Genetics and Genomics

Latest articles

1. 1. Evolutionary Biology
   2. Genetics and Genomics

   Multi-Level Selection: The perils of cheating

   M Florencia Camus

   Experiments on mitochondrial DNA in worms highlight that cheating does not always pay off.
2. 1. Evolutionary Biology
   2. Genetics and Genomics

   Nutrient status shapes selfish mitochondrial genome dynamics across different levels of selection

   Bryan L Gitschlag et al.

   Food supply and nutrient stress tolerance coordinately shape the multilevel selection dynamics of a mitochondrial cheater by promoting cheater persistence at both within-host and between-host levels of selection.
3. 1. Evolutionary Biology
   2. Genetics and Genomics

   The effect of hybridization on transposable element accumulation in an undomesticated fungal species

   Mathieu Hénault et al.
4. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Genetic mapping of etiologic brain cell types for obesity

   Pascal N Timshel et al.

   Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
5. 1. Genetics and Genomics
   2. Medicine

   PTPRG is an ischemia risk locus essential for HCO₃^--dependent regulation of endothelial function and tissue perfusion

   Kristoffer B Hansen et al.
6. 1. Genetics and Genomics

   ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

   Daniel Wells et al.

   ZCWPW1 has co-evolved with PRDM9, in particular the PRDM9-SET domain, and although not involved in PRDM9's role in positioning recombination events, it is required for PRDM9's role in pairing chromosomes.
7. 1. Epidemiology and Global Health
   2. Genetics and Genomics

   Clusters of polymorphic transmembrane genes control resistance to schistosomes in snail vectors

   Jacob A Tennessen et al.

   A region of the Biomphalaria genome, containing highly divergent haplotypes with different combinations of transmembrane genes, strongly impacts whether these snails can transmit parasitic schistosomes.
8. 1. Genetics and Genomics

   Sexual Reproduction: Reading the epigenetic code for exchanging DNA

   Mathilde Biot, Bernard de Massy

   Three independent studies show that a protein called ZCWPW1 is able to recognize the histone modifications that initiate the recombination of genetic information during meiosis.
9. 1. Developmental Biology
   2. Genetics and Genomics

   Speciation and the developmental alarm clock

   Asher D Cutter, Joanna D Bundus

   Integrating speciation genetics with ontogeny can identify predictable rules in the molecular evolution of developmental pathways and in the accumulation of reproductive isolation as genomes diverge.
10. 1. Genetics and Genomics

    A regulatory pathway that selectively up-regulates elongasome function in the absence of class A PBPs

    Yesha Patel et al.

    Balanced peptidoglycan synthesis requires regulators, including sigma-I and WalKR, that coordinate the diffusive action of class A PBPs and the directional motion of the MreB-directed elongasome.