Insights

Latest articles

1. 1. Cell Biology
   2. Neuroscience

   Vision: A pathway to sight

   Katherine J Wert

   The breakdown of glutamine is an important metabolic pathway for the health and survival of rod photoreceptors within the retina.
2. 1. Neuroscience

   Synaptic Plasticity: A new mode of action for unconventional NMDA receptors

   Ikuko Smith

   Presynaptic NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role.
3. 1. Genetics and Genomics
   2. Neuroscience

   Pain: Epidermal cells and sensory neurons team up

   Jean-Christophe Boivin, Tomoko Ohyama

   Experiments in fruit fly larvae show that epidermal cells can communicate with sensory neurons to drive responses to pain.
4. 1. Chromosomes and Gene Expression

   Gene Regulation: Linking O-GlcNAc and intron retention

   John A Hanover

   An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.
5. 1. Cell Biology
   2. Developmental Biology

   Cell Signaling: Not all dimers are equal

   Jeet H Patel, Mary C Mullins

   Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.
6. 1. Immunology and Inflammation

   Bacterial Clearance: With a little help from T cells

   Troy Burtchett, Neal Hammer

   Specific host factors, such as immune cell activity, sex hormones and microbiota composition, influence the ability of Staphylococcus aureus bacteria to colonize the gut of mice.
7. 1. Neuroscience

   Cognition: When working memory works for our goals

   Jacob A Miller

   When navigating environments with changing rules, human brain circuits flexibly adapt how and where we retain information to help us achieve our immediate goals.
8. 1. Cancer Biology
   2. Cell Biology

   Breast Cancer: How cell crowding causes cancer cells to spread

   Rui Hua, Jean X Jiang

   Cell crowding causes high-grade breast cancer cells to become more invasive by activating a molecular switch that causes the cells to shrink and spread.
9. 1. Neuroscience

   Pain: Revisiting the role of Substance P and CGRPα

   Weihua Cai, Arkady Khoutorsky

   Mice lacking two neuropeptides thought to be essential for processing pain show no change in how they respond to a wide range of harmful stimuli.
10. 1. Genetics and Genomics
    2. Neuroscience

    Neuronal Signaling: Cell-specific tools for understanding behavior

    Brandon L Holder, Stephane Dissel

    Novel tools that allow neuron-specific investigations of the structure controlling sleep regulation in fruit flies reveal the extent of neuronal heterogeneity.