Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration

  1. Kuchuan Chen
  2. Guang Lin
  3. Nele A Haelterman
  4. Tammy Szu-Yu Ho
  5. Tongchao Li
  6. Zhihong Li
  7. Lita Duraine
  8. Brett H Graham
  9. Manish Jaiswal
  10. Shinya Yamamoto
  11. Matthew N Rasband
  12. Hugo J Bellen  Is a corresponding author
  1. Baylor College of Medicine, United States
  2. Howard Hughes Medical Institute, Baylor College of Medicine, United States

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  1. Version of Record published
  2. Accepted Manuscript published
  3. Accepted
  4. Received

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  1. Kuchuan Chen
  2. Guang Lin
  3. Nele A Haelterman
  4. Tammy Szu-Yu Ho
  5. Tongchao Li
  6. Zhihong Li
  7. Lita Duraine
  8. Brett H Graham
  9. Manish Jaiswal
  10. Shinya Yamamoto
  11. Matthew N Rasband
  12. Hugo J Bellen
(2016)
Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration
eLife 5:e16043.
https://doi.org/10.7554/eLife.16043

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https://doi.org/10.7554/eLife.16043