Developmental Biology

Latest articles

1. 1. Developmental Biology

   Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

   Néstor Saiz et al.

   A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
2. 1. Developmental Biology

   Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

   Shreyasi Mukherjee et al.

   Genomic analysis of Xenopus gastrula reveal that the transcription factor Sox17 interacts with the Wnt signaling effector ß-catenin on enhancers to regulate the transcriptional program underlying endoderm germ layer formation.
3. 1. Developmental Biology
   2. Physics of Living Systems

   Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia

   Matthew A Heinrich et al.

   Epithelia exhibit size-dependent growth dynamics caused by a decoupling between boundary and bulk cellular dynamics that enable robust expansion and drive cell cycling, collective migration, and tissue-spanning vortices.
4. 1. Cell Biology
   2. Developmental Biology

   TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis

   Maorong Chen et al.
5. 1. Developmental Biology

   An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes

   Nathan D Lawson et al.

   Computational efforts yield a zebrafish transcriptome annotation that provides more sensitive and comprehensive gene detection over existing annotations when used for bulk or single-cell RNA-seq.
6. 1. Developmental Biology

   Building the vertebrate codex using the gene breaking protein trap library

   Noriko Ichino et al.

   The analysis of the first 1000 revertible protein trap alleles in zebrafish resulted in new functional genomic annotations and produced a panel of potential new models of human disease.
7. 1. Developmental Biology
   2. Neuroscience

   Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity

   Shinichiro Oku et al.

   Inclusion of a neuroligin alternatively spliced insert that interacts with a neurexin glycan modification promote development of functional synaptic connections between neurons and may help alleviate consequences of NLGN mutations.
8. 1. Developmental Biology

   Stem Cells: More than just a pool

   Amanda Cinquin, Olivier Cinquin

   An intricate stem cell niche boundary formed by finger-like extensions generates asymmetry in stem cell divisions.
9. 1. Computational and Systems Biology
   2. Developmental Biology

   Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

   Sumeda Nandadasa et al.
10. 1. Cancer Biology
    2. Developmental Biology

    SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells

    Erik Oliemuller et al.