Developmental Biology

Latest articles

1. 1. Cell Biology
   2. Developmental Biology

   Asymmetric recruitment and actin-dependent cortical flows drive the neuroblast polarity cycle

   Chet Huan Oon, Kenneth E Prehoda

   Neural stem cells dynamically polarize through the stepwise activity of polarized cortical targeting and cortical flows that coalescence discontinuous cortical patches into an organized cap structure.
2. 1. Developmental Biology
   2. Neuroscience

   FOXP2 exhibits neuron class specific expression, but is not required for multiple aspects of cortical histogenesis

   Ryan J Kast et al.
3. 1. Developmental Biology

   Reciprocal action of Casein Kinase Iε on core planar polarity proteins regulates clustering and asymmetric localisation

   Helen Strutt et al.
4. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Hierarchical stem cell topography splits growth and homeostatic functions in the fish gill

   Julian Stolper et al.
5. 1. Developmental Biology

   Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk

   Lin Grimm et al.

   Genetic studies reveal a role for Yap1 in lymphatic endothelial progenitor cell sprouting and proliferation during early zebrafish lymphatic vascular development.
6. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction

   Mohsen Afshar Bakooshli et al.

   Human skeletal muscle progenitors and motor neurons self-organize in three-dimensional co-culture to form functional neuromuscular junctions that developmentally mature from the embryonic to the adult state.
7. 1. Developmental Biology

   The Hox transcription factor Ubx stabilizes lineage commitment by suppressing cellular plasticity in Drosophila

   Katrin Domsch et al.

   The Hox transcription factor Ultrabithorax (Ubx) represses alternative gene programs during lineage development by lineage-specific Polycomb protein complex retention at Ubx-targeted chromatin sites.
8. 1. Developmental Biology
   2. Genetics and Genomics

   Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers

   Chris Cho et al.

   Discs large homologue 1 (Dlg1) activates beta-catenin (i.e., canonical Wnt) signaling in CNS endothelial cells to regulate retinal angiogenesis and the development and maintenance of the blood-brain and blood-retina barriers.
9. 1. Developmental Biology
   2. Neuroscience

   Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1

   Hsin-I Jen et al.

   The mammalian utricle can better regenerate hair cells compared to the cochlea because it maintains hair cell gene loci in a more transcriptionally accessible state.
10. 1. Developmental Biology
    2. Neuroscience

    Neurotransmitter identity is acquired in a lineage-restricted manner in the Drosophila CNS

    Haluk Lacin et al.

    Lineally related neurons in the adult Drosophila ventral nerve cord use the same neurotransmitter to communicate with other neurons.