Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

   Angela Schulz et al.

   Genetic and functional studies reveal a previously unrecognized role for a transmembrane protein in glomerular filtration barrier function.
2. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Functional evaluation of transposable elements as enhancers in mouse embryonic and trophoblast stem cells

   Christopher D Todd et al.
3. 1. Cancer Biology
   2. Genetics and Genomics

   Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA

   Jin Xu et al.

   Epigenome and Mitochondrial Barcode of Lineage from Endogenous Mutations (EMBLEM) enable tracking cell lineage in combination with chromatin profile in ATAC-seq data.
4. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency

   Maxim Van Cleef Greenberg et al.
5. 1. Cancer Biology
   2. Genetics and Genomics

   Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

   Jianing Xu et al.

   A distinct class of kidney tumors is characterized not by patterns of somatic mutations, but by a distinct metabolism.
6. 1. Cell Biology
   2. Genetics and Genomics

   Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity

   Nicolas J Lehrbach, Gary Ruvkun

   SKN-1A/Nrf1 promotes healthy aging by activating protein degradation in response to accumulation of misfolded proteins.
7. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Panton–Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS

   Bernadette C Young et al.

   Genome-wide association studies have established staphylococcal pyomyositis as a disease whose pathogenesis depends critically on expression of a single toxin, Panton–Valentine leukocidin.
8. 1. Evolutionary Biology
   2. Genetics and Genomics

   Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

   Stefan Zdraljevic et al.

   Quantitative genetics approaches using Caenorhabditis elegans facilitate the discovery of a novel arsenic toxicity mechanism.
9. 1. Evolutionary Biology
   2. Genetics and Genomics

   Population Genetics: Why structure matters

   Nick Barton et al.

   Great care is needed when interpreting claims about the genetic basis of human variation based on data from genome-wide association studies.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

    Mashaal Sohail et al.

    Polygenic selection signals in humans estimated from previously existing GWAS should be viewed with caution due to concerns about residual population stratification.