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Insight articles are related to original research papers in eLife and explain why the results reported in the paper are significant in a given field of research. Insight articles are commissioned by eLife staff.
Computational and Systems Biology
Machine Learning: Lighting up protein design
Grzegorz Kudla, Marcin Plech
Using a neural network to predict how green fluorescent proteins respond to genetic mutations illuminates properties that could help design new proteins.
Immunology and Inflammation
Autoimmunity: Redoxing PTPN22 activity
Magdalena Shumanska, Ivan Bogeski
The oxidative state of a critical cysteine residue determines the enzymatic activity of a phosphatase involved in T-cell immune responses.
Biochemistry and Chemical Biology
Genetic Code: Expanding codon size
Tarana Siddika et al.
Engineering transfer RNAs to read codons consisting of four bases requires changes in tRNA that go beyond the anticodon sequence.
Genetics and Genomics
Cancer: The aging epigenome
Brandon L Pierce
A new approach helps to assess the impact of accelerated epigenetic aging on the risk of cancer.
Learning: The devil is in the task structure
Orit Nafcha, Uri Hertz
Conflicting evidence about how the brain processes social and individual learning stems from which type of information is presented as the primary source of knowledge during experiments.
Perception: Where functional MRI stops, metabolism starts
Polytimi Frangou, William T Clarke
Combining techniques that track blood oxygenation and biochemicals during neuronal activity reveals how the brain computes perceived and unperceived stimuli.
Structural Biology and Molecular Biophysics
Artificial Intelligence: Exploring the conformational diversity of proteins
Avner Schlessinger, Massimiliano Bonomi
An artificial intelligence-based method can predict distinct conformational states of membrane transporters and receptors.
Chromosomes and Gene Expression
Microbiology and Infectious Disease
Viruses: A frameshift in time
Martina M Yordanova, Pavel V Baranov
The efficiency with which ribosomes shift reading frames when decoding viral RNA may change over the course of an infection.
Sexual Conflict: Evolving new ways to secure a mate
Xiaodan Lin, Dong Ren
Fossils shed light on mating strategies in scorpionflies.
Cytoskeleton: Capturing intermediate filament networks
Pierre A Coulombe
Mapping intermediate filaments in three dimensions reveals that the organization of these filaments differs across cell types.
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