Genetics and Genomics

Latest articles

1. 1. Evolutionary Biology
   2. Genetics and Genomics

   Cis-regulation and natural selection in the evolution of human DNA methylation

   Zhenzhen Ma, Alexander L Starr ... Hunter B Fraser

   Cis-acting changes account for most methylation divergence between humans and chimpanzees, with lineage-specific selection on gene expression and promoter methylation at pathways tied to human speech, cognition, and disease susceptibility.
2. 1. Cancer Biology
   2. Genetics and Genomics

   Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma

   Olivia G Waltner, April A Apfelbaum ... Scott N Furlan

   In Ewing sarcoma, a mesenchymal gene program normally repressed by the oncogenic fusion is reactivated by TGF-β signaling, and is associated with more aggressive disease.
3. 1. Genetics and Genomics
   2. Computational and Systems Biology

   Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

   Jia-Ying Su, Wei-Ping Li ... Chien-Ling Lin
4. 1. Genetics and Genomics

   Analysis of RNA processing directly from spatial transcriptomics data reveals previously unknown regulation

   Julia Olivieri, Julia Salzman
5. 1. Genetics and Genomics
   2. Plant Biology

   Multi-omic integration using interpretable machine learning reveals genetic mechanisms of trait variation and phenotypic plasticity in switchgrass

   Paulo Izquierdo, Xiaoyu Weng ... Shin-Han Shiu
6. 1. Genetics and Genomics
   2. Neuroscience

   The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit

   Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser

   Genetic induction of the hypoxic response promotes longevity through a cell-nonautonomous neuronal to intestinal circuit governed by serotonin, tyramine/adrenaline, GABA, and neuropeptide signaling.
7. 1. Genetics and Genomics
   2. Medicine

   Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

   Tobias Kaufmann, Pål Marius Bjørnstad ... Timothy Hughes

   Previously overlooked information in standard head MRI scans combined with a novel deep learning method enables large-scale investigation of human bone marrow biology across existing imaging cohorts.
8. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Transition of Staphylococcus aureus tetracycline resistance plasmid pT181 from independent multicopy replicon to predominantly integrated chromosomal element over 65 years

   Megan A Phillips, Robert A Petit ... Timothy D Read
9. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania

   Gabriel H Negreira, Pieter Monsieurs ... Malgorzata A Domagalska
10. 1. Ecology
    2. Genetics and Genomics

    Plasticity associated with adoption of social roles in clown anemonefish

    Lili F Vizer, Douglas Alvarado ... Pete Buston

    During the establishment of size-based dominance hierarchies in clown anemonefish, an individual's social context shapes its growth trajectory through coordinated changes in feeding behavior, aggressive behaviors, and gene expression.