Alterations of in vivo CA1 network activity in Dp(16)1Yey Down syndrome model mice

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Cite this article as: eLife 2018;7:e31543 doi: 10.7554/eLife.31543

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Abstract

Down syndrome, the leading genetic cause of intellectual disability, results from an extra-copy of chromosome 21. Mice engineered to model this aneuploidy exhibit Down syndrome-like memory deficits in spatial and contextual tasks. While abnormal neuronal function has been identified in these models, most studies have relied on in vitro measures. Here, using in vivo recording in the Dp(16)1Yey model, we find alterations in the organization of spiking of hippocampal CA1 pyramidal neurons, including deficits in the generation of complex spikes. These changes lead to poorer spatial coding during exploration and less coordinated activity during sharp-wave ripples, events involved in memory consolidation. Further, the density of CA1 inhibitory neurons expressing neuropeptide Y, a population key for the generation of pyramidal cell bursts, were significantly increased in Dp(16)1Yey mice. Our data refine the 'over-suppression' theory of Down syndrome pathophysiology and suggest specific neuronal subtypes involved in hippocampal dysfunction in these model mice.

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Matthieu Raveau

Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako-shi, Japan

Competing interests
The authors declare that no competing interests exist.
Denis Polygalov

Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wako-shi, Japan

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0002-8165-5257
Roman Boehringer

Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wako-shi, Japan

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0003-2856-3262
Kenji Amano

Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako-shi, Japan

Competing interests
The authors declare that no competing interests exist.
Kazuhiro Yamakawa

Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako-shi, Japan

For correspondence
yamakawa@brain.riken.jp

Competing interests
The authors declare that no competing interests exist.
Thomas J McHugh

Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wako-shi, Japan

For correspondence
tjmchugh@brain.riken.jp

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0002-1243-5189

Funding

RIKEN Brain Science Institute

Kazuhiro Yamakawa
Thomas J McHugh

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Animal experimentation: All handling and experiments were conducted in accordance with the protocols approved by the RIKEN Animal Care and Use Committee (#H29-2-218(2) , # H29-2-224(3)).

Reviewing Editor

Eunjoon Kim, Institute for Basic Science, Korea Advanced Institute of Science and Technology, Korea (South), Republic of

Publication history

Received: August 25, 2017
Accepted: February 25, 2018
Accepted Manuscript published: February 27, 2018 (version 1)
Version of Record published: March 7, 2018 (version 2)

Copyright

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.