Dorsolateral striatum (including dorsal caudate putamen) | Interneuron | tonically active, 2–10 Hz baseline firing rate | Local - striatal spiny projection neurons and fast spiking interneurons | Thalamus, sensorimotor cortex, striatal spiny projection neurons, striatal interneurons | E12-E15 | MGE | ~E16 |
Dorsomedial striatum (including ventral caudate putamen) | Interneuron | tonically active, 2–10 Hz baseline firing rate | Local - striatal spiny projection neurons and fast spiking interneurons | Thalamus, association cortices, striatal spiny projection neurons, striatal interneurons | E12-E15 | MGE | ~E16 |
Nucleus accumbens | Interneuron | tonically active, 0.6–12 Hz baseline firing rate | Local - striatal spiny projection neurons and fast spiking interneurons | Thalamus, frontal cortex, striatal spiny projection neurons, striatal interneurons | E12-E15 | MGE | ~E16 |
Basal forebrain | Projection neuron | Tonic/burst, subtype dependent | Cortex (Nucleus Basalis Complex), Hippocampus (Septal) | Medulla, locus ceruleus, substantia nigra, ventral tegmental area, hypothalamic nuclei, nucleus accumbens, amygdala, local intrinsic GABAergic and glutamatergic collaterals | E11-E15 | POA/MGE | ~E15-16 |
Cholinergic Brainstem | Projection neuron | episodic | Midbrain, superior colliculus, thalamus, globus pallidus, hypothalamus, septum, striatum, cortex | Brainstem reticular formation, midbrain central gray, lateral hypothalamus-zona incerta, cortex, amygdala, basal forebrain, basal ganglia output nuclei, brainstem and spinal cord sensory nuclei | E12-E13 | Ventral rhombomere 1 (r1) | |
Primary Motor Neurons | Projection neuron | subtype dependent | Muscle | Motor Cortex, local spinal cord interneurons and sensory neurons | E11-E12 | Ventral spinal cord progenitor domains | E13 |