Genetics and Genomics

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   The deubiquitylase Ubp15 couples transcription to mRNA export

   Fanny Eyboulet et al.

   Ubp15 regulates the ubiquitylation of the export adaptor Mex67.
2. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Combined transient ablation and single cell RNA sequencing reveals the development of medullary thymic epithelial cells

   Kristen L Wells et al.
3. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Repression of interrupted and intact rDNA by the SUMO pathway in Drosophila melanogaster

   Yicheng Luo et al.

   SUMO-dependent pathway is responsible for selective repression of damaged rDNA and silencing of intact surplus units revealing an epigenetic mechanism that controls the differential expression of identical sequences in the same cell.
4. 1. Genetics and Genomics

   Mutations primarily alter the inclusion of alternatively spliced exons

   Pablo Baeza-Centurion et al.

   Deep mutagenesis reveals that mutations rarely alter the inclusion of highly-included exons.
5. 1. Genetics and Genomics

   Genetic profiling of protein burden and nuclear export overload

   Reiko Kintaka et al.

   A comprehensive analysis of yeast mutants has provided clues to understanding the physiological conditions caused by protein overexpression.
6. 1. Cell Biology
   2. Genetics and Genomics

   Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells

   Neel S Singhal et al.

   A genetic basis underlying cell resilience against metabolic stress in cells of a hibernator, Arctic ground squirrels, has been discovered.
7. 1. Epidemiology and Global Health
   2. Genetics and Genomics

   Demographic history mediates the effect of stratification on polygenic scores

   Arslan A Zaidi, Iain Mathieson
8. 1. Genetics and Genomics

   Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation

   Christian Brion et al.
9. 1. Genetics and Genomics
   2. Neuroscience

   Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology

   Yubo Cheng et al.
10. 1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Transcription termination and antitermination of bacterial CRISPR arrays

    Anne M Stringer et al.

    Many bacteria use the Nus factor antitermination complex to prevent premature Rho-dependent transcription termination of their CRISPR arrays.