Developmental Biology

Latest articles

1. 1. Developmental Biology
   2. Neuroscience

   Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

   Gerrit Cornelis Beekhof et al.

   Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.
2. 1. Cell Biology
   2. Developmental Biology

   Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

   Qian Yu et al.

   Corneal aging is regulated by the NF-κB-retinoic acid pathway and can be delayed by retinoic acid administration.
3. 1. Developmental Biology
   2. Genetics and Genomics

   Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris

   Brent A Wilkerson et al.

   The elucidation of the cellular composition of the crista and the genes expressed in each cell type is a critical step toward understanding inner ear development, function, and vestibulopathies.
4. 1. Cell Biology
   2. Developmental Biology

   Protein-based condensation mechanisms drive the assembly of RNA-rich P granules

   Helen Schmidt et al.
5. 1. Developmental Biology

   SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients

   Fei Liang et al.

   Combined evidence of human genetics, in vitro cardiomyocyte differentiation, and mouse model indicates that SORBS2 is a regulator of second heart field development and its deficiency causes seemingly opposite atrial septal defects.
6. 1. Developmental Biology
   2. Neuroscience

   Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons

   Eljo Van Battum et al.
7. 1. Cell Biology
   2. Developmental Biology

   Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree

   Audrey M Hendley et al.

   Single-cell RNA-sequencing analyses and functional studies define heterogeneity within the pancreatic ductal tree and unique properties of subpopulations of duct cells including an epithelial-mesenchymal transcriptomic axis and roles in chronic pancreatic inflammation.
8. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

   Yulong Wei et al.

   Meniscal Gli1+ cells are mesenchymal progenitors that contribute to the development and injury repair of meniscus.
9. 1. Developmental Biology

   Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations

   Wenqing Li et al.

   Genetic studies reveal that mosaic inactivation of ccm2 causes characteristic cerebral cavernous malformations in adult zebrafish and aberrant responses to blood flow that induce the formation of a lethal embryonic multi-cavernous venous malformation.
10. 1. Developmental Biology

    Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

    Kazuhide S Okuda et al.

    Live-imaging of a transgenic reporter of vascular Erk signalling in zebrafish reveals sequential signalling mechanisms during the initiation of regeneration in wounded blood vessels.