L Kroll
2. 1. Developmental Biology

   Endocardial TIE1 synergizes with TIE2 to regulate the atrial internal muscular network assembly

   Kai Ding, Beibei Xu ... Yulong He
3. 1. Computational and Systems Biology
   2. Developmental Biology

   A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales

   Alice Gros, Jules Vanaret ... Sham Tlili

   The Tapenade pipeline enables single-cell, whole-mount 3D quantification in dense multilayer organoids, linking spatial gene co-expression and nuclear deformation to emerging tissue-scale organization.
4. 1. Developmental Biology
   2. Genetics and Genomics

   In situ mutational screening and CRISPR interference define apterous cis-regulatory inputs during compartment boundary formation

   Gustavo Aguilar, Michèle E Sickmann ... Martin Müller

   Early enhancer logic precisely aligns developmental boundaries by integrating HOX, GATA, and signaling inputs, ensuring correct tissue patterning and preventing mirror-image duplications in the developing wing.
5. 1. Developmental Biology
   2. Immunology and Inflammation

   Mitochondrial metabolic remodeling drives innate immune activation in Drosophila hemocytes

   Daewon Lee, Ferdinand Koranteng ... Jiwon Shim
6. 1. Developmental Biology

   Single-cell transcriptomics-informed induced pluripotent stem cells differentiation to tenogenic lineage

   Angela Papalamprou, Victoria Yu ... Dmitriy Sheyn

   Exploring the differentiation of iPSC to trunk tenocytes and how the single-cell RNA sequencing and pathway analysis can assist in making it more specific.
7. 1. Developmental Biology
   2. Neuroscience

   The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development; Eml3 null mice are a model of cobblestone brain malformation

   Isabelle Carrier, Eduardo Diez ... Roderick R McInnes
8. 1. Developmental Biology

   Peristaltic contractions drive gut anisotropic growth through collective cell rearrangements

   Koji Kawamura, Yoshiko Takahashi, Masafumi Inaba
9. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Lineage priming and cell type proportioning depends on the interplay between stochastic and deterministic factors

   William Salvidge, Chris Brimson ... Chris Thompson

   Experiments and mathematical modelling show cell fate in Dictyostelium discoideum partly depends on cell-cycle phase, but also on stochastic gene-expression variability which enhances robustness of developmental responses to cell-cycle perturbation.
10. 1. Cancer Biology
    2. Developmental Biology

    Tumors mimic the niche to inhibit neighboring stem cell differentiation

    Yang Zhang, Yuejia Wang ... Shaowei Zhao

    Drosophila female germline tumors mutant for bam or bgcn mimic the stem cell niche to inhibit the differentiation of neighboring wild-type germline stem cells.