Insights

Insight articles are related to original research papers in eLife and explain why the results reported in the paper are significant in a given field of research. Insight articles are commissioned by eLife staff.

Latest articles

    1. Neuroscience

    Neuronal Signaling: At the crossroads of calcium signaling, protein synthesis and neuropeptide release

    Jakob Rupert, Dragomir Milovanovic
    By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.
    Version of Record
    Insight
    1. Cell Biology
    2. Developmental Biology

    Lens Development: Bringing signaling complexity into focus

    Sarah Y Coomson, Salil A Lachke
    A study in mice reveals key interactions between proteins involved in fibroblast growth factor signaling and how they contribute to distinct stages of eye lens development.
    Version of Record
    Insight
    1. Immunology and Inflammation

    Inflammasomes: A tale of two caspases

    Denise M Monack
    Macrophages control intracellular pathogens like Salmonella by using two caspase enzymes at different times during infection.
    Version of Record
    Insight
    1. Neuroscience

    Memory: Integrating past experiences

    Thomas MW Leir, Matthew PH Gardner
    New results help address a longstanding debate regarding which learning strategies allow animals to anticipate negative events based on past associations between sensory stimuli.
    Version of Record
    Insight
    1. Neuroscience

    Hippocampus: Mapping out overlapping connectivity patterns

    Myrthe Faber, Koen V Haak
    Untangling the functional organisation of a brain region crucial for memory and learning helps reveal how individual differences are linked to variations in recall ability, aging and dopamine receptor distribution.
    Version of Record
    Insight
    1. Cell Biology
    2. Developmental Biology

    Ovarian Biology: Revisiting the rete ovarii

    Yan Zhang, Hua Zhang
    Long thought to have little relevance to ovarian physiology, the rete ovarii may have a role in follicular dynamics and reproductive health.
    Version of Record
    Insight
    1. Microbiology and Infectious Disease

    Viruses: How herpes is assembled

    Dawid S Zyla
    A combination of imaging techniques reveals how herpes simplex virus type 1 assembles within infected cells, highlighting the roles of essential viral proteins in viral assembly and exit.
    Version of Record
    Insight
    1. Neuroscience

    Metabolism: Insulin control in fruit flies

    Omowumi Kayode
    Investigating how the production of insulin is regulated in fruit flies reveals surprising insights that may help to better understand how this process unfolds in humans.
    Version of Record
    Insight
    1. Developmental Biology
    2. Genetics and Genomics

    Vascular Development: Enhancing our understanding of endothelial cells

    Guillermo Luxán
    What determines whether an endothelial cell becomes part of an artery, a vein or a capillary?
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cellular Energy Production: Mycofactocin and the mycobacterial electron transport chain

    Stephanie M Stuteley, Ghader Bashiri
    In the bacterium M. smegmatis, an enzyme called MftG allows the cofactor mycofactocin to transfer electrons released during ethanol metabolism to the electron transport chain.
    Version of Record
    Insight