Developmental Biology

Latest articles

1. 1. Developmental Biology
   2. Neuroscience

   DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation

   Laura Morcom et al.

   Axon guidance molecules DCC and NTN1 regulate astroglial-mediated interhemispheric remodelling required for corpus callosum formation in humans and mice.
2. 1. Developmental Biology
   2. Immunology and Inflammation

   T cell self-reactivity during thymic development dictates the timing of positive selection

   Lydia K Lutes et al.

   Developing T cells whose TCRs have relatively low reactivity experience very brief TCR signaling events, experience delayed positive selection, and retaina preselection gene expression signature as they mature.
3. 1. Developmental Biology
   2. Neuroscience

   A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS

   Brandon Mark et al.
4. 1. Cell Biology
   2. Developmental Biology

   EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice

   Yuki Osawa et al.

   EXOC1 contributes to the proper differentiation balance of spermatogonial stem cells and spermatocyte syncytia formation by regulating the morphology of male germ cells.
5. 1. Developmental Biology
   2. Neuroscience

   Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

   Gerrit Cornelis Beekhof et al.
6. 1. Developmental Biology

   A calcineurin-mediated scaling mechanism that controls a K⁺-leak channel to regulate morphogen and growth factor transcription

   Chao Yi et al.

   Calcineurin regulates an electrophysiological mechanism that activates the transcription of specific developmental genes in a heirarchical manner to scale fish appendages.
7. 1. Developmental Biology

   Ongoing repair of migration-coupled DNA damage allows planarian adult stem cells to reach wound sites

   Sounak Sahu et al.

   Adult stem cells acquire increased DNA damage as they migrate to a wound site and require active DNA repair mechanisms for normal migration.
8. 1. Developmental Biology
   2. Plant Biology

   Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

   Elvira Hernandez-Lagana et al.
9. 1. Cancer Biology
   2. Developmental Biology

   An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

   Rediet Zewdu et al.

   Genetically engineered murine models reveal novel mechanisms of cell identity regulation in lung cancer and provide insights into the complex interplay between lineage specifiers and oncogenic signaling pathways in this disease.
10. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in Xenopus laevis larvae

    Andrew M Hamilton et al.