Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Genetics and Genomics
    2. Immunology and Inflammation

    ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB mediated signaling pathway in humans and mice

    Chong Chen, Qian Liu ... Xinting Liu
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Genetics and Genomics

    Tradeoffs in Modeling Context Dependency in Complex Trait Genetics

    Eric Weine, Samuel Pattillo Smith ... Arbel Harpak
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria

    Chinmaya Jena, Saillesh Chinnaraj ... Nishad Matange
    Gene duplication in antibiotic-resistant bacteria mitigates elevated demand for expression, facilitating adaptation to antibiotics and alleviating costs of proteolytic instability of the drug target.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction

    James Boocock, Noah Alexander ... Leonid Kruglyak
    Using single-cell RNA sequencing, we mapped thousands of expression quantitative trait loci in yeast, including a variant in GPA1 that influences gene expression, cell-cycle occupancy, and mating efficiency.
    1. Developmental Biology
    2. Genetics and Genomics

    Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers

    Svanhild Nornes, Susann Bruche ... Sarah De Val
    Identification and characterization of enhancers for eight key arterial genes reveal transcription factors associated with different aspects of endothelial gene expression specificity and provide a tool for a better understanding of arterial differentiation.
    1. Genetics and Genomics
    2. Neuroscience

    Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus

    Akanksha Bafna, Gareth Banks ... Patrick M Nolan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Solid
    1. Cell Biology
    2. Genetics and Genomics

    Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma

    Keva Li, Nicholas Tolman ... UK Biobank Eye and Vision Consortium
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Genetics and Genomics

    Vascular Development: Enhancing our understanding of endothelial cells

    Guillermo Luxán
    What determines whether an endothelial cell becomes part of an artery, a vein or a capillary?
    Version of Record
    Insight
    1. Cell Biology
    2. Genetics and Genomics

    DNA replication in primary hepatocytes without the six-subunit ORC

    Róża K Przanowska, Yuechuan Chen ... Anindya Dutta
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Evolutionary Biology

    The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems

    Xiaopei Wang, Yongsen Ruan ... Haijun Wen
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Adèle L Marston
    University of Edinburgh, United Kingdom
  3. Alan Moses
    University of Toronto, Canada
  4. See more editors