Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

   Angela Schulz et al.
2. 1. Evolutionary Biology
   2. Genetics and Genomics

   Population Genetics: Why structure matters

   Nick Barton et al.

   Great care is needed when interpreting claims about the genetic basis of human variation based on data from genome-wide association studies.
3. 1. Evolutionary Biology
   2. Genetics and Genomics

   Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

   Mashaal Sohail et al.

   Polygenic selection signals in humans estimated from previously existing GWAS should be viewed with caution due to concerns about residual population stratification.
4. 1. Evolutionary Biology
   2. Genetics and Genomics

   Reduced signal for polygenic adaptation of height in UK Biobank

   Jeremy J Berg et al.

   Many prior signals of polygenic adaptation on human height do not replicate in the UK Biobank.
5. 1. Evolutionary Biology
   2. Genetics and Genomics

   Long-term balancing selection drives evolution of immunity genes in Capsella

   Daniel Koenig et al.

   Retention of genetic diversity at immune-related loci drives the pattern of genetic variation in selfing Capsella.
6. 1. Cell Biology
   2. Genetics and Genomics

   Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome

   Martin Wegner et al.

   Cloning-free 3Cs technology is developed for the generation of sequence-bias-free covalently closed circular synthesized (3Cs) CRISPR/Cas gRNA libraries that can interrogate the coding and noncoding human genome.
7. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Nuclear genetic regulation of the human mitochondrial transcriptome

   Aminah T Ali et al.

   Common nuclear genetic variants are associated with fundamental biological processes occurring in human mitochondria and potentially point to novel roles for nuclear genes in transcriptional regulation of the mitochondrial genome.
8. 1. Genetics and Genomics

   Environmentally-induced epigenetic conversion of a piRNA cluster

   Karine Casier et al.

   Activation of a piRNA cluster is achieved by high temperature and without maternal inheritance of homologous piRNAs highlighting how variations of species natural habitat can become heritable and shape epigenome.
9. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   H3K9me3 is required for inheritance of small RNAs that target a unique subset of newly evolved genes

   Itamar Lev et al.

   In Caenorhabditis elegans histone methylation (H3K9me3) controls the synthesis of heritable small RNAs in a gene-specific manner and thus enables 'flagging' of newly-acquired genes.
10. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PUMILIO hyperactivity drives premature aging of Norad-deficient mice

    Florian Kopp et al.

    Long noncoding RNA Norad performs an essential function in mammalian physiology by inhibiting the activity of PUMILIO RNA binding proteins, thereby suppressing a multi-system degenerative phenotype resembling premature aging.