Developmental Biology

Developmental Biology

eLife publishes research in areas including cell migration, proliferation and differentiation, and inductive and signaling interactions. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Developmental Biology

    Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation

    Rodrigo M Young et al.
    The inclusion of a new alternatively spliced exon in Tcf7l2 can switch its function to repress transcription of Wnt target genes.
    1. Developmental Biology
    2. Human Biology and Medicine

    Prolonged ovarian storage of mature Drosophila oocytes dramatically increases meiotic spindle instability

    Ethan J Greenblatt et al.
    Meiotic chromosome segregation in mature Drosophila oocytes is sensitive to prolonged quiescence, suggesting that human oocyte instability may result from storage of mature rather than primordial oocytes and be modifiable.
    1. Cell Biology
    2. Developmental Biology

    Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila

    Jean-André Lapart et al.
    Genetic analyses in Drosophila establish the functional hierarchy of the ciliary transition zone module, Dzip1/Fam92/Cby, and reveal tissue specific variations in basal body anchoring pathways in fly ciliated tissues.
    1. Developmental Biology
    2. Neuroscience

    Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

    Max Koppers et al.
    Multiple axonal guidance receptors control the local and selective translation of mRNAs by binding to ribosomes, specific mRNAs and RNA-binding proteins.
    1. Developmental Biology
    2. Neuroscience

    Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans

    Menghao Lu, Kota Mizumoto
    Genetic analyses revealed the critical role of local Wnt in neuronal patterning by instructing neurite pruning.
    1. Developmental Biology
    2. Neuroscience

    Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth

    Ryan T Willett et al.
    The first born excitatory cerebellar nuclei neurons influence the survival of their Purkinje cell partners which stimulate the expansion of granule cells and interneurons to produce functional local circuits.
    1. Developmental Biology
    2. Plant Biology

    Coordination of tissue cell polarity by auxin transport and signaling

    Carla Verna et al.
    GNOM controls both auxin transport and auxin signaling to coordinate tissue cell polarity during vein patterning in plants.

Highlights

    1. Developmental Biology
    2. Genetics and Genomics

    Silencing alternatives in neurogenesis

    Priya Sivaramakrishnan, John Isaac Murray

Senior editors

  1. Marianne E Bronner
    Marianne E Bronner
    California Institute of Technology, United States
  2. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  3. Mike Eisen
    Michael B Eisen
    HHMI, University of California, Berkeley, United States
  4. See more editors