1. Developmental Biology
Download icon

Totipotency: A developmental insurance policy

  1. Nestor Saiz
  2. Anna-Katerina Hadjantonakis  Is a corresponding author
  1. Memorial Sloan Kettering Cancer Center, United States
Insight
Cite this article as: eLife 2017;6:e26260 doi: 10.7554/eLife.26260
1 figure

Figures

Cell differentiation in mammalian embryos.

Cells that develop into the trophectoderm (TE) express the transcription factor CDX2 (denoted here as CDX2+) and commit to their cell fate at around the 32-cell stage. Cells that will develop into the inner cell mass (ICM) keep their options open and only commit to their cell fate at a time between the 32- and 64-cell stage; these cells do not express CDX2 (denoted here as CDX2-). As embryos grow from the 32- to the 64-cell stage, ICM cells start to differentiate into two new cell lineages: the embryonic epiblast (future fetus) and the extra-embryonic primitive endoderm (future yolk sac).

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)