Computational models of O-LM cells are recruited by low or high theta frequency inputs depending on h-channel distributions

  1. Vladislav Sekulić  Is a corresponding author
  2. Frances K Skinner  Is a corresponding author
  1. University Health Network, Canada

Abstract

Although biophysical details of inhibitory neurons are becoming known, it is challenging to map these details onto function. Oriens-lacunosum/moleculare (O-LM) cells are inhibitory cells in the hippocampus that gate information flow, firing while phase-locked to theta rhythms. We build on our existing computational model database of O-LM cells to link model with function. We place our models in high-conductance states and modulate inhibitory inputs at a wide range of frequencies. We find preferred spiking recruitment of models at high (4-9 Hz) or low (2-5 Hz) theta depending on, respectively, the presence or absence of h-channels on their dendrites. This also depends on slow delayed-rectifier potassium channels, and preferred theta ranges shift when h-channels are potentiated by cyclic AMP. Our results suggest that O-LM cells can be differentially recruited by frequency-modulated inputs depending on specific channel types and distributions. This work exposes a strategy for understanding how biophysical characteristics contribute to function.

Article and author information

Author details

  1. Vladislav Sekulić

    Krembil Research Institute, University Health Network, Toronto, Canada
    For correspondence
    vlad.sekulic@gmail.com
    Competing interests
    No competing interests declared.
  2. Frances K Skinner

    Krembil Research Institute, University Health Network, Toronto, Canada
    For correspondence
    frances.skinner@gmail.com
    Competing interests
    Frances K Skinner, Reviewing editor, eLife.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-7819-4202

Funding

Natural Sciences and Engineering Research Council of Canada (Discovery Grant,RGPIN 2016-06182,RGPIN 203700-11)

  • Frances K Skinner

Ontario Graduate Scholarship (Graduate Student Award)

  • Frances K Skinner

SciNet High Performance Consortium (SciNet HPC Consortium)

  • Frances K Skinner

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Copyright

© 2017, Sekulić & Skinner

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Vladislav Sekulić
  2. Frances K Skinner
(2017)
Computational models of O-LM cells are recruited by low or high theta frequency inputs depending on h-channel distributions
eLife 6:e22962.
https://doi.org/10.7554/eLife.22962

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https://doi.org/10.7554/eLife.22962