(A) Subjects performed a face-detection task on a touchscreen device that was mounted to their home cages. Subjects were unconstrained, initiated trials at will, and scanned the array freely. (B) Upon initiating a trial, an array of 24 objects appeared on the screen, one of which was the target belonging to one of three categories – faces, bodies, or shoes (green circles). (C) Neural activity in face-patch ML (yellow regions) was silenced by targeted microinjections of muscimol. (Top) The extent of diffusion and targeting accuracy was evaluated by coinjecting gadolinium, which appeared as a bright volume in post-injection anatomical scans. Labels: SAG - sagittal slice, HOR - horizontal slice, COR - coronal slice, A - anterior, P - posterior, D - dorsal, V – ventral. (Bottom) The locations of all four targeted muscimol microinjections (heatmap) from one subject's left hemisphere relative to face-patch locations (green outlines, face area labels as in Tsao et al., 2008). (D) Volumetric overlap between the inactivation injections and ML (red; n = 11) and off-target injections and ML (blue; n = 10). Lines correspond to ±1 s.e.m., and the intersection point is the mean along each axis. Symbols correspond to the mean values from individual hemispheres (circle – Subject ‘I’, LH; square – Subject ‘O’, RH; triangle – Subject ‘O’, LH).