Genetics and Genomics

Genetics and Genomics

eLife publishes research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory

    Bethany Sump et al.
    During epigenetic transcriptional memory in budding yeast, histone H3 lysine 4 dimethylation - dependent on Nup1000 and independent of RNA polymerase II - regulates binding of a critical transcription factor and, once established, is mitotically heritable for at least four cell divisions.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Epistatic selection on a selfish Segregation Distorter supergene – drive, recombination, and genetic load

    Beatriz Navarro-Dominguez et al.
    African haplotypes of a meiotic drive supergene in Drosophila melanogaster called Segregation Distorter show signs of a recent selective sweep, reduced recombination, and increased genetic load.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation

    Noushin Hadadi et al.
    Integrative analysis of multi-tissue transcriptomics data of mice subjected to cold, mild warm or room temperature places the thermal adaptation of individual tissues in a whole-organism perspective.
    1. Genetics and Genomics
    2. Neuroscience

    Machine learning sequence prioritization for cell type-specific enhancer design

    Alyssa J Lawler et al.
    A new cross-species machine learning-based strategy is applied to find enhancers that specifically label parvalbumin neurons in the mouse and macaque.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species

    Osvaldo Villa et al.
    Leveraging the US Health and Retirement Study and C. elegans genetics reveals ALDH4A1/alh-6 as an evolutionarily conserved biomarker for normal muscle function over the lifespan.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid genome diversification

    Gabriel Machado Matos et al.
    Unique mechanisms of genetic exchange in the important protozoan pathogen Trypanosome cruzi were characterized in detail using genome analyses of hybrid clones at different time points, showing initial tetraploids followed by genome erosion.
    1. Genetics and Genomics
    2. Neuroscience

    Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

    Xinrui L Zhang et al.
    Terminal selectors reorganize postmitotic neuronal chromatin to select cis-regulatory elements during 5-HT neuron maturation.

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Mike Eisen
    Michael B Eisen
    HHMI, University of California, Berkeley, United States
  3. George H Perry
    Pennsylvania State University, United States
  4. See more editors