Developmental Biology

Latest articles

1. 1. Developmental Biology
   2. Genetics and Genomics

   Hedgehog regulation of epithelial cell state and morphogenesis in the larynx

   Janani Ramachandran, Weiqiang Zhou ... Steven A Vokes

   HH signaling prevents precocious EMT and cell death to maintain epithelial cell states during early stages of larynx development.
2. 1. Developmental Biology

   m⁶A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina

   Yanling Xin, Qinghai He ... Shuyi Chen

   m⁶A fine-tunes transcriptomic transition from neural progenitors to glial cells in the retina.
3. 1. Developmental Biology
   2. Genetics and Genomics

   Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis

   Xiaodong Li, Patrick J Gordon ... Edward M Levine

   The LIM-homedomain transcription factor Lhx2 confers competence to retinal progenitor cells to activate and maintain Sonic Hedgeghog signaling at physiological levels during a key phase of tissue growth and cell type generation.
4. 1. Developmental Biology

   Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis

   Zhongxiao Wang, Felix Yemanyi ... Jing Chen

   Experimental analysis of SLC38A5 (solute carrier family 38 member 5) in mouse models and cell culture reveals its novel role as a metabolic regulator of retinal angiogenesis by controlling nutrient uptake and homeostasis in blood vessel endothelium.
5. 1. Developmental Biology
   2. Genetics and Genomics

   Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology

   Elizabeth A Bearce, Zoe H Irons ... Daniel T Grimes
6. 1. Developmental Biology
   2. Neuroscience

   Presynaptic contact and activity opposingly regulate postsynaptic dendrite outgrowth

   Emily L Heckman, Chris Q Doe
7. 1. Computational and Systems Biology
   2. Developmental Biology

   Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice

   Feng Xian, Julia Regina Sondermann ... Manuela Schmidt

   Proteomics uncovers thus far unknown age and sex differences in sciatic nerve and skin of naïve mice, highlighting the importance of adequate age matching and parallel investigation of male and female mice in biomedical studies.
8. 1. Developmental Biology
   2. Immunology and Inflammation

   Thymic macrophages consist of two populations with distinct localization and origin

   Tyng-An Zhou, Hsuan-Po Hsu ... Ivan L Dzhagalov
9. 1. Computational and Systems Biology
   2. Developmental Biology

   Large-scale analysis and computer modeling reveal hidden regularities behind variability of cell division patterns in Arabidopsis thaliana embryogenesis

   Elise Laruelle, Katia Belcram ... Philippe Andrey

   Self-organization based on a feedback loop between cell geometry and division plane positioning plays a central role in the building of tissue architectures in Arabidopsis thaliana embryo through both stereotyped and variable division patterns.
10. 1. Developmental Biology
    2. Physics of Living Systems

    Mother cells control daughter cell proliferation in intestinal organoids to minimize proliferation fluctuations

    Guizela Huelsz-Prince, Rutger Nico Ulbe Kok ... Jeroen S van Zon

    Tracking of all cells in intestinal organoids crypts to fully reconstruct cell lineages reveals that proliferative behavior is highly symmetric between sisters cells, while simulations show that this observed symmetry minimizes random fluctuations in cell proliferation, thereby ensuring homeostasis.