Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   Telomeres: Getting to grips with circular chromosomes

   Constance Nugent, Katsunori Sugimoto

   A strain of budding yeast that contains one large chromosome reveals how the telomere capping complex CST maintains linear but not circular chromosomes.
2. 1. Genetics and Genomics

   Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions

   Zhi-Jing Wu et al.

   Cdc13 prevents chromosomes from end-to-end fusion.
3. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Transposase-assisted tagmentation of RNA/DNA hybrid duplexes

   Bo Lu et al.

   Tn5 transposase has direct tagmentation activity towards RNA/DNA hybrids, which is harnessed as a more convenient and faster RNA-seq library construction method and will benefit RNA and chromatin research.
4. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   S-phase-independent silencing establishment in Saccharomyces cerevisiae

   Davis Goodnight, Jasper Rine

   Cell-cycle progression is crucial for heterochromatin formation in budding yeast because S phase promotes the removal of active chromatin marks.
5. 1. Evolutionary Biology
   2. Genetics and Genomics

   Drosophila seminal sex peptide associates with rival as well as own sperm, providing SP function in polyandrous females

   Snigdha Misra, Mariana F Wolfner

   A seminal protein from a mating-male can bind sperm previously stored in his mate, providing direct benefits to the sperm from the prior male that mated with her.
6. 1. Genetics and Genomics

   ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair

   Daniel Wells et al.
7. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins

   Matthew WK Wong et al.

   A minor subset of plasma lipids are heritable, and this is associated with gene expression of transcripts related to roles beyond lipid metabolism, including immune function and cell signalling.
8. 1. Developmental Biology
   2. Genetics and Genomics

   Gap junctions deliver malonyl-CoA from soma to germline to support embryogenesis in Caenorhabditis elegans

   Todd A Starich et al.
9. 1. Developmental Biology
   2. Genetics and Genomics

   An atlas of cell types in the mammalian epididymis and vas deferens

   Vera D Rinaldi et al.
10. 1. Genetics and Genomics
    2. Human Biology and Medicine

    Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

    Sebastian I Arriola Apelo et al.

    Metabolic health and longevity can be separated by ovariectomy, which also protects female mice lacking hepatic mTORC2 from midlife mortality.