Celldetective is an open-source software integrating segmentation, tracking, and event detection to perform high-throughput end-to-end study of dynamic cell interactions, without requiring coding skills, demonstrated on microscopy immunological assays.
David L Haggerty, Caleb Browning Darden, David Lovinger
Integrated pose estimation, video acquisition, and edge deployment tools make real-time behavioral analysis more accessible to neuroscience laboratories.
David Sidarta-Oliveira, Ana I Domingos, Licio A Velloso
A framework for analyzing single-cell genomics data, in which geometrical properties are harnessed to obtain insights on cellular diversity, including precise clustering, clear visualizations, and intuitive diagnostics.
Andrea Cuentas-Condori, Patricia Chanabá-López ... Daniel A Colón-Ramos
Endogenous tagging and conditional silencing of vesicular transporters reveal widespread, conserved co-transmission, and enable causal dissection of transmitter-specific synaptic function, linking molecular identity to circuit dynamics and behavior in vivo.
Transcriptomic profiling of the developing human outflow tract and adult aortic valves reveals that adult valve cells retain distinct embryonic molecular signatures.
Simultaneous tagging of multiple genes with different fluorophores provides a proof of concept for the scalability of tagging all genes in the Caenorhabditis elegans genome.
Giovanni Diana, B Semihcan Sermet ... David A DiGregorio
A Bayesian particle Gibbs framework enables unbiased spike time inference with millisecond resolution and jointly estimates uncertainties in both spike timing and model parameters from fast calcium imaging.
The Tapenade pipeline enables single-cell, whole-mount 3D quantification in dense multilayer organoids, linking spatial gene co-expression and nuclear deformation to emerging tissue-scale organization.
