Genetics and Genomics

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Genome plasticity in Candida albicans is driven by long repeat sequences

   Robert T Todd et al.

   Previously uncharacterized long repeat sequences are associated with significant genome variation that can increase fitness and promote antifungal drug resistance in diverse isolates of Candida albicans.
2. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Improved CUT&RUN chromatin profiling tools

   Michael P Meers et al.
3. 1. Developmental Biology
   2. Genetics and Genomics

   Thyroid hormone regulates distinct paths to maturation in pigment cell lineages

   Lauren M Saunders et al.

   Single-cell transcriptomics combined with genetic analyses identify post-embryonic neural crest subpopulations and thyroid hormone dependencies in zebrafish adult pigment pattern development.
4. 1. Genetics and Genomics

   The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

   Karole N D'Orazio et al.
5. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Communication between distinct subunit interfaces of the cohesin complex promotes its topological entrapment of DNA

   Vincent Guacci et al.

   The interface formed where Smc3p and Mcd1p bind each other regulates cohesin DNA binding and cohesion by a mechanism independently from its putative role as a DNA exit gate.
6. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research

   Franziska Mohring et al.

   Optimised genome editing in P. knowlesi enables transgenic expression of a lead P. vivax vaccine candidate, revealing roles in host cell tropisms and providing tools for scalable vaccine efficacy testing.
7. 1. Evolutionary Biology
   2. Genetics and Genomics

   Predominance of cis-regulatory changes in parallel expression divergence of sticklebacks

   Jukka-Pekka Verta, Felicity C Jones

   Cis-regulation such as enhancers and promoters plays a major role in parallel gene expression divergence and has features that make it a well-poised substrate for adaptive evolution.
8. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Global donor and acceptor splicing site kinetics in human cells

   Leonhard Wachutka et al.

   Transient transcriptome sequencing and kinetic modeling suggest how the kinetics and yield of RNA splicing are encoded in the human genome.
9. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   A combination of transcription factors mediates inducible interchromosomal contacts

   Seungsoo Kim et al.

   A pooled mutational scanning approach for 3D chromosome conformation reveals how multiple transcription factors can jointly specify condition-specific genome conformations.
10. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Functional evaluation of transposable elements as enhancers in mouse embryonic and trophoblast stem cells

    Christopher D Todd et al.

    Genetic and epigenetic editing experiments establish causal links between transposon-derived enhancers and gene regulation in mouse embryonic and extraembryonic lineages.