Developmental Biology

Developmental Biology

eLife publishes research in areas including cell migration, proliferation and differentiation, and inductive and signaling interactions. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Developmental Biology

    Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina

    Swathy Babu et al.
    Banp is a transcription activator of cell cycle genes like cenpt, ncapg, and wrnip1 to prevent genotoxic stress during rapid cell division and its repercussions on development and disease.
    1. Developmental Biology

    Positive feedback regulation of frizzled-7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate

    Takayoshi Yamamoto et al.
    Biomolecular experiments and computer simulations revealed that morphogen receptors expressed via a positive feedback loop impart robustness against variations in morphogen secretion rate and speed of development.
    1. Developmental Biology

    Targeted depletion of uterine glandular Foxa2 induces embryonic diapause in mice

    Mitsunori Matsuo et al.
    Leukemia inhibitory factor (LIF) suppression is not sufficient to maintain long-term uterine quiescence like in ovariectomized mice maintained on progesterone supplement, and estrogen has an adverse impact on uterine quiescence independent of FOXA2 (forkhead box protein A2)/LIF.
    1. Developmental Biology

    Maternal H3K36 and H3K27 HMTs protect germline development via regulation of the transcription factor LIN-15B

    Chad Steven Cockrum, Susan Strome
    The H3K36 and H3K27 histone methyltransferases MES-4 and PRC2 protect survival of the nascent germline in Caenorhabditis elegans by repressing expression of X-linked genes, including the key transcription factor LIN-15B.
    1. Developmental Biology
    2. Neuroscience

    Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in the Drosophila larval nerve cord

    Yi-wen Wang et al.
    A newly identified pattern of circuit assembly shows connectivity between small groups of neurons born in tight time windows from different stem cells, with outputs from one lineage born before inputs from other lineages.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Decoding the activated stem cell phenotype of the neonatally maturing pituitary

    Emma Laporte et al.
    The neonatally maturing pituitary harbors an activated stem cell compartment and shows prominent regenerative capacity, as revealed by single-cell transcriptomic profiling and in vitro (organoid) and in vivo (mouse) exploration.
    1. Cell Biology
    2. Developmental Biology

    A non-transcriptional function of Yap regulates the DNA replication program in Xenopus laevis

    Rodrigo Meléndez García et al.
    Yap interacts with Rif1, a major DNA replication timing factor, and functions as a brake to control the DNA replication program in Xenopus early embryos and post-embryonic stem cells.

Senior editors

  1. Utpal Banerjee
    University of California, Los Angeles, United States
  2. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  3. Claude Desplan
    New York University, United States
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