Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila
- Janelia Research Campus, Howard Hughes Medical Institute, United States
Abstract
Animals consolidate some, but not all, learning experiences into long-term memory. Across the animal kingdom, sleep has been found to have a beneficial effect on the consolidation of recently formed memories into long-term storage. However, the underlying mechanisms of sleep dependent memory consolidation are poorly understood. Here, we show that consolidation of courtship long-term memory in Drosophila is mediated by reactivation during sleep of dopaminergic neurons that were earlier involved in memory acquisition. We identify specific fan-shaped body neurons that induce sleep after the learning experience and activate dopaminergic neurons for memory consolidation. Thus, we provide a direct link between sleep, neuronal reactivation of dopaminergic neurons, and memory consolidation.
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Source data files have been provided for Figure 1-figure supplement 1 and 2, Figure 2, Figure 2-figure supplement 1 and 2 and Figure 5 and Figure 5-figure supplement
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Funding
Howard Hughes Medical Institute (N/A)
- Krystyna Keleman
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Copyright
© 2019, Dag et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila
eLife 8:e42786.
https://doi.org/10.7554/eLife.42786
