Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Major genetic discontinuity and novel toxigenic species in Clostridioides difficile taxonomy

   Daniel R Knight et al.
2. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Detecting adaptive introgression in human evolution using convolutional neural networks

   Graham Gower et al.

   Convolutional neural networks are an effective tool for detecting archaic adaptive introgression from genomic data.
3. 1. Developmental Biology
   2. Genetics and Genomics

   Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris

   Brent A Wilkerson et al.

   The elucidation of the cellular composition of the crista and the genes expressed in each cell type is a critical step toward understanding inner ear development, function, and vestibulopathies.
4. 1. Genetics and Genomics
   2. Medicine

   Tendon and motor phenotypes in the Crtap^-/- mouse model of recessive osteogenesis imperfecta

   Matthew William Grol et al.

   Ultrastructural, biochemical, and behavioral assessments reveal that the Crtap^-/- mouse model of severe, recessive Osteogenesis Imperfecta presents with defects in tendon structure and strength that correlate with severe motor deficits.
5. 1. Genetics and Genomics

   Science Forum: The critical importance of vouchers in genomics

   Janet C Buckner et al.

   Geneticists should include links to and information about permanently preserved voucher specimens on genome databases and publications.
6. 1. Genetics and Genomics

   Start codon disruption with CRISPR/Cas9 prevents murine Fuchs' endothelial corneal dystrophy

   Hironori Uehara et al.
7. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status

   Ilhame Diboun et al.

   PDB-associated differences in DNA methylation are reproducible and reflect key environmental modulators of bone homeostasis including viral processes, vitamin D metabolism, as well as mechanical sheer load.
8. 1. Genetics and Genomics

   HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

   Jessica SY Ho et al.
9. 1. Genetics and Genomics
   2. Neuroscience

   Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

   Eric N Anderson et al.

   Traumatic injury leads to functional defects in nucleocytoplasmic transport and TDP-43 pathology in multiple model systems.
10. 1. Genetics and Genomics
    2. Medicine

    A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease

    Qingyuan Zhao et al.

    High-density lipoprotein (HDL) subfraction traits appear to have heterogeneous effects on coronary artery disease, giving support to the HDL function hypothesis.