Developmental Biology

Developmental Biology

eLife reviews research in areas including cell migration, proliferation and differentiation, and inductive and signaling interactions. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Developmental Biology

    Quantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation

    Morena Raiola, Miquel Sendra ... Miguel Torres
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Developmental Biology
    2. Genetics and Genomics

    PIK3CA-related overgrowth spectrum (PROS) zebrafish models reveal pan-lineage developmental dysregulation

    Hannah Brunsdon, Nuoya Wang ... E Elizabeth Patton
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Developmental Biology
    2. Neuroscience

    Complementary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

    Kang-Han Lee, April M Stafford ... Daniel Vogt
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Developmental Biology
    2. Computational and Systems Biology

    Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids

    Catherine G Triandafillou, Pranav Sompalle ... Arjun Raj
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Developmental Biology

    The NTR/prodrug revolution: Tools for controlling cell loss and regeneration

    Gha-Hyun J Kim, Michael Parsons
    Improved nitroreductase variants, optimized prodrugs, and careful experimental design enable scalable, precise cell ablation across model systems for disease modeling, regeneration studies, and high-throughput discovery.
    1. Developmental Biology

    HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis

    Yuqian Shen, Ziyang Wang ... Dong Liu
    HSD17B7-dependent cholesterol biosynthesis is essential for hair cell function, implicating HSD17B7 disruption in the pathogenesis of hearing loss.
    1. Developmental Biology
    2. Neuroscience

    ARHGEF6-dependent cytoskeletal regulation underlies a conserved program of forebrain interneuron development

    Carla Liaci, Beatrice Savarese ... Giorgio R Merlo
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Developmental Biology

    Paternal over- and under-nutrition program fetal and placental development in a sex-specific manner in mice

    Hannah L Morgan, Nader Eid ... Adam J Watkins
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Developmental Biology

    Mural cells protect the adult brain from hemorrhage but do not control the blood–brain barrier in developing zebrafish

    Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
    Pericytes regulate cerebrovascular development, while vascular smooth muscle cells prevent hemorrhage and blood–brain barrier breakdown at vascular hotspots in juvenile and adult zebrafish.
    1. Developmental Biology

    Tatton-Brown-Rahman Syndrome-associated DNMT3A mutations de-repress cortical interneuron differentiation to disrupt neuronal network function

    Gareth Chapman, Julianna J Determan ... Kristen L Kroll
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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Highlights

    1. Developmental Biology

    Oocyte Development: The discovery of the mammalian fusome

    Michael Buszczak, Anirban Dasgupta
    1. Developmental Biology
    2. Genetics and Genomics

    Written out of history

    Lisa M Thomann, Julie Batut
    1. Developmental Biology

    Limb Patterning: The cellular logic of limb regeneration

    Matthew Cherubino, Catherine D McCusker

Senior editors

  1. Albert Cardona
    University of Cambridge, United Kingdom
  2. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  3. Jürgen Kleine-Vehn
    University of Freiburg, Germany
  4. See more editors