Genetics and Genomics

Genetics and Genomics

eLife publishes research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Stress conditions promote Leishmania hybridization in vitro marked by expression of the ancestral gamete fusogen HAP2 as revealed by single-cell RNA-seq

    Isabelle Louradour et al.
    Following exposure of Leishmania culture promastigotes to DNA stress, single-cell RNA sequencing reveals discrete clusters of cells associated with efficient generation of hybrids between different species and strains in vitro marked by expression of the ancestral gamete fusogen HAP2.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Unique structure and positive selection promote the rapid divergence of Drosophila Y chromosomes

    Ching-Ho Chang et al.
    Differences in the usage of DNA repair pathways may give rise to the unique patterns of Y-linked mutations that, together with natural selection, shape rapid Y chromosome evolution.
    1. Genetics and Genomics
    2. Plant Biology

    The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation

    Laura Arribas-Hernández et al.
    The Arabidopsis N6-methyladenosine (m6A) binding proteins ECT2 and ECT3 act redundantly in the cytoplasm to regulate m6A-containing mRNAs whose abundances are reduced in ect2/ect3/ect4 knockout plants although the locations of their polyadenylation sites remain unaffected, contrary to currently held beliefs.
    1. Genetics and Genomics
    2. Plant Biology

    Principles of mRNA targeting via the Arabidopsis m6A-binding protein ECT2

    Laura Arribas-Hernández et al.
    The Arabidopsis N6-methyladenosine (m6A)-binding protein ECT2 binds to m6A in the canonical RR[m6A]CH motif, not a plant-specific motif as previously thought, and its intrinsically disordered region contributes to mRNA binding via contacts with U-rich motifs.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe

    José Fabricio López Hernández et al.
    Mating phenotypes are diverse in Schizosaccharomyces pombe and the natural variation can impact the spread of wtf meiotic drivers.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

    Susan Martin et al.
    Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.
    1. Developmental Biology
    2. Genetics and Genomics

    A low-tech, cost-effective and efficient method for safeguarding genetic diversity by direct cryopreservation of poultry embryonic reproductive cells

    Tuanjun Hu et al.
    A simple cryopreservation method using chicken eggs will be a valuable tool to safeguard genetic diversity and conserve the 1600 local breeds of chicken on the planet.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Plants: Why do sunflowers have invisible colors?

    Jason Laurich, Anna M O'Brien
    In the common sunflower, patterns of UV-absorbing pigments are controlled by a newly identified regulatory region and may be under the influence of environmental factors.
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Highlights

    1. Genetics and Genomics

    Getting to grips with circular chromosomes

    Constance Nugent, Katsunori Sugimoto

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  3. Mike Eisen
    Michael B Eisen
    HHMI, University of California, Berkeley, United States
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