Rat behavior and dopamine release are modulated by conspecific distress
- University of Maryland, United States
- Boys Town National Research Hospital, United States
- University of Maryland School of Medicine, United States
Figures
Figure 1
Pavlovian Social Distress Paradigm.
(A) Rats were placed side by side, separated by a divider, during ‘together’ trial blocks. The conspecific was removed during ‘alone’ trial blocks. (B–D) Trial types. All trials started with …
Figure 2
Beam breaks in food cup.
An infrared beam was placed above the recording rat’s food cup. (A) and (B) illustrate percent bream breaks over trial time during ‘self’ and ‘other’ trials, respectively (n = 40 sessions; 8 rats). …
Figure 3
Freezing and Approach.
(A–D) Percent freezing over 12 trial types for ‘self’ (A,B; solid) and ‘other’ (C,D; open) trials during the 5 s directional cue epoch (A,C) and the 5 s outcome epoch (B,D) when rats were ‘alone’ …
Figure 4 with 3 supplements
Dopamine release when the outcome was delivered to the recording rat (i.e., self).
(A) Average DA release over trial time (n = 40 sessions, 8 rats). See Figure 4—figure supplements 1 and 2 for example sessions. Shock trials (red) are truncated due to shock artifact. (B–D) During …
Figure 4—figure supplement 1
Example false-color plots for reward-self, reward-other, and shock-other trial-types.
In the main text we show average DA release over all rats and sessions on ‘other’ trials during performance of the Pavlovian social distress paradigm to make the point that DA release was reduced …
Figure 4—figure supplement 2
Example false-color plots for shock-self and shock-other trial-types when together and alone.
In the main text we show average DA release over all rats and sessions during performance of the Pavlovian social distress paradigm on shock-self trials to make the point that DA release was not …
Figure 4—figure supplement 3
Regressions between alone and together for beam breaks and DA release during shock-self trials.
In the main text we show that DA release is less inhibited on self-shock trials when rats are together during the Pavlovian conspecific distress paradigm. We interpret this result as a consolation …
Figure 5 with 1 supplement
Dopamine release when the outcome was delivered to the conspecific (i.e., other).
(A) Average DA release over trial time (n = 40 sessions, 8 rats). See Figure 4—figure supplements 1 and 2 for example sessions. (B–D) During the directional cue epoch of each session indices were …
Figure 5—figure supplement 1
Regressions between alone and together for beam breaks and DA release during shock-other trials.
In the main text we show that DA release increased at the time of conspecific shock during the Pavlovian conspecific distress paradigm. As in Figure 5—figure supplement 1 we explored correlations …
Figure 6
Instrumental Social Distress Task.
(A–D). Rats performed a task during which three independent auditory stimuli predicted three different trial-types. All lever presses led to one sucrose pellet delivery. One stimulus signaled that a …
Figure 7 with 2 supplements
DA release during performance of the Instrumental Social Distress Task.
(A) Average DA release (n = 24 sessions, 9 rats) over time for no-shock press trials (blue), shock-self no press trials (red), shock-other no press trials (orange), and no-shock non-press trials …
Figure 7—figure supplement 1
Example false-color plots for no-shock press, shock-self no press, and shock-other no press trial-types.
In the main text we show average DA release over all rats and sessions during performance of the instrumental social distress task to show high DA release during no-shock press trials and shock-self …
Figure 7—figure supplement 2
Regressions between ‘self’ and ‘other’ for behavior and DA release.
In the main text we show that during performance of the Instrumental conspecific distress paradigm that on shock-self and shock-other trials where shock was avoided (i.e., non-press trials) that DA …
Additional files
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Transparent reporting form
- https://doi.org/10.7554/eLife.38090.015
