The top row shows where there are ‘valid’ edge connections in either of the two groups. Colours, with a key at the top of the figure, indicate regions of brain areas that the connections originate from. The numbers on the plots show the number of valid edges found. Note that Low Gamma is not shown as no ‘valid’ edges were found. The second row shows the unpaired t-statistic for APOE-ɛ4 carriers compared to non-carriers. Increases are displayed in red and decreases in blue and only those connections significant at p<0.05 (uncorrected) are shown. The numbers on each plot (n+/n-) show the number of significant increases and decreases found in each map. Note that, across all tests, only one edge connection, in the Theta band, was found to be significantly different when corrected for multiple comparisons (p<0.036, right parietal). Using the cluster-level network-based size statistic, shown in the third row, significantly large clusters were found for the theta and Combined maps. The bottom, fourth row, shows the results of the cohort random sampling analysis. Edges are only shown if they are within the 95% confidence limit for APOE-ɛ4 -related increases (red) or decreases (blue). Note that, in general, the predominant effect is for edges to show increases in connectivity in APOE-ɛ4 carriers, compared to non-carriers and that this is most clearly shown in the Combined map (right-hand column), in which the most valid connections are identified and the most significant, and consistent, differences are seen. In all connection plots, line opacity indicates relative connection strength within the plot (most opaque = strongest). Data and scripts needed to generate this figure can be found at http://dx.doi.org/10.17605/OSF.IO/E4CJX.