Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Genetics and Genomics

    Convergent evolution of epigenome recruited DNA repair across the Tree of Life

    J Grey Monroe, Chaehee Lee ... Daniel Runcie
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction system

    Ozanna Burnicka-Turek, Katy A Trampel ... Ivan P Moskowitz
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Household clustering and seasonal genetic variation of Plasmodium falciparum at the community-level in The Gambia

    Marc-Antoine Guery, Sukai Ceesay ... Antoine Claessens
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Neuroscience

    Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation

    Tanya Wolff, Mark Eddison ... Gerald M Rubin
    Genetic tools were generated and used to determine the neurotransmitters and neuropeptides used by individual cell types within the Drosophila central complex and to study their roles in sleep regulation.
    1. Cancer Biology
    2. Genetics and Genomics

    Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

    Tackhoon Kim, Byung-Sun Park ... Timothy Lu
    Pairwise CRISPR screen identified FYN and KDM4 as key regulator of tyrosine kinase inhibitor resistance in triple negative breast cancer (TNBC).
    1. Genetics and Genomics
    2. Neuroscience

    Antagonist actions of CMK-1/CaMKI and TAX-6/Calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli

    Martina Rudgalvyte, Zehan Hu ... Dominique A Glauser
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

    Laura S Kremer, Guanbin Gao ... Nils-Göran Larsson
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Evolutionary Biology
    2. Genetics and Genomics

    The potential of inversions to accumulate balanced sexual antagonism is supported by simulations and Drosophila experiments

    Christopher S McAllester, John E Pool
    Sexually antagonistic pleiotropy involving frequency-dependent traits like mating display maintains linkage blocks like inversions as balanced polymorphisms in simulation, and may explain common inversion polymorphisms maintained at intermediate frequencies.
    1. Cancer Biology
    2. Genetics and Genomics

    Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity

    Hirokazu Kimura, Kamel Lahouel ... Nicholas Jason Roberts
    High-throughput characterization of all possible CDKN2A missense variants identifies functionally deleterious variants and establishes accuracy of variant effect predictors.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans

    Yixuan Jiang, Ying Liang ... Youbao Zhao
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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Highlights

    1. Genetics and Genomics
    2. Neuroscience

    Targeting single neurons

    Brandon L Holder, Stephane Dissel
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

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    1. Genetics and Genomics
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Senior editors

  1. Murim Choi
    Seoul National University College of Medicine, South Korea
  2. Yamini Dalal
    National Cancer Institute, United States
  3. Adèle L Marston
    University of Edinburgh, United Kingdom
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