Genetics and Genomics

Genetics and Genomics

eLife publishes research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Developmental Biology
    2. Genetics and Genomics

    Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality

    Ankit Sabharwal, Mark D Wishman ... Stephen C Ekker
    A revertible Leigh Syndrome French Canadian Type (LSFC) disease model recapitulates the clinical phenotypes which can be rescued using a liver-specific genetic model therapy.
    1. Genetics and Genomics
    2. Neuroscience

    MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size

    Michael J Lafferty, Nil Aygün ... Jason L Stein
    Inter-individual differences in miRNA expression during fetal cortical development informs genetic mechanisms for complex brain phenotypes.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Interdependent progression of bidirectional sister replisomes in E. coli

    Po Jui Chen, Anna B McMullin ... David Bates
    Physical association between sister replisomes early in the E. coli replication phase promotes rapid fork progression and inhibits fork stalling.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis

    Cheng Zhang, Shasha Zhao ... Wensheng Deng
    The miR-106a-5p links STAT3 with TP73 to activate Pol III-dependent transcription and cancer cell proliferative activity.
    1. Genetics and Genomics

    A method for low-coverage single-gamete sequence analysis demonstrates adherence to Mendel’s first law across a large sample of human sperm

    Sara A Carioscia, Kathryn J Weaver ... Rajiv C McCoy
    A computational method and genome-wide scan of low-coverage single-cell sequencing data from a large sample of human sperm suggests balanced transmission of alleles to the gamete pool.
    1. Genetics and Genomics

    The missing link between genetic association and regulatory function

    Noah J Connally, Sumaiya Nazeen ... Shamil R Sunyaev
    A common conceptual model exists in which trait-associated genetic variants that do not alter protein structure act by changing gene expression, but, in the context in which expression is often measured, this model is inconsistent with observed data.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Effects of an IgE receptor polymorphism acting on immunity, susceptibility to infection, and reproduction in a wild rodent

    Klara M Wanelik, Mike Begon ... Steve Paterson
    Genetic variation can have multiple effects on different phenotypic traits in organisms living in the natural environment.
    1. Developmental Biology
    2. Genetics and Genomics

    Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology

    Elizabeth A Bearce, Zoe H Irons ... Daniel T Grimes
    Urp1 and Urp2 peptides, expressed in CSF-contacting neurons in the spinal canal, prevent abnormal curvature of the zebrafish spine.

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Mike Eisen
    Michael B Eisen
    HHMI, University of California, Berkeley, United States
  4. See more editors