Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Epidemiology and Global Health

   Heterogenous associations of polygenic indices of 35 traits with mortality

   Hannu Lahtinen, Jaakko Kaprio ... Pekka Martikainen
2. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania

   Gabriel H Negreira, Pieter Monsieurs ... Malgorzata A Domagalska
3. 1. Genetics and Genomics

   The RNA-binding protein HuR modulates the expression of the disease-linked CCL2 rs1024611G-rs13900T haplotype

   Feroz Akhtar, Joselin Hernandez Ruiz ... Srinivas Mummidi

   Bioinformatics, RNA-protein interactions, and HuR-based functional studies demonstrated that the rs13900T allele modulates CCL2 transcript levels, providing a functional link between the CCL2 rs1024611G-rs13900T haplotype and disease susceptibility/progression.
4. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Chromosomes: Finding a role for non-coding DNA in trypanosomes

   Markus R Schmidt

   Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.
5. 1. Genetics and Genomics

   Khdc3 Regulates Metabolism Across Generations in a DNA-Independent Manner

   Liana Senaldi, Nora Hassan ... Matthew Smith-Raska
6. 1. Genetics and Genomics

   The Impact of Stability Considerations on Genetic Fine-mapping

   Alan J Aw, Lionel Chentian Jin ... Yun S Song
7. 1. Developmental Biology
   2. Genetics and Genomics

   In situ mutational screening and CRISPR interference reveal that the apterous Early enhancer is required for developmental boundary positioning

   Gustavo Aguilar, Michèle Sickmann ... Martin Müller
8. 1. Cell Biology
   2. Genetics and Genomics

   Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in Caenorhabditis elegans, challenges a proposed role in heme trafficking

   Sarah E Sandkuhler, Kayla S Youngs ... Samuel J Mackenzie

   Evidence from multiple model systems supports a shift away from heme transport and toward metabolic dysfunction and oxidative stress as key drivers of TANGO2 deficiency.
9. 1. Genetics and Genomics
   2. Physics of Living Systems

   Raman Spectroscopy: Probing the proteome

   Wei-Hsiang Lin, Chia-Liang Cheng

   Raman spectroscopy can be used to predict cellular physiology and proteome composition in E. coli.
10. 1. Cancer Biology
    2. Genetics and Genomics

    Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

    Jiadong Zhou, Xiao Albert Zhou ... Jiadong Wang

    A replication stress–ELF3 axis enables luminal progenitor transformation in BRCA1-deficient breast cancer by reducing genomic instability and promoting progenitor identity.