Genetics and Genomics

Latest articles

1. 1. Developmental Biology
   2. Genetics and Genomics

   Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line

   Mahdi Moradi Marjaneh, Edwin P Kirk ... Richard P Harvey
2. 1. Genetics and Genomics

   Allele-specific gene editing approach for vision loss restoration in RHO-associated Retinitis Pigmentosa

   Xiaozhen Liu, Jing Qiao ... Liping Yang
3. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy

   Karthickeyan Chella Krishnan, Elie-Julien El Hachem ... Aldons J Lusis

   The discovery of three distinct and independent trans-regulating genomic loci influencing heart mass using a well-characterized mouse reference population provides evidence in support of the hypothesis that genetic diversity in the mitochondrial proteome plays a critical role in heart pathophysiology.
4. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

   Anil Kumar Vijjamarri, Xiao Niu ... Alan G Hinnebusch
5. 1. Genetics and Genomics

   Engineering of the endogenous HBD promoter increases HbA2

   Mandy Y Boontanrart, Elia Mächler ... Jacob E Corn
6. 1. Genetics and Genomics

   Limitations of principal components in quantitative genetic association models for human studies

   Yiqi Yao, Alejandro Ochoa

   It is always better to use mixed effects models over principal components association regression for genetic association studies of continuous traits, since the former models family structure and close relatives are always found in real human studies.
7. 1. Cancer Biology
   2. Genetics and Genomics

   MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

   Changyu Zhu, Yadira M Soto-Feliciano ... Scott W Lowe
8. 1. Genetics and Genomics
   2. Neuroscience

   Behavioral dissection of hunger states in Drosophila

   KJ Weaver, S Raju ... SD Pletcher
9. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Broad functional profiling of fission yeast proteins using phenomics and machine learning

   María Rodríguez-López, Nicola Bordin ... Jürg Bähler
10. 1. Genetics and Genomics

    Sparse dimensionality reduction approaches in Mendelian randomisation with highly correlated exposures

    Vasileios Karageorgiou, Dipender Gill ... Verena Zuber

    Applied and computational results show how dimensionality reduction approaches can help in grouping correlated genetic variant-exposure associations and improve causal inference in the Mendelian randomisation framework.