Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Stress conditions promote Leishmania hybridization in vitro marked by expression of the ancestral gamete fusogen HAP2 as revealed by single-cell RNA-seq

   Isabelle Louradour et al.

   Following exposure of Leishmania culture promastigotes to DNA stress, single-cell RNA sequencing reveals discrete clusters of cells associated with efficient generation of hybrids between different species and strains in vitro marked by expression of the ancestral gamete fusogen HAP2.
2. 1. Evolutionary Biology
   2. Genetics and Genomics

   Unique structure and positive selection promote the rapid divergence of Drosophila Y chromosomes

   Ching-Ho Chang et al.

   Differences in the usage of DNA repair pathways may give rise to the unique patterns of Y-linked mutations that, together with natural selection, shape rapid Y chromosome evolution.
3. 1. Genetics and Genomics
   2. Plant Biology

   The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation

   Laura Arribas-Hernández et al.

   The Arabidopsis N6-methyladenosine (m⁶A) binding proteins ECT2 and ECT3 act redundantly in the cytoplasm to regulate m⁶A-containing mRNAs whose abundances are reduced in ect2/ect3/ect4 knockout plants although the locations of their polyadenylation sites remain unaffected, contrary to currently held beliefs.
4. 1. Genetics and Genomics
   2. Plant Biology

   Principles of mRNA targeting via the Arabidopsis m⁶A-binding protein ECT2

   Laura Arribas-Hernández et al.

   The Arabidopsis N6-methyladenosine (m⁶A)-binding protein ECT2 binds to m⁶A in the canonical RR[m⁶A]CH motif, not a plant-specific motif as previously thought, and its intrinsically disordered region contributes to mRNA binding via contacts with U-rich motifs.
5. 1. Evolutionary Biology
   2. Genetics and Genomics

   Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe

   José Fabricio López Hernández et al.

   Mating phenotypes are diverse in Schizosaccharomyces pombe and the natural variation can impact the spread of wtf meiotic drivers.
6. 1. Epidemiology and Global Health
   2. Genetics and Genomics

   Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

   Susan Martin et al.

   Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.
7. 1. Developmental Biology
   2. Genetics and Genomics

   A low-tech, cost-effective and efficient method for safeguarding genetic diversity by direct cryopreservation of poultry embryonic reproductive cells

   Tuanjun Hu et al.

   A simple cryopreservation method using chicken eggs will be a valuable tool to safeguard genetic diversity and conserve the 1600 local breeds of chicken on the planet.
8. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies

   Jun Xu et al.
9. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Distinguishing between recruitment and spread of silent chromatin structures in Saccharomyces cerevisiae

   Molly Brothers, Jasper Rine
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Plants: Why do sunflowers have invisible colors?

    Jason Laurich, Anna M O'Brien

    In the common sunflower, patterns of UV-absorbing pigments are controlled by a newly identified regulatory region and may be under the influence of environmental factors.