Genetics and Genomics

Latest articles

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Evaluation of in silico predictors on short nucleotide variants in HBA1, HBA2 and HBB associated with haemoglobinopathies

   Stella Tamana, Maria Xenophontos ... Petros Kountouris
2. 1. Developmental Biology
   2. Genetics and Genomics

   Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology

   Elizabeth A Bearce, Zoe H Irons ... Daniel T Grimes
3. 1. Cell Biology
   2. Genetics and Genomics

   Unleashing a novel function of Endonuclease G in mitochondrial genome instability

   Sumedha Dahal, Humaira Siddiqua ... Sathees C Raghavan

   A new role for Endonuclease G with respect to the generation of mtDNA deletions is identified, which is dependent on the formation of G4 DNA within human mitochondria.
4. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   The RAM signaling pathway links morphology, thermotolerance, and CO₂ tolerance in the global fungal pathogen Cryptococcus neoformans

   Benjamin J Chadwick, Tuyetnhu Pham ... Xiaorong Lin

   In the fungal pathogen Cryptococcus neoformans, the RAM pathway, potentially through post-transcriptional regulation, plays an essential role in adaptation to host temperature and CO₂.
5. 1. Developmental Biology
   2. Genetics and Genomics

   Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver-Russell syndrome-like mouse models

   Suhee Chang, Diana Fulmer ... Marisa S Bartolomei

   Precise dosage of the imprinted H19 and Igf2 genes is critical for normal embryonic development, especially related to the cardiac-placental axis.
6. 1. Evolutionary Biology
   2. Genetics and Genomics

   Comparative genomics reveals insight into the evolutionary origin of massively scrambled genomes

   Yi Feng, Rafik Neme ... Laura F Landweber
7. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Nucleotide-level linkage of transcriptional elongation and polyadenylation

   Joseph V Geisberg, Zarmik Moqtaderi ... Kevin Struhl
8. 1. Genetics and Genomics

   The genetic risk of gestational diabetes in South Asian women

   Amel Lamri, Jayneel Limbachia ... Sonia S Anand

   A type 2 diabetes polygenic risk score and family history of diabetes are strongly and independently associated with multiple gestational diabetes-related traits in women of South Asian descent.
9. 1. Genetics and Genomics

   Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice

   Yanis Zekri, Romain Guyot ... Karine Gauthier

   T3 regulates BAT thermogenesis by controlling the expression of genes involved in the management of metabolic fuels as well as tissue plasticity.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation after a sudden change in environment

    Laura Katharine Hayward, Guy Sella

    A shift in fitness optimum of a polygenic trait rapidly introduces small frequency differences between alleles with effects aligned with and opposing the shift, which gradually translate into small differences in fixation probability.