Tools and Resources

A Tools and Resources article allows authors to publish the details of new experimental techniques, datasets, software tools, and other resources.

Latest articles

    1. Cell Biology
    2. Microbiology and Infectious Disease

    Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

    Yi Fan, Ping Lyu ... Chenchen Zhou
    1. Cell Biology

    A CRISPR screen in intestinal epithelial cells identifies novel factors for polarity and apical transport

    Katharina MC Klee, Michael W Hess ... Lukas A Huber
    Applying a CRISPR knockout screen in polarized intestinal epithelial cells and subsequent phenotypic analyses identified various genes, of which several were previously not associated with epithelial homeostasis, to be relevant for proper epithelial polarization, apical cargo transport, and endo/lysosomal morphology.
    1. Cell Biology

    Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue

    Theodore J Zwang, Rachel E Bennett ... Bradley T Hyman
    Conditions for multiplexed antibody labeling in mouse brain tissue translates to effective labeling in human brain tissue when samples are prepared similarly.
    1. Developmental Biology

    A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

    Vincent Loreau, Renate Rees ... Dirk Görlich
    A collection of 22 nanobodies against 11 different Drosophila sarcomeric protein epitopes was generated, validated in stainings and for some transgenic fly lines were generated to monitor the dynamics of the sarcomeric proteins in muscles in vivo.
    1. Computational and Systems Biology
    2. Neuroscience

    A hardware system for real time decoding of in vivo calcium imaging data

    Zhe Chen, Garrett J Blair ... Hugh T Blair
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The use of non-functional clonotypes as a natural calibrator for quantitative bias correction in adaptive immune receptor repertoire profiling

    Anastasia O Smirnova, Anna M Miroshnichenkova ... Alexander Komkov
    1. Microbiology and Infectious Disease

    Ribosomal RNA (rRNA) sequences from 33 globally distributed mosquito species for improved metagenomics and species identification

    Cassandra Koh, Lionel Frangeul ... Maria-Carla Saleh
    1. Neuroscience

    Multimodal mapping of cell types and projections in the central nucleus of the amygdala

    Yuhan Wang, Sabine Krabbe ... Scott Sternson
    1. Neuroscience

    Histological E-data registration in rodent brain spaces

    Jingyi Guo Fuglstad, Pearl Saldanha ... Jonathan R Whitlock
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single cell resolution

    Marina Ainciburu, Teresa Ezponda ... Felipe Prosper
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