Simulations were conducted under different levels of horizontal pleiotropy for two different models; the causal model (where the simulated exposure has a causal effect on the outcome) and the null …
A receiver operating characteristic (ROC) curve to compare the sensitivity and specificity of polygenic risk scores (PRS) and individuals with ischaemic heart disease (defined using ICD 10 codes …
Each point on this plot represents the association between the schizophrenia polygenic risk score (based on p<5×10−05) and a complex trait in the UK Biobank study. Along the y-axis are –log10 …
A receiver operating characteristic (ROC) curve to compare the sensitivity and specificity of polygenic risk scores (PRS) and individuals with self-reported gout in the UK Biobank study. The scores …
(a) Mediation Mendelian randomization (MR) framework to investigate whether urate mediates the effect of body mass index (BMI) and triglycerides (TG) on gout risk. The various analyses undertaken …
Supplementary Tables.
Supplementary file 1a: A list of the 162 traits and corresponding GWAS identified to construct polygenic risk scores. Supplementary file 1b: A list of the 551 complex traits analysed in the UK Biobank study. Supplementary file 1c: An evaluation of weighted and unweighted PRS where samples overlap between discovery and application. Supplementary file 1d: A phenome-wide evaluation of schizophrenia genetic liability. Supplementary file 1e: Mendelian randomization analysis to investigate the effect of schizophrenia genetic liability on neurological traits. Supplementary file 1f: Mendelian randomization analysis to investigate the effect of neurological traits on schizophrenia risk. Supplementary file 1g: Mendelian randomization analysis to investigate the effect of schizophrenia genetic liability on cognitive traits. Supplementary file 1h: Mendelian randomization analysis to investigate the effect of cognitive traits on schizophrenia risk. Supplementary file 1i: Mendelian randomization analysis to investigate the effect of schizophrenia genetic liability on smoking traits. Supplementary file 1j: Mendelian randomization analysis to investigate the effect of smoking traits on schizophrenia risk. Supplementary file 1k: Mendelian randomization analysis to investigate the effect of schizophrenia genetic liability on body mass index. Supplementary file 1l: Mendelian randomization analysis to investigate the effect of body mass index on schizophrenia risk. Supplementary file 1m: A genetic-liability phenome scan for self-reported gout. Supplementary file 1n: Mendelian randomization analysis to investigate the effect of body mass index on triglycerides, urate and gout. Supplementary file 1o: Mendelian randomization analysis to investigate the effect of triglycerides on body mass index, urate and gout. Supplementary file 1p: Mendelian randomization analysis to investigate the effect of urate on body mass index, triglycerides and gout. Supplementary file 1q: Multivariable Mendelian randomization analysis to investigate the effect of body mass index, triglycerides and urate on gout risk. Supplementary file 1r: Multivariable Mendelian randomization analysis to investigate the effect of body mass index and urate on gout risk. Supplementary file 1s: Multivariable Mendelian randomization analysis to investigate the effect of triglycerides and urate on gout risk. Supplementary file 1t: Multivariable Mendelian randomization analysis to investigate the effect of body mass index and triglycerides on gout risk.