Genetics and Genomics

Genetics and Genomics

eLife publishes research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology
    2. Genetics and Genomics

    Unsupervised detection of fragment length signatures of circulating tumor DNA using non-negative matrix factorization

    Gabriel Renaud et al.
    Non-negative Matrix Factorization is a powerful strategy for unsupervised analysis of cell-free DNA that enables simultaneous estimation of the blood tumor fraction and the fragment length distribution of circulating tumor DNA.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

    Liselot Dewachter et al.
    High-throughput single-cell based, genome-wide gene silencing screening (sCRilecs-seq) revealed that drugging the mevalonate pathway resensitizes amoxicillin-resistant pneumococci.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye

    Henrike Indrischek et al.
    Specific evolutionary gene loss signatures indicated an eye-related function for the uncharacterized SERPINE3 gene, which was experimentally confirmed by zebrafish gene knockouts, showing how comparative genomics can provide insights into the function of uncharacterized genes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution: Poor eyesight reveals a new vision gene

    Tathagata Biswas et al.
    Comparing the genomes of mammals which evolved to have poor vision identifies an important gene for eyesight.
    Available as:
    • HTML
    • PDF
    1. Cell Biology
    2. Genetics and Genomics

    Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation

    Anthony J Veltri et al.
    Genetic screens and functional assays utilizing reporter mRNAs triggering NGD or COMD provide a basis for understanding the unique contributions of each pathway to translation-coupled mRNA decay and contextualizes their effects in the larger cellular process of translation surveillance.
    1. Ecology
    2. Genetics and Genomics

    Genomic evidence for global ocean plankton biogeography shaped by large-scale current systems

    Daniel J Richter et al.
    Analysis of genomic DNA composition of surface plankton communities reveals a stable, ocean basin-scale plankton biogeography that emerges from the intertwined effects of environmental variations and currents.

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  3. Mike Eisen
    Michael B Eisen
    HHMI, University of California, Berkeley, United States
  4. See more editors