Genetics and Genomics

Latest articles

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Downregulation of glial genes involved in synaptic function mitigates Huntington's Disease pathogenesis

   Tarik Seref Onur et al.
2. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo

   Thomas J Etheridge et al.
3. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Improving oligo-conjugated antibody signal in multimodal single-cell analysis

   Terkild B Buus et al.

   Oligo-conjugated antibodies are a powerful tool but require thorough optimization to reduce background signal, increase sensitivity, and reduce sequencing costs.
4. 1. Genetics and Genomics

   Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement

   Astrid Hoermann et al.

   Minimal genetic modifications of endogenous mosquito genes allow the tissue-specific expression of anti-malarial effectors and convert them into efficient non-autonomous gene drives.
5. 1. Developmental Biology
   2. Genetics and Genomics

   Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose

   Zhejun Ji et al.

   Cell competition is an important mechanism selecting against aneuploid cells.
6. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

   Tingting Wang et al.

   The transcription factor (TF)-binding specificities of Pseudomonas aeruginosa allow us to predict virulence-associated TFs and their target genes, which will facilitate to find effective treatment and prevention for its associated diseases.
7. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq

   Elliott Swanson et al.

   Simultaneous multimodal measurement of chromatin accessibility, gene expression, and protein expression provides a unified view of the molecular underpinnings of immune cell state in health and disease.
8. 1. Evolutionary Biology
   2. Genetics and Genomics

   Ancient DNA reveals the lost domestication history of South American camelids in Northern Chile and across the Andes

   Paloma Diaz-Maroto et al.

   aDNA revealed a model of domestication where an ancient guanaco population no longer exists, the loss of the ancient vicuña genetic variation in the modern populations, and frequently interbreeding practices.
9. 1. Genetics and Genomics

   

   Quantitative Genetics: A Collection of Articles

   Edited by Patricia Wittkopp et al.

   eLife publishes advances in quantitative genetics, including the genetic basis of complex traits, the maintenance of genetic variation, and their roles in evolution.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    High social status males experience accelerated epigenetic aging in wild baboons

    Jordan A Anderson et al.