Tools and Resources

A Tools and Resources article allows authors to publish the details of new experimental techniques, datasets, software tools, and other resources.

Latest articles

    1. Neuroscience

    Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage assisted behavioral innovation and testing system

    Bowen Yu, Penghai Li ... Yaoyao Hao
    Fully autonomous home-cage training system HABITS enables mice to learn complex cognitive behaviors without human intervention, expanding behavioral paradigms and optimizing training efficiency through machine teaching algorithms.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium

    David W Wolfson, Joshua A Hull ... Kenneth D Poss
    Bioluminescence imaging in live mice was used to assess the abilities of systemically introduced adeno-associated viral capsids containing enhancer regulatory sequences to target transgene expression to myocardial injuries.
    1. Neuroscience

    Mining the neuroimaging literature

    Jérome Dockès, Kendra M Oudyk ... Jean-Baptiste Poline
    New tools for literature mining, such as automated analysis of the research literature, are accessible, scalable, and reliable.
    1. Neuroscience

    Kilohertz transcranial magnetic perturbation (kTMP) as a new non-invasive method to modulate cortical excitability

    Ludovica Labruna, Christina Merrick ... Daniel Sheltraw
    kTMP is a novel, non-invasive brain stimulation method that, via continuous magnetic induction, safely and effectively increases cortical excitability without any tactile sensation.
    1. Neuroscience

    Automatic and accurate reconstruction of long-range axonal projections of single-neuron in mouse brain

    Lin Cai, Taiyu Fan ... Shaoqun Zeng
    A novel point assignment method achieves 80% f1-score in single-neuron reconstruction across broad brain regions, enabling high-throughput brain-wide projection mapping.
    1. Genetics and Genomics

    Identifying in vivo genetic dependencies of melanocyte and melanoma development

    Sarah Perlee, Yilun Ma ... Richard M White
    A zebrafish Cas9 knock-in model enables lineage-specific gene disruption to uncover genetic dependencies in development and disease.
    1. Computational and Systems Biology

    Unsupervised pipeline for the identification of cortical excitatory and inhibitory neurons in high-density multielectrode arrays with ground-truth validation

    Eloise Giraud, Michael Lynn ... Jean-Philippe Thivierge
    A novel software tool and ground-truth optogenetic validation is provided to automatically detect putative excitatory and inhibitory cells in neuronal recordings performed with large-scale multielectrode arrays.
    1. Cell Biology
    2. Neuroscience

    The promise and peril of comparing fluorescence lifetime in biology revealed by simulations

    Pingchuan Ma, Peter Chen ... Yao Chen
    A versatile computational framework realistically simulates fluorescence lifetime data in biological systems, enhancing rigor by quantifying signal variance and identifying limitations, and enabling innovations such as multiplexed dynamic biosensor imaging.
    1. Developmental Biology

    Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs

    Çağrı Çevrim, Béryl Laplace-Builhé ... Michalis Averof
    Live imaging allows tracking cellular behaviours and cell fates during the entire course of leg regeneration, spanning approximately one week, in a crustacean model.
    1. Biochemistry and Chemical Biology

    Phage-displayed synthetic library and screening platform for nanobody discovery

    Baolong Xia, Ah-Ram Kim ... Norbert Perrimon
    A phage-displayed synthetic library and screening platform offer a streamlined, cost-effective solution for nanobody discovery.