Tools and Resources

A Tools and Resources article allows authors to publish the details of new experimental techniques, datasets, software tools, and other resources.

Latest articles

    1. Stem Cells and Regenerative Medicine

    Generation of functional hepatocytes by forward programming with nuclear receptors

    Rute A Tomaz et al.
    Forward programming of human pluripotent stem cells with a combination of four transcription factors allows the production of functional hepatocytes.
    1. Neuroscience

    Exploring the expression patterns of palmitoylating and de-palmitoylating enzymes in the mouse brain using the curated RNA-seq database BrainPalmSeq

    Angela R Wild et al.
    A curated resource to study the brain RNA expression patterns of the genes that regulate palmitoylation is presented, alongside a detailed exploration of how these patterns can inform future research.
    1. Cancer Biology

    Robust and Efficient Assessment of Potency (REAP) as a quantitative tool for dose-response curve estimation

    Shouhao Zhou et al.
    A novel approach together with a user-friendly web-based analytic tool, coined 'REAP', was proposed to improve the quantitative assessment of dose-response relationship and drug potency.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Green fluorescent protein-like pigments optimise the internal light environment in symbiotic reef-building corals

    Elena Bollati et al.
    Scalar irradiance microsensor measurements performed inside the tissue of living corals show that absorption and fluorescence emission by host pigments produce dramatic spectral alterations in the light environment experienced by the symbionts.
    1. Immunology and Inflammation

    A CD4+ T cell reference map delineates subtype-specific adaptation during acute and chronic viral infections

    Massimo Andreatta et al.
    Description of the transcriptional and clonal landscape of virus-specific CD4+ T cells in acute and chronic viral infections, and a new reference map to interpret CD4 T cell diversity across tissues and biological models.
    1. Neuroscience

    A viral toolbox for conditional and transneuronal gene expression in zebrafish

    Chie Satou et al.
    Novel procedures for viral gene transfer in zebrafish enable visualization and manipulation of specific neurons.
    1. Immunology and Inflammation

    A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding

    Brooke D Huisman et al.
    Yeast surface-displayed libraries, when coupled with pooled oligonucleotide synthesis and next-generation sequencing, can be used as a platform to assess binding of whole viral proteomes to class II major histocompatibility complex proteins.