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Insight articles are related to original research papers in eLife and explain why the results reported in the paper are significant in a given field of research. Insight articles are commissioned by eLife staff.
Structural Biology and Molecular Biophysics
Intraflagellar Transport: Moving proteins along in the cilium
Narcis Adrian Petriman, Esben Lorentzen
The structures of the bovine and human BBSome reveal that a conformational change is required to recruit the complex to the ciliary membrane.
Physics of Living Systems
Speech Biomechanics: Shaping new sounds
Timothy D Griffiths et al.
MRI experiments have revealed how throat singers from Tuva produce their characteristic sound.
Microscopy: Looking below the surface in plants
Rui Wang, Anna A Dobritsa
A new way to culture and image flowers is uncovering the processes that take place in reproductive cells buried deep in plants.
Epidemiology and Global Health
Mortality: The challenges of estimating biological age
A comparison of nine different approaches over a period of 20 years reveals the most promising indicators for biological age.
Physical Inference: How the brain represents mass
Grant Fairchild, Jacqueline C Snow
New fMRI experiments and machine learning are helping to identify how the mass of objects is processed in the brain.
Plant Reproduction: Shaping the genome of plants
Ajeet Chaudhary et al.
Fertilization of an egg cell by more than one sperm cell can produce viable progeny in a flowering plant.
Heart Development and Regeneration: Metabolism makes and mends the heart
Megan L Martik
Experiments in zebrafish have shed new light on the relationship between development and regeneration in the heart.
Chromosomes and Gene Expression
Genetics and Genomics
Epigenetics: A memory of longevity
Felicity Emerson et al.
Worms with increased levels of the epigenetic mark H3K9me2 have a longer lifespan that can be passed down to future generations.
Microbiology and Infectious Disease
Two-component Signaling Pathways: A bacterial Goldilocks mechanism
Irene M Kim, Hendrik Szurmant
can measure the activity of the enzymes that remodel the cell wall to ensure that the levels of activity are ‘just right’.
Cortical Development: Do progenitors play dice?
Esther Klingler, Denis Jabaudon
The wide range of cell types produced by single progenitors in the neocortex of mice may result from stochastic rather than deterministic processes.
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