Genetics and Genomics

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Chromatin accessibility dynamics across C. elegans development and ageing

   Jürgen Jänes et al.

   Profiling chromatin accessibility and nuclear transcription across Caenorhabditis elegans development and ageing generated the first map of transcriptional regulatory elements and their activities across an animal's life.
2. 1. Developmental Biology
   2. Genetics and Genomics

   Zygotic gene activation in the chicken occurs in two waves, the first involving only maternally derived genes

   Young Sun Hwang et al.
3. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Organisms with alternative genetic codes resolve unassigned codons via mistranslation and ribosomal rescue

   Natalie Jing Ma et al.

   Cells resolve unassigned codons with near-cognate suppression, frameshifting, and ribosomal rescue mechanisms, demonstrating that unassigned codons are permissible in both natural and engineered genetic codes as barriers to horizontal gene transfer.
4. 1. Genetics and Genomics

   Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

   Niko Välimäki et al.

   Genetic predisposition to uterine leiomyomas arises from variation at loci for genetic stability and genitourinary development, and in part explains the frequent occurrence of the condition in women with African origin.
5. 1. Genetics and Genomics

   Genome-wide Association Study: Not so benign

   Barbara Rivera

   Susceptibility to uterine fibroids, benign tumors that affect the health of many women, is linked to genes that are responsible for preserving genome integrity and promoting genitourinary development.
6. 1. Genetics and Genomics

   Differing isoforms of the cobalamin binding photoreceptor AerR oppositely regulate photosystem expression

   Haruki Yamamoto et al.

   A novel B12 containing photoreceptor is synthesized as two different isoforms that interact with the same transcription factor, with one isoform directing activation and the other promoting repression of photosystem synthesis.
7. 1. Developmental Biology
   2. Genetics and Genomics

   2018 Gairdner Awards: The discovery and importance of genomic imprinting

   Anne C Ferguson-Smith, Deborah Bourc'his

   Research into genomic imprinting has provided a foundation for the study of epigenetic mechanisms, especially during development, and has also shed light on a range of rare genetic disorders and common diseases.
8. 1. Computational and Systems Biology
   2. Genetics and Genomics

   A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast

   David G Hendrickson et al.
9. 1. Genetics and Genomics

   Firefly genomes illuminate parallel origins of bioluminescence in beetles

   Timothy R Fallon et al.

   The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Brain Size: Gene losses did not stop the evolution of big brains

    Cristian Cañestro, Vittoria Roncalli

    Elephants and fruit bats have evolved large brains even though they have lost a gene that is fundamental to the supply of energy to the brain when glucose is not available.