Insights

Insight articles are related to original research papers in eLife and explain why the results reported in the paper are significant in a given field of research. Insight articles are commissioned by eLife staff.

Latest articles

    1. Developmental Biology

    Blastomeres: Tracing cell fates in embryos

    Ying Zhang, Qi Chen
    Differences in the activity of an enzyme called CARM1 influence the timing of blastomere polarization and whether they become part of the embryo or the placenta.
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    Insight
    1. Cancer Biology

    Transcription Factor-Dependent Cancers: Targeting chromatin remodeling complexes to treat uveal melanoma

    Jonas A Nilsson
    A novel compound that inhibits the BAF chromatin remodeling complex causes regression in an animal model of the incurable cancer uveal melanoma.
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    Insight
    1. Structural Biology and Molecular Biophysics

    Enzyme Dynamics: Capturing enzymes in motion

    Álvaro de la Gándara, Agnieszka A Kendrick
    A combination of cryogenic electron microscopy and molecular simulations has been used to study the structure and dynamics of an enzyme called ACE.
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    Insight
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Wnt Signaling: Exploring the origins of a signaling pathway

    Balaji Santhanam
    The 19 Wnt proteins found in humans are part of a larger superfamily of proteins that are also found in Archaea and Bacteria.
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    Insight
    1. Developmental Biology

    Morphogenesis: Regulating closure of the neural tube in humans

    Leon Qarawani, Jacob H Hanna
    An organoid-based screening platform that allows one-gene-at-a-time knockdown across a whole tissue has been used to identify the genes that regulate closure of the neural tube in humans.
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    Insight
    1. Neuroscience

    Numerical Cognition: Is ‘number sense’ a sense?

    Toshiya Matsushima
    Experiments on domestic chicks shed light on the links between brain lateralization and the left-to-right mental number line.
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    Insight
    1. Neuroscience

    Dorsal Vagal Complex: A cell atlas to guide research into appetite control

    Greta Lommi, Thomas A Lutz
    An atlas of all the cell types in the dorsal vagal complex of rodents will help neuroscientists seeking to understand appetite and researchers working to design better drugs for the treatment of obesity and related disorders.
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    Insight
    1. Neuroscience

    Connectomes: The wiring diagram of an entire animal

    Alex M Winsor, Paul S Katz
    A digital atlas of every cell in a developing marine worm reveals how networks across the body coordinate sensing and movement, and provides insights into the evolution of the nervous system.
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    Insight
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Homologous Recombination: Snapshot of an intermediate structure

    Akira Shinohara
    Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination.
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    Insight
    1. Evolutionary Biology

    Microfossils: Mimicking early life-forms in the lab

    Maarten Lubbers, Dennis Claessen
    Studying the growth of bacteria without cell walls in an artificial environment can shed new light on the proliferation of primitive life-forms billions of years ago.
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    Insight