Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   Relating multivariate shapes to genescapes using phenotype-biological process associations for craniofacial shape

   Jose D Aponte et al.

   Multivariate genotype-phenotype mapping enables quantification of pathway and process-level effects on complex phenotypes and predicts phenotypic effects of novel mutations.
2. 1. Computational and Systems Biology
   2. Genetics and Genomics

   A computational screen for alternative genetic codes in over 250,000 genomes

   Yekaterina Shulgina, Sean R Eddy

   Five previously unknown alternative genetic codes are found in a screen of bacterial and archaeal genomes by a new computational method called Codetta, lending new insights into the process of their evolution.
3. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Remote immune processes revealed by immune-derived circulating cell-free DNA

   Ilana Fox-Fisher et al.
4. 1. Genetics and Genomics

   Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast

   Alaattin Kaya et al.

   Analysis of molecular signatures of lifespan variation across wild yeast isolates revealed how Nature employs environment to modify genotype, gene expression, and metabolome to arrive at different lifespan, while preserving fitness in various ecological niches.
5. 1. Developmental Biology
   2. Genetics and Genomics

   Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis

   Juliet R Girard et al.

   A combination of mRNA sequencing and genetic analysis reveals mechanisms that govern the development of distinct differentiated blood cell types from hematopoietic progenitors.
6. 1. Cancer Biology
   2. Genetics and Genomics

   BRAF^V600E induces reversible mitotic arrest in human melanocytes via microrna-mediated suppression of AURKB

   Andrew S McNeal et al.

   Oncogenic BRAF causes genome duplication and reversible growth arrest in human melanocytes that is conditional on microRNA expression and differentiation state.
7. 1. Evolutionary Biology
   2. Genetics and Genomics

   Mutation saturation for fitness effects at human CpG sites

   Ipsita Agarwal, Molly Przeworski
8. 1. Developmental Biology
   2. Genetics and Genomics

   Quantitative spatial and temporal assessment of regulatory element activity in zebrafish

   Shipra Bhatia et al.

   A new method for quantitative assessment of altered regulatory potential of human enhancers bearing disease-associated mutations using live imaging in zebrafish embryos.
9. 1. Genetics and Genomics
   2. Neuroscience

   Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders

   Jonathan Gilley et al.
10. 1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pan-genome analysis identifies intersecting roles for Pseudomonas specialized metabolites in potato pathogen inhibition

    Alba Pacheco-Moreno et al.