Developmental Biology

Latest articles

1. 1. Cell Biology
   2. Developmental Biology

   Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration

   Eunjin Cho, Xiangguo Che ... Tae-Hoon Lee

   Peroxiredoxin 5 contributes to the maintenance of bone homeostasis by regulating osteoblast differentiation.
2. 1. Developmental Biology

   MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice

   Greta Rossi, Gabriele Ordazzo ... Vania Broccoli

   The endoplasmic reticulum (ER)-resident protein wolframin regulates MCT1 protein levels in retinal glial cells controlling the shuttling of energy metabolites to both somata and axons of retinal ganglion cells and, thus, supporting their fitness and survival.
3. 1. Developmental Biology

   A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus

   Kavitha Chinnaiya, Sarah Burbridge ... Marysia Placzek
4. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Efficient generation of marmoset primordial germ cell-like cells using induced pluripotent stem cells

   Yasunari Seita, Keren Cheng ... Kotaro Sasaki
5. 1. Developmental Biology

   Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles

   Florian Schueder, Pierre Mangeol ... Frank Schnorrer

   The two Drosophila titin homologs Sallimus and Projectin display a precise tandem arrangement in the sarcomere that may explain how sarcomere length is regulated outside of vertebrates.
6. 1. Developmental Biology

   A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

   Vincent Loreau, Renate Rees ... Dirk Görlich

   A collection of 22 nanobodies against 11 different Drosophila sarcomeric protein epitopes was generated, validated in stainings and for some transgenic fly lines were generated to monitor the dynamics of the sarcomeric proteins in muscles in vivo.
7. 1. Developmental Biology
   2. Evolutionary Biology

   Metamorphosis of memory circuits in Drosophila reveals a strategy for evolving a larval brain

   James W Truman, Jacquelyn Price ... Tzumin Lee
8. 1. Developmental Biology

   Sex-specific role of myostatin signaling in neonatal muscle growth, denervation atrophy, and neuromuscular contractures

   Marianne E Emmert, Parul Aggarwal ... Roger Cornwall

   Myostatin signaling governs neonatal longitudinal muscle growth and neuromuscular contractures in a sex-dependent manner, identifying a potential avenue for contracture treatment and underscoring the need to consider sex as a biological variable in the pathophysiology of acquired neuromuscular disorders.
9. 1. Developmental Biology
   2. Genetics and Genomics

   Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality

   Ankit Sabharwal, Mark D Wishman ... Stephen C Ekker

   A revertible Leigh Syndrome French Canadian Type (LSFC) disease model recapitulates the clinical phenotypes which can be rescued using a liver-specific genetic model therapy.
10. 1. Chromosomes and Gene Expression
    2. Developmental Biology

    Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8

    Nan Wang, Jing He ... Kehkooi Kee

    The lncRNA landscapes in human germ cells are comprehensively profiled and the functional role of an lncRNA LNC1845 in regulating gene expression of a neighboring coding gene LHX8 is elucidated.