Tools and Resources

A Tools and Resources article allows authors to publish the details of new experimental techniques, datasets, software tools, and other resources.

Latest articles

    1. Neuroscience

    DANCE provides an open-source and low-cost approach to quantify aggression and courtship in Drosophila

    R Sai Prathap Yadav, Paulami Dey ... Pavan Agrawal
    A low-cost, portable platform combining machine learning–based classifiers enables accurate quantification of Drosophila aggression and courtship, expanding access to behavioral neuroscience in resource-limited settings.
    1. Microbiology and Infectious Disease

    A system for functional studies of the major virulence factor of malaria parasites

    Jakob Cronshagen, Johannes Allweier ... Tobias Spielmann
    The generation of malaria parasites expressing only one of the multiple variants of their most important virulence factor enables the study of different aspects of this virulence factor.
    1. Neuroscience

    DendroTweaks, an interactive approach for unraveling dendritic dynamics

    Roman Makarov, Spyridon Chavlis, Panayiota Poirazi
    An interactive toolbox for standardizing, validating, simulating, reducing, and exploring detailed biophysical models that can be used to reveal how morpho-electric properties map to dendritic and neuronal outputs.
    1. Neuroscience

    Virtual Brain Inference (VBI), a flexible and integrative toolkit for efficient probabilistic inference on whole-brain models

    Abolfazl Ziaeemehr, Marmaduke Woodman ... Meysam Hashemi
    The Virtual Brain Inference (VBI) toolkit enables efficient, accurate, and scalable Bayesian inference over whole-brain network models, improving parameter estimation, uncertainty quantification, and predictive modeling across neuroimaging modalities toward precision medicine.
    1. Neuroscience

    Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p

    Jure Majnik, Manon Mantez ... Rosa Cossart
    A novel algorithm allowed for the continuous tracking of neurons throughout early postnatal development, revealing a transition in neural firing statistics coinciding with the onset of behaviour-dependent activity.
    1. Biochemistry and Chemical Biology

    Deep learning reveals endogenous sterols as allosteric modulators of the GPCR–Gα interface

    Sanjay Kumar Mohanty, Aayushi Mittal ... Gaurav Ahuja
    An AI-driven computational toolkit, Gcoupler, integrates ligand design, statistical modeling, and graph neural networks to predict endogenous metabolites that allosterically modulate the GPCR–Gα interface and regulate downstream signaling.
    1. Computational and Systems Biology
    2. Developmental Biology

    MorphoNet 2.0: An innovative approach for qualitative assessment and segmentation curation of large-scale 3D time-lapse imaging datasets

    Benjamin Gallean, Tao Laurent ... Emmanuel Faure
    A collaborative open-source platform enabling interactive 3D visualization, quantitative evaluation, and expert curation of complex biological morphologies to enhance the quality and reproducibility of large-scale imaging studies.
    1. Epidemiology and Global Health

    Using step selection functions to analyse human mobility using telemetry data in infectious disease epidemiology: a case study of leptospirosis

    Pablo Ruiz Cuenca, Fábio N Souza ... Emanuele Giorgi
    Step selection functions are a useful tool for analysing fine-scale human movements to understand environmental interactions in the context of infectious disease epidemiology.
    1. Neuroscience

    Hierarchical Bayesian modeling of multiregion brain cell count data

    Sydney Dimmock, Benjamin MS Exley ... Cian O'Donnell
    Bayesian hierarchical models offer powerful statistical tools for neuroscientists to analyze whole-brain cell count data, as demonstrated here using two example datasets from different laboratories.
    1. Computational and Systems Biology

    Martinize2 and Vermouth provide a unified framework for molecular topology generation

    Peter C Kroon, Fabian Grünewald ... Siewert J Marrink
    Enabling high-throughput simulations of proteins within the Martini framework.