Genetics and Genomics

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Phenotypic Diversity: Setting the bar

   Charles Y Feigin, Ricardo Mallarino

   Analyzing the genomes of rock pigeons demonstrates that genetic variation comes in many forms and can have unexpected origins.
2. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Introgression of regulatory alleles and a missense coding mutation drive plumage pattern diversity in the rock pigeon

   Anna I Vickrey et al.

   Different kinds of molecular changes at one genetic locus control different feather pigmentation patterns, and the darkest patterns resulted from hybridization with another species.
3. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Genetics of trans-regulatory variation in gene expression

   Frank Wolfgang Albert et al.
4. 1. Epidemiology and Global Health
   2. Genetics and Genomics

   Association mapping from sequencing reads using k-mers

   Atif Rahman et al.

   Associations can be mapped using k-mer frequencies in sequencing reads without prior sequencing of a reference genome enabling detection of associations to variants of multiple types and outside of the reference.
5. 1. Cell Biology
   2. Genetics and Genomics
   3. Evolutionary Biology

   Phylogenetic divergence of cell biological features

   Michael Lynch

   Cell biological features are subject to stochastic forces of mutation and random genetic drift, which together cause lineages exposed to identical selection pressures to diverge, and mean phenotypes to deviate from expectations under optimizing selection.
6. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Neolithic and medieval virus genomes reveal complex evolution of hepatitis B

   Ben Krause-Kyora et al.

   Ancient hepatitis B virus (HBV) genomes were reconstructed from up to 7000-year-old Stone Age human skeletons, suggesting a long-time complex co-evolution with human populations.
7. 1. Genetics and Genomics
   2. Evolutionary Biology

   Current CRISPR gene drive systems are likely to be highly invasive in wild populations

   Charleston Noble et al.

   If released in the wild, current CRISPR-based gene drive systems designed to alter populations could spread much farther than intended, despite the evolution of drive resistance.
8. 1. Genetics and Genomics

   Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

   David A Knowles et al.

   Genetic variants that modulate transcriptomic response to doxorubicin in human iPSC-derived cardiomyocytes are predictive of cardiac damage and in vivo sensitivity to anthracycline cardiotoxicity.
9. 1. Microbiology and Infectious Disease
   2. Genetics and Genomics

   Dissection of the in vitro developmental program of Hammondia hammondi reveals a link between stress sensitivity and life cycle flexibility in Toxoplasma gondii

   Sarah L Sokol et al.

   A derived stress response trait may have contributed to the emergence of a globally dominant and promiscuous parasite.
10. 1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Transmission genetics of drug-resistant hepatitis C virus

    Nicholas van Buuren et al.

    Interactions between viral genomes within the same cells can impact the selection of drug-resistant variants and this has been finessed by hepatitis C virus.