Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior
The fruit fly can evaluate its energy state and decide whether to pursue food-related cues. Here, we reveal that the mushroom body (MB) integrates hunger and satiety signals to control food-seeking behavior. We have discovered five pathways in the MB essential for hungry flies to locate and approach food. Blocking the MB-intrinsic Kenyon cells (KCs) and the MB output neurons (MBONs) in these pathways impairs food-seeking behavior. Starvation bi-directionally modulates MBON responses to a food odor, suggesting that hunger and satiety controls occur at the KC-to-MBON synapses. These controls are mediated by six types of dopaminergic neurons (DANs). By manipulating these DANs, we could inhibit food-seeking behavior in hungry flies or promote food seeking in fed flies. Finally, we show that the DANs potentially receive multiple inputs of hunger and satiety signals. This work demonstrates an information-rich central circuit in the fly brain that controls hunger-driven food-seeking behavior.
Article and author information
Ministry of Science and Technology, Taiwan (105-2628-B-001-005-MY3)
- Suewei Lin
- Suewei Lin
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
- Kristin Scott, University of California, Berkeley, Berkeley, United States
- Received: January 22, 2018
- Accepted: March 15, 2018
- Accepted Manuscript published: March 16, 2018 (version 1)
- Version of Record published: April 20, 2018 (version 2)
© 2018, Tsao et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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