Soham Mukhopadhyay, Muhammad Asim Javed ... Edel Perez-Lopez
Comparative structural genomics identifies unique effector architectures and ankyrin-mediated host targeting, revealing central and conserved strategies that underpin the pathogenicity of diverse gall-forming microbial species across evolutionary lineages.
David Ferreiro, Luis Daniel González-Vázquez ... Miguel Arenas
Forecasting protein evolution in terms of folding stability using state-of-the-art population genetics and substitution models is feasible in rugged fitness landscapes, whereas forecasting exact amino acid sequences remains more challenging.
Fully autonomous home-cage training system HABITS enables mice to learn complex cognitive behaviors without human intervention, expanding behavioral paradigms and optimizing training efficiency through machine teaching algorithms.
Bioluminescence imaging in live mice was used to assess the abilities of systemically introduced adeno-associated viral capsids containing enhancer regulatory sequences to target transgene expression to myocardial injuries.
Ludovica Labruna, Christina Merrick ... Daniel Sheltraw
kTMP is a novel, non-invasive brain stimulation method that, via continuous magnetic induction, safely and effectively increases cortical excitability without any tactile sensation.
A novel point assignment method achieves 80% f1-score in single-neuron reconstruction across broad brain regions, enabling high-throughput brain-wide projection mapping.
Eloise Giraud, Michael Lynn ... Jean-Philippe Thivierge
A novel software tool and ground-truth optogenetic validation is provided to automatically detect putative excitatory and inhibitory cells in neuronal recordings performed with large-scale multielectrode arrays.
A versatile computational framework realistically simulates fluorescence lifetime data in biological systems, enhancing rigor by quantifying signal variance and identifying limitations, and enabling innovations such as multiplexed dynamic biosensor imaging.
