Genetics and Genomics

Latest articles

1. 1. Cell Biology
   2. Genetics and Genomics

   Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

   Maja Kneissig et al.

   A method to generate human cells with massive chromosomal aberrations on a specific chromosome allows analysis of their consequences.
2. 1. Genetics and Genomics
   2. Human Biology and Medicine

   Single cell transcriptional signatures of the human placenta in term and preterm parturition

   Roger Pique-Regi et al.
3. 1. Genetics and Genomics

   Novel genetic loci affecting facial shape variation in humans

   Ziyi Xiong et al.

   A comprehensive genome scan of 18,000 multi-ethnic individuals with 3-dimensional facial images highlighted multiple face-associated genetic loci for which regulatory activities in human neural cells were established.
4. 1. Genetics and Genomics

   Diversification of the Caenorhabditis heat shock response by Helitron transposable elements

   Jacob M Garrigues et al.
5. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease

   Matteo D'Antonio et al.

   Analysis of the major histocompatibility complex using whole genome sequencing and RNA-seq data from hundreds of individuals provides novel insights into mechanisms underlying associations of this interval with disease.
6. 1. Evolutionary Biology
   2. Genetics and Genomics

   Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome

   Andrew B Morgenthaler et al.
7. 1. Genetics and Genomics
   2. Neuroscience

   Probe-Seq enables transcriptional profiling of specific cell types from heterogeneous tissue by RNA-based isolation

   Ryoji Amamoto et al.

   Probe-Seq is a cell type specific bulk RNA sequencing method that can be applied to a wide-ranging tissue types from both vertebrates and invertebrates without genetic labeling.
8. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans

   Teresa W Lee et al.
9. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126

   Nealia CM House et al.
10. 1. Genetics and Genomics

    Extensive impact of low-frequency variants on the phenotypic landscape at population-scale

    Téo Fournier et al.

    Genome-wide association studies on a diallel yeast panel revealed the relevance of low-frequency variants on the phenotypic diversity and consequently on the missing heritability at a population-scale.