Developmental Biology

Latest articles

1. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids

   Anna Yoney et al.

   The requirement for WNT signaling in mesendoderm differentiation is temporally separate from that of ACTIVIN signaling and acts to switch the output of ACTIVIN/SMAD2 from pluripotency maintenance to mesendoderm patterning.
2. 1. Developmental Biology
   2. Evolutionary Biology

   Decoupling from yolk sac is required for extraembryonic tissue spreading in the scuttle fly Megaselia abdita

   Francesca Caroti et al.

   Extraembryonic tissue spreading in the scuttle fly Megaselia abdita requires mechanical decoupling from the underlying yolk sac.
3. 1. Stem Cells and Regenerative Medicine
   2. Developmental Biology

   Hair follicle epidermal stem cells define a niche for tactile sensation

   Chun-Chun Cheng et al.

   Heterogeneous epidermal stem cells define a niche for tactile sensation via providing a unique ECM and tissue architecture for nerves, revealing their new functions in coordinated sensory organ formation.
4. 1. Computational and Systems Biology
   2. Developmental Biology

   Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression

   C Matthew Hope et al.

   Tuned protein–protein interaction affinity optimizes the repressive function of the ETS family transcription factor Yan in order to contribute specificity and robustness to cell fate specification in the developing Drosophila eye.
5. 1. Developmental Biology

   Feedback regulation of cytoneme-mediated transport shapes a tissue-specific FGF morphogen gradient

   Lijuan Du et al.

   FGF morphogen gradient self-generates a recipient tissue-specific contour by feedback-regulating its cytoneme-mediated dispersion.
6. 1. Developmental Biology
   2. Neuroscience

   Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

   Ya-Ping Yen et al.

   LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
7. 1. Developmental Biology

   A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusion

   Richard W Naylor et al.
8. 1. Cell Biology
   2. Developmental Biology

   Optogenetic dissection of mitotic spindle positioning in vivo

   Lars-Eric Fielmich et al.

   New germline gene expression, knockout, and optogenetic tools reveal essential roles for Gα-GPR-1,2/Pins as a regulatable membrane anchor and LIN-5/NuMA as an activator of cortical dynein in mitotic spindle positioning.
9. 1. Developmental Biology
   2. Genetics and Genomics

   Zygotic gene activation in the chicken occurs in two waves, the first involving only maternally derived genes

   Young Sun Hwang et al.
10. 1. Developmental Biology

    The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

    Lena Tveriakhina et al.

    Regions outside the major receptor binding interface of DLL1 and DLL4 contribute to context-dependent divergence of ligand function in vivo and differential Notch1 and Notch2 activation in vitro.