Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   Human genetic analyses of organelles highlight the nucleus in age-related trait heritability

   Rahul Gupta et al.

   Although cellular organelles show a functional deterioration in aging, genetic loci associated with common age-associated disease instead nominate nuclear transcription factors across several age-related diseases.
2. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Comparison of transcriptional initiation by RNA polymerase II across eukaryotic species

   Natalia Petrenko, Kevin Struhl

   Although the preinitiation complex for transcriptional initiation by RNA polymerase II contains highly conserved general transcription factors, there are kinetic and compositional differences in the initiation process among eukaryotic species.
3. 1. Genetics and Genomics

   NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants

   Gabriel A Guerrero et al.

   Separate genetic pathways mediate longevity, pathogen resistance, and cell-nonautonomous regulation of xenobiotic detoxification in chemosensory defective Caenorhabditis elegans mutants.
4. 1. Epidemiology and Global Health
   2. Genetics and Genomics

   A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

   Mohd Anisul et al.

   Genetic integration of human protein abundance variation and COVID-19 susceptibility identifies proteins with potential causal roles in antiviral responses, coagulation, cytokine activation, and direct receptor interactions with SARS-CoV-2.
5. 1. Genetics and Genomics

   The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae

   Clara Bouyx et al.

   The role of amyloid-β-aggregation sequence and of the various domains in the physiological function of the FLO11-encoded adhesin in the yeast Saccharomyces cerevisiae are disclosed in this report.
6. 1. Genetics and Genomics
   2. Neuroscience

   A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

   Gha-Hyun J Kim et al.

   In vivo dopamine neuron imaging-based neuroprotective small molecule screen in larval zebrafish and mechanistic investigation using conditional CRISPR knockout and cell-type-specific RNA-seq analysis, coupled with cross-species analyses including human clinical data interrogation, uncover potential disease-modifying therapeutics for Parkinson's disease (PD).
7. 1. Evolutionary Biology
   2. Genetics and Genomics

   The whale shark genome reveals patterns of vertebrate gene family evolution

   Milton Tan et al.

   The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.
8. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   A prion accelerates proliferation at the expense of lifespan

   David M Garcia et al.

   In its capacity to switch into a heritable, prionogenic form, a conserved RNA-modifying enzyme epigenetically alters fundamental growth, aging, and protein synthesis properties of eukaryotic cells.
9. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Variation in human herpesvirus 6B telomeric integration, excision and transmission between tissues and individuals

   Michael L Wood et al.
10. 1. Cell Biology
    2. Genetics and Genomics

    Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage

    Regina Rillo-Bohn et al.

    Investigation of meiosis in the nematode Pristionchus pacificus has illuminated evolutionary variation in this essential aspect of reproduction and established a new model for future study.