Insights

Insight articles are related to original research papers in eLife and explain why the results reported in the paper are significant in a given field of research. Insight articles are commissioned by eLife staff.

Latest articles

    1. Neuroscience

    Vision: Framing orientation selectivity

    Floris P de Lange, Matthias Ekman
    The ongoing debate on the neural basis of orientation selectivity in the primary visual cortex continues.
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    1. Cancer Biology
    2. Immunology and Inflammation

    Contagious Cancers: A ‘devil’ of a problem

    Victoria L Hansen, Robert D Miller
    The discovery of a second facial tumor disease in the Tasmanian devil has provided insights into the emergence of contagious cancers.
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    1. Computational and Systems Biology

    Protein Overexpression: Reaching the limit

    Benedetta Bolognesi, Ben Lehner
    How many copies of a protein can be made before it becomes toxic to the cell?
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    1. Structural Biology and Molecular Biophysics

    Ion Channels: Exploiting natural regulation

    Catherine Proenza
    Using a short peptide to regulate the activity of HCN ion channels illustrates how physiological modulators could inspire new drugs. .
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    1. Developmental Biology
    2. Evolutionary Biology

    Patterning: Fishing for ancestry

    Hannah Brunsdon, E Elizabeth Patton
    The same genes and signalling pathways control the formation of skin appendages in both fish and land animals.
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    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Viruses: The secrets of the stability of the HIV-1 capsid

    Martin Obr, Hans-Georg Kräusslich
    Structural and biophysical studies help to follow the disassembly of the HIV-1 capsid in vitro, and reveal the role of a small molecule called IP6 in regulating capsid stability.
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    1. Neuroscience

    Sound localization: These are not the neurons you are looking for

    Victor Benichoux, Daniel J Tollin
    Studies that looked into how the auditory brainstem processes the difference in the intensity of a sound as it reaches each ear may have wrongly assumed which neurons were being recorded.
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    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Mechanobiology: A brighter force gauge for cells

    Victor Pui-Yan Ma, Khalid Salaita
    An improved biosensor sheds new light on tension within proteins.
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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Phenotypic Diversity: Setting the bar

    Charles Y Feigin, Ricardo Mallarino
    Analyzing the genomes of rock pigeons demonstrates that genetic variation comes in many forms and can have unexpected origins.
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    1. Cancer Biology

    Pancreatic Cell Fate: To be or not to be

    Zhe Zhang, Elisabeth Hessmann
    Chromatin remodeling processes can drive acinar cell fate decisions.
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