Science Forum: Challenges in validating candidate therapeutic targets in cancer
Tables
Table 1
Articles suggesting a link between MELK and human cancers.
The 33 articles listed in column 1 of this table suggest that MELK has a role in a variety of human cancers, which makes in a candidate therapeutic target for cancer drugs. Columns 2–5 indicate which articles reported certain kinds of evidence to make the link between MELK and cancer, column 6 indicates the studies that used a MELK inhibitor called OTS167 (which is currently undergoing clinical trials). However, three recent papers (Lin et al., 2017; Huang et al., 2017; Giuliano et al., 2018) suggest that MELK should not be considered as a candidate therapeutic target.
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Science Forum: Challenges in validating candidate therapeutic targets in cancer
eLife 7:e32402.
https://doi.org/10.7554/eLife.32402