Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Genetics and Genomics
    2. Evolutionary Biology

    Most Beefalo cattle have no detectable bison genetic ancestry

    Beth Shapiro, Jonas Oppenheimer ... Timothy PL Smith
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Genome-wide identification of stable RNA-chromatin interactions

    Xingzhao Wen, Sheng Zhong
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Saccharomyces cerevisiae Rev7 promotes non-homologous end-joining by blocking Mre11 nuclease and Rad50’s ATPase activities and homologous recombination

    Sugith Badugu, Kshitiza Mohan Dhyani ... Kalappa Muniyappa
    A combination of genetic and biochemical approaches suggest that yeast Rev7 promotes DNA double-strand break repair via NHEJ and inhibits homologous recombination by blocking Mre11 nuclease and Rad50’s ATPase activities.
    1. Genetics and Genomics

    PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

    Thomas E Forman, Marcin P Sajek ... Katherine A Fantauzzo
    Upon PDGFRα signaling in mouse embryonic palatal mesenchyme cells, Srsf3 exhibits differential transcript binding, resulting in retention of the receptor in early endosomes and increased downstream PI3K-mediated Akt signaling.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    An H3-K9-me-independent binding of Swi6/HP1 to siRNA-DNA hybrids initiates heterochromatin assembly at cognate dg-dh repeats in Fission Yeast

    Jyotsna Kumar, Swati Haldar ... Jagmohan Singh
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Understanding genetic variants in context

    Nasa Sinnott-Armstrong, Stanley Fields ... Christine Queitsch
    Multiplexed assays of variant effect are an increasingly important tool in genetic research and including more context specificity in their design would aid interpretation and discovery.
    1. Genetics and Genomics
    2. Neuroscience

    Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy

    Eric R Wengert, Melody A Cheng ... Ethan M Goldberg
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics
    2. Genetics and Genomics

    Tom1p ubiquitin ligase structure, interaction with Spt6p, and function in maintaining normal transcript levels and the stability of chromatin in promoters

    Jennifer Madrigal, Heidi L Schubert ... Christopher P Hill
    Not revised
    Reviewed Preprint v1
    1. Developmental Biology
    2. Genetics and Genomics

    Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition

    Anne-Sophie Pepin, Patrycja A Jazwiec ... Sarah Kimmins
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Household clustering and seasonal genetic variation of Plasmodium falciparum at the community-level in The Gambia

    Marc-Antoine Guery, Sukai Ceesay ... Antoine Claessens
    Not revised
    Reviewed Preprint v1
Load more

Highlights

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Genetics and Genomics
    2. Neuroscience
    hands typing on a laptop keyboard

    Read public reviews for ‘A “tour-de-force” study of neuronal maturation’

    1. Genetics and Genomics

    Quantitative Genetics: Explore our collection of articles

    Edited by Patricia Wittkopp et al.

Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Yamini Dalal
    National Cancer Institute, United States
  3. Benoît Kornmann
    University of Oxford, United Kingdom
  4. See more editors