Genetics and Genomics

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans

   Meng Huang, Minjie Hong ... Xuezhu Feng

   The depletion of a new class of putative histone methyltransferases, including MET-2, SET-6, SET-19, SET-20, SET-21, SET-32, and SET-33, induced synergistic lifespan extension in daf-2 animals to an average lifespan nearly three times that of wild-type animals.
2. 1. Cell Biology
   2. Genetics and Genomics

   Resurrecting essential amino acid biosynthesis in mammalian cells

   Julie Trolle, Ross M McBee ... Harris H Wang
3. 1. Developmental Biology
   2. Genetics and Genomics

   Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves

   Melanie MY Chan, Omid Sadeghi-Alavijeh ... Daniel P Gale

   A genome-wide association study using whole-genome sequencing data identifies the first known susceptibility genes for posterior urethral valves, the most common cause of kidney failure in boys, implicating the transcription factor TBX5 and planar cell polarity gene PTK7.
4. 1. Cell Biology
   2. Genetics and Genomics

   Differential requirements for mitochondrial electron transport chain components in the adult murine liver

   Nicholas P Lesner, Xun Wang ... Prashant Mishra
5. 1. Developmental Biology
   2. Genetics and Genomics

   Fibroblast-derived Hgf controls recruitment and expansion of muscle during morphogenesis of the mammalian diaphragm

   Elizabeth M Sefton, Mirialys Gallardo ... Gabrielle Kardon

   HGF derived from fibroblasts is critical for complete muscularization of the mammalian diaphragm, and loss-of-function experiments reveal that partial muscularization of the diaphragm is not sufficient to cause congenital diaphragmatic hernias.
6. 1. Evolutionary Biology
   2. Genetics and Genomics

   Polygenic adaptation after a sudden change in environment

   Laura Katharine Hayward, Guy Sella
7. 1. Cell Biology
   2. Genetics and Genomics

   The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat

   Shawn P Shortill, Mia S Frier ... Elizabeth Conibear

   The yeast VARP homolog forms a new sorting nexin complex that promotes its own membrane recruitment through GEF activity and regulates the distribution of endosomal proteins.
8. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Rapid, reference-free human genotype imputation with denoising autoencoders

   Raquel Dias, Doug Evans ... Ali Torkamani
9. 1. Evolutionary Biology
   2. Genetics and Genomics

   Most cancers carry a substantial deleterious load due to Hill-Robertson interference

   Susanne Tilk, Svyatoslav Tkachenko ... Christopher D McFarland

   The absence of negative selection observed in most cancer genomes can be explained by the intrinsic genome-wide linkage in somatic evolution and creates a substantial proteotoxic load.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Fitness effects of CRISPR endonucleases in Drosophila melanogaster populations

    Anna M Langmüller, Jackson Champer ... Philipp W Messer