Genetics and Genomics

Genetics and Genomics

eLife publishes research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans

    Teresa Wei-sy Lee et al.
    The transgenerational inheritance of lifespan is facilitated by the accumulation of repressive chromatin across generations.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetics: A memory of longevity

    Felicity Emerson et al.
    Worms with increased levels of the epigenetic mark H3K9me2 have a longer lifespan that can be passed down to future generations.
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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcriptional adaptation in Caenorhabditis elegans

    Vahan Serobyan et al.
    Genes implicated in mutant mRNA decay and small RNA maturation and transport into the nucleus are required for transcriptional adaptation in C. elegans.
    1. Developmental Biology
    2. Genetics and Genomics

    Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices

    Claudia Racioppi et al.
    ATAC-seq, CRISPR/Cas9 mutagenesis, reporter and gene expression assays revealed dynamic chromatin accessibility profiles governing differential gene expression during heart vs. pharyngeal muscle fate choices in the powerful chordate model Ciona.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Single cell transcriptional signatures of the human placenta in term and preterm parturition

    Roger Pique-Regi et al.
    Parturition gene regulation across multiple cell-types and placental compartments is deciphered at single cell resolution, highlighting the common role of the NFKB pathway in both term and preterm birth.
    1. Genetics and Genomics
    2. Neuroscience

    A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture

    Mark F Sabbagh, Jeremy Nathans
    In vitro culture of brain endothelial cells leads to a rapid loss of the blood-brain barrier transcriptional and accessible chromatin landscapes that is resistant to the effects of beta-catenin stabilization.

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Diethard Tautz
    Max-Planck Institute for Evolutionary Biology, Germany
  3. Detlef Weigel
    Max Planck Institute for Developmental Biology, Germany
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