Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   The Photorhabdus asymbiotica virulence cassettes deliver protein effectors directly into target eukaryotic cells

   Isabella Vlisidou et al.

   The insect pathogenic bacterium Photorhabdus has evolved astonishing nano-scale analogues of hypodermic syringes that it uses to inject toxins into host cells.
2. 1. Genetics and Genomics
   2. Plant Biology

   Epigenetic silencing of a multifunctional plant stress regulator

   Mark Zander et al.

   Interplay between histone demethylation and chromatin remodeling shapes the chromatin environment of the essential stress regulator ETHYLENE-INSENSITIVE2.
3. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   A genetic selection reveals functional metastable structures embedded in a toxin-encoding mRNA

   Sara Masachis et al.

   A genetic selection of toxicity suppressors coupled to high-throughput sequencing has captured metastable RNA structures that co-transcriptionally inhibit the translation of a bacterial toxin.
4. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Interferon lambda 4 impacts the genetic diversity of hepatitis C virus

   M Azim Ansari et al.

   Interferon lambda 4, a protein part of the innate immune response, drives major amino acids selection in patients chronically infected with hepatitis C virus.
5. 1. Genetics and Genomics

   Single-amino acid variants reveal evolutionary processes that shape the biogeography of a global SAR11 subclade

   Tom O Delmont et al.

   An in-depth metagenomic analysis of possibly the most abundant and widespread microbial lineage in the surface ocean teases apart evolutionary processes that maintain its genomic heterogeneity and biogeography.
6. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Host-Pathogen Interactions: What makes the hepatitis C virus evolve?

   Thomas R O'Brien et al.

   Polymorphisms in the IFNL4 gene that affect both the form and the activity of the coded protein are associated with changes in the hepatitis C virus.
7. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes

   Nimisha Chaturvedi et al.

   Integrated analysis of IFN-λ and HCV amino acid variation indicates the key role of host innate immunity in viral control.
8. 1. Evolutionary Biology
   2. Genetics and Genomics

   Spermatogenesis: A hotspot for new genes

   Anne-Marie Dion-Côté

   Single-cell RNA-sequencing in fruit flies gives an unprecedented picture of how new genes are expressed during the formation of sperm.
9. 1. Genetics and Genomics
   2. Neuroscience

   Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans

   Yung-Chi Huang et al.

   Caenorhabditis elegans studies indicate that gain-of-function mutations in the presynaptic voltage-gated calcium, associated with familial hemiplegic migraine in humans, result in excitatory-inhibitory imbalance in the nervous system.
10. 1. Genetics and Genomics

    Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

    Yue Zhang et al.

    Modulating the nutrient sensor TORC1 only in neurons in C. elegans is sufficient to regulate systemic longevity via inter-tissue signals that remodel mitochondria networks in non neuronal cells.