Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging

   Isabelle Schiffer et al.

   Coordinate control of lysosomal v-ATPase subunits and biogenesis factor TFEB by miR-1 identifies a key regulatory axis with strong links to age-related proteotoxic disease.
2. 1. Genetics and Genomics
   2. Plant Biology

   Repression of CHROMOMETHYLASE 3 prevents epigenetic collateral damage in Arabidopsis

   Ranjith K Papareddy et al.
3. 1. Evolutionary Biology
   2. Epidemiology and Global Health
   3. Microbiology and Infectious Disease
   4. Genetics and Genomics

   

   Evolutionary Medicine: A Special Issue

   Edited by George H Perry et al.

   eLife is pleased to present a Special Issue to highlight recent advances in the growing and increasingly interdisciplinary field of evolutionary medicine.
4. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Linking plasmid-based beta-lactamases to their bacterial hosts using single-cell fusion PCR

   Peter J Diebold et al.

   One-step Isolation and Lysis (OIL) PCR offers a robust, versatile, accessible, and high-throughput method for linking mobile DNA with bacterial hosts in natural microbial communities.
5. 1. Evolutionary Biology
   2. Genetics and Genomics

   Introgression shapes fruit color convergence in invasive Galápagos tomato

   Matthew JS Gibson et al.

   A wild tomato species adopts local fruit color via introgression from an endemic relative, during its invasion onto the Galápagos Islands.
6. 1. Developmental Biology
   2. Genetics and Genomics

   Somatic aging pathways regulate reproductive plasticity in Caenorhabditis elegans

   Maria C Ow et al.

   Somatic aging and germline RNAi pathways promote inheritance of ancestral starvation memory through reallocation of fat storage in Caenorhabditis elegans.
7. 1. Cell Biology
   2. Genetics and Genomics

   Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

   Jiajia Ma et al.

   The serine protease Matriptase orchestrates simultaneous epithelial cell motility and inflammation in pathological states through respective activation of the MAPK pathway and generation of hydrogen peroxide.
8. 1. Genetics and Genomics

   Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease

   Surender Rajasekaran et al.

   Genetic sequencing has led to the increased diagnoses of rare diseases, strategies such as repurposing drugs and global metabolomics offer promise and bring hope to afflicted families.
9. 1. Cell Biology
   2. Genetics and Genomics

   An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development

   Courtney M Schroeder et al.

   Non-canonical ‘testis-specific’ actin-related protein (Arp), Arp53D, is critical for early embryonic development in Drosophila, revealing important roles for lineage-specific, divergent, testis-expressed non-canonical Arps outside the male germline in animals.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Highly contiguous assemblies of 101 drosophilid genomes

    Bernard Y Kim et al.