Removal of inhibition uncovers latent movement potential during preparation
- University of Pittsburgh, United States
Figures
Figure 1
Conceptual schematic of saccade and pre-saccade motor potential revealed by disinhibition.
(a) Under normal conditions, premotor activity accumulates at different rates on different trials (three example traces in top row) to a movement initiation criterion, opening downstream gating …
Figure 2
Determining goal-directed saccade onset in blink-triggered eye movements.
(a) Left column: horizontal (top row) and vertical (bottom row) eye velocity profiles during blink-related eye movements obtained during fixation (BREMs, thin gray traces) and three example …
Figure 3
Time course and accuracy of blink-triggered saccades.
(a) Saccade reaction time as a function of blink onset time across all trials (n = 7891 control trials, 1615 blink trials) and sessions (n = 43). Red filled circles are individual blink trials, and …
Figure 4 with 1 supplement
Motor potential during control saccades.
(a) Estimating motor potential as correlation between neural activity and saccade kinematics. Horizontal and vertical velocity traces (top two rows) on control trials are converted to radial …
Figure 4—figure supplement 1
Motor potential during control saccades, computed with raw velocities.
(a) As in Figure 4a, horizontal and vertical velocity traces (top two rows) on control trials are converted to radial velocity (third row). In contrast to Figure 4a, the velocities are used as is to …
Figure 5 with 2 supplements
Motor potential on blink trials.
(a) Computation of the kinematic variable for blink-triggered movements. Horizontal and vertical velocities (thick black traces in top two rows) are converted to residual velocities (gray fill) …
Figure 5—figure supplement 1
Motor potential on blink trials, computed with raw velocities.
(a) As in Figure 5a, horizontal and vertical velocity traces (top two rows) during blink-triggered movements are converted to radial velocity (third row). In contrast to Figure 5a, the residual …
Figure 5—figure supplement 2
‘Main sequence’ velocity-amplitude relationship.
(a) Peak velocity of the saccadic component of blink-triggered movement as a function of movement amplitude. Each point represents one trial. Points are colored by individual subjects, but since the …
Figure 6
Analysis of putative threshold.
(a) Average normalized population activity (thick traces) aligned on saccade onset for control (blue trace) and blink (red trace) trials. The thin lines represent s.e.m. The colored swatches at the …
Figure 7
Analysis of accumulation rate change following perturbation.
(a) Schematic illustrating the computation of accumulation rates before and after the blink. The snippet shows the average population activity (dashed lines) s.e.m (thin lines) centered on blink …
Author response image 1
Movement initiation models in the population dynamics framework.
In all cases, population activity is represented as an evolving trajectory in multi-dimensional space – only the activity of 3 neurons/3 latent dimensions are displayed. (a) The optimal/potent …
Author response image 2
Self-correlation of velocity profiles.
Left – Across-trial correlated variability of instantaneous velocity on control trials. These correlations are computed similarly to the activity-velocity correlations in Figures 4C and 5C, except …
Additional files
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Transparent reporting form
- https://doi.org/10.7554/eLife.29648.013
