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Insight articles are related to original research papers in eLife and explain why the results reported in the paper are significant in a given field of research. Insight articles are commissioned by eLife staff.
Neurodegeneration: Fly model sheds light on brain disease
Martin H Berryer et al.
Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPɑ contributes to the progressive brain disease CLN4.
Genetics and Genomics
Genetic Variation: Searching for solutions to the missing heritability problem
Luisa F Pallares
Rare genetic variants in yeast explain a large amount of phenotypic variation in a complex trait like growth.
Microbiology and Infectious Disease
Plant Disease: Cycling in synchrony
Míriam Osés-Ruiz, Nicholas J Talbot
The corn smut fungus uses two different mechanisms to control its cell cycle when it is infecting plants.
Immunology and Inflammation
Autoimmunity: Bringing on the itch
Daniel A Waizman et al.
Neutrophils are the first immune cells that enter the skin and cause itch in atopic dermatitis.
Multicellularity: How contraction has shaped evolution
Two new unicellular organisms reveal that coordinated contractions of groups of cells using actomyosin predated animal multicellularity during evolution.
Behavior: The cerebellum shows its stripes
Ashley L Holloway, Talia N Lerner
New studies examine how the different sub-structures in the cerebellum are organized to receive information during complex behavioral tasks.
Brain Development: The impact of light during the night
Sophia TC Leung et al.
Exposing chicks to one hour of light during the night disrupts the releaseof a hormone that is needed by cells in the developing brain to survive.
Stem Cells and Regenerative Medicine
Regeneration: Lymphatic vessels help mend broken hearts
Catherine Pfefferli, Anna Jaźwińska
Experiments on zebrafish show that the regeneration of the heart after an injury depends on lymphatic vessels.
Biochemistry and Chemical Biology
Enzyme Mechanisms: Wedging open a catalytic site
The activation mechanism of the nitric oxide receptor has been revealed by cryo-electron microscopy.
Prefrontal Cortex: A tale of two pathways
Jonathan A Oler, Julie L Fudge
A combination of invasive and non-invasive techniques has allowed researchers to take a closer look at the two major neural pathways that connect the amygdala and the prefrontal cortex.
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