Atypical intrinsic neural timescale in autism
- University College London, United Kingdom
- RIKEN Centre for Brain Science, Japan
- University of Bristol, United Kingdom
Figures
Figure 1 with 2 supplements
Definition and validation of intrinsic timescales based on resting-state fMRI data.
(a) To estimate an intrinsic neural timescale of an fMRI signal, we first calculated the sum of autocorrelation function (ACF) values of the signals in the initial positive period of the ACF. The …
Figure 1—figure supplement 1
Power spectrum of the preprocessed EEG data.
To examine the magnitude of fMRI-induced gradient noise, we estimated power spectra of the independent components of the preprocessed EEG data. (a) Power spectra of the preprocessed EEG data …
Figure 1—figure supplement 2
Comparisons between fMRI-based and EEG-based intrinsic timescales.
As shown in Figure 1c, the fMRI-based intrinsic timescale was strongly correlated with those based on the gamma band of EEG signals. We also examined such correlations for different EEG bands, and …
Figure 2
Voxel-wise comparison of the intrinsic neural timescale.
(a) In both ASD and TD groups, we found longer intrinsic timescales in frontoparietal areas and shorter timescales in sensory-related areas. The colour bar indicates the intrinsic neural timescales …
Figure 3 with 1 supplement
Associations between the intrinsic neural timescale and ASD symptoms.
(a) We found negative associations between the intrinsic timescale and the overall severity of ASD in the bilateral postcentral gyri and right IOG but not in the bilateral middle temporal gyri …
Figure 3—figure supplement 1
Brain-symptom associations in independent datasets.
To assure statistical independence between the ROI definition and the brain-symptom association analysis, we analysed two independent datasets that were not used in the ROI definition (panel (a): …
Figure 4
Analysis of a longitudinal developmental dataset.
Atypical intrinsic neural timescales and their associations with symptoms of ASD were investigated in a longitudinal fMRI dataset obtained from adolescent children (Supplementary Table 2 in Supplemen…
Figure 5 with 2 supplements
Neuroanatomical basis of the intrinsic neural timescale.
(a) At a group level, intrinsic timescale was correlated with local grey matter volume (GMV). Each circle represents an across-participant average of the intrinsic timescale and that of the GMV in …
Figure 5—figure supplement 1
Reproducibility test 1: ETH Zürich dataset.
The main findings were replicated in an independent dataset collected in ETH Zürich. In a whole-brain analysis, the bilateral postcentral gyri and right IOG showed atypically shorter intrinsic …
Figure 5—figure supplement 2
Reproducibility test 2: Indiana University dataset.
The main findings were replicated in an independent dataset collected in Indiana University. In a whole-brain analysis, the bilateral postcentral gyri and right IOG showed atypical reduction in the …
Tables
Table 1
Demographic data.
https://doi.org/10.7554/eLife.42256.006| Typically developing (TD) | Autism spectrum disorder (ASD) | P value | |
|---|---|---|---|
| Number of participants | 26 | 25 | - |
| Age | 25.3 ± 6.3 (18.1–39.4) | 27.3 ± 7.9 (18.4–50) | 0.4 |
| Sex | Male | Male | - |
| Laterality | Right-handed | Right-handed | - |
| Full IQ | 112.6 ± 12.0 (89–131) | 109.4 ± 13.6 (90–132) | 0.4 |
| Verbal IQ | 112.1 ± 12.1 (88–130) | 106.6 ± 13.8 (83–130) | 0.2 |
| Performance IQ | 110.3 ± 10.4 (90–129) | 110.9 ± 15.9 (83–133) | 0.9 |
| ADOS Social | - | 4.3 ± 1.4 (1–8) | - |
| ADOS Communication | - | 7.6 ± 2.3 (4–11_ | - |
| ADOS RRB | - | 1.1 ± 1.2 (0–3) | - |
| Mean head motion (mm) | 1.1 ± 0.6 (0.21–2.4) | 1.5 ± 0.8 (0.25–2.5) | 0.1 |
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Mean ±SD (min–max)
Table 2
Results of whole-brain intrinsic timescale analysis
https://doi.org/10.7554/eLife.42256.008| Coordinates | ||||||
|---|---|---|---|---|---|---|
| Right/Left | Anatomical label | X | Y | Z | Cluster size | T value |
| TD > ASD | ||||||
| Right | Post-central gyrus | 58 | –14 | 44 | 470 | 5.2 |
| Left | Post-central gyrus | –58 | –14 | 40 | 309 | 4.3 |
| Right | Middle temporal gyrus | 60 | 2 | –26 | 170 | 4.8 |
| Left | Middle temporal gyrus | –70 | –26 | –6 | 321 | 4.3 |
| Right | Inferior occipital gyrus | 52 | –74 | –6 | 168 | 4.2 |
| Right | Inferior parietal lobule | 50 | –44 | 32 | 121 | 4.7 |
| Right | Middle insula | 50 | 10 | –4 | 228 | 4.3 |
| ASD > TD | ||||||
| Right | Caudate | 14 | 20 | 12 | 41 | 3.7 |
| Threshold: PFDR < 0.05. | ||||||
Additional files
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Supplementary file 1
Supplementary table 1: Dataset for the reproducibility test. Supplementary table 2: Properties of the longitudinal dataset.
- https://doi.org/10.7554/eLife.42256.015
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Transparent reporting form
- https://doi.org/10.7554/eLife.42256.016
