(A) Class I GR binding sites (GBSs) reside within relatively closed regions of chromatin and have little dex-dependent chromatin remodeling or recruitment of BRG1 and pioneer factors. Despite this, greater than a quarter of Class I GBSs exhibit dex-dependent transcription. (B) Class II GBSs represent GR binding to active and occupied regions of chromatin. These GBSs are bound by BRG1 prior to hormone treatment, and also exhibit hormone independent H3K27 acetylation, chromatin accessibility, pioneer factor binding, and transcriptional activity. (C) Class III GBSs behave the most like the model described at the MMTV promoter. Upon hormone treatment, GR binds to regions of relatively inaccessible chromatin that may be pre-occupied by low levels of pioneer factors. Upon GR binding, BRG1 and additional pioneer factors are recruited, chromatin remodeling yields increased accessibility, and more than a third of these GBSs gain transcriptional activity.