Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   Closely related type II-C Cas9 orthologs recognize diverse PAMs

   Jingjing Wei et al.
2. 1. Cell Biology
   2. Genetics and Genomics

   Circadian oscillations in Trichoderma atroviride and the role of core clock components in secondary metabolism, development, and mycoparasitism against the phytopathogen Botrytis cinerea

   Marlene Henríquez-Urrutia et al.
3. 1. Cancer Biology
   2. Genetics and Genomics

   Unsupervised detection of fragment length signatures of circulating tumor DNA using non-negative matrix factorization

   Gabriel Renaud et al.

   Non-negative Matrix Factorization is a powerful strategy for unsupervised analysis of cell-free DNA that enables simultaneous estimation of the blood tumor fraction and the fragment length distribution of circulating tumor DNA.
4. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

   Liselot Dewachter et al.

   High-throughput single-cell based, genome-wide gene silencing screening (sCRilecs-seq) revealed that drugging the mevalonate pathway resensitizes amoxicillin-resistant pneumococci.
5. 1. Genetics and Genomics

   Nomograms of human hippocampal volume shifted by polygenic scores

   Mohammed Janahi et al.
6. 1. Cell Biology
   2. Genetics and Genomics

   The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat

   Shawn P Shortill et al.
7. 1. Evolutionary Biology
   2. Genetics and Genomics

   Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye

   Henrike Indrischek et al.

   Specific evolutionary gene loss signatures indicated an eye-related function for the uncharacterized SERPINE3 gene, which was experimentally confirmed by zebrafish gene knockouts, showing how comparative genomics can provide insights into the function of uncharacterized genes.
8. 1. Evolutionary Biology
   2. Genetics and Genomics

   Evolution: Poor eyesight reveals a new vision gene

   Tathagata Biswas et al.

   Comparing the genomes of mammals which evolved to have poor vision identifies an important gene for eyesight.
9. 1. Cell Biology
   2. Genetics and Genomics

   Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation

   Anthony J Veltri et al.

   Genetic screens and functional assays utilizing reporter mRNAs triggering NGD or COMD provide a basis for understanding the unique contributions of each pathway to translation-coupled mRNA decay and contextualizes their effects in the larger cellular process of translation surveillance.
10. 1. Ecology
    2. Genetics and Genomics

    Genomic evidence for global ocean plankton biogeography shaped by large-scale current systems

    Daniel J Richter et al.

    Analysis of genomic DNA composition of surface plankton communities reveals a stable, ocean basin-scale plankton biogeography that emerges from the intertwined effects of environmental variations and currents.