Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish

   Wenyuan Li et al.

   Conditional gene knockout in combination with fluorescent labeling of different alleles can be achieved with high efficiency in zebrafish through NHEJ-mediated targeted insertion using a CRISPR/Cas system.
2. 1. Genetics and Genomics
   2. Immunology and Inflammation

   SCGN deficiency results in colitis susceptibility

   Luis F Sifuentes-Dominguez et al.

   A novel mutation in SCGN is associated with risk for inflammatory bowel disease and implicates the intestinal neuroendocrine compartment in the pathogenesis of this disorder.
3. 1. Developmental Biology
   2. Genetics and Genomics

   The GATOR complex regulates an essential response to meiotic double-stranded breaks in Drosophila

   Youheng Wei et al.

   The GATOR complex regulates TORC1 activity during meiosis.
4. 1. Genetics and Genomics
   2. Neuroscience

   Modular transcriptional programs separately define axon and dendrite connectivity

   Yerbol Z Kurmangaliyev et al.
5. 1. Genetics and Genomics

   An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms

   Oguz Kanca et al.
6. 1. Cell Biology
   2. Genetics and Genomics

   Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

   David W Morgens et al.
7. 1. Evolutionary Biology
   2. Genetics and Genomics

   Philosophy of Biology: The meanings of 'function' in biology and the problematic case of de novo gene emergence

   Diane Marie Keeling et al.

   A lexicon to help scientists and philosophers discuss the meaning of function in molecular biology more clearly is proposed.
8. 1. Evolutionary Biology
   2. Genetics and Genomics

   Comment on 'Single nucleus sequencing reveals evidence of inter-nucleus recombination in arbuscular mycorrhizal fungi'

   Benjamin Auxier, Anna Bazzicalupo

   We are writing to comment on the article by Chen et al. (2018) about inter-nucleus recombination in arbuscular mycorrhizal fungi.
9. 1. Genetics and Genomics

   Extensive impact of low-frequency variants on the phenotypic landscape at population-scale

   Téo Fournier et al.
10. 1. Genetics and Genomics

    Rare variants contribute disproportionately to quantitative trait variation in yeast

    Joshua S Bloom et al.