Genetics and Genomics

Genetics and Genomics

eLife publishes research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans

    Meng Huang, Minjie Hong ... Xuezhu Feng
    The depletion of a new class of putative histone methyltransferases, including MET-2, SET-6, SET-19, SET-20, SET-21, SET-32, and SET-33, induced synergistic lifespan extension in daf-2 animals to an average lifespan nearly three times that of wild-type animals.
    1. Cell Biology
    2. Genetics and Genomics

    Resurrecting essential amino acid biosynthesis in mammalian cells

    Julie Trolle, Ross M McBee ... Harris H Wang
    1. Developmental Biology
    2. Genetics and Genomics

    Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves

    Melanie MY Chan, Omid Sadeghi-Alavijeh ... Daniel P Gale
    A genome-wide association study using whole-genome sequencing data identifies the first known susceptibility genes for posterior urethral valves, the most common cause of kidney failure in boys, implicating the transcription factor TBX5 and planar cell polarity gene PTK7.
    1. Developmental Biology
    2. Genetics and Genomics

    Fibroblast-derived Hgf controls recruitment and expansion of muscle during morphogenesis of the mammalian diaphragm

    Elizabeth M Sefton, Mirialys Gallardo ... Gabrielle Kardon
    HGF derived from fibroblasts is critical for complete muscularization of the mammalian diaphragm, and loss-of-function experiments reveal that partial muscularization of the diaphragm is not sufficient to cause congenital diaphragmatic hernias.
    1. Cell Biology
    2. Genetics and Genomics

    The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat

    Shawn P Shortill, Mia S Frier ... Elizabeth Conibear
    The yeast VARP homolog forms a new sorting nexin complex that promotes its own membrane recruitment through GEF activity and regulates the distribution of endosomal proteins.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Most cancers carry a substantial deleterious load due to Hill-Robertson interference

    Susanne Tilk, Svyatoslav Tkachenko ... Christopher D McFarland
    The absence of negative selection observed in most cancer genomes can be explained by the intrinsic genome-wide linkage in somatic evolution and creates a substantial proteotoxic load.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Fitness effects of CRISPR endonucleases in Drosophila melanogaster populations

    Anna M Langmüller, Jackson Champer ... Philipp W Messer

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  3. Murim Choi
    Seoul National University College of Medicine, South Korea
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