An excitatory cortical feedback loop gates retinal wave transmission in rodent thalamus
- George Washington University, United States
Figures
Figure 1
Thalamic spindle-burst oscillations are transmitted to visual cortex.
(A) Experimental setup. Simultaneous recordings from visual thalamus (lateral geniculate nucleus, LGN) and primary monocular visual cortex (VC) were acquired with two single shank multi-electrode …
Figure 2
Spindle-burst oscillations require retinal and thalamic activity.
(A) Blockade of spontaneous retinal waves reduces thalamic firing and spindle-burst oscillations. (A1) Ocular injection of glutamate receptor antagonists APV and CNQX to silence retinal activity …
Figure 3
Corticothalamic feedback amplifies retinal waves in thalamus.
(A) Experimental set-up: silencing VC with local application of APV and CNQX while recording in LGN. (B) Representative spontaneous activity in LGN before (B1) and after VC silencing in a P10 rat (B2…
Figure 4
Increasing reliability and recruitment of inhibition transforms corticothalamic function.
(A) Experimental setup: Optogenetic stimulation of VC neurons expressing Chronos-GFP while simultaneously recording in LGN and VC. AAV-Chronos-GFP was injected into VC at P0-1. (B) Representative …
Figure 5
Corticothalamic feedback required for spindle-burst oscillations but not early-gamma oscillations.
(A) Visually evoked MUA responses were measured in LGN before (A1) and after (A2) VC silencing. Visual stimulus was 100 ms flash. (B) Representative evoked LGN MUA before (B1) and after VC silencing …
