Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60

   Chun Kew et al.

   The splicing factor RNP-6/PUF60 suppresses immunity by modulating host splicing and transcriptional responses to infection.
2. 1. Evolutionary Biology
   2. Genetics and Genomics

   Predicting geographic location from genetic variation with deep neural networks

   CJ Battey et al.

   Neural networks allow fast and accurate prediction of individual spatial locations from genotypes or sequencing data.
3. 1. Genetics and Genomics

   A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21

   Yasuhiro Kazuki et al.
4. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   The Role of Rif1 in telomere length regulation is separable from its role in origin firing

   Calla B Shubin, Carol W Greider
5. 1. Genetics and Genomics

   Alternative polyadenylation mediates genetic regulation of gene expression

   Briana E Mittleman et al.
6. 1. Cell Biology
   2. Genetics and Genomics

   The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair

   Tao Huang et al.

   ZCWPW1 is a histone modification reader that localizes to DMC1-labelled double-strand break hotspots in a largely PRDM9-dependent manner, where it facilitates completion of synapsis by mediating DSB repair process.
7. 1. Developmental Biology
   2. Genetics and Genomics

   Genome editing enables reverse genetics of multicellular development in the choanoflagellate Salpingoeca rosetta

   David S Booth, Nicole King

   Genome editing in the choanoflagellate Salpingoeca rosetta opens newfound possibilities to functionally probe choanoflagellate genes that may illuminate the origin of their closest relatives, the animals.
8. 1. Genetics and Genomics
   2. Neuroscience

   A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

   Benjamin W Okaty et al.

   Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
9. 1. Cell Biology
   2. Genetics and Genomics

   A trans-eQTL network regulates osteoclast multinucleation and bone mass

   Marie Pereira et al.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Genomic and phenotypic evolution of Escherichia coli in a novel citrate-only resource environment

    Zachary D Blount et al.

    Transposable elements and gene amplifications can provide variation needed for novel trait refinement and adaptation to new niches, though a recalcitrant organism-environment mismatch may persist.