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The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life

  1. Sean Froudist-Walsh
  2. Michael AP Bloomfield
  3. Mattia Veronese
  4. Jasmin Kroll
  5. Vyacheslav R Karolis
  6. Sameer Jauhar
  7. Ilaria Bonoldi
  8. Philip K McGuire
  9. Shitij Kapur
  10. Robin M Murray
  11. Chiara Nosarti  Is a corresponding author
  12. Oliver Howes  Is a corresponding author
  1. King's College London, United Kingdom
  2. MRC Clinical Sciences Centre, Hammersmith Hospital, United Kingdom
  3. Imperial College London, Hammersmith Hospital, United Kingdom
  4. Icahn School of Medicine, United States
  5. University College London, United Kingdom
Research Article
Cite this article as: eLife 2017;6:e29088 doi: 10.7554/eLife.29088
2 figures, 3 tables and 1 additional file

Figures

Whole striatal dopamine synthesis capacity by group.

Individuals who suffered macroscopic perinatal brain injury related to VPT birth had significantly lower dopamine synthesis capacity in the whole striatum compared to other adults born VPT with no macroscopic perinatal brain injury (corrected p=0.023, Cohen’s d = 1.36) and full term-born controls (corrected p=0.01, Cohen’s d = 1.07).

https://doi.org/10.7554/eLife.29088.004
Figure 1—source data 1

fig1_source_data.csv – Can be used with create_fig1.m to recreate Figure 1.

https://doi.org/10.7554/eLife.29088.005
Relationship between hippocampal volume and dopamine synthesis capacity in the (A) caudate and (B) nucleus accumbens.
https://doi.org/10.7554/eLife.29088.008
Figure 2—source data 1

fig2_source_data.csv - csv – Can be used with create_fig2.m to recreate Figure 2.

https://doi.org/10.7554/eLife.29088.009

Tables

Table 1
Neonatal, socio-demographic, cognitive and scanning measures.
https://doi.org/10.7554/eLife.29088.003
Very preterm-perinatal
brain injury
Very preterm-no
diagnosed injury
ControlsTest statisticSignificance
(n = 16)(n = 13)(n = 14)
Gestational age in weeks Mean (SD)28.44 (2.28)30.46 (1.76)U27 = 47.00p=0.011
Birth weight in grams Mean (SD)1203.19 (304.95)1557.15 (364.98)U27 = 46.50p=0.012
Age in years Mean (SD)30.21 (1.78)30.85 (2.09)29.81 (3.24)F2,40 = 1.50p=0.236
Sex (female:male)03:1304:0905:09X 22 = 1.14p=0.564
High SES (%)*68.7569.2361.53X 22 =0.22p=0.894
IQ Mean (SD)106.67 (14.52)107.73 (10.07)110.40 (10.52)F2,33 = 0.28p=0.755
Alcohol consumption (Units/week)7.40 (11.30)12.50 (11.99)5.50 (4.72)X 22 =3.172p=0.205
Injected dose (MBq)
Mean (SD)
146.44 (2.15)146.25 (2.52)145.73 (2.38)F2,40 = 0.23p=0.793
  1. *SES was collapsed into two groups; the percent of participants belonging to the high SES (level 1–2) category is presented in the table.

Table 2
Striatal subregion dopamine synthesis capacity†.
https://doi.org/10.7554/eLife.29088.006
Striatal subregionAnova, group differencesVery preterm-perinatal brain injury vs controlsVery preterm-perinatal brain injury vs Very preterm-no diagnosed injuryVery preterm-no diagnosed injury vs controls
Whole StriatumF = 6.07
p=0.010
partial eta-squared = 0.233
t = −3.12
p=0.010
t = −2.81
p=0.023
t = −0.24
p=1;
CaudateF = 7.75
p=0.004
partial eta-squared = 0.279
t = −3.84
p=0.001
t = −2.52
p=0.047
t = −1.20
p=0.707
PutamenF = 2.98
p=0.062
Nucleus Accumbens

F = 5.26
p=0.012
partial eta-squared = 0.208
t = −2.41
p=0.045
t = −2.95
p=0.016
t = 0.45
p=1
  1. Statistically significant group differences are shown in bold. Displayed p-values are corrected for multiple comparisons (see methods).

Table 3
Subcortical volumes (mm3) *.
https://doi.org/10.7554/eLife.29088.007
Very preterm-perinatal brain injury
mean (sd)
Very preterm-no diagnosed injury
mean (sd)
Control
mean (sd)
AnovaVery preterm-perinatal brain injury vs ControlVery preterm-perinatal brain injury vs very preterm-no diagnosed injuryVery preterm-no diagnosed injury vs Control
Hippocampus8624 (1329)9557 (1113)10090
(1329)
F = 4.928
P=0.013
t = -3.10 p = 0.011t = -1.97 p = 0.168t = -1.13 p = 0.802
Striatum (whole)19098 (3217)19767 (2495)21487
(2322)
F = 2.70
P = 0.081
t = -2.17 p = 0.092t = -0.59 p = 1t = -1.82 p = 0.341
Caudate7491 (1516)7609 (998)8250
(910)
F =1.581
P =0.22
t = -1.55 p = 0.322t = -0.23 p = 1t = -1.71 p = 0.514
Putamen10541 (1682)10973 (1480)11977
(1655)
F =2.824
P =0.11
t = -2.25 p = 0.079t = -0.70 p = 1t = -1.68 p = 0.343
Nucleus Accumbens1066 (210)1185 (167)1260 (227)F =3.023
P =0.11
t = -2.26 p = 0.06t = -1.60 p = 0.43t = -0.96 p = 1
  1. *Statistically significant group differences are shown in bold. p-values for ANOVA tests of the striatal subregions adjusted using FDR method for positively correlated samples. p-values for the post-hoc t-tests are corrected for multiple comparisons using the Bonferroni method.

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