Anosognosia for hemiplegia as a tripartite disconnection syndrome
- Sapienza University of Rome, Italy
- University of Verona, Italy
- Sorbonne Universities, France
- UPMC UMRS 1127, Inserm U 1127, CNRS UMR 7225, France
- The University of Texas at Austin Dell Medical School, United States
- University of Hertfordshire, United Kingdom
- IRCSS Sacro Cuore-Don Calabria Hospital, Italy
- University College London, United Kingdom
- Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA University of Bordeaux, France
Figures
Figure 1
On the top half, statistical mapping of the lesioned areas in AHP.
(a) right hemisphere (b) striatum (c) insula (d) axial sections. Pal: pallidum; Put: putamen; ALg: anterior long gyrus; PSg: posterior short gyrus; MSg: middle short gyrus; Tp: temporal pole. On the bottom half, statistical mapping of the brain disconnections in AHP. (e) right hemisphere lateral view; (f) right hemisphere medial view; (g) axial sections. TPJ: temporo-parietal junction; VPF: ventral prefrontal cortex; preSMA: pre-supplementary area; H: hippocampus; Cing: cingulum; SLF III: third (ventral) branch of the superior longitudinal fasciculus; PreSMA: pre-supplementary motor area.
Figure 2
Motor awareness network.
(a) right hemisphere medial view (left) right hemisphere lateral view (right); (b-c) Bayes Factors for all models, each one representing the hypothesis that the damage to grey matter structure and/or the tract disconnection is necessary to explain AHP, against the clinical/demographic model. Ins: insula; TP: temporal pole; Put: putamen; FST: fronto-striatal tract; Cing: cingulum; FAT: frontal aslant tract; SLF III: third branch of the superior longitudinal fasciculus.
Tables
Table 1
For AHP and control groups, mean and (±standard deviation) of demographic and clinical variables, neurological and neuropsychological assessments are reported.
https://doi.org/10.7554/eLife.46075.004| Ahp (N = 95) | Hp (N = 79) | |
|---|---|---|
| Demographic and clinical | ||
| Age (years) | 68.48 ± 12.54 | 63,01 ± 13.49 |
| Education (years) | 9.46 ± 3.74 | 11 ± 3.77 |
| Interval (days) | 35.74 ± 40.58 | 44.42 ± 46.7 |
| Lesion Size (voxels) | 134327.74 ± 113196.17 | 113082.73 ± 120844.22 |
| Anosognosia | ||
| Bisiach score | 2.46 ± 0.6 | 0 ± 0 |
| Personal neglect | ||
| Comb | −0.3 ± 0.4 | −0.06 ± 0.47 |
| Extra-personal neglect | ||
| Line cancellation (number of items cancelled) | 19.26 ± 11.9 | 28.35 ± 10.77 |
| Memory Span | ||
| Digit/verbal span (number of items recalled) | 5.65 ± 2.14 | 6.83 ± 2.46 |
| Motor index | ||
| MRC (LUL) | 0.15 ± 0.42 | 0.6 ± 0.99 |
Additional files
-
Source data 1
- https://doi.org/10.7554/eLife.46075.005
-
Transparent reporting form
- https://doi.org/10.7554/eLife.46075.006
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Anosognosia for hemiplegia as a tripartite disconnection syndrome
eLife 8:e46075.
https://doi.org/10.7554/eLife.46075
