Tools and Resources

Latest articles

1. 1. Developmental Biology and Stem Cells

   Live cell-lineage tracing and machine learning reveal patterns of organ regeneration

   Oriol Viader-Llargués et al.

   A combination of live cell tracking, cell-lineage tracing and machine learning shows that injured sensory organs repair accurately regardless of the extent of damage.
2. 1. Chromosomes and Gene Expression

   A gene-specific T2A-GAL4 library for Drosophila

   Pei-Tseng Lee et al.

   A library of a thousand gene-specific intronic GAL4 insertions was generated, which caused a severe loss of function, permitted the assessing of gene expression, allowed the rescue of mutated gene with UAS-cDNA constructs, and provided a tool for the reversion of mutant phenotypes in specific cells or tissues.
3. 1. Developmental Biology and Stem Cells
   2. Neuroscience

   Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex

   Marta Florio et al.

   Transcriptomic and genomic analysis provides a resource of 50 primate-specific genes preferentially expressed in neural progenitors of fetal human neocortex, 15 of which are specific to humans.
4. 1. Chromosomes and Gene Expression

   Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts

   Jason C Bell et al.
5. 1. Cell Biology
   2. Developmental Biology and Stem Cells

   An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein

   Pooran Singh Dewari et al.
6. 1. Neuroscience

   A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo

   Pierre Yger et al.

   A spike sorting toolbox to quickly and reliably access the activity of thousands of neurons recorded with dense extracellular probes.
7. 1. Developmental Biology and Stem Cells

   Multi-view light-sheet imaging and tracking with the MaMuT software reveals the cell lineage of a direct developing arthropod limb

   Carsten Wolff et al.
8. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Method for identification of condition-associated public antigen receptor sequences

   Mikhail V Pogorelyy et al.

   Without using control cohorts, a statistical method identifies candidates for immune receptors associated with diseases from repertoire sequencing datasets.
9. 1. Neuroscience

   Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data

   Pengcheng Zhou et al.

   A new open-source computational toolbox for processing in vivo microendoscopic calcium imaging data performs signal demixing and denoising much more accurately than previously available methods, significantly improving the utility of this imaging modality.
10. 1. Cell Biology
    2. Genomics and Evolutionary Biology

    Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites

    Adam J Reid et al.

    Plasmodium parasite transcription shifts dramatically along asexual development, and transmission stages variably express important immune evasion genes, suggesting much interesting biology has until now been hidden by bulk analyses.