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Tools and Resources
A Tools and Resources article allows authors to publish the details of new experimental techniques, datasets, software tools, and other resources.
Structural Biology and Molecular Biophysics
Locating Macromolecular Assemblies in Cells by 2D Template Matching with
Bronwyn A Lucas et al.
An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish
Dianne Lumaquin et al.
A novel transgenic lipid droplet reporter in transparent
zebrafish allows direct visualization of individual lipid droplets in a living animal.
Computational and Systems Biology
Genetics and Genomics
Detecting adaptive introgression in human evolution using convolutional neural networks
Graham Gower et al.
Convolutional neural networks are an effective tool for detecting archaic adaptive introgression from genomic data.
Epidemiology and Global Health
FnCas9 based CRISPR diagnostic for rapid and accurate detection of major SARS-CoV2 variants on a paper strip
Manoj Kumar et al.
High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion
Haining Zhong et al.
Introduction to the EQIPD quality system
Anton Bespalov et al.
A system has been developed that supports generation of reliable basic biomedical research data while being open-access and lean with no negative impact on freedom of scientific exploration.
Cross-species analysis defines the conservation of anatomically segregated VMH neuron populations
Alison H Affinati et al.
This atlas and analysis of conserved ventromedial hypothalamic nucleus (VMH) neuron populations provides an unbiased starting point for the analysis of VMH circuitry and function.
Metal microdrive and head cap system for silicon probe recovery in freely moving rodent
Mihály Vöröslakos et al.
A reusable system of 3D printed stainless steel microdrive and plastic head cap allows stable recording of electrophysiological data in mice and rats and easy recovery of silicon probes.
Optogenetic strategies for high-efficiency all-optical interrogation using blue-light-sensitive opsins
Angelo Forli et al.
A new soma-targeted variant of the large-conductance blue-light-sensitive opsin CoChR combined with advanced optical stimulation methods allows high-efficiency all-optical neuronal imaging and stimulation in mouse brain in vivo.
Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis
Kazuhide S Okuda et al.
Live-imaging of a transgenic reporter of vascular Erk signalling in zebrafish reveals sequential signalling mechanisms during the initiation of regeneration in wounded blood vessels.
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