Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Stem Cells and Regenerative Medicine

   Delivery of A Jagged1-PEG-MAL hydrogel with Pediatric Human Bone Cells Regenerates Critically-Sized Craniofacial Bone Defects

   Archana Kamalakar, Brendan Tobin ... Steven L Goudy
2. 1. Genetics and Genomics

   Deficiency of IQCH causes male infertility in humans and mice

   Tiechao Ruan, Ruixi Zhou ... Ying Shen

   IQCH is required for acrosome and axoneme development during spermatogenesis in humans and mice.
3. 1. Genetics and Genomics

   Tradeoffs in Modeling Context Dependency in Complex Trait Genetics

   Eric Weine, Samuel Pattillo Smith ... Arbel Harpak
4. 1. Genetics and Genomics
   2. Epidemiology and Global Health

   Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry

   Wei Q Deng, Nathan Cawte ... Sonia S Anand
5. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank

   Ardalan Naseri, Degui Zhi, Shaojie Zhang

   ROH-DICE is an efficient method for detecting ROH clusters in biobank data, enabling the study of population history of large cohorts, and providing a new genome-wide association analysis approach for finding disease-causing loci with multi-marker recessive effects.
6. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals

   Lisa Baumgartner, Jonathan J Ipsaro ... Julius Brennecke

   Genetic and biochemical characterization reveals how a single amino acid change in the chromodomain of the HP1 protein Rhino enables its specific interaction with the guidance factor Kipferl.
7. 1. Genetics and Genomics
   2. Cancer Biology

   Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases

   Joakim Karlsson, Vasu R Sah ... Jonas A Nilsson
8. 1. Genetics and Genomics

   PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

   Thomas E Forman, Marcin P Sajek ... Katherine A Fantauzzo
9. 1. Genetics and Genomics
   2. Epidemiology and Global Health

   Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits

   Rashmi Sukumaran, Achuthsankar S. Nair, Moinak Banerjee
10. 1. Genetics and Genomics

    Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

    Xiuling Cao, Xiang Wu ... Beidong Liu