Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Global genome diversity of the Leishmania donovani complex

   Susanne U Franssen et al.

   Genomic data for the parasites that cause visceral leishmaniasis provides the first global picture of the diversity and evolution of the pathogen and the epidemiology of this fatal tropical disease.
2. 1. Genetics and Genomics

   Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria

   Tracy L McGregor et al.
3. 1. Genetics and Genomics

   Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity

   Nicholas Sciascia et al.

   Analysis of genome integrity in primary murine B-cells reveals how depleting 26S proteasome activity enhanced cell survival following treatment with topoisomerase poisons.
4. 1. Genetics and Genomics
   2. Neuroscience

   Identification of a molecular basis for the juvenile sleep state

   Leela Chakravarti Dilley et al.
5. 1. Genetics and Genomics

   Science Forum: The single-cell eQTLGen consortium

   MGP van der Wijst et al.

   The single-cell eQTLGen consortium aims to pinpoint the cellular contexts in which disease-causing genetic variants affect gene expression and its regulation.
6. 1. Genetics and Genomics
   2. Immunology and Inflammation

   PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation

   Kenneth T Farabaugh et al.
7. 1. Evolutionary Biology
   2. Genetics and Genomics

   The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress

   Marco Fumasoni, Andrew W Murray

   Evolutionary adaptation to a constitutive perturbation of DNA replication reveals that adaptive mutations in three conserved pathways interact to restore faithful chromosome replication and segregation.
8. 1. Evolutionary Biology
   2. Genetics and Genomics

   Comprehensive fitness maps of Hsp90 show widespread environmental dependence

   Julia M Flynn et al.

   Environmental conditions strongly impact the fitness effects of Hsp90, resulting in the selection of Hsp90 sequences in nature that are robust to a variety of stressful conditions.
9. 1. Genetics and Genomics

   Polygenic Scores: It is time to get real when trying to predict educational performance

   Cecile Janssens

   A study of 3,500 children in the UK shows that data on socioeconomic background and previous educational achievements can better predict how students will perform at school than genetic data.
10. 1. Genetics and Genomics

    Variable prediction accuracy of polygenic scores within an ancestry group

    Hakhamanesh Mostafavi et al.

    The prediction accuracies of polygenic scores in humans vary depending on the characteristics of the samples, as well as based on the study design, within a single ancestry group.