Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Genetics and Genomics
    2. Neuroscience

    The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit

    Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    The C. elegans gustatory receptor homolog LITE-1 is a chemoreceptor required for diacetyl avoidance

    Alan Koh, Eduard Bokman ... André EX Brown
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Genetics and Genomics

    A systematic interactome of Saccharomyces cerevisiae SET1C expands its functional landscape and identifies candidate regulatory connections

    Pierre Luciano, Kihyun Park ... Vincent Geli
    A comprehensive two-hybrid map of the Set1C interactome broadens understanding of Set1C subunit functions and identifies a novel link between Set1C and arginine methylation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determination

    Emily A Masser, Tyler D Noble ... Christopher L Sansam
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Evolutionary Biology
    2. Genetics and Genomics

    Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci

    Michele Marconcini, Steeve Cruchet ... Richard Benton
    Selection of animal populations and of cultured cells provides complementary datasets to identify candidate genes involved in conferring resistance to a natural insecticide.
    1. Genetics and Genomics

    Environmental Learning: How experience shapes individuality

    Bassem A Hassan
    Behavioural diversity across fruit flies changes with individual learning, even when genetic, past and momentary environmental factors are held constant.
    Version of Record
    Insight
    1. Genetics and Genomics

    The genetic control of rapid genome content divergence in Arabidopsis thaliana

    Christopher J Fiscus, Daniel Koenig
    Repeat variation in wild Arabidopsis thaliana arises from centromere-proximal sequence changes and rare variants in DNA replication, repair, and methylation genes, consistent with purifying selection constraining genome expansion.
    1. Genetics and Genomics

    AGES for Ageing: Evaluating the auxin-inducible gene expression system for use in Drosophila ageing studies

    Taylor McGilvary, Kriti Gupta ... Nathan Woodling
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria

    James Marks, Emma Young, Markus Hafner
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Separable downmodulation of meiotic axis protein deposition and DNA break induction at chromosome ends

    Adhithi R Raghavan, Kieron May ... Andreas Hochwagen
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
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Highlights

    1. Genetics and Genomics
    Microscopy image of a fruit fly. Image credit: USGS (CC0)

    How experience shapes individuality

    Bassem A Hassan
    1. Genetics and Genomics
    2. Medicine

    Responding to peer reviewers

    Eric Kalkhoven, Manon Kluijtmans
    1. Developmental Biology
    2. Genetics and Genomics

    Written out of history

    Lisa M Thomann, Julie Batut

Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Adèle L Marston
    University of Edinburgh, United Kingdom
  4. See more editors