Restoration of molecular and morphological symmetry and mechanical integrity following epithelial fusion relies on adaptive changes that are mediated by cytoskeletal tension and Bazooka dependent modulation of fusing interface geometry.
A multi-phase wrinkling model accounts for the radial and circumferential tension and differential expansion between a uniformly proliferating outer fluid-like layer and an incompressible core that together drive cerebellar folding.
At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.
Newly forming descending pathways are arranged to function in parallel to existing ones and contribute to increasingly sophisticated locomotor behaviors that emerge postnatally with suitable connectivity patterns and biophysical properties.
Elevating beta-catenin signaling converts endothelial cells in typically fenestrated central nervous system vasculature to a blood-brain barrier (BBB) phenotype and promotes a BBB gene expression program and chromatin landscape.
Unique heterochrony in the cranial segments in bichirs triggers the early formation of their external gills, and might be informative about developmental mechanisms facilitating increased breathing capacity.