1. Neuroscience
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A thalamocortical circuit for updating action-outcome associations

  1. Virginie Fresno
  2. Shauna L Parkes
  3. Angélique Faugère
  4. Etienne Coutureau  Is a corresponding author
  5. Mathieu Wolff  Is a corresponding author
  1. CNRS, INCIA, UMR 5287, France
  2. Université de Bordeaux, INCIA, UMR 5287, France
Research Advance
Cite this article as: eLife 2019;8:e46187 doi: 10.7554/eLife.46187
4 figures and 1 additional file

Figures

Unilateral cortical and thalamic lesions.

Photomicrographs of thionin-stained coronal sections showing representative OFC (A), MD (B) and Sub (C) lesions. A dotted line highlights thalamic lesions. The extent of each lesion for the included rats is shown on the right (D–F) with the largest lesion shown in gray and the smallest in black (from top to bottom: OFC, MD and Sub). Numbers indicate approximate location relative to bregma (in mm).

https://doi.org/10.7554/eLife.46187.002
Experimental paradigm to assess flexible goal-directed responding.

The design is adapted from Parkes et al. (2018) and consists in providing a choice test following outcome devaluation after an initial instrumental training phase (green), but also after reversal of action-outcome contingencies (orange).

https://doi.org/10.7554/eLife.46187.003
Disconnecting the OFC and the MD.

Mean rate of lever presses (± sem) during instrumental conditioning (A) or during action-outcome contingency reversal (D). Lever presses (% Baseline,+ sem) during the initial choice test (B) or following contingency reversal (E). Consumption tests following the initial choice test (C) and the post-reversal test (F).

https://doi.org/10.7554/eLife.46187.004
Disconnecting the OFC and the Sub.

Mean rate of lever presses (± sem) during instrumental conditioning (A) or during action-outcome contingency reversal (D). Lever presses (% Baseline,+ sem) during the choice test that followed outcome devaluation immediately after initial instrumental conditioning (B) or contingency reversal (E). Consumption tests following the initial choice test (C) or the post-reversal one (F).

https://doi.org/10.7554/eLife.46187.005

Data availability

All data generated or analysed during this study are included in the manuscript and supporting files.

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