Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Neuroscience

   A genetic, genomic, and computational resource for exploring neural circuit function

   Fred P Davis et al.

   Transcriptomes of cells in the Drosophila visual system combined with anatomy and other information reveal new functional insight into the visual circuit.
2. 1. Genetics and Genomics

   Loss of centromere function drives karyotype evolution in closely related Malassezia species

   Sundar Ram Sankaranarayanan et al.

   The centromeres in Malassezia species, by breakage or inactivation, facilitate genome rearrangements that can result in varying karyotypes and contribute to the evolution of these species.
3. 1. Genetics and Genomics

   Suppressing proteasome mediated processing of Topoisomerase II DNA-protein complexes preserves genome integrity

   Nicholas Sciascia et al.
4. 1. Developmental Biology
   2. Genetics and Genomics

   A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila

   Fillip Port et al.
5. 1. Evolutionary Biology
   2. Genetics and Genomics

   The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress

   Marco Fumasoni, Andrew W Murray
6. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Pan-mammalian analysis of molecular constraints underlying extended lifespan

   Amanda Kowalczyk et al.

   Cancer control, DNA repair, and immunity are key functionalities underlying the evolution of extended lifespan in mammals.
7. 1. Computational and Systems Biology
   2. Genetics and Genomics

   CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications

   Sebastià Franch-Expósito et al.

   CNApp is a novel and unique web-based software that enables the performance of comprehensive and integrative analysis of genomic copy number alterations to uncover new associations with patient-oriented relevance.
8. 1. Developmental Biology
   2. Genetics and Genomics

   celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

   Chunmei Li et al.

   The use of forward genetic screens in zebrafish identifies a new model of vertebrate aging, defining the regulating of the onset of aging phenotypes through maintenance of progenitor cell populations.
9. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

   Agata Wesolowska-Andersen et al.

   Combination of deep learning models trained on tissue-specific genomic data and fine-mapping approaches supports efforts to identify causal variants and mechanisms at GWAS loci.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Attacks on genetic privacy via uploads to genealogical databases

    Michael D Edge, Graham Coop

    Direct-to-consumer genetic genealogy services that allow users to upload their own datasets are vulnerable to attacks on genetic privacy that exploit the structure of genetic variation.