Developmental Biology

Latest articles

1. 1. Developmental Biology

   Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility

   Hatice Duygu Saatcioglu et al.

   Single-cell RNA sequencing of neonatal uterus revealed an Misr2+ endometrial stromal progenitor whose inhibition by ectopic administration of MIS caused uterine hypoplasia and infertility in adulthood.
2. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Multi-enhancer transcriptional hubs confer phenotypic robustness

   Albert Tsai et al.

   Multiple enhancers in physical proximity can reinforce shared transcriptional 'hubs' to preserve their transcriptional output, providing a buffer during environmental stresses and genetic perturbations to preserve phenotypic robustness.
3. 1. Computational and Systems Biology
   2. Developmental Biology

   Modularity, criticality, and evolvability of a developmental gene regulatory network

   Berta Verd et al.

   A new approach focusing on dynamic modularity helps overcome traditional challenges detecting modularity in complex adaptive systems.
4. 1. Developmental Biology
   2. Neuroscience

   The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop

   Merve Deniz Abdusselamoglu et al.

   Odd-paired (opa) is required for the progression of temporal patterning in Drosophila neural progenitors to regulate temporal identities via an incoherent feed-forward loop.
5. 1. Developmental Biology
   2. Genetics and Genomics

   Splicing in a single neuron is coordinately controlled by RNA binding proteins and transcription factors

   Morgan Thompson et al.

   Single-cell splicing of a conserved neuronal kinase is established by a combinatorial code of fate-determining transcription factors and neuronal RNA binding proteins, with different combinations in different neuron types.
6. 1. Developmental Biology
   2. Neuroscience

   Anterior CNS expansion driven by brain transcription factors

   Jesús Rodriguez Curt et al.

   The expansion of the anterior Drosophila CNS is driven by increased progenitor generation and prolonged proliferation, mediated by brain-restricted genes and the PRC2.
7. 1. Developmental Biology

   Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice

   Jorge López-Tello et al.

   Fetus and trophoblast interplay to regulate fetal nutrient supply and, ultimately, affect healthy growth.
8. 1. Developmental Biology

   Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification

   Heejin Nam et al.
9. 1. Developmental Biology
   2. Genetics and Genomics

   Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism

   Samuel Andrew Malone et al.

   Mouse in vivo and in vitro analysis and human genetic screening highlight the role of anti-Müllerian hormone (AMH) signaling in GnRH neuronal development and function, and identify mutations in AMH and AMHR2 in CHH patients.
10. 1. Developmental Biology

    Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival

    Marshall Lukacs et al.

    Anchoring of proteins to the cell membrane through the glycosylphosphatidylinositol (GPI) anchor is critical for the survival of the cells that will give rise to the brain and face.