Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy

    Karthickeyan Chella Krishnan, Elie-Julien El Hachem ... Aldons J Lusis
    The discovery of three distinct and independent trans-regulating genomic loci influencing heart mass using a well-characterized mouse reference population provides evidence in support of the hypothesis that genetic diversity in the mitochondrial proteome plays a critical role in heart pathophysiology.
    1. Genetics and Genomics

    Engineering of the endogenous HBD promoter increases HbA2

    Mandy Y Boontanrart, Elia Mächler ... Jacob E Corn
    1. Genetics and Genomics

    Limitations of principal components in quantitative genetic association models for human studies

    Yiqi Yao, Alejandro Ochoa
    It is always better to use mixed effects models over principal components association regression for genetic association studies of continuous traits, since the former models family structure and close relatives are always found in real human studies.
    1. Cancer Biology
    2. Genetics and Genomics

    MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

    Changyu Zhu, Yadira M Soto-Feliciano ... Scott W Lowe
    1. Genetics and Genomics
    2. Neuroscience

    Behavioral dissection of hunger states in Drosophila

    KJ Weaver, S Raju ... SD Pletcher
    1. Genetics and Genomics

    Sparse dimensionality reduction approaches in Mendelian randomisation with highly correlated exposures

    Vasileios Karageorgiou, Dipender Gill ... Verena Zuber
    Applied and computational results show how dimensionality reduction approaches can help in grouping correlated genetic variant-exposure associations and improve causal inference in the Mendelian randomisation framework.

Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Martin Pollak
    Harvard Medical School, United States
  4. See more editors