Genetics and Genomics

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory

   Bethany Sump et al.

   During epigenetic transcriptional memory in budding yeast, histone H3 lysine 4 dimethylation - dependent on Nup1000 and independent of RNA polymerase II - regulates binding of a critical transcription factor and, once established, is mitotically heritable for at least four cell divisions.
2. 1. Genetics and Genomics
   2. Neuroscience

   Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3

   Junhao Li et al.
3. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Dcp2 C-terminal cis-binding elements control selective targeting of the decapping enzyme by forming distinct decapping complexes

   Feng He et al.
4. 1. Evolutionary Biology
   2. Genetics and Genomics

   Epistatic selection on a selfish Segregation Distorter supergene – drive, recombination, and genetic load

   Beatriz Navarro-Dominguez et al.

   African haplotypes of a meiotic drive supergene in Drosophila melanogaster called Segregation Distorter show signs of a recent selective sweep, reduced recombination, and increased genetic load.
5. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation

   Noushin Hadadi et al.

   Integrative analysis of multi-tissue transcriptomics data of mice subjected to cold, mild warm or room temperature places the thermal adaptation of individual tissues in a whole-organism perspective.
6. 1. Genetics and Genomics
   2. Neuroscience

   Machine learning sequence prioritization for cell type-specific enhancer design

   Alyssa J Lawler et al.

   A new cross-species machine learning-based strategy is applied to find enhancers that specifically label parvalbumin neurons in the mouse and macaque.
7. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Transcription elongation is finely tuned by dozens of regulatory factors

   Mary Couvillion et al.
8. 1. Evolutionary Biology
   2. Genetics and Genomics

   Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species

   Osvaldo Villa et al.

   Leveraging the US Health and Retirement Study and C. elegans genetics reveals ALDH4A1/alh-6 as an evolutionarily conserved biomarker for normal muscle function over the lifespan.
9. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid genome diversification

   Gabriel Machado Matos et al.

   Unique mechanisms of genetic exchange in the important protozoan pathogen Trypanosome cruzi were characterized in detail using genome analyses of hybrid clones at different time points, showing initial tetraploids followed by genome erosion.
10. 1. Genetics and Genomics
    2. Neuroscience

    Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

    Xinrui L Zhang et al.

    Terminal selectors reorganize postmitotic neuronal chromatin to select cis-regulatory elements during 5-HT neuron maturation.