Genetics and Genomics

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   5' modifications improve potency and efficacy of DNA donors for precision genome editing

   Krishna S Ghanta et al.
2. 1. Genetics and Genomics
   2. Neuroscience

   The structure of behavioral variation within a genotype

   Zachary Werkhoven et al.

   Multidimensional analysis of data from high-throughput behavioral assays reveals many independent axes of behavioral variation among inbred animals reared in the same environment.
3. 1. Genetics and Genomics

   Ssl2/TFIIH function in transcription start site scanning by RNA Polymerase II in Saccharomyces cerevisiae

   Tingting Zhao et al.
4. 1. Evolutionary Biology
   2. Genetics and Genomics

   Evolutionary dynamics of circular RNAs in primates

   Gabriela Santos-Rodriguez et al.

   An analysis of the genomic features that distinguish conserved from species-specific circular RNAs reveals that the expansion of the downstream intron by insertion of retrotransposons stabilizes circular RNAs' production across 30+ millions years of evolution.
5. 1. Evolutionary Biology
   2. Genetics and Genomics

   Circular RNA repertoires are associated with evolutionarily young transposable elements

   Franziska Gruhl et al.

   Evolutionary analyses suggest that most mammalian circRNAs did not emerge from common ancestral circRNA precursors, arguing against widespread functional conservation.
6. 1. Genetics and Genomics

   The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila

   Brian Brown et al.

   The transcription factor Xrp1 mediates a previously unrecognized branch of stress-response signaling, specifically as a downstream effector of eIF2alpha kinases.
7. 1. Developmental Biology
   2. Genetics and Genomics

   Tbx5 drives aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

   Scott A Rankin et al.
8. 1. Genetics and Genomics

   Utility of polygenic embryo screening for disease depends on the selection strategy

   Todd Lencz et al.

   Preimplantation screening of embryos using polygenic risk scores may substantially reduce risk for a given complex disease, but this effect depends on several quantifiable factors and raises significant ethical issues.
9. 1. Genetics and Genomics

   Polygenic Screening: What’s the use?

   Jason M Fletcher et al.

   A theoretical framework predicts that using polygenic screening to select embryos against traits that depend on many genes has few benefits.
10. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression

    Pamela Himadewi et al.

    The 3'HS1 CTCF binding site directly modulates chromosomal loops to regulate γ-globin expression through the accession of the hereditary persistence of fetal hemoglobin enhancer.