Top panel: The same three macaque monkeys (MK1, MK2, MK3) participated in experiments 1 and 2, and a control experiment conducted in the absence of TUS. Three other monkeys (MK4, MK5, MK6) … see more
(a) Stimulation target positions in SMA are shown for each of the three individual animals in three different colours on sagittal and coronal views. (b) Estimates of the focused ultrasound peak … see more
The left panels show activity coupling between SMA and the rest of the brain in the control state (a), after SMA TUS (b), and after FPC TUS (c). The right panels show activity coupling between FPC … see more
Panels on the left show activity coupling between SMA and the rest of the brain in the control state (a), after FPC TUS in experiment 2 (b), and after FPC TUS in experiment 3 (in three new animals) … see more
The left panels show activity coupling between SMA and the rest of the brain in the control state (a), the differential effect of SMA TUS for areas positively coupled (z > 0.1) with SMA in the … see more
Fingerprint target regions were drawn from the literature and chosen based on their known and distinct connectivity, either strong or weak, with the seed region. Activity coupling in the control … see more
Whole-brain pattern of the standard deviation of the BOLD signal over time in the control state (top), after SMA TUS (middle), and after FPC TUS (bottom). The temporal standard deviation of the … see more
In fully processed fMRI data, unconfounded by global nuisance sources, effects of TUS were not immediately apparent outside the stimulated areas. (a,d) For example, the whole-brain connectivity … see more
(a) Whole-brain connectivity pattern of area POp, a region removed from the stimulation sites, in the control state without TUS. (d) This region’s connectivity is unaffected by TUS over FPC, … see more
Examination of T1-weighted structural MRI images did not reveal any evidence for oedema after TUS. For two monkeys (top and bottom row, respectively), T1w images were acquired immediately following … see more
(a) Dorsal view of perfused macaque brain. A post-mortem examination of the brain did not reveal macroscopic damage to the brain. (b) Histological assessment of 50-micron thick sections obtained at … see more