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Activation of the same mGluR5 receptors in the amygdala causes divergent effects on specific versus indiscriminate fear

  1. Mohammed Mostafizur Rahman
  2. Sonal Kedia
  3. Giselle Fernandes
  4. Sumantra Chattarji  Is a corresponding author
  1. National Centre for Biological Sciences, Tata Institute of Fundamental Research, India
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Cite this article as: eLife 2017;6:e25665 doi: 10.7554/eLife.25665

Abstract

Although mGluR5-antagonists prevent fear and anxiety, little is known about how the same receptor in the amygdala gives rise to both. Combining in vitro and in vivo activation of mGluR5 in rats, we identify specific changes in intrinsic excitability and synaptic plasticity in basolateral amygdala neurons that give rise to temporally distinct and mutually exclusive effects on fear-related behaviors. The immediate impact of mGluR5 activation is to produce anxiety manifested as indiscriminate fear of both tone and context. Surprisingly, this state does not interfere with the proper encoding of tone-shock associations that eventually lead to enhanced cue-specific fear. These results provide a new framework for dissecting the functional impact of amygdalar mGluR-plasticity on fear versus anxiety in health and disease.

Article and author information

Author details

  1. Mohammed Mostafizur Rahman

    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India
    Competing interests
    The authors declare that no competing interests exist.
  2. Sonal Kedia

    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India
    Competing interests
    The authors declare that no competing interests exist.
  3. Giselle Fernandes

    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India
    Competing interests
    The authors declare that no competing interests exist.
  4. Sumantra Chattarji

    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India
    For correspondence
    shona@ncbs.res.in
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-2804-2600

Funding

Department of Atomic Energy, Government of India (NCBS-4143)

  • Sumantra Chattarji

Department of Biotechnology , Ministry of Science and Technology (DBT-BT/MB-CNDS/2013)

  • Sumantra Chattarji

Wadhwani Foundation

  • Sumantra Chattarji

Madan and Usha Sethi Fellowship

  • Sumantra Chattarji

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Animal experimentation: All animal care and experimentation procedures were approved by the Institutional Animal Ethics Committee, National Centre for Biological Sciences (Approval No: SC-5/2009) and Committee for thePurpose of Control and Supervision of Experiments on Animals, Government of India (Registration No: 109/CPCSEA).

Reviewing Editor

  1. Jennifer L Raymond, Stanford School of Medicine, United States

Publication history

  1. Received: February 2, 2017
  2. Accepted: May 26, 2017
  3. Accepted Manuscript published: May 30, 2017 (version 1)
  4. Accepted Manuscript updated: June 6, 2017 (version 2)
  5. Version of Record published: June 12, 2017 (version 3)

Copyright

© 2017, Rahman et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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