Genetics and Genomics

Genetics and Genomics

eLife publishes research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Developmental Biology
    2. Genetics and Genomics

    Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology

    Elizabeth A Bearce, Zoe H Irons ... Daniel T Grimes
    1. Cell Biology
    2. Genetics and Genomics

    Unleashing a novel function of Endonuclease G in mitochondrial genome instability

    Sumedha Dahal, Humaira Siddiqua ... Sathees C Raghavan
    A new role for Endonuclease G with respect to the generation of mtDNA deletions is identified, which is dependent on the formation of G4 DNA within human mitochondria.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans

    Benjamin J Chadwick, Tuyetnhu Pham ... Xiaorong Lin
    In the fungal pathogen Cryptococcus neoformans, the RAM pathway, potentially through post-transcriptional regulation, plays an essential role in adaptation to host temperature and CO2.
    1. Developmental Biology
    2. Genetics and Genomics

    Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver-Russell syndrome-like mouse models

    Suhee Chang, Diana Fulmer ... Marisa S Bartolomei
    Precise dosage of the imprinted H19 and Igf2 genes is critical for normal embryonic development, especially related to the cardiac-placental axis.
    1. Genetics and Genomics

    The genetic risk of gestational diabetes in South Asian women

    Amel Lamri, Jayneel Limbachia ... Sonia S Anand
    A type 2 diabetes polygenic risk score and family history of diabetes are strongly and independently associated with multiple gestational diabetes-related traits in women of South Asian descent.
    1. Genetics and Genomics

    Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice

    Yanis Zekri, Romain Guyot ... Karine Gauthier
    T3 regulates BAT thermogenesis by controlling the expression of genes involved in the management of metabolic fuels as well as tissue plasticity.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation after a sudden change in environment

    Laura Katharine Hayward, Guy Sella
    A shift in fitness optimum of a polygenic trait rapidly introduces small frequency differences between alleles with effects aligned with and opposing the shift, which gradually translate into small differences in fixation probability.

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  3. Murim Choi
    Seoul National University College of Medicine, South Korea
  4. See more editors