Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Immunology and Inflammation

   ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB mediated signaling pathway in humans and mice

   Chong Chen, Qian Liu ... Xinting Liu
2. 1. Genetics and Genomics

   Tradeoffs in Modeling Context Dependency in Complex Trait Genetics

   Eric Weine, Samuel Pattillo Smith ... Arbel Harpak
3. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria

   Chinmaya Jena, Saillesh Chinnaraj ... Nishad Matange

   Gene duplication in antibiotic-resistant bacteria mitigates elevated demand for expression, facilitating adaptation to antibiotics and alleviating costs of proteolytic instability of the drug target.
4. 1. Evolutionary Biology
   2. Genetics and Genomics

   Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction

   James Boocock, Noah Alexander ... Leonid Kruglyak

   Using single-cell RNA sequencing, we mapped thousands of expression quantitative trait loci in yeast, including a variant in GPA1 that influences gene expression, cell-cycle occupancy, and mating efficiency.
5. 1. Developmental Biology
   2. Genetics and Genomics

   Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers

   Svanhild Nornes, Susann Bruche ... Sarah De Val

   Identification and characterization of enhancers for eight key arterial genes reveal transcription factors associated with different aspects of endothelial gene expression specificity and provide a tool for a better understanding of arterial differentiation.
6. 1. Genetics and Genomics
   2. Neuroscience

   Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus

   Akanksha Bafna, Gareth Banks ... Patrick M Nolan
7. 1. Cell Biology
   2. Genetics and Genomics

   Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma

   Keva Li, Nicholas Tolman ... UK Biobank Eye and Vision Consortium
8. 1. Developmental Biology
   2. Genetics and Genomics

   Vascular Development: Enhancing our understanding of endothelial cells

   Guillermo Luxán

   What determines whether an endothelial cell becomes part of an artery, a vein or a capillary?
9. 1. Cell Biology
   2. Genetics and Genomics

   DNA replication in primary hepatocytes without the six-subunit ORC

   Róża K Przanowska, Yuechuan Chen ... Anindya Dutta
10. 1. Genetics and Genomics
    2. Evolutionary Biology

    The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems

    Xiaopei Wang, Yongsen Ruan ... Haijun Wen