At the end of the predefined study period (Day 12), tumors from the xenograft experiment reported in Figure 1 were excised and weighed. Box and whisker plot with median represented as the line through the box, means represented as the solid red circle, and whiskers representing values within 1.5 IQR of the first and third quartile. Number of mice: A549 tumors: n=14 (vehicle), n=13 (cimetidine), n=4 (doxorubicin). ACHN tumors: n=15 (vehicle), n=15 (cimetidine). Two-tailed Welch’s t-test between vehicle or doxorubicin treated A549 tumors; t(4.078) = 0.771, p=0.483. Two-way ANOVA interaction between cell line (A549 or ACHN) and treatment (vehicle or cimetidine); F(1,53) = 0.00005, p=0.994. Two-way ANOVA main effect of cell line (A549 or ACHN); F(1,53) = 7.56, p=0.00814. Additional details for this experiment can be found at https://osf.io/fh6gn/.