Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Genetics and Genomics
    2. Neuroscience

    Atherosclerosis, Intracranial Aneurysms, and Intermediate Biomarkers: Real-World Observational and Mendelian Randomization Research

    Wei Liu, Zhaoxu Zheng ... Dong Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcriptional coregulation in cis around a contact insulation site revealed by single-molecule microscopy

    Maciej A Kerlin, Ilham Aboulfath-Ladid ... Antoine Coulon
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology
    2. Genetics and Genomics

    Kinesin Autoinhibition Requires Elbow Phosphorylation

    Guanghan Chen, Zhengyang Guo ... Guangshuo Ou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Genetics and Genomics

    Molecular requirements for C. elegans transgenerational epigenetic inheritance of pathogen avoidance

    Rachel Kaletsky, Rebecca S Moore ... Coleen T Murphy
    Deviating from established protocols is the most likely reason why Gainey et al. (2024) could not reproduce earlier results in a Caenorhabditis elegans transgenerational inheritance paradigm, and the earlier findings are also supported by tests with over 30 new genes.
    Version of Record
    Short Report
    • Fundamental
    • Compelling
    1. Genetics and Genomics
    2. Neuroscience

    Rapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis

    Johanna Ganssauge, Sophie Hawkins ... Akshay Bhinge
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cancer Biology
    2. Genetics and Genomics

    Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer

    Arkajyoti Bhattacharya, Thijs S Stutvoet ... Rudolf SN Fehrmann
    Independent component analysis of ovarian cancer transcriptomes reveals distinct transcriptional patterns associated with overall survival.
    1. Developmental Biology
    2. Genetics and Genomics

    The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo

    Mengyang Shi, Jie Li ... Bin Zhou
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs

    Jiro Yoshino, Sonali S Mali ... Jay Z Parrish
    Epidermal mechanosensory responses contribute to acute detection of noxious mechanical stimuli and promote a form of prolonged mechanical hypersensitivity.
    1. Genetics and Genomics
    2. Neuroscience

    Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease

    Zachary Gaertner, Cameron Oram ... Rajeshwar Awatramani
    A high-resolution atlas of the mouse dopaminergic system was obtained using single-nuclei RNA sequencing and spatial transcriptomics revealing molecular changes in a prodromal model of Parkinson's disease.
    1. Genetics and Genomics
    2. Neuroscience

    Pain: Epidermal cells and sensory neurons team up

    Jean-Christophe Boivin, Tomoko Ohyama
    Experiments in fruit fly larvae show that epidermal cells can communicate with sensory neurons to drive responses to pain.
    Version of Record
    Insight
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Highlights

    1. Genetics and Genomics
    2. Neuroscience

    Responding to pain

    Jean-Christophe Boivin, Tomoko Ohyama
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

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Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
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