The development of an automated micronucleus segmentation program enables population-level comparisons between cells with and without micronuclei and defines a highly limited response to micronucleus formation or rupture.
AACDB provides a comprehensive, manually curated antigen-antibody interface dataset with rich metadata, interaction annotations, and therapeutic target annotations to advance antibody drug development.
Sarah Benkeder, Son-Michel Dinh ... Jean-Christophe Comte
MorphoCellSorter is a versatile, user-friendly tool that automates microglial morphology ranking, enabling standardized, reproducible analysis across diverse models, imaging techniques, and conditions using principal component analysis and Andrews plots.
Derek G Epiney, Gonzalo Morales Chaya ... Chris Q Doe
The central complex of the adult Drosophila brain, required for sensorimotor integration, is transcriptionally complex as detected by single-cell transcriptome analysis.
Noëmie Mermet-Joret, Andrea Moreno ... Sadegh Nabavi
An optogenetic system capable of precise, high-frequency neuronal excitation using red pulsed light and rapid, millisecond inhibition using blue light.
ADPT enhances the robustness of animal pose estimation by minimizing keypoint tracking drift, enabling more accurate multi-animal tracking and facilitating refined behavioral analysis across species.
Novel genetically encoded tools PFE3, paGFE3, and chGFE3 can be used to reversibly ablate excitatory synapses constitutively, and inhibitory synapses in a light- or chemically dependent manner.
SAVEMONEY is a computational tool that guides users to mix plasmids prior to nanopore sequencing, reducing the effective cost of whole-plasmid sequencing to below that of Sanger sequencing.
The established under-flow migration tracker (UFMTrack) framework allows for automated and scalable studies of immune cell interactions with and extravasation across endothelial monolayer under flow in vitro.
Eric R Brooks, Andrew R Moorman ... Jennifer A Zallen
Single-cell RNA sequencing and computational analysis define a spatial and temporal map of gene expression during early patterning and morphogenesis of the mouse cranial neural plate, providing a resource for elucidating the transcriptional basis of mammalian brain development.
