Tools and Resources

Latest articles

1. 1. Microbiology and Infectious Disease

   Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes

   William J Watterson et al.

   High-throughput droplet-based cultivation of gut microbes reduces biases of traditional cultivation strategies and thereby enables detection of difficult-to-culture organisms, which is required in applications such as antibiotic screening.
2. 1. Neuroscience

   A Matlab-based toolbox for characterizing behavior of rodents engaged in string-pulling

   Samsoon Inayat et al.

   Analysis methods for video data of rodents engaged in string-pulling behavior have been developed and used to highlight differences in motion profiles of Swiss Webster and C57Bl/6 mice.
3. 1. Cell Biology
   2. Genetics and Genomics

   A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing

   Weina Zhang et al.
4. 1. Cell Biology

   Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

   Jan N Hansen et al.

   Trafficking of optogenetic tools to primary cilia using nanobodies allows to study cAMP signaling with spatial and temporal resolution independent of the cell body.
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations

   Lucas Farnung et al.

   The structure of the chromatin remodeller CHD4 bound to a nucleosome reveals differences to the known Chd1-nucleosome complex and maps cancer mutations.
6. 1. Neuroscience

   Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages

   Timothy H Murphy et al.

   A new methodology and protocol use automated brain imaging and task training technology to probe links between behavior and mouse cortical circuits.
7. 1. Evolutionary Biology
   2. Genetics and Genomics

   Predicting geographic location from genetic variation with deep neural networks

   CJ Battey et al.

   Neural networks allow fast and accurate prediction of individual spatial locations from genotypes or sequencing data.
8. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Topologically correct synthetic reconstruction of pathogen social behavior found during Yersinia growth in deep tissue sites

   Stacie A Clark et al.

   Tissue infection by an extracellular pathogen is recapitulated by encasing a bacterial colony within a droplet gel to allow immune cell attack, driving spatially-controlled microbial social behavior.
9. 1. Immunology and Inflammation
   2. Neuroscience

   Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain

   Jeremy Carlos Burns et al.
10. 1. Computational and Systems Biology
    2. Evolutionary Biology

    A community-maintained standard library of population genetic models

    Jeffrey R Adrion et al.