Developmental Biology

Latest articles

1. 1. Cell Biology
   2. Developmental Biology

   Cytoskeletal tension and Bazooka tune interface geometry to ensure fusion fidelity and sheet integrity during dorsal closure

   Piyal Taru Das Gupta, Maithreyi Narasimha

   Restoration of molecular and morphological symmetry and mechanical integrity following epithelial fusion relies on adaptive changes that are mediated by cytoskeletal tension and Bazooka dependent modulation of fusing interface geometry.
2. 1. Developmental Biology
   2. Physics of Living Systems

   Cerebellar folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern

   Andrew K Lawton et al.

   A multi-phase wrinkling model accounts for the radial and circumferential tension and differential expansion between a uniformly proliferating outer fluid-like layer and an incompressible core that together drive cerebellar folding.
3. 1. Developmental Biology
   2. Neuroscience

   Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

   Hirofumi Noguchi et al.

   Sufu controls dentate gyrus stem cell quiescence by acting as a positive regulator of Shh signaling and loss of Sufu leads to dramatic failure to produce sufficient quiescent stem cells.
4. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Transitions in cell potency during early mouse development are driven by Notch

   Sergio Menchero et al.
5. 1. Developmental Biology

   Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo

   Bechara Saykali et al.

   At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.
6. 1. Developmental Biology
   2. Neuroscience

   Chronology-based architecture of descending circuits that underlie the development of locomotor repertoire after birth

   Avinash Pujala, Minoru Koyama

   Newly forming descending pathways are arranged to function in parallel to existing ones and contribute to increasingly sophisticated locomotor behaviors that emerge postnatally with suitable connectivity patterns and biophysical properties.
7. 1. Developmental Biology

   Low Wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

   Fabienne Benz et al.
8. 1. Developmental Biology
   2. Neuroscience

   Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures

   Yanshu Wang et al.

   Elevating beta-catenin signaling converts endothelial cells in typically fenestrated central nervous system vasculature to a blood-brain barrier (BBB) phenotype and promotes a BBB gene expression program and chromatin landscape.
9. 1. Developmental Biology
   2. Evolutionary Biology

   Bichir external gills arise via heterochronic shift that accelerates hyoid arch development

   Jan Stundl et al.

   Unique heterochrony in the cranial segments in bichirs triggers the early formation of their external gills, and might be informative about developmental mechanisms facilitating increased breathing capacity.
10. 1. Developmental Biology

    Guy1, a Y-linked embryonic signal, regulates dosage compensation in Anopheles stephensi by increasing X gene expression

    Yumin Qi et al.

    For the first time in a mosquito species an initial Y chromosome signal has been shown to regulate dosage compensation by increasing X chromosome gene expression.