Genetics and Genomics

Genetics and Genomics

eLife publishes research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Herpes simplex viral nucleoprotein creates a competitive transcriptional environment facilitating robust viral transcription and host shut off

    Sarah E Dremel, Neal A DeLuca
    Herpes simplex ICP4 preferentially binds to and delineates the viral genome, ultimately resulting in robust viral transcription at the expense of the host.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Cis-regulatory basis of sister cell type divergence in the vertebrate retina

    Daniel P Murphy et al.
    While photoreceptor and bipolar cells exhibit very similar cis-regulatory grammars, subtle differences in homeodomain motif enrichment represent a key distinction driving the divergence in their transcriptomes.
    1. Cell Biology
    2. Genetics and Genomics

    The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response

    Karina Perlaza et al.
    A genetic screen in a unicellular photosynthetic organism uncovers the first essential signaling component in the chloroplast unfolded protein response that relays information from the chloroplast to the nuclear compartment.
    1. Genetics and Genomics
    2. Neuroscience

    Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption

    Rebecca Delventhal et al.
    Through novel, cell-specific CRISPR tools to disrupt molecular clock genes, it was revealed that circadian rhythms are coordinated through a network, rather than by the clock of 'master regulatory' neurons.
    1. Cell Biology
    2. Genetics and Genomics

    Protein Homeostasis: How chloroplasts protect themselves from unfolded proteins

    Felix Kessler, Paolo Longoni
    A genetic screen has identified the first signaling component of the unfolded protein response in chloroplasts.
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    1. Evolutionary Biology
    2. Genetics and Genomics

    Mating Behavior: When structure meets function

    Sarah A Signor
    A new study upturns the long-held belief that in fruit flies, the yellow gene determines sex-specific behaviors by acting in the brain.
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    1. Evolutionary Biology
    2. Genetics and Genomics

    The yellow gene influences Drosophila male mating success through sex comb melanization

    Jonathan H Massey et al.
    Melanization of a secondary sexual structure facilitates male mating success in Drosophila.
    1. Cell Biology
    2. Genetics and Genomics

    NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling

    Malini Rajan et al.
    Nuclear receptor NHR-14 regulates the subcellular localization of the zinc transcription factor PQM-1 to coordinate innate immunity with iron sequestration during pathogen infection in C. elegans..
    1. Genetics and Genomics
    2. Neuroscience

    A scalable platform for the development of cell-type-specific viral drivers

    Sinisa Hrvatin et al.
    Highly paralleled functional evaluation of enhancer activity in single cells generates new cell-type-specific tools with broad medical and scientific applications.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Sex-specific transcriptomic responses to changes in the nutritional environment

    M Florencia Camus et al.
    Male and female Drosophila share core metabolic responses to different nutritional environments, but show opposing patterns of nutrient-dependent reproductive regulation.

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  3. Mark McCarthy
    Mark McCarthy
    Genentech, United States
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