Genetics and Genomics

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans

   Teresa Wei-sy Lee et al.

   The transgenerational inheritance of lifespan is facilitated by the accumulation of repressive chromatin across generations.
2. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Epigenetics: A memory of longevity

   Felicity Emerson et al.

   Worms with increased levels of the epigenetic mark H3K9me2 have a longer lifespan that can be passed down to future generations.
3. 1. Genetics and Genomics

   Loss of centromere function drives karyotype evolution in closely related Malassezia species

   Sundar Ram Sankaranarayanan et al.
4. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Transcriptional adaptation in Caenorhabditis elegans

   Vahan Serobyan et al.

   Genes implicated in mutant mRNA decay and small RNA maturation and transport into the nucleus are required for transcriptional adaptation in C. elegans.
5. 1. Genetics and Genomics
   2. Neuroscience

   A genetic, genomic, and computational resource for exploring neural circuit function

   Fred P Davis et al.
6. 1. Computational and Systems Biology
   2. Genetics and Genomics

   CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications

   Sebastià Franch-Expósito et al.
7. 1. Developmental Biology
   2. Genetics and Genomics

   Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices

   Claudia Racioppi et al.

   ATAC-seq, CRISPR/Cas9 mutagenesis, reporter and gene expression assays revealed dynamic chromatin accessibility profiles governing differential gene expression during heart vs. pharyngeal muscle fate choices in the powerful chordate model Ciona.
8. 1. Genetics and Genomics
   2. Human Biology and Medicine

   Single cell transcriptional signatures of the human placenta in term and preterm parturition

   Roger Pique-Regi et al.

   Parturition gene regulation across multiple cell-types and placental compartments is deciphered at single cell resolution, highlighting the common role of the NFKB pathway in both term and preterm birth.
9. 1. Genetics and Genomics
   2. Neuroscience

   A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture

   Mark F Sabbagh, Jeremy Nathans

   In vitro culture of brain endothelial cells leads to a rapid loss of the blood-brain barrier transcriptional and accessible chromatin landscapes that is resistant to the effects of beta-catenin stabilization.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Attacks on genetic privacy via uploads to genealogical databases

    Michael D Edge, Graham Coop