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Cloning-free 3Cs technology is developed for the generation of sequence-bias-free covalently closed circular synthesized (3Cs) CRISPR/Cas gRNA libraries that can interrogate the coding and noncoding human genome.
Common nuclear genetic variants are associated with fundamental biological processes occurring in human mitochondria and potentially point to novel roles for nuclear genes in transcriptional regulation of the mitochondrial genome.
Activation of a piRNA cluster is achieved by high temperature and without maternal inheritance of homologous piRNAs highlighting how variations of species natural habitat can become heritable and shape epigenome.
Long noncoding RNA Norad performs an essential function in mammalian physiology by inhibiting the activity of PUMILIO RNA binding proteins, thereby suppressing a multi-system degenerative phenotype resembling premature aging.