Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Genetics and Genomics

    CNN-based learning of single-cell transcriptomes reveals a blood-detectable multi-cancer signature of brain metastasis

    Ryan Lusby, Debojyoti Chowdhury ... Vijay K Tiwari
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Genetics and Genomics

    Non-visual light modulates behavioral memory and gene expression in C. elegans

    Zhijian Ji, Bingying Wang ... Dengke K Ma
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics
    2. Evolutionary Biology

    Lifestyles shape genome size and gene content in fungal pathogens

    Anna Fijarczyk, Pauline Hessenauer ... Christian R Landry
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Genetics and Genomics

    Genomic privacy risks in GWAS summary statistics

    Ao Lan, Yudi Pawitan, Xia Shen
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Genetics and Genomics

    Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

    Laura Lopez-Blanch, Cristina Rodríguez-Marin ... Manuel Irimia
    A multi-level assessment of the relevance of 18 highly conserved neural zebrafish microexons showed that individual deletions of most microexons did not exhibit strong phenotypes, likely because of compensatory changes.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    JAX Animal Behavior System (JABS): A genetics informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse

    Anshul Choudhary, Brian Q Geuther ... Vivek Kumar
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12

    Paige M Lemen, Yanning Zuo ... Hao Chen
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Genetics and Genomics

    Independent validation of transgenerational inheritance of learned pathogen avoidance in Caenorhabditis elegans

    Aalimah Akinosho, Joseph Alexander ... Andres Gabriel Vidal-Gadea
    Independent replication confirms that avoidance of pathogenic PA14 learned by Caenorhabditis elegans persists through the F2 generation using standardized sodium azide immobilization choice assays, clarifying prior reproducibility concerns.
    1. Genetics and Genomics

    Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

    Lesley T MacNeil
    Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Ecology

    Microbial consortia in salt marsh sediments are sequentially buried over millennia and genomic complementarity analysis indicates an important role in complex carbon decomposition

    Joseph H Vineis, Ashley N Bulseco ... Jennifer L Bowen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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Highlights

    1. Genetics and Genomics

    Epigenetic inheritance in C. elegans

    Lesley T MacNeil
    1. Genetics and Genomics
    2. Neuroscience

    How stress can extend lifespan

    Loren Cocciolone, Valeria Uvarova, Patricija van Oosten-Hawle
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

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Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
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