Developmental Biology

Developmental Biology

eLife reviews research in areas including cell migration, proliferation and differentiation, and inductive and signaling interactions. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Developmental Biology

    Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration

    Eunjin Cho, Xiangguo Che ... Tae-Hoon Lee
    Peroxiredoxin 5 contributes to the maintenance of bone homeostasis by regulating osteoblast differentiation.
    1. Developmental Biology

    MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice

    Greta Rossi, Gabriele Ordazzo ... Vania Broccoli
    The endoplasmic reticulum (ER)-resident protein wolframin regulates MCT1 protein levels in retinal glial cells controlling the shuttling of energy metabolites to both somata and axons of retinal ganglion cells and, thus, supporting their fitness and survival.
    1. Developmental Biology

    A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus

    Kavitha Chinnaiya, Sarah Burbridge ... Marysia Placzek
    1. Developmental Biology

    Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles

    Florian Schueder, Pierre Mangeol ... Frank Schnorrer
    The two Drosophila titin homologs Sallimus and Projectin display a precise tandem arrangement in the sarcomere that may explain how sarcomere length is regulated outside of vertebrates.
    1. Developmental Biology

    A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

    Vincent Loreau, Renate Rees ... Dirk Görlich
    A collection of 22 nanobodies against 11 different Drosophila sarcomeric protein epitopes was generated, validated in stainings and for some transgenic fly lines were generated to monitor the dynamics of the sarcomeric proteins in muscles in vivo.
    1. Developmental Biology

    Sex-specific role of myostatin signaling in neonatal muscle growth, denervation atrophy, and neuromuscular contractures

    Marianne E Emmert, Parul Aggarwal ... Roger Cornwall
    Myostatin signaling governs neonatal longitudinal muscle growth and neuromuscular contractures in a sex-dependent manner, identifying a potential avenue for contracture treatment and underscoring the need to consider sex as a biological variable in the pathophysiology of acquired neuromuscular disorders.
    1. Developmental Biology
    2. Genetics and Genomics

    Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality

    Ankit Sabharwal, Mark D Wishman ... Stephen C Ekker
    A revertible Leigh Syndrome French Canadian Type (LSFC) disease model recapitulates the clinical phenotypes which can be rescued using a liver-specific genetic model therapy.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8

    Nan Wang, Jing He ... Kehkooi Kee
    The lncRNA landscapes in human germ cells are comprehensively profiled and the functional role of an lncRNA LNC1845 in regulating gene expression of a neighboring coding gene LHX8 is elucidated.

Highlights

    1. Developmental Biology
    2. Medicine

    Reproductive organs need more research

    Natalie D Mercuri, Brian J Cox
    1. Developmental Biology
    2. Evolutionary Biology

    Natural History of Model Organisms: E. coqui

    Sarah E Westrick, Mara Laslo, Eva K Fischer
    1. Cell Biology
    2. Developmental Biology

    Imaging methods are vastly underreported

    Guillermo Marqués, Thomas Pengo, Mark A Sanders

Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Claude Desplan
    New York University, United States
  3. Mike Eisen
    Michael B Eisen
    HHMI, University of California, Berkeley, United States
  4. See more editors