(Ai) The expression of 256 orthologous KRAB-ZNF genes curated by Kapopoulou et al. Genes that are identified as being significantly differentially expressed at an FDR < 1% are represented in red (131/256 genes = 51%). (Aii) The expression of all orthologous genes (8,420/17,354 genes differentially expressed = 49%). (B) KRAB-ZNF gene expression divergence stratified by H3K9me3 enrichment at the TSS. Genes with higher expression in chimpanzee and significantly lower H3K9me3 in chimpanzee compared to human (blue box): ZNF582, ZNF471, ZNF585A, ZNF667, ZNF583. Genes with higher expression in human and significantly lower H3K9me3 in human compared to chimpanzee (brown box): ZFP82, ZNF662, ZNF429, ZNF100, ZNF43.