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Proprioceptive and cutaneous sensations in humans elicited by intracortical microstimulation

  1. Michelle Armenta Salas
  2. Luke Bashford
  3. Spencer Kellis
  4. Matiar Jafari
  5. HyeongChan Jo
  6. Daniel Kramer
  7. Kathleen Shanfield
  8. Kelsie Pejsa
  9. Brian Lee
  10. Charles Y Liu
  11. Richard A Andersen  Is a corresponding author
  1. California Institute of Technology, United States
  2. Keck School of Medicine of USC, United States
  3. UCLA-Caltech Medical Scientist Training Program, United States
  4. Rancho Los Amigos National Rehabilitation Center, United States
Short Report
Cite this article as: eLife 2018;7:e32904 doi: 10.7554/eLife.32904
3 figures, 1 table and 2 additional files

Figures

Array implant locations on rendered MRI image of the left hemisphere of FG.

96-channel microelectrode arrays were implanted into ventral premotor cortex (PMv) and supramarginal gyrus (SMG), and two 48-channel stimulating arrays were implanted into primary somatosensory cortex (S1). The insert shows the in situ array locations.

https://doi.org/10.7554/eLife.32904.003
Receptive fields and sensation modality across all amplitude mapping experiments.

(A) Receptive field location on anterior (lighter shades) and posterior (darker shades) planes of the right upper arm (green), forearm (pink), and hand (cyan). Grid is the same that the subject referenced during the experiment. (B) Schematic of the two electrode arrays implanted over S1 (Figure 1). Left side panels display the reported receptive fields at each electrode location, and right side panels display the sensation modality (cutaneous - red, proprioceptive - blue). Light gray boxes show electrodes with no reported sensation, while dark gray boxes represent reference channels which are not used in recording. The five electrodes with a thick black outline represent the subset tested in the additional parameter-wide mapping task. Yellow and magenta asterisks mark the inferior-posterior corner of the implants, for the medial and lateral arrays respectively.

https://doi.org/10.7554/eLife.32904.004
Proprioceptive and cutaneous responses.

(A) Kernel density estimate and box plot showing the difference in the distribution of amplitudes associated with each report of proprioceptive (blue) or cutaneous (red) responses. (B) The median percentage of responses in the bootstrapped sample (solid line) for proprioceptive and cutaneous responses at each amplitude tested. Dashed line shows 1st-order polynomial fit. (C) Kernel density estimates of the distribution of slopes from 1st-order polynomial fits in each bootstrap iteration. (D) Pie charts show the percentage of total stimulations of responses for the subset of electrodes tested over a range of both current amplitudes and pulse frequencies. The left panel shows an individual example electrode (six trials per combination of amplitude and frequency) and the right panel shows data pooled over all five electrodes (30 total stimulations per combination). The percentage of no response (white), proprioceptive (blue) or cutaneous (red) are shown. (E) A normalized histogram of proprioceptive (blue) and cutaneous (red) responses at each of the amplitudes tested in experiment 2.

https://doi.org/10.7554/eLife.32904.006

Tables

Table 1
Descriptions of the most prevalent sensations by percentage of total responses.

Entries cover 90% of 381 reported sensations, with the final 10% comprising a mixture of other naturalistic cutaneous and proprioceptive descriptors. Each sensation is accompanied by the mode and 25th-75th percentiles in the distribution of amplitudes that elicited each sensation, and by the same quantities for the perceived reported intensities (on a scale of 1 [weak] to 10 [strong]).

https://doi.org/10.7554/eLife.32904.005
Description% Total Sensations (381 total)Amplitude μA
(mode)
Amplitude μA
(25th, 75th percentile)
Intensity
(mode)
Intensity
(25th, 75th percentile)
Squeeze24.94040, 87.574, 7
Tap17.37040, 8011, 4
Right movement9.79055, 9011, 3
Vibration8.14040, 9022, 3
Blowing6.66030, 8011, 2
Forward Movement5.87040, 8011, 4
Pinch5.54040, 9033, 6
Press5.04040, 7074, 7
Upward Movement3.97070, 8511.25, 4
Goosebumps3.110060, 9052, 5

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