Genetics and Genomics

Latest articles

1. 1. Developmental Biology
   2. Genetics and Genomics

   Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality

   Ankit Sabharwal, Mark D Wishman ... Stephen C Ekker

   A revertible Leigh Syndrome French Canadian Type (LSFC) disease model recapitulates the clinical phenotypes which can be rescued using a liver-specific genetic model therapy.
2. 1. Genetics and Genomics
   2. Neuroscience

   MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size

   Michael J Lafferty, Nil Aygün ... Jason L Stein

   Inter-individual differences in miRNA expression during fetal cortical development informs genetic mechanisms for complex brain phenotypes.
3. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Interdependent progression of bidirectional sister replisomes in E. coli

   Po Jui Chen, Anna B McMullin ... David Bates

   Physical association between sister replisomes early in the E. coli replication phase promotes rapid fork progression and inhibits fork stalling.
4. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis

   Cheng Zhang, Shasha Zhao ... Wensheng Deng

   The miR-106a-5p links STAT3 with TP73 to activate Pol III-dependent transcription and cancer cell proliferative activity.
5. 1. Genetics and Genomics

   A method for low-coverage single-gamete sequence analysis demonstrates adherence to Mendel’s first law across a large sample of human sperm

   Sara A Carioscia, Kathryn J Weaver ... Rajiv C McCoy

   A computational method and genome-wide scan of low-coverage single-cell sequencing data from a large sample of human sperm suggests balanced transmission of alleles to the gamete pool.
6. 1. Evolutionary Biology
   2. Genetics and Genomics

   Relating pathogenic loss-of function mutations in humans to their evolutionary fitness costs

   Ipsita Agarwal, Zachary L Fuller ... Molly Przeworski
7. 1. Genetics and Genomics

   The missing link between genetic association and regulatory function

   Noah J Connally, Sumaiya Nazeen ... Shamil R Sunyaev

   A common conceptual model exists in which trait-associated genetic variants that do not alter protein structure act by changing gene expression, but, in the context in which expression is often measured, this model is inconsistent with observed data.
8. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Effects of an IgE receptor polymorphism acting on immunity, susceptibility to infection, and reproduction in a wild rodent

   Klara M Wanelik, Mike Begon ... Steve Paterson

   Genetic variation can have multiple effects on different phenotypic traits in organisms living in the natural environment.
9. 1. Developmental Biology
   2. Genetics and Genomics

   Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology

   Elizabeth A Bearce, Zoe H Irons ... Daniel T Grimes

   Urp1 and Urp2 peptides, expressed in CSF-contacting neurons in the spinal canal, prevent abnormal curvature of the zebrafish spine.
10. 1. Computational and Systems Biology
    2. Genetics and Genomics

    Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single cell resolution

    Marina Ainciburu, Teresa Ezponda ... Felipe Prosper