Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   Molecular safeguarding of CRISPR gene drive experiments

   Jackson Champer et al.
2. 1. Evolutionary Biology
   2. Genetics and Genomics

   Immune genes are hotspots of shared positive selection across birds and mammals

   Allison J Shultz, Timothy B Sackton

   Pathogens, particularly viruses, target the same genes over deep evolutionary time, resulting in shared signatures of positive selection and transcriptional responses at the same genes.
3. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Fine-mapping cis-regulatory variants in diverse human populations

   Ashley Tehranchi et al.

   A map of the genetic variants affecting chromatin accessibility in 1000 individuals from 10 diverse populations reveals how cis-regulatory variants impact transcription and disease.
4. 1. Genetics and Genomics
   2. Stem Cells and Regenerative Medicine

   Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons

   Chongyuan Luo et al.

   Induced neuronal cells acquire epigenomic signatures specific to matured neurons.
5. 1. Genetics and Genomics

   Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

   Paul RHJ Timmers et al.

   Genomic associations with lifespan principally reflect heart disease/smoking/dementia but not other cancers, and distinguish lifespan differences of five years between top/bottom deciles of a score derived from DNA alone.
6. 1. Genetics and Genomics
   2. Human Biology and Medicine

   Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of FSHD

   Sujatha Jagannathan et al.
7. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Meiotic drive of female-inherited supernumerary chromosomes in a pathogenic fungus

   Michael Habig et al.

   Female-inherited supernumerary chromosomes that lack a male-inherited homolog are transmitted to all meiotic products instead of the expected half, which indicates an additional amplification of unpaired chromosomes during meiosis.
8. 1. Genetics and Genomics

   Single cell functional genomics reveals the importance of mitochondria in cell-to-cell phenotypic variation

   Riddhiman Dhar et al.
9. 1. Genetics and Genomics
   2. Stem Cells and Regenerative Medicine

   The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

   Cheen Euong Ang et al.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Drought adaptation in Arabidopsis thaliana by extensive genetic loss-of-function

    J Grey Monroe et al.

    Gene knockouts provide valuable genetic fuel for climate adaptation in nature.