Genetics and Genomics

Latest articles

1. 1. Evolutionary Biology
   2. Genetics and Genomics

   Universal and taxon-specific trends in protein sequences as a function of age

   Jennifer E James et al.

   Ancient protein domains remain shaped by amino acid availability during early life, while young animal proteins are shaped by a need for high intrinsic structural disorder.
2. 1. Genetics and Genomics
   2. Plant Biology

   The Arabidopsis active demethylase ROS1 cis-regulates defense genes by erasing DNA methylation at promoter-regulatory regions

   Thierry Halter et al.
3. 1. Evolutionary Biology
   2. Genetics and Genomics

   Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde

   Iman Hamid et al.

   Admixture-mediated adaptation to malaria in a human population demonstrates that detectible signatures in genomic patterns of ancestry can be leveraged to better characterize recent selection in populations with mixed ancestry.
4. 1. Genetics and Genomics

   Serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice

   Yang Lyu et al.
5. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci

   Reza K Hammond et al.

   By integrating GWAS data sets with ATAC-seq and promoter-focused Capture C data, one can uncover further loci beyond those that reach genome-wide significance (p<5x10^-8).
6. 1. Cancer Biology
   2. Genetics and Genomics

   Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells

   Iris E Glykofridis et al.
7. 1. Developmental Biology
   2. Genetics and Genomics

   Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity

   Jason W Millington et al.
8. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations

   Marcos H de Moraes et al.
9. 1. Genetics and Genomics
   2. Neuroscience

   Fruitless mutant male mosquitoes gain attraction to human odor

   Nipun S Basrur et al.

   Engineering male mosquitoes lacking the fruitless gene induces them to be attracted to humans.
10. 1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Mixed cytomegalovirus genotypes in HIV-positive mothers show compartmentalization and distinct patterns of transmission to infants

    Juanita Pang et al.

    Genomic analyses provide new insights into natural history and pathogenesis of cytomegalovirus infection and suggest new testable hypotheses that could be important for the design and implementation of new vaccines.