(A) Distribution of fasting genes annotated with BCL6 and/or PPARα binding peaks. Differential fasting genes here include all significantly different genes with fasting (adjusted p-value<0.05). (B) Histogram showing the frequency of shared BCL6-PPARα peaks, PPARα only peaks, and BCL6 only peaks per fasting-regulated gene. Inset shows box plots of peaks per gene, denoting interquartile range (colored box), median (horizontal black line), mean (black ‘+’), and min to max (whiskers). (C) Absolute value of log2 fold change (|LFC|) in expression of genes differentially expressed with fasting (adjusted p-value<0.05) with a nearby shared BCL6-PPARα peak; PPARα only peak; BCL6 only peak; non-overlapping BCL6 and PPARα peaks; or no BCL6 or PPARα peak (neither). Violin plots display median (white square), interquartile range (black rectangle), 95% confidence interval (black line), and frequency (colored density plot). For (B) and (C), the Kruskal-Wallis test and Dunn’s post-hoc testing were used to compare significant differences between groups. ∗p<0.05, ∗∗p<0.01, ∗∗∗p<0.001 compares to genes with a nearby shared BCL6-PPARα peak. Similarly, ‘#’ denotes comparison to PPARα only, ‘ and ’ denotes comparison to BCL6 only, and ‘^’ denotes comparison to neither. (D) Metascape gene enrichment and clustering analysis of genes differentially expressed with fasting that have an annotated shared BCL6-PPARα peak; PPARα only peak; or neither.