Genetics and Genomics

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

   Nairita Maitra et al.

   Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
2. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

   Gernot Wolf et al.
3. 1. Genetics and Genomics
   2. Human Biology and Medicine

   Point of View: Bioengineering horizon scan 2020

   Luke Kemp et al.

   20 emerging issues in bioengineering that will have profound impacts on society have been identified.
4. 1. Evolutionary Biology
   2. Genetics and Genomics

   Genomic and phenotypic evolution of Escherichia coli in a novel citrate-only resource environment

   Zachary David Blount et al.
5. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Universally high transcript error rates in bacteria

   Weiyi Li, Michael Lynch

   Fundamental details of the rate and molecular spectrum of transcript errors were revealed in four bacterial species, providing novel insights into transcriptional fidelity and RNA quality-control in prokaryotes.
6. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres

   Krishnendu Guin et al.
7. 1. Genetics and Genomics
   2. Human Biology and Medicine

   Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell

   Eran Mick et al.

   Mitochondrial electron transport chain dysfunction triggers the integrated stress response due to an asparagine deficiency downstream of impaired NADH oxidation in proliferating myoblasts, but not in differentiated myotubes.
8. 1. Genetics and Genomics

   Transgenesis and web resources in quail

   Olivier Serralbo et al.
9. 1. Genetics and Genomics

   Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance

   Anne Ramsay Bowden et al.

   The protein p53 negatively impacts the ability of a CRISPR screen to discriminate between essential and non-essential genes, hence, p53 status should be considered in these screens.
10. 1. Developmental Biology
    2. Genetics and Genomics

    Nuclear receptor Ftz-f1 promotes follicle maturation and ovulation partly via bHLH/PAS transcription factor Sim

    Elizabeth M Knapp et al.

    Genetic analyses illustrate the novel requirement of Ftz-f1 and Sim in adult Drosophila ovaries for regulating follicle cell differentiation and ovulation that is likely conserved in mammals.